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Abnormality of cardiovascular system electrophysiology

MedGen UID:
1393551
•Concept ID:
C4476872
•
Finding
HPO: HP:0030956

Definition

An anomaly of the electrical conduction physiology of the heart. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormality of cardiovascular system electrophysiology

Professional guidelines

PubMed

Inappropriate Sinus Tachycardia: Etiology, Pathophysiology, and Management: JACC Review Topic of the Week.
Ahmed A, Pothineni NVK, Charate R, Garg J, Elbey M, de Asmundis C, LaMeir M, Romeya A, Shivamurthy P, Olshansky B, Russo A, Gopinathannair R, Lakkireddy D
J Am Coll Cardiol 2022 Jun 21;79(24):2450-2462. doi: 10.1016/j.jacc.2022.04.019. PMID: 35710196
Diagnosis of arrhythmogenic cardiomyopathy: The Padua criteria.
Corrado D, Perazzolo Marra M, Zorzi A, Beffagna G, Cipriani A, Lazzari M, Migliore F, Pilichou K, Rampazzo A, Rigato I, Rizzo S, Thiene G, Anastasakis A, Asimaki A, Bucciarelli-Ducci C, Haugaa KH, Marchlinski FE, Mazzanti A, McKenna WJ, Pantazis A, Pelliccia A, Schmied C, Sharma S, Wichter T, Bauce B, Basso C
Int J Cardiol 2020 Nov 15;319:106-114. Epub 2020 Jun 16 doi: 10.1016/j.ijcard.2020.06.005. PMID: 32561223
2019 HRS expert consensus statement on evaluation, risk stratification, and management of arrhythmogenic cardiomyopathy.
Towbin JA, McKenna WJ, Abrams DJ, Ackerman MJ, Calkins H, Darrieux FCC, Daubert JP, de Chillou C, DePasquale EC, Desai MY, Estes NAM 3rd, Hua W, Indik JH, Ingles J, James CA, John RM, Judge DP, Keegan R, Krahn AD, Link MS, Marcus FI, McLeod CJ, Mestroni L, Priori SG, Saffitz JE, Sanatani S, Shimizu W, van Tintelen JP, Wilde AAM, Zareba W
Heart Rhythm 2019 Nov;16(11):e301-e372. Epub 2019 May 9 doi: 10.1016/j.hrthm.2019.05.007. PMID: 31078652

Recent clinical studies

Etiology

The U-wave: A remaining enigma of the electrocardiogram.
Kihlgren M, Almqvist C, Amankhani F, Jonasson L, Norman C, Perez M, Ebrahimi A, Gottfridsson C
J Electrocardiol 2023 Jul-Aug;79:13-20. Epub 2023 Mar 5 doi: 10.1016/j.jelectrocard.2023.03.001. PMID: 36907158
2019 HRS expert consensus statement on evaluation, risk stratification, and management of arrhythmogenic cardiomyopathy.
Towbin JA, McKenna WJ, Abrams DJ, Ackerman MJ, Calkins H, Darrieux FCC, Daubert JP, de Chillou C, DePasquale EC, Desai MY, Estes NAM 3rd, Hua W, Indik JH, Ingles J, James CA, John RM, Judge DP, Keegan R, Krahn AD, Link MS, Marcus FI, McLeod CJ, Mestroni L, Priori SG, Saffitz JE, Sanatani S, Shimizu W, van Tintelen JP, Wilde AAM, Zareba W
Heart Rhythm 2019 Nov;16(11):e301-e372. Epub 2019 May 9 doi: 10.1016/j.hrthm.2019.05.007. PMID: 31078652
MR-guided Cardiac Interventions.
Pushparajah K, Chubb H, Razavi R
Top Magn Reson Imaging 2018 Jun;27(3):115-128. doi: 10.1097/RMR.0000000000000156. PMID: 29870464
Bradyarrhythmias in Congenital Heart Disease.
Carlson SK, Patel AR, Chang PM
Card Electrophysiol Clin 2017 Jun;9(2):177-187. Epub 2017 Mar 22 doi: 10.1016/j.ccep.2017.02.002. PMID: 28457234
hERG K(+) channels: structure, function, and clinical significance.
Vandenberg JI, Perry MD, Perrin MJ, Mann SA, Ke Y, Hill AP
Physiol Rev 2012 Jul;92(3):1393-478. doi: 10.1152/physrev.00036.2011. PMID: 22988594

Diagnosis

The U-wave: A remaining enigma of the electrocardiogram.
Kihlgren M, Almqvist C, Amankhani F, Jonasson L, Norman C, Perez M, Ebrahimi A, Gottfridsson C
J Electrocardiol 2023 Jul-Aug;79:13-20. Epub 2023 Mar 5 doi: 10.1016/j.jelectrocard.2023.03.001. PMID: 36907158
Diagnosis of arrhythmogenic cardiomyopathy: The Padua criteria.
Corrado D, Perazzolo Marra M, Zorzi A, Beffagna G, Cipriani A, Lazzari M, Migliore F, Pilichou K, Rampazzo A, Rigato I, Rizzo S, Thiene G, Anastasakis A, Asimaki A, Bucciarelli-Ducci C, Haugaa KH, Marchlinski FE, Mazzanti A, McKenna WJ, Pantazis A, Pelliccia A, Schmied C, Sharma S, Wichter T, Bauce B, Basso C
Int J Cardiol 2020 Nov 15;319:106-114. Epub 2020 Jun 16 doi: 10.1016/j.ijcard.2020.06.005. PMID: 32561223
2019 HRS expert consensus statement on evaluation, risk stratification, and management of arrhythmogenic cardiomyopathy.
Towbin JA, McKenna WJ, Abrams DJ, Ackerman MJ, Calkins H, Darrieux FCC, Daubert JP, de Chillou C, DePasquale EC, Desai MY, Estes NAM 3rd, Hua W, Indik JH, Ingles J, James CA, John RM, Judge DP, Keegan R, Krahn AD, Link MS, Marcus FI, McLeod CJ, Mestroni L, Priori SG, Saffitz JE, Sanatani S, Shimizu W, van Tintelen JP, Wilde AAM, Zareba W
Heart Rhythm 2019 Nov;16(11):e301-e372. Epub 2019 May 9 doi: 10.1016/j.hrthm.2019.05.007. PMID: 31078652
MR-guided Cardiac Interventions.
Pushparajah K, Chubb H, Razavi R
Top Magn Reson Imaging 2018 Jun;27(3):115-128. doi: 10.1097/RMR.0000000000000156. PMID: 29870464
The preexcitation syndromes.
Gallagher JJ, Pritchett EL, Sealy WC, Kasell J, Wallace AG
Prog Cardiovasc Dis 1978 Jan-Feb;20(4):285-327. doi: 10.1016/0033-0620(78)90015-4. PMID: 146210

Therapy

Review article: Risk of cardiovascular events in patients with inflammatory bowel disease receiving small molecule drugs.
Olivera PA, Lasa JS, Peretto G, Zuily S, Danese S, Peyrin-Biroulet L
Aliment Pharmacol Ther 2023 Jun;57(11):1231-1248. Epub 2023 Apr 10 doi: 10.1111/apt.17509. PMID: 37038269
Management of cardiac conduction abnormalities and arrhythmia in aircrew.
Guettler N, Bron D, Manen O, Gray G, Syburra T, Rienks R, d'Arcy J, Davenport ED, Nicol ED
Heart 2019 Jan;105(Suppl 1):s38-s49. doi: 10.1136/heartjnl-2018-313057. PMID: 30425085Free PMC Article
Enhanced Cardiomyocyte NLRP3 Inflammasome Signaling Promotes Atrial Fibrillation.
Yao C, Veleva T, Scott L Jr, Cao S, Li L, Chen G, Jeyabal P, Pan X, Alsina KM, Abu-Taha I Dr, Ghezelbash S, Reynolds CL, Shen YH, LeMaire SA, Schmitz W, Müller FU, El-Armouche A, Tony Eissa N, Beeton C, Nattel S, Wehrens XHT, Dobrev D, Li N
Circulation 2018 Nov 13;138(20):2227-2242. doi: 10.1161/CIRCULATIONAHA.118.035202. PMID: 29802206Free PMC Article
The Current State and Future Potential of Pediatric and Congenital Electrophysiology.
Sanatani S, Cunningham T, Khairy P, Cohen MI, Hamilton RM, Ackerman MJ
JACC Clin Electrophysiol 2017 Mar;3(3):195-206. Epub 2017 Mar 20 doi: 10.1016/j.jacep.2017.01.008. PMID: 29759513
Pediatric electrophysiology.
Kanter RJ
Curr Opin Cardiol 1993 Jan;8(1):119-27. doi: 10.1097/00001573-199301000-00015. PMID: 10148090

Prognosis

Electrocardiogram in patients with pulmonary hypertension.
Ley L, Höltgen R, Bogossian H, Ghofrani HA, Bandorski D
J Electrocardiol 2023 Jul-Aug;79:24-29. Epub 2023 Mar 5 doi: 10.1016/j.jelectrocard.2023.02.007. PMID: 36913785
The U-wave: A remaining enigma of the electrocardiogram.
Kihlgren M, Almqvist C, Amankhani F, Jonasson L, Norman C, Perez M, Ebrahimi A, Gottfridsson C
J Electrocardiol 2023 Jul-Aug;79:13-20. Epub 2023 Mar 5 doi: 10.1016/j.jelectrocard.2023.03.001. PMID: 36907158
Atrial fibrillation: Neurogenic or myogenic?
Scridon A, Şerban RC, Chevalier P
Arch Cardiovasc Dis 2018 Jan;111(1):59-69. Epub 2017 Dec 8 doi: 10.1016/j.acvd.2017.11.001. PMID: 29229215
Cellular and molecular electrophysiology of atrial fibrillation initiation, maintenance, and progression.
Heijman J, Voigt N, Nattel S, Dobrev D
Circ Res 2014 Apr 25;114(9):1483-99. doi: 10.1161/CIRCRESAHA.114.302226. PMID: 24763466
Preexcitation.
Ferrer MI
Am J Med 1977 May;62(5):715-30. doi: 10.1016/0002-9343(77)90875-0. PMID: 324276

Clinical prediction guides

Loss of the Atrial Fibrillation-Related Gene, Zfhx3, Results in Atrial Dilation and Arrhythmias.
Jameson HS, Hanley A, Hill MC, Xiao L, Ye J, Bapat A, Ronzier E, Hall AW, Hucker WJ, Clauss S, Barazza M, Silber E, Mina JA, Tucker NR, Mills RW, Dong JT, Milan DJ, Ellinor PT
Circ Res 2023 Aug 4;133(4):313-329. Epub 2023 Jul 14 doi: 10.1161/CIRCRESAHA.123.323029. PMID: 37449401Free PMC Article
Ion Channels in the Development and Remodeling of the Aortic Valve.
Simard C, Aize M, Chaigne S, Mpweme Bangando H, Guinamard R
Int J Mol Sci 2023 Mar 20;24(6) doi: 10.3390/ijms24065860. PMID: 36982932Free PMC Article
The U-wave: A remaining enigma of the electrocardiogram.
Kihlgren M, Almqvist C, Amankhani F, Jonasson L, Norman C, Perez M, Ebrahimi A, Gottfridsson C
J Electrocardiol 2023 Jul-Aug;79:13-20. Epub 2023 Mar 5 doi: 10.1016/j.jelectrocard.2023.03.001. PMID: 36907158
Electromechanical reciprocity and arrhythmogenesis in long-QT syndrome and beyond.
Odening KE, van der Linde HJ, Ackerman MJ, Volders PGA, Ter Bekke RMA
Eur Heart J 2022 Aug 21;43(32):3018-3028. doi: 10.1093/eurheartj/ehac135. PMID: 35445703Free PMC Article
Atrial fibrillation: Neurogenic or myogenic?
Scridon A, Şerban RC, Chevalier P
Arch Cardiovasc Dis 2018 Jan;111(1):59-69. Epub 2017 Dec 8 doi: 10.1016/j.acvd.2017.11.001. PMID: 29229215

Recent systematic reviews

Chiari network for the interventional cardiologist: A hidden enemy at the heart gate - A systematic review of the literature.
Ali H, Lupo P, Cristiano E, Nicolì L, Foresti S, De Ambroggi G, Anderson RH, De Lucia C, Turturiello D, Paganini EM, Bessi R, Farghaly AAA, Butera G, Cappato R
Int J Cardiol 2023 Mar 15;375:23-28. Epub 2022 Dec 29 doi: 10.1016/j.ijcard.2022.12.046. PMID: 36587656
Systematic review of electrophysiology procedures in patients with obstruction of the inferior vena cava.
Al-Sinan A, Chan KH, Young GD, Martin A, Sepahpour A, Sy RW
J Cardiovasc Electrophysiol 2022 Jun;33(6):1300-1311. Epub 2022 Apr 30 doi: 10.1111/jce.15505. PMID: 35441755Free PMC Article
The cardiovascular effects of amodiaquine and structurally related antimalarials: An individual patient data meta-analysis.
Chan XHS, Haeusler IL, Win YN, Pike J, Hanboonkunupakarn B, Hanafiah M, Lee SJ, Djimdé A, Fanello CI, Kiechel JR, Lacerda MV, Ogutu B, Onyamboko MA, Siqueira AM, Ashley EA, Taylor WR, White NJ
PLoS Med 2021 Sep;18(9):e1003766. Epub 2021 Sep 7 doi: 10.1371/journal.pmed.1003766. PMID: 34492005Free PMC Article
Clinical presentation, diagnosis, and treatment of atrioesophageal fistula resulting from atrial fibrillation ablation.
Della Rocca DG, Magnocavallo M, Natale VN, Gianni C, Mohanty S, Trivedi C, Lavalle C, Forleo GB, Tarantino N, Romero J, Zhang X, Bassiouny M, Al-Ahmad A, Burkhardt DJ, Gallinghouse JG, Sanchez JE, Horton RP, Di Biase L, Natale A
J Cardiovasc Electrophysiol 2021 Sep;32(9):2441-2450. Epub 2021 Jul 27 doi: 10.1111/jce.15168. PMID: 34260115
Clinical Potential of Beat-to-Beat Diastolic Interval Control in Preventing Cardiac Arrhythmias.
Kulkarni K, Walton RD, Armoundas AA, Tolkacheva EG
J Am Heart Assoc 2021 Jun;10(11):e020750. Epub 2021 May 22 doi: 10.1161/JAHA.121.020750. PMID: 34027678Free PMC Article

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