Infertility associated with multi-tailed spermatozoa and excessive DNA- MedGen UID:
- 98020
- •Concept ID:
- C0403812
- •
- Disease or Syndrome
Spermatogenic failure-5 (SPGF5) is a form of male infertility associated with large-headed, multiflagellar, polyploid spermatozoa (Dieterich et al., 2007).
For a general phenotypic description and a discussion of genetic heterogeneity of spermatogenic failure, see SPGF1 (258150).
Spermatogenic failure 51- MedGen UID:
- 1780365
- •Concept ID:
- C5543033
- •
- Disease or Syndrome
Spermatogenic failure-51 (SPGF51) is characterized by male infertility due to severe asthenoteratozoospermia. Patients exhibit multiple morphologic abnormalities of the flagella (MMAF), including absent, short, bent, coiled, and irregular-caliber tails, resulting in severely reduced to absent motility. Abnormalities of the sperm head, base, and acrosome have also been observed (Martinez et al., 2020).
For a discussion of genetic heterogeneity of spermatogenic failure, see SPGF1 (258150).