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Abnormality of cardiovascular system electrophysiology

MedGen UID:
1393551
•Concept ID:
C4476872
•
Finding
HPO: HP:0030956

Definition

An anomaly of the electrical conduction physiology of the heart. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormality of cardiovascular system electrophysiology

Professional guidelines

PubMed

Inappropriate Sinus Tachycardia: Etiology, Pathophysiology, and Management: JACC Review Topic of the Week.
Ahmed A, Pothineni NVK, Charate R, Garg J, Elbey M, de Asmundis C, LaMeir M, Romeya A, Shivamurthy P, Olshansky B, Russo A, Gopinathannair R, Lakkireddy D
J Am Coll Cardiol 2022 Jun 21;79(24):2450-2462. doi: 10.1016/j.jacc.2022.04.019. PMID: 35710196
Diagnosis of arrhythmogenic cardiomyopathy: The Padua criteria.
Corrado D, Perazzolo Marra M, Zorzi A, Beffagna G, Cipriani A, Lazzari M, Migliore F, Pilichou K, Rampazzo A, Rigato I, Rizzo S, Thiene G, Anastasakis A, Asimaki A, Bucciarelli-Ducci C, Haugaa KH, Marchlinski FE, Mazzanti A, McKenna WJ, Pantazis A, Pelliccia A, Schmied C, Sharma S, Wichter T, Bauce B, Basso C
Int J Cardiol 2020 Nov 15;319:106-114. Epub 2020 Jun 16 doi: 10.1016/j.ijcard.2020.06.005. PMID: 32561223
2019 HRS expert consensus statement on evaluation, risk stratification, and management of arrhythmogenic cardiomyopathy.
Towbin JA, McKenna WJ, Abrams DJ, Ackerman MJ, Calkins H, Darrieux FCC, Daubert JP, de Chillou C, DePasquale EC, Desai MY, Estes NAM 3rd, Hua W, Indik JH, Ingles J, James CA, John RM, Judge DP, Keegan R, Krahn AD, Link MS, Marcus FI, McLeod CJ, Mestroni L, Priori SG, Saffitz JE, Sanatani S, Shimizu W, van Tintelen JP, Wilde AAM, Zareba W
Heart Rhythm 2019 Nov;16(11):e301-e372. Epub 2019 May 9 doi: 10.1016/j.hrthm.2019.05.007. PMID: 31078652

Recent clinical studies

Etiology

2019 HRS expert consensus statement on evaluation, risk stratification, and management of arrhythmogenic cardiomyopathy.
Towbin JA, McKenna WJ, Abrams DJ, Ackerman MJ, Calkins H, Darrieux FCC, Daubert JP, de Chillou C, DePasquale EC, Desai MY, Estes NAM 3rd, Hua W, Indik JH, Ingles J, James CA, John RM, Judge DP, Keegan R, Krahn AD, Link MS, Marcus FI, McLeod CJ, Mestroni L, Priori SG, Saffitz JE, Sanatani S, Shimizu W, van Tintelen JP, Wilde AAM, Zareba W
Heart Rhythm 2019 Nov;16(11):e301-e372. Epub 2019 May 9 doi: 10.1016/j.hrthm.2019.05.007. PMID: 31078652
Catheter Ablation of Idiopathic Ventricular Arrhythmias.
Pathak RK, Ariyarathna N, Garcia FC, Sanders P, Marchlinski FE
Heart Lung Circ 2019 Jan;28(1):102-109. Epub 2018 Oct 17 doi: 10.1016/j.hlc.2018.10.012. PMID: 30554597
Bradyarrhythmias in Congenital Heart Disease.
Carlson SK, Patel AR, Chang PM
Card Electrophysiol Clin 2017 Jun;9(2):177-187. Epub 2017 Mar 22 doi: 10.1016/j.ccep.2017.02.002. PMID: 28457234
Long term risk of Wolff-Parkinson-White pattern and syndrome.
Kim SS, Knight BP
Trends Cardiovasc Med 2017 May;27(4):260-268. Epub 2016 Dec 5 doi: 10.1016/j.tcm.2016.12.001. PMID: 28108086
hERG K(+) channels: structure, function, and clinical significance.
Vandenberg JI, Perry MD, Perrin MJ, Mann SA, Ke Y, Hill AP
Physiol Rev 2012 Jul;92(3):1393-478. doi: 10.1152/physrev.00036.2011. PMID: 22988594

Diagnosis

Diagnosis of arrhythmogenic cardiomyopathy: The Padua criteria.
Corrado D, Perazzolo Marra M, Zorzi A, Beffagna G, Cipriani A, Lazzari M, Migliore F, Pilichou K, Rampazzo A, Rigato I, Rizzo S, Thiene G, Anastasakis A, Asimaki A, Bucciarelli-Ducci C, Haugaa KH, Marchlinski FE, Mazzanti A, McKenna WJ, Pantazis A, Pelliccia A, Schmied C, Sharma S, Wichter T, Bauce B, Basso C
Int J Cardiol 2020 Nov 15;319:106-114. Epub 2020 Jun 16 doi: 10.1016/j.ijcard.2020.06.005. PMID: 32561223
2019 HRS expert consensus statement on evaluation, risk stratification, and management of arrhythmogenic cardiomyopathy.
Towbin JA, McKenna WJ, Abrams DJ, Ackerman MJ, Calkins H, Darrieux FCC, Daubert JP, de Chillou C, DePasquale EC, Desai MY, Estes NAM 3rd, Hua W, Indik JH, Ingles J, James CA, John RM, Judge DP, Keegan R, Krahn AD, Link MS, Marcus FI, McLeod CJ, Mestroni L, Priori SG, Saffitz JE, Sanatani S, Shimizu W, van Tintelen JP, Wilde AAM, Zareba W
Heart Rhythm 2019 Nov;16(11):e301-e372. Epub 2019 May 9 doi: 10.1016/j.hrthm.2019.05.007. PMID: 31078652
The Current State and Future Potential of Pediatric and Congenital Electrophysiology.
Sanatani S, Cunningham T, Khairy P, Cohen MI, Hamilton RM, Ackerman MJ
JACC Clin Electrophysiol 2017 Mar;3(3):195-206. Epub 2017 Mar 20 doi: 10.1016/j.jacep.2017.01.008. PMID: 29759513
Pediatric electrophysiology.
Kanter RJ
Curr Opin Cardiol 1993 Jan;8(1):119-27. doi: 10.1097/00001573-199301000-00015. PMID: 10148090
Preexcitation.
Ferrer MI
Am J Med 1977 May;62(5):715-30. doi: 10.1016/0002-9343(77)90875-0. PMID: 324276

Therapy

PM(2.5)-induced iron homeostasis imbalance triggers cardiac hypertrophy through ferroptosis in a selective autophagy crosstalk manner.
Li T, Sun M, Sun Q, Ren X, Xu Q, Sun Z, Duan J
Redox Biol 2024 Jun;72:103158. Epub 2024 Apr 12 doi: 10.1016/j.redox.2024.103158. PMID: 38631121Free PMC Article
Half-Dose Direct Oral Anticoagulation Versus Standard Antithrombotic Therapy After Left Atrial Appendage Occlusion.
Della Rocca DG, Magnocavallo M, Di Biase L, Mohanty S, Trivedi C, Tarantino N, Gianni C, Lavalle C, Van Niekerk CJ, Romero J, Briceño DF, Bassiouny M, Al-Ahmad A, Burkhardt JD, Natale VN, Gallinghouse GJ, Del Prete A, Forleo GB, Sanchez J, Lakkireddy D, Horton RP, Gibson DN, Natale A
JACC Cardiovasc Interv 2021 Nov 8;14(21):2353-2364. Epub 2021 Oct 13 doi: 10.1016/j.jcin.2021.07.031. PMID: 34656496
Enhanced Cardiomyocyte NLRP3 Inflammasome Signaling Promotes Atrial Fibrillation.
Yao C, Veleva T, Scott L Jr, Cao S, Li L, Chen G, Jeyabal P, Pan X, Alsina KM, Abu-Taha I Dr, Ghezelbash S, Reynolds CL, Shen YH, LeMaire SA, Schmitz W, Müller FU, El-Armouche A, Tony Eissa N, Beeton C, Nattel S, Wehrens XHT, Dobrev D, Li N
Circulation 2018 Nov 13;138(20):2227-2242. doi: 10.1161/CIRCULATIONAHA.118.035202. PMID: 29802206Free PMC Article
The Current State and Future Potential of Pediatric and Congenital Electrophysiology.
Sanatani S, Cunningham T, Khairy P, Cohen MI, Hamilton RM, Ackerman MJ
JACC Clin Electrophysiol 2017 Mar;3(3):195-206. Epub 2017 Mar 20 doi: 10.1016/j.jacep.2017.01.008. PMID: 29759513
Pediatric electrophysiology.
Kanter RJ
Curr Opin Cardiol 1993 Jan;8(1):119-27. doi: 10.1097/00001573-199301000-00015. PMID: 10148090

Prognosis

Characterization of unipolar electrogram morphology: a novel tool for quantifying conduction inhomogeneity.
Ye Z, van Schie MS, Pool L, Heida A, Knops P, Taverne YJHJ, Brundel BJJM, de Groot NMS
Europace 2023 Nov 2;25(11) doi: 10.1093/europace/euad324. PMID: 37931071Free PMC Article
Atrial fibrillation: Neurogenic or myogenic?
Scridon A, Şerban RC, Chevalier P
Arch Cardiovasc Dis 2018 Jan;111(1):59-69. Epub 2017 Dec 8 doi: 10.1016/j.acvd.2017.11.001. PMID: 29229215
Long term risk of Wolff-Parkinson-White pattern and syndrome.
Kim SS, Knight BP
Trends Cardiovasc Med 2017 May;27(4):260-268. Epub 2016 Dec 5 doi: 10.1016/j.tcm.2016.12.001. PMID: 28108086
Cellular and molecular electrophysiology of atrial fibrillation initiation, maintenance, and progression.
Heijman J, Voigt N, Nattel S, Dobrev D
Circ Res 2014 Apr 25;114(9):1483-99. doi: 10.1161/CIRCRESAHA.114.302226. PMID: 24763466
Preexcitation.
Ferrer MI
Am J Med 1977 May;62(5):715-30. doi: 10.1016/0002-9343(77)90875-0. PMID: 324276

Clinical prediction guides

PM(2.5)-induced iron homeostasis imbalance triggers cardiac hypertrophy through ferroptosis in a selective autophagy crosstalk manner.
Li T, Sun M, Sun Q, Ren X, Xu Q, Sun Z, Duan J
Redox Biol 2024 Jun;72:103158. Epub 2024 Apr 12 doi: 10.1016/j.redox.2024.103158. PMID: 38631121Free PMC Article
Characterization of unipolar electrogram morphology: a novel tool for quantifying conduction inhomogeneity.
Ye Z, van Schie MS, Pool L, Heida A, Knops P, Taverne YJHJ, Brundel BJJM, de Groot NMS
Europace 2023 Nov 2;25(11) doi: 10.1093/europace/euad324. PMID: 37931071Free PMC Article
Loss of the Atrial Fibrillation-Related Gene, Zfhx3, Results in Atrial Dilation and Arrhythmias.
Jameson HS, Hanley A, Hill MC, Xiao L, Ye J, Bapat A, Ronzier E, Hall AW, Hucker WJ, Clauss S, Barazza M, Silber E, Mina JA, Tucker NR, Mills RW, Dong JT, Milan DJ, Ellinor PT
Circ Res 2023 Aug 4;133(4):313-329. Epub 2023 Jul 14 doi: 10.1161/CIRCRESAHA.123.323029. PMID: 37449401Free PMC Article
Half-Dose Direct Oral Anticoagulation Versus Standard Antithrombotic Therapy After Left Atrial Appendage Occlusion.
Della Rocca DG, Magnocavallo M, Di Biase L, Mohanty S, Trivedi C, Tarantino N, Gianni C, Lavalle C, Van Niekerk CJ, Romero J, Briceño DF, Bassiouny M, Al-Ahmad A, Burkhardt JD, Natale VN, Gallinghouse GJ, Del Prete A, Forleo GB, Sanchez J, Lakkireddy D, Horton RP, Gibson DN, Natale A
JACC Cardiovasc Interv 2021 Nov 8;14(21):2353-2364. Epub 2021 Oct 13 doi: 10.1016/j.jcin.2021.07.031. PMID: 34656496
Atrial fibrillation: Neurogenic or myogenic?
Scridon A, Şerban RC, Chevalier P
Arch Cardiovasc Dis 2018 Jan;111(1):59-69. Epub 2017 Dec 8 doi: 10.1016/j.acvd.2017.11.001. PMID: 29229215

Recent systematic reviews

Chiari network for the interventional cardiologist: A hidden enemy at the heart gate - A systematic review of the literature.
Ali H, Lupo P, Cristiano E, Nicolì L, Foresti S, De Ambroggi G, Anderson RH, De Lucia C, Turturiello D, Paganini EM, Bessi R, Farghaly AAA, Butera G, Cappato R
Int J Cardiol 2023 Mar 15;375:23-28. Epub 2022 Dec 29 doi: 10.1016/j.ijcard.2022.12.046. PMID: 36587656
Systematic review of electrophysiology procedures in patients with obstruction of the inferior vena cava.
Al-Sinan A, Chan KH, Young GD, Martin A, Sepahpour A, Sy RW
J Cardiovasc Electrophysiol 2022 Jun;33(6):1300-1311. Epub 2022 Apr 30 doi: 10.1111/jce.15505. PMID: 35441755Free PMC Article
Absent pulmonary valve with tricuspid atresia/stenosis: literature review with new three long-term cases.
Kawasaki Y, Murakami Y, Fujino M, Sasaki T, Nakamura K, Yoshida Y, Suzuki T, Nishigaki K, Ehara E
Heart Vessels 2022 Jan;37(1):142-151. Epub 2021 Jun 5 doi: 10.1007/s00380-021-01887-y. PMID: 34089363
The cardiovascular effects of amodiaquine and structurally related antimalarials: An individual patient data meta-analysis.
Chan XHS, Haeusler IL, Win YN, Pike J, Hanboonkunupakarn B, Hanafiah M, Lee SJ, Djimdé A, Fanello CI, Kiechel JR, Lacerda MV, Ogutu B, Onyamboko MA, Siqueira AM, Ashley EA, Taylor WR, White NJ
PLoS Med 2021 Sep;18(9):e1003766. Epub 2021 Sep 7 doi: 10.1371/journal.pmed.1003766. PMID: 34492005Free PMC Article
Clinical Potential of Beat-to-Beat Diastolic Interval Control in Preventing Cardiac Arrhythmias.
Kulkarni K, Walton RD, Armoundas AA, Tolkacheva EG
J Am Heart Assoc 2021 Jun;10(11):e020750. Epub 2021 May 22 doi: 10.1161/JAHA.121.020750. PMID: 34027678Free PMC Article

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