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Abnormal circulating antimullerian hormone concentration

MedGen UID:
1393783
•Concept ID:
C4476970
•
Finding
Synonym: Abnormal antimullerian hormone level
 
HPO: HP:0031101

Definition

Any deviation from the normal range of the antimullerian hormone, a peptide produced by the granulosa cells of follicles. Anti-Mullerian hormone (AMH), also known as Mullerian inhibiting substance, is produced by the granulosa cells of small antral follicles of the ovary. AMH has an inhibiting role in the ovary, contributing to follicular arrest. AMH levels in women are low until the age of 8, rise rapidly until puberty and decline steadily from the age of 25 until menopause, when AMH production ceases. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal circulating antimullerian hormone concentration

Recent clinical studies

Etiology

PCOS Features and Steroid Profiles Among Young Adult Women with a History of Premature Adrenarche.
Tennilä J, Jääskeläinen J, Utriainen P, Voutilainen R, Häkkinen M, Auriola S, Morin-Papunen L, Liimatta J
J Clin Endocrinol Metab 2021 Aug 18;106(9):e3335-e3345. doi: 10.1210/clinem/dgab385. PMID: 34060603Free PMC Article
Low AMH levels as a marker of reduced ovarian reserve in young women affected by Down's syndrome.
Romualdi D, Proto C, De Cicco S, Immediata V, Barone C, Romano C, Lanzone A
Menopause 2016 Nov;23(11):1247-1251. doi: 10.1097/GME.0000000000000695. PMID: 27465716
Vitamin D increases serum levels of the soluble receptor for advanced glycation end products in women with PCOS.
Irani M, Minkoff H, Seifer DB, Merhi Z
J Clin Endocrinol Metab 2014 May;99(5):E886-90. Epub 2014 Feb 27 doi: 10.1210/jc.2013-4374. PMID: 24606102
Serum anti-Mullerian hormone levels in the main phenotypes of polycystic ovary syndrome.
Sahmay S, Atakul N, Oncul M, Tuten A, Aydogan B, Seyisoglu H
Eur J Obstet Gynecol Reprod Biol 2013 Sep;170(1):157-61. Epub 2013 Jun 24 doi: 10.1016/j.ejogrb.2013.05.019. PMID: 23806449
Anti-Mullerian hormone is increased in follicular fluid from unstimulated ovaries in women with polycystic ovary syndrome.
Das M, Gillott DJ, Saridogan E, Djahanbakhch O
Hum Reprod 2008 Sep;23(9):2122-6. Epub 2008 Jun 10 doi: 10.1093/humrep/den185. PMID: 18550512

Diagnosis

Vitamin D increases serum levels of the soluble receptor for advanced glycation end products in women with PCOS.
Irani M, Minkoff H, Seifer DB, Merhi Z
J Clin Endocrinol Metab 2014 May;99(5):E886-90. Epub 2014 Feb 27 doi: 10.1210/jc.2013-4374. PMID: 24606102
Serum anti-Mullerian hormone levels in the main phenotypes of polycystic ovary syndrome.
Sahmay S, Atakul N, Oncul M, Tuten A, Aydogan B, Seyisoglu H
Eur J Obstet Gynecol Reprod Biol 2013 Sep;170(1):157-61. Epub 2013 Jun 24 doi: 10.1016/j.ejogrb.2013.05.019. PMID: 23806449
Serum concentrations of Anti-Müllerian Hormone (AMH) in 95 patients with Klinefelter syndrome with or without cryptorchidism.
Aksglaede L, Christiansen P, Sørensen K, Boas M, Linneberg A, Main KM, Andersson AM, Skakkebaek NE, Juul A
Acta Paediatr 2011 Jun;100(6):839-45. Epub 2011 Feb 25 doi: 10.1111/j.1651-2227.2011.02148.x. PMID: 21251056

Therapy

PCOS Features and Steroid Profiles Among Young Adult Women with a History of Premature Adrenarche.
Tennilä J, Jääskeläinen J, Utriainen P, Voutilainen R, Häkkinen M, Auriola S, Morin-Papunen L, Liimatta J
J Clin Endocrinol Metab 2021 Aug 18;106(9):e3335-e3345. doi: 10.1210/clinem/dgab385. PMID: 34060603Free PMC Article
Congenital hypogonadotropic hypogonadism and Kallmann syndrome as models for studying hormonal regulation of human testicular endocrine functions.
Trabado S, Lamothe S, Maione L, Bouvattier C, Sarfati J, Brailly-Tabard S, Young J
Ann Endocrinol (Paris) 2014 May;75(2):79-87. Epub 2014 May 9 doi: 10.1016/j.ando.2014.04.011. PMID: 24815726
Vitamin D increases serum levels of the soluble receptor for advanced glycation end products in women with PCOS.
Irani M, Minkoff H, Seifer DB, Merhi Z
J Clin Endocrinol Metab 2014 May;99(5):E886-90. Epub 2014 Feb 27 doi: 10.1210/jc.2013-4374. PMID: 24606102
Serum concentrations of Anti-Müllerian Hormone (AMH) in 95 patients with Klinefelter syndrome with or without cryptorchidism.
Aksglaede L, Christiansen P, Sørensen K, Boas M, Linneberg A, Main KM, Andersson AM, Skakkebaek NE, Juul A
Acta Paediatr 2011 Jun;100(6):839-45. Epub 2011 Feb 25 doi: 10.1111/j.1651-2227.2011.02148.x. PMID: 21251056

Prognosis

PCOS Features and Steroid Profiles Among Young Adult Women with a History of Premature Adrenarche.
Tennilä J, Jääskeläinen J, Utriainen P, Voutilainen R, Häkkinen M, Auriola S, Morin-Papunen L, Liimatta J
J Clin Endocrinol Metab 2021 Aug 18;106(9):e3335-e3345. doi: 10.1210/clinem/dgab385. PMID: 34060603Free PMC Article
Follicular fluid soluble receptor for advanced glycation end-products (sRAGE): a potential indicator of ovarian reserve.
Merhi Z, Irani M, Doswell AD, Ambroggio J
J Clin Endocrinol Metab 2014 Feb;99(2):E226-33. Epub 2013 Nov 25 doi: 10.1210/jc.2013-3839. PMID: 24276462
Serum anti-Mullerian hormone levels in the main phenotypes of polycystic ovary syndrome.
Sahmay S, Atakul N, Oncul M, Tuten A, Aydogan B, Seyisoglu H
Eur J Obstet Gynecol Reprod Biol 2013 Sep;170(1):157-61. Epub 2013 Jun 24 doi: 10.1016/j.ejogrb.2013.05.019. PMID: 23806449

Clinical prediction guides

Low AMH levels as a marker of reduced ovarian reserve in young women affected by Down's syndrome.
Romualdi D, Proto C, De Cicco S, Immediata V, Barone C, Romano C, Lanzone A
Menopause 2016 Nov;23(11):1247-1251. doi: 10.1097/GME.0000000000000695. PMID: 27465716
Follicular fluid soluble receptor for advanced glycation end-products (sRAGE): a potential indicator of ovarian reserve.
Merhi Z, Irani M, Doswell AD, Ambroggio J
J Clin Endocrinol Metab 2014 Feb;99(2):E226-33. Epub 2013 Nov 25 doi: 10.1210/jc.2013-3839. PMID: 24276462
Serum anti-Mullerian hormone levels in the main phenotypes of polycystic ovary syndrome.
Sahmay S, Atakul N, Oncul M, Tuten A, Aydogan B, Seyisoglu H
Eur J Obstet Gynecol Reprod Biol 2013 Sep;170(1):157-61. Epub 2013 Jun 24 doi: 10.1016/j.ejogrb.2013.05.019. PMID: 23806449

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