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Congenital laryngeal adductor palsy(LAP)

MedGen UID:
140759
Concept ID:
C0396060
Disease or Syndrome
Synonyms: LAP; Laryngeal adductor paralysis; VOCAL CORD DYSFUNCTION, ADDUCTOR TYPE
SNOMED CT: Congenital laryngeal adductor paralysis (232443006); Congenital laryngeal adductor palsy (232443006)
 
Monarch Initiative: MONDO:0007877
OMIM®: 150270

Clinical features

From HPO
Paralysis
MedGen UID:
105510
Concept ID:
C0522224
Finding
Paralysis of voluntary muscles means loss of contraction due to interruption of one or more motor pathways from the brain to the muscle fibers. Although the word paralysis is often used interchangeably to mean either complete or partial loss of muscle strength, it is preferable to use paralysis or plegia for complete or severe loss of muscle strength, and paresis for partial or slight loss. Motor paralysis results from deficits of the upper motor neurons (corticospinal, corticobulbar, or subcorticospinal). Motor paralysis is often accompanied by an impairment in the facility of movement.
Hoarse voice
MedGen UID:
5602
Concept ID:
C0019825
Sign or Symptom
Hoarseness refers to a change in the pitch or quality of the voice, with the voice sounding weak, very breathy, scratchy, or husky.

Recent clinical studies

Etiology

Lee JW, Bon-Mardion N, Smith ME, Marie JP
JAMA Otolaryngol Head Neck Surg 2020 May 1;146(5):401-407. doi: 10.1001/jamaoto.2019.4863. PMID: 32191278Free PMC Article
Bathini L, Jomah M, Krajacic A, Jeffery C, Campbell S, El-Hakim H
Int J Pediatr Otorhinolaryngol 2014 Nov;78(11):1866-9. Epub 2014 Aug 17 doi: 10.1016/j.ijporl.2014.08.012. PMID: 25218340
Berkowitz RG
Ann Otol Rhinol Laryngol 2003 Sep;112(9 Pt 1):764-7. doi: 10.1177/000348940311200904. PMID: 14535559
Berkowitz RG
Ann Otol Rhinol Laryngol 1996 Mar;105(3):207-12. doi: 10.1177/000348949610500306. PMID: 8615584

Diagnosis

Anderson WC 3rd, Stukus DR
J Allergy Clin Immunol Pract 2018 May-Jun;6(3):1083-1084.e9. doi: 10.1016/j.jaip.2017.09.005. PMID: 29747972
Bathini L, Jomah M, Krajacic A, Jeffery C, Campbell S, El-Hakim H
Int J Pediatr Otorhinolaryngol 2014 Nov;78(11):1866-9. Epub 2014 Aug 17 doi: 10.1016/j.ijporl.2014.08.012. PMID: 25218340
Berkowitz RG
Ann Otol Rhinol Laryngol 1996 Mar;105(3):207-12. doi: 10.1177/000348949610500306. PMID: 8615584

Therapy

Bathini L, Jomah M, Krajacic A, Jeffery C, Campbell S, El-Hakim H
Int J Pediatr Otorhinolaryngol 2014 Nov;78(11):1866-9. Epub 2014 Aug 17 doi: 10.1016/j.ijporl.2014.08.012. PMID: 25218340
Irfan M, Shahid H, Baharudin A, Friedrich G
Med J Malaysia 2009 Mar;64(1):89-90. PMID: 19852333

Prognosis

Berkowitz RG
Ann Otol Rhinol Laryngol 1996 Mar;105(3):207-12. doi: 10.1177/000348949610500306. PMID: 8615584

Clinical prediction guides

Lee JW, Bon-Mardion N, Smith ME, Marie JP
JAMA Otolaryngol Head Neck Surg 2020 May 1;146(5):401-407. doi: 10.1001/jamaoto.2019.4863. PMID: 32191278Free PMC Article
Berkowitz RG
Ann Otol Rhinol Laryngol 2003 Sep;112(9 Pt 1):764-7. doi: 10.1177/000348940311200904. PMID: 14535559

Recent systematic reviews

Bathini L, Jomah M, Krajacic A, Jeffery C, Campbell S, El-Hakim H
Int J Pediatr Otorhinolaryngol 2014 Nov;78(11):1866-9. Epub 2014 Aug 17 doi: 10.1016/j.ijporl.2014.08.012. PMID: 25218340

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