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Anaplastic ganglioglioma

MedGen UID:
140906
Concept ID:
C0431112
Neoplastic Process
Synonyms: AGNG; Anaplastic Ganglioglioma; anaplastic ganglioglioma; Ganglioglioma, anaplastic
SNOMED CT: Ganglioglioma, anaplastic (128912009); Anaplastic ganglioglioma (1157071000)
 
Monarch Initiative: MONDO:0016734
Orphanet: ORPHA251957

Definition

A rare mixed neuronal-glial tumor characterized by a mostly supratentorial space-occupying lesion often involving the temporal lobe, although it may occur anywhere in the central nervous system. The tumor shows anaplastic features in its glial component and is considered WHO grade III, which may, albeit inconsistently, indicate more aggressive behavior and less favorable prognosis. Clinical symptoms vary according to the location, the most common manifestation being seizures. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAnaplastic ganglioglioma
Follow this link to review classifications for Anaplastic ganglioglioma in Orphanet.

Professional guidelines

PubMed

Rosenberg T, Yeo KK, Mauguen A, Alexandrescu S, Prabhu SP, Tsai JW, Malinowski S, Joshirao M, Parikh K, Farouk Sait S, Rosenblum MK, Benhamida JK, Michaiel G, Tran HN, Dahiya S, Kachurak K, Friedman GK, Krystal JI, Huang MA, Margol AS, Wright KD, Aguilera D, MacDonald TJ, Chi SN, Karajannis MA
Neuro Oncol 2022 Nov 2;24(11):1964-1975. doi: 10.1093/neuonc/noac096. PMID: 35397478Free PMC Article
Mallick S, Benson R, Melgandi W, Giridhar P, Rath GK
Childs Nerv Syst 2018 Jun;34(6):1207-1213. Epub 2018 Mar 29 doi: 10.1007/s00381-018-3780-3. PMID: 29594461

Recent clinical studies

Etiology

Reinhardt A, Pfister K, Schrimpf D, Stichel D, Sahm F, Reuss DE, Capper D, Wefers AK, Ebrahimi A, Sill M, Felsberg J, Reifenberger G, Becker A, Prinz M, Staszewski O, Hartmann C, Schittenhelm J, Gramatzki D, Weller M, Olar A, Rushing EJ, Bergmann M, Farrell MA, Blümcke I, Coras R, Beckervordersandforth J, Kim SH, Rogerio F, Dimova PS, Niehusmann P, Unterberg A, Platten M, Pfister SM, Wick W, Herold-Mende C, von Deimling A
Neuropathol Appl Neurobiol 2022 Dec;48(7):e12847. Epub 2022 Sep 16 doi: 10.1111/nan.12847. PMID: 35977725
Abdel Razek AAK, Elsebaie NA, Zamora C, Castillo M
J Comput Assist Tomogr 2020 May/Jun;44(3):356-369. doi: 10.1097/RCT.0000000000001010. PMID: 32217897
Kaley T, Touat M, Subbiah V, Hollebecque A, Rodon J, Lockhart AC, Keedy V, Bielle F, Hofheinz RD, Joly F, Blay JY, Chau I, Puzanov I, Raje NS, Wolf J, DeAngelis LM, Makrutzki M, Riehl T, Pitcher B, Baselga J, Hyman DM
J Clin Oncol 2018 Dec 10;36(35):3477-3484. Epub 2018 Oct 23 doi: 10.1200/JCO.2018.78.9990. PMID: 30351999Free PMC Article
Zanello M, Pagès M, Roux A, Peeters S, Dezamis E, Puget S, Devaux B, Sainte-Rose C, Zerah M, Louvel G, Dumont SN, Meder JF, Grill J, Huberfeld G, Chrétien F, Parraga E, Sauvageon X, Varlet P, Pallud J
Br J Neurosurg 2017 Apr;31(2):227-233. Epub 2016 Aug 23 doi: 10.1080/02688697.2016.1220506. PMID: 27550627
Scoccianti S, Giordano F, Agresti B, Detti B, Cipressi S, Franceschini D, Greto D, Mussa F, Sardi I, Buccoliero A, Aricò M, Genitori L, Biti G
Pediatr Neurosurg 2012;48(1):35-41. Epub 2012 Aug 21 doi: 10.1159/000340067. PMID: 22922381

Diagnosis

Reinhardt A, Pfister K, Schrimpf D, Stichel D, Sahm F, Reuss DE, Capper D, Wefers AK, Ebrahimi A, Sill M, Felsberg J, Reifenberger G, Becker A, Prinz M, Staszewski O, Hartmann C, Schittenhelm J, Gramatzki D, Weller M, Olar A, Rushing EJ, Bergmann M, Farrell MA, Blümcke I, Coras R, Beckervordersandforth J, Kim SH, Rogerio F, Dimova PS, Niehusmann P, Unterberg A, Platten M, Pfister SM, Wick W, Herold-Mende C, von Deimling A
Neuropathol Appl Neurobiol 2022 Dec;48(7):e12847. Epub 2022 Sep 16 doi: 10.1111/nan.12847. PMID: 35977725
Vaz A, Cavalcanti MS, da Silva Junior EB, Ramina R, de Almeida Teixeira BC
AJNR Am J Neuroradiol 2022 Aug;43(8):1080-1089. Epub 2022 May 5 doi: 10.3174/ajnr.A7465. PMID: 35512827Free PMC Article
Vlachos N, Lampros MG, Zigouris A, Voulgaris S, Alexiou GA
Neurosurg Rev 2022 Feb;45(1):295-304. Epub 2021 Jul 27 doi: 10.1007/s10143-021-01612-3. PMID: 34312775
Abdel Razek AAK, Elsebaie NA, Zamora C, Castillo M
J Comput Assist Tomogr 2020 May/Jun;44(3):356-369. doi: 10.1097/RCT.0000000000001010. PMID: 32217897
Demir MK, Yapıcıer O, Yılmaz B, Kılıç T
Acta Neurol Belg 2018 Sep;118(3):379-386. Epub 2018 Jul 9 doi: 10.1007/s13760-018-0981-1. PMID: 29987554

Therapy

Rosenberg T, Yeo KK, Mauguen A, Alexandrescu S, Prabhu SP, Tsai JW, Malinowski S, Joshirao M, Parikh K, Farouk Sait S, Rosenblum MK, Benhamida JK, Michaiel G, Tran HN, Dahiya S, Kachurak K, Friedman GK, Krystal JI, Huang MA, Margol AS, Wright KD, Aguilera D, MacDonald TJ, Chi SN, Karajannis MA
Neuro Oncol 2022 Nov 2;24(11):1964-1975. doi: 10.1093/neuonc/noac096. PMID: 35397478Free PMC Article
Andrews LJ, Thornton ZA, Saincher SS, Yao IY, Dawson S, McGuinness LA, Jones HE, Jefferies S, Short SC, Cheng HY, McAleenan A, Higgins JPT, Kurian KM
Neuro Oncol 2022 Apr 1;24(4):528-540. doi: 10.1093/neuonc/noab247. PMID: 34718782Free PMC Article
Kaley T, Touat M, Subbiah V, Hollebecque A, Rodon J, Lockhart AC, Keedy V, Bielle F, Hofheinz RD, Joly F, Blay JY, Chau I, Puzanov I, Raje NS, Wolf J, DeAngelis LM, Makrutzki M, Riehl T, Pitcher B, Baselga J, Hyman DM
J Clin Oncol 2018 Dec 10;36(35):3477-3484. Epub 2018 Oct 23 doi: 10.1200/JCO.2018.78.9990. PMID: 30351999Free PMC Article
Lüdemann W, Banan R, Hartmann C, Bertalanffy H, Di Rocco C
Childs Nerv Syst 2017 Feb;33(2):227-231. Epub 2016 Dec 5 doi: 10.1007/s00381-016-3302-0. PMID: 27921213
Zanello M, Pagès M, Roux A, Peeters S, Dezamis E, Puget S, Devaux B, Sainte-Rose C, Zerah M, Louvel G, Dumont SN, Meder JF, Grill J, Huberfeld G, Chrétien F, Parraga E, Sauvageon X, Varlet P, Pallud J
Br J Neurosurg 2017 Apr;31(2):227-233. Epub 2016 Aug 23 doi: 10.1080/02688697.2016.1220506. PMID: 27550627

Prognosis

Reinhardt A, Pfister K, Schrimpf D, Stichel D, Sahm F, Reuss DE, Capper D, Wefers AK, Ebrahimi A, Sill M, Felsberg J, Reifenberger G, Becker A, Prinz M, Staszewski O, Hartmann C, Schittenhelm J, Gramatzki D, Weller M, Olar A, Rushing EJ, Bergmann M, Farrell MA, Blümcke I, Coras R, Beckervordersandforth J, Kim SH, Rogerio F, Dimova PS, Niehusmann P, Unterberg A, Platten M, Pfister SM, Wick W, Herold-Mende C, von Deimling A
Neuropathol Appl Neurobiol 2022 Dec;48(7):e12847. Epub 2022 Sep 16 doi: 10.1111/nan.12847. PMID: 35977725
Vlachos N, Lampros MG, Zigouris A, Voulgaris S, Alexiou GA
Neurosurg Rev 2022 Feb;45(1):295-304. Epub 2021 Jul 27 doi: 10.1007/s10143-021-01612-3. PMID: 34312775
Lisievici AC, Pasov D, Georgescu TA, Lisievici MG, Sajin M
J Med Life 2021 Mar-Apr;14(2):170-175. doi: 10.25122/jml-2021-0054. PMID: 34104239Free PMC Article
Zanello M, Pagès M, Roux A, Peeters S, Dezamis E, Puget S, Devaux B, Sainte-Rose C, Zerah M, Louvel G, Dumont SN, Meder JF, Grill J, Huberfeld G, Chrétien F, Parraga E, Sauvageon X, Varlet P, Pallud J
Br J Neurosurg 2017 Apr;31(2):227-233. Epub 2016 Aug 23 doi: 10.1080/02688697.2016.1220506. PMID: 27550627
Lucas JT Jr, Huang AJ, Mott RT, Lesser GJ, Tatter SB, Chan MD
J Neurooncol 2015 May;123(1):171-7. Epub 2015 Apr 11 doi: 10.1007/s11060-015-1781-6. PMID: 25862009Free PMC Article

Clinical prediction guides

Lisievici AC, Pasov D, Georgescu TA, Lisievici MG, Sajin M
J Med Life 2021 Mar-Apr;14(2):170-175. doi: 10.25122/jml-2021-0054. PMID: 34104239Free PMC Article
Kaley T, Touat M, Subbiah V, Hollebecque A, Rodon J, Lockhart AC, Keedy V, Bielle F, Hofheinz RD, Joly F, Blay JY, Chau I, Puzanov I, Raje NS, Wolf J, DeAngelis LM, Makrutzki M, Riehl T, Pitcher B, Baselga J, Hyman DM
J Clin Oncol 2018 Dec 10;36(35):3477-3484. Epub 2018 Oct 23 doi: 10.1200/JCO.2018.78.9990. PMID: 30351999Free PMC Article
Zanello M, Pagès M, Roux A, Peeters S, Dezamis E, Puget S, Devaux B, Sainte-Rose C, Zerah M, Louvel G, Dumont SN, Meder JF, Grill J, Huberfeld G, Chrétien F, Parraga E, Sauvageon X, Varlet P, Pallud J
Br J Neurosurg 2017 Apr;31(2):227-233. Epub 2016 Aug 23 doi: 10.1080/02688697.2016.1220506. PMID: 27550627
Romero-Rojas AE, Diaz-Perez JA, Chinchilla-Olaya SI, Amaro D, Lozano-Castillo A, Restrepo-Escobar LI
Neurocirugia (Astur) 2013 Nov-Dec;24(6):237-43. Epub 2013 Sep 9 doi: 10.1016/j.neucir.2013.07.001. PMID: 24028967
Selvanathan SK, Hammouche S, Salminen HJ, Jenkinson MD
J Neurooncol 2011 Dec;105(3):539-45. Epub 2011 May 29 doi: 10.1007/s11060-011-0615-4. PMID: 21626070

Recent systematic reviews

Andrews LJ, Thornton ZA, Saincher SS, Yao IY, Dawson S, McGuinness LA, Jones HE, Jefferies S, Short SC, Cheng HY, McAleenan A, Higgins JPT, Kurian KM
Neuro Oncol 2022 Apr 1;24(4):528-540. doi: 10.1093/neuonc/noab247. PMID: 34718782Free PMC Article
Bouali S, Ben Said I, Zehani A, Drissi C, Bouhoula A, Kallel J, Jemel H
World Neurosurg 2018 Nov;119:220-231. Epub 2018 Aug 8 doi: 10.1016/j.wneu.2018.07.278. PMID: 30098436

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