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Neuropathy

MedGen UID:
141046
Concept ID:
C0442874
Disease or Syndrome
Synonym: Neuropathy (nerve damage)
SNOMED CT: Neuropathy (386033004); Neuropathy (nerve damage) (386033004)

Definition

A disorder affecting the cranial nerves or the peripheral nervous system. It manifests with pain, tingling, numbness, and muscle weakness. It may be the result of physical injury, toxic substances, viral diseases, diabetes, renal failure, cancer, and drugs. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNeuropathy

Professional guidelines

PubMed

Blonde L, Umpierrez GE, Reddy SS, McGill JB, Berga SL, Bush M, Chandrasekaran S, DeFronzo RA, Einhorn D, Galindo RJ, Gardner TW, Garg R, Garvey WT, Hirsch IB, Hurley DL, Izuora K, Kosiborod M, Olson D, Patel SB, Pop-Busui R, Sadhu AR, Samson SL, Stec C, Tamborlane WV Jr, Tuttle KR, Twining C, Vella A, Vellanki P, Weber SL
Endocr Pract 2022 Oct;28(10):923-1049. Epub 2022 Aug 11 doi: 10.1016/j.eprac.2022.08.002. PMID: 35963508Free PMC Article
Baughman RP, Valeyre D, Korsten P, Mathioudakis AG, Wuyts WA, Wells A, Rottoli P, Nunes H, Lower EE, Judson MA, Israel-Biet D, Grutters JC, Drent M, Culver DA, Bonella F, Antoniou K, Martone F, Quadder B, Spitzer G, Nagavci B, Tonia T, Rigau D, Ouellette DR
Eur Respir J 2021 Dec;58(6) Epub 2021 Dec 16 doi: 10.1183/13993003.04079-2020. PMID: 34140301
Stein JD, Khawaja AP, Weizer JS
JAMA 2021 Jan 12;325(2):164-174. doi: 10.1001/jama.2020.21899. PMID: 33433580

Recent clinical studies

Etiology

Devigili G, Cazzato D, Lauria G
Expert Rev Neurother 2020 Sep;20(9):967-980. Epub 2020 Jul 23 doi: 10.1080/14737175.2020.1794825. PMID: 32654574
Siao P, Kaku M
Semin Neurol 2019 Oct;39(5):519-530. Epub 2019 Oct 22 doi: 10.1055/s-0039-1694747. PMID: 31639835
Feldman EL, Callaghan BC, Pop-Busui R, Zochodne DW, Wright DE, Bennett DL, Bril V, Russell JW, Viswanathan V
Nat Rev Dis Primers 2019 Jun 13;5(1):42. doi: 10.1038/s41572-019-0097-9. PMID: 31197183Free PMC Article
Hanewinckel R, Ikram MA, Van Doorn PA
Handb Clin Neurol 2016;138:263-82. doi: 10.1016/B978-0-12-802973-2.00015-X. PMID: 27637963
Hayreh SS
Prog Retin Eye Res 2009 Jan;28(1):34-62. Epub 2008 Nov 27 doi: 10.1016/j.preteyeres.2008.11.002. PMID: 19063989

Diagnosis

Rossor AM, Reilly MM
Acta Neurol Scand 2022 Oct;146(4):325-331. Epub 2022 May 25 doi: 10.1111/ane.13650. PMID: 35611606Free PMC Article
Morrow MJ
Continuum (Minneap Minn) 2019 Oct;25(5):1215-1235. doi: 10.1212/CON.0000000000000767. PMID: 31584535
Feldman EL, Callaghan BC, Pop-Busui R, Zochodne DW, Wright DE, Bennett DL, Bril V, Russell JW, Viswanathan V
Nat Rev Dis Primers 2019 Jun 13;5(1):42. doi: 10.1038/s41572-019-0097-9. PMID: 31197183Free PMC Article
Barrell K, Smith AG
Med Clin North Am 2019 Mar;103(2):383-397. Epub 2018 Dec 17 doi: 10.1016/j.mcna.2018.10.006. PMID: 30704689
Watson JC, Dyck PJ
Mayo Clin Proc 2015 Jul;90(7):940-51. doi: 10.1016/j.mayocp.2015.05.004. PMID: 26141332

Therapy

Colvin LA
Pain 2019 May;160 Suppl 1(Suppl 1):S1-S10. doi: 10.1097/j.pain.0000000000001540. PMID: 31008843Free PMC Article
Dimitrova A, Murchison C, Oken B
J Altern Complement Med 2017 Mar;23(3):164-179. Epub 2017 Jan 23 doi: 10.1089/acm.2016.0155. PMID: 28112552Free PMC Article
Caliandro P, La Torre G, Padua R, Giannini F, Padua L
Cochrane Database Syst Rev 2016 Nov 15;11(11):CD006839. doi: 10.1002/14651858.CD006839.pub4. PMID: 27845501Free PMC Article
Scott K, Hayden PJ, Will A, Wheatley K, Coyne I
Cochrane Database Syst Rev 2016 Apr 20;4(4):CD010816. doi: 10.1002/14651858.CD010816.pub2. PMID: 27096326Free PMC Article
Deepmala, Slattery J, Kumar N, Delhey L, Berk M, Dean O, Spielholz C, Frye R
Neurosci Biobehav Rev 2015 Aug;55:294-321. Epub 2015 May 6 doi: 10.1016/j.neubiorev.2015.04.015. PMID: 25957927

Prognosis

Chwalisz B, Gilbert AL, Gittinger JW Jr
Semin Ophthalmol 2018;33(1):17-22. Epub 2017 Sep 7 doi: 10.1080/08820538.2017.1353807. PMID: 28881162
Hanewinckel R, Ikram MA, Van Doorn PA
Handb Clin Neurol 2016;138:263-82. doi: 10.1016/B978-0-12-802973-2.00015-X. PMID: 27637963
Hermans G, Van den Berghe G
Crit Care 2015 Aug 5;19(1):274. doi: 10.1186/s13054-015-0993-7. PMID: 26242743Free PMC Article
Comarmond C, Pagnoux C, Khellaf M, Cordier JF, Hamidou M, Viallard JF, Maurier F, Jouneau S, Bienvenu B, Puéchal X, Aumaître O, Le Guenno G, Le Quellec A, Cevallos R, Fain O, Godeau B, Seror R, Dunogué B, Mahr A, Guilpain P, Cohen P, Aouba A, Mouthon L, Guillevin L; French Vasculitis Study Group
Arthritis Rheum 2013 Jan;65(1):270-81. doi: 10.1002/art.37721. PMID: 23044708
Casasnovas C, Cano LM, Albertí A, Céspedes M, Rigo G
Foot Ankle Spec 2008 Dec;1(6):350-4. Epub 2008 Oct 22 doi: 10.1177/1938640008326247. PMID: 19825739

Clinical prediction guides

Thomaier L, Darst BF, Jewett P, Hoffmann C, Brown K, Makaram A, Blaes A, Argenta P, Teoh D, Vogel RI
Gynecol Oncol 2021 Dec;163(3):578-582. Epub 2021 Oct 18 doi: 10.1016/j.ygyno.2021.10.006. PMID: 34674889Free PMC Article
Bandyk DF
Semin Vasc Surg 2018 Jun-Dec;31(2-4):43-48. Epub 2019 Feb 6 doi: 10.1053/j.semvascsurg.2019.02.001. PMID: 30876640
Brocco E, Ninkovic S, Marin M, Whisstock C, Bruseghin M, Boschetti G, Viti R, Forlini W, Volpe A
J Cardiovasc Surg (Torino) 2018 Oct;59(5):670-684. Epub 2018 May 29 doi: 10.23736/S0021-9509.18.10606-9. PMID: 29808982
Seretny M, Currie GL, Sena ES, Ramnarine S, Grant R, MacLeod MR, Colvin LA, Fallon M
Pain 2014 Dec;155(12):2461-2470. Epub 2014 Sep 23 doi: 10.1016/j.pain.2014.09.020. PMID: 25261162
Paternostro-Sluga T, Grim-Stieger M, Posch M, Schuhfried O, Vacariu G, Mittermaier C, Bittner C, Fialka-Moser V
J Rehabil Med 2008 Aug;40(8):665-71. doi: 10.2340/16501977-0235. PMID: 19020701

Recent systematic reviews

Liampas A, Parperis K, Erotocritou MF, Nteveros A, Papadopoulou M, Moschovos C, Akil M, Coaccioli S, Hadjigeorgiou GM, Hadjivassiliou M, Zis P
Eur J Neurol 2023 Jan;30(1):255-265. Epub 2022 Sep 23 doi: 10.1111/ene.15555. PMID: 36086910Free PMC Article
Finsterer J
Int J Mol Sci 2022 Nov 17;23(22) doi: 10.3390/ijms232214222. PMID: 36430700Free PMC Article
Streckmann F, Balke M, Cavaletti G, Toscanelli A, Bloch W, Décard BF, Lehmann HC, Faude O
Sports Med 2022 May;52(5):1043-1065. Epub 2021 Dec 29 doi: 10.1007/s40279-021-01596-6. PMID: 34964950
Stein J, Geisel J, Obeid R
Eur J Neurol 2021 Jun;28(6):2054-2064. Epub 2021 Mar 15 doi: 10.1111/ene.14786. PMID: 33619867
Seretny M, Currie GL, Sena ES, Ramnarine S, Grant R, MacLeod MR, Colvin LA, Fallon M
Pain 2014 Dec;155(12):2461-2470. Epub 2014 Sep 23 doi: 10.1016/j.pain.2014.09.020. PMID: 25261162

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