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Blister

MedGen UID:
14155
•Concept ID:
C0005758
•
Finding
Synonyms: Bleb; Blebs; Blisters; Bulla; Bullae; Bullous Lesion; Bullous Lesions; Lesion, Bullous; Lesions, Bullous; Vesication; Vesications
SNOMED CT: Blister (339008); Bulla (339008); Bleb (339008); Blisters (339008); Blistering (339008)

Definition

A fluid-filled, raised, often translucent lesion, greater than 1 cm in diameter [from SNOMEDCT_US]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBlister

Professional guidelines

PubMed

Technologies for Medication Adherence Monitoring and Technology Assessment Criteria: Narrative Review.
Mason M, Cho Y, Rayo J, Gong Y, Harris M, Jiang Y
JMIR Mhealth Uhealth 2022 Mar 10;10(3):e35157. doi: 10.2196/35157. PMID: 35266873Free PMC Article
What are the treatment options for blister-like aneurysms?
Meling TR
Neurosurg Rev 2017 Oct;40(4):587-593. Epub 2017 Aug 17 doi: 10.1007/s10143-017-0893-1. PMID: 28819696
Bullous Pemphigoid: A Review of its Diagnosis, Associations and Treatment.
Bernard P, Antonicelli F
Am J Clin Dermatol 2017 Aug;18(4):513-528. doi: 10.1007/s40257-017-0264-2. PMID: 28247089

Recent clinical studies

Etiology

Immunoglobulin M pemphigoid.
Boch K, Hammers CM, Goletz S, Kamaguchi M, Ludwig RJ, Schneider SW, Zillikens D, Hadaschik E, Schmidt E
J Am Acad Dermatol 2021 Dec;85(6):1486-1492. Epub 2021 Jan 13 doi: 10.1016/j.jaad.2021.01.017. PMID: 33453342
Expanding Indications for Flow Diverters: Ruptured Aneurysms, Blister Aneurysms, and Dissecting Aneurysms.
Kan P, Sweid A, Srivatsan A, Jabbour P
Neurosurgery 2020 Jan 1;86(Suppl 1):S96-S103. doi: 10.1093/neuros/nyz304. PMID: 31838529
Suction Blisters.
Yu WY, Wei ML
JAMA Dermatol 2019 Feb 1;155(2):237. doi: 10.1001/jamadermatol.2018.3277. PMID: 30540360
A Systematic Review and Meta-Analysis of Treatment and Outcome of Blister-Like Aneurysms.
Peschillo S, Cannizzaro D, Caporlingua A, Missori P
AJNR Am J Neuroradiol 2016 May;37(5):856-61. Epub 2015 Dec 3 doi: 10.3174/ajnr.A4606. PMID: 26635287Free PMC Article
Fracture blisters.
Giordano CP, Koval KJ, Zuckerman JD, Desai P
Clin Orthop Relat Res 1994 Oct;(307):214-21. PMID: 7924035

Diagnosis

Comparison of samples of blister fluid and scales in the diagnosis of dermatomycosis.
Xia H, Mo XH, Yang LJ, Yang H, Tan JW, Yu Q, Zhang PF, Tan F
Mycoses 2022 Oct;65(10):969-975. Epub 2022 Jul 25 doi: 10.1111/myc.13494. PMID: 35815924
Fracture Blisters.
Zapata J, Price E, Wlodarczyk S
J Gen Intern Med 2022 Aug;37(11):2866. Epub 2022 Apr 13 doi: 10.1007/s11606-022-07568-4. PMID: 35419743Free PMC Article
Cimicosis.
Kohn D
Dtsch Arztebl Int 2019 Mar 8;116(11):194. doi: 10.3238/arztebl.2019.0194b. PMID: 31014457Free PMC Article
Vesicants.
McManus J, Huebner K
Crit Care Clin 2005 Oct;21(4):707-18, vi. doi: 10.1016/j.ccc.2005.06.005. PMID: 16168310
Angina bullosa hemorrhagica.
Grinspan D, Abulafia J, Lanfranchi H
Int J Dermatol 1999 Jul;38(7):525-8. doi: 10.1046/j.1365-4362.1999.00682.x. PMID: 10440282

Therapy

Negative pressure wound therapy for surgical wounds healing by primary closure.
Norman G, Shi C, Goh EL, Murphy EM, Reid A, Chiverton L, Stankiewicz M, Dumville JC
Cochrane Database Syst Rev 2022 Apr 26;4(4):CD009261. doi: 10.1002/14651858.CD009261.pub7. PMID: 35471497Free PMC Article
Effect of Prophylactic Negative Pressure Wound Therapy vs Standard Wound Dressing on Surgical-Site Infection in Obese Women After Cesarean Delivery: A Randomized Clinical Trial.
Tuuli MG, Liu J, Tita ATN, Longo S, Trudell A, Carter EB, Shanks A, Woolfolk C, Caughey AB, Warren DK, Odibo AO, Colditz G, Macones GA, Harper L
JAMA 2020 Sep 22;324(12):1180-1189. doi: 10.1001/jama.2020.13361. PMID: 32960242Free PMC Article
Negative pressure wound therapy for surgical wounds healing by primary closure.
Norman G, Goh EL, Dumville JC, Shi C, Liu Z, Chiverton L, Stankiewicz M, Reid A
Cochrane Database Syst Rev 2020 Jun 15;6(6):CD009261. doi: 10.1002/14651858.CD009261.pub6. PMID: 32542647Free PMC Article
Negative pressure wound therapy for surgical wounds healing by primary closure.
Webster J, Liu Z, Norman G, Dumville JC, Chiverton L, Scuffham P, Stankiewicz M, Chaboyer WP
Cochrane Database Syst Rev 2019 Mar 26;3(3):CD009261. doi: 10.1002/14651858.CD009261.pub4. PMID: 30912582Free PMC Article
Randomized, controlled trial of TNF-α antagonist in CTL-mediated severe cutaneous adverse reactions.
Wang CW, Yang LY, Chen CB, Ho HC, Hung SI, Yang CH, Chang CJ, Su SC, Hui RC, Chin SW, Huang LF, Lin YY, Chang WY, Fan WL, Yang CY, Ho JC, Chang YC, Lu CW, Chung WH; the Taiwan Severe Cutaneous Adverse Reaction (TSCAR) Consortium
J Clin Invest 2018 Mar 1;128(3):985-996. Epub 2018 Feb 5 doi: 10.1172/JCI93349. PMID: 29400697Free PMC Article

Prognosis

Epidermolysis bullosa.
Bardhan A, Bruckner-Tuderman L, Chapple ILC, Fine JD, Harper N, Has C, Magin TM, Marinkovich MP, Marshall JF, McGrath JA, Mellerio JE, Polson R, Heagerty AH
Nat Rev Dis Primers 2020 Sep 24;6(1):78. doi: 10.1038/s41572-020-0210-0. PMID: 32973163
Bullous Drug Reactions.
Mockenhaupt M
Acta Derm Venereol 2020 Feb 12;100(5):adv00057. doi: 10.2340/00015555-3408. PMID: 32039459Free PMC Article
Suction Blisters.
Yu WY, Wei ML
JAMA Dermatol 2019 Feb 1;155(2):237. doi: 10.1001/jamadermatol.2018.3277. PMID: 30540360
Epidermolysis bullosa and the partnership with autoimmunity: what should we assimilate?
Esposito S, Guez S, Manzoni F, Bosco A, Rigante D
Immunol Res 2015 Feb;61(1-2):63-9. doi: 10.1007/s12026-014-8583-3. PMID: 25412732
Bullous pemphigoid.
Korman N
J Am Acad Dermatol 1987 May;16(5 Pt 1):907-24. doi: 10.1016/s0190-9622(87)70115-7. PMID: 3294944

Clinical prediction guides

Mechanisms Causing Acantholysis in Pemphigus-Lessons from Human Skin.
Egu DT, Schmitt T, Waschke J
Front Immunol 2022;13:884067. Epub 2022 May 20 doi: 10.3389/fimmu.2022.884067. PMID: 35720332Free PMC Article
Dyshidrosiform Bullous Pemphigoid.
Cohen PR
Medicina (Kaunas) 2021 Apr 20;57(4) doi: 10.3390/medicina57040398. PMID: 33924249Free PMC Article
Immunoglobulin M pemphigoid.
Boch K, Hammers CM, Goletz S, Kamaguchi M, Ludwig RJ, Schneider SW, Zillikens D, Hadaschik E, Schmidt E
J Am Acad Dermatol 2021 Dec;85(6):1486-1492. Epub 2021 Jan 13 doi: 10.1016/j.jaad.2021.01.017. PMID: 33453342
Comparison of clinical and histopathological characteristics of short-term progressive and non-progressive blood blister-like aneurysms.
Wen D, Chen R, Kieran NW, Sharifian-Dorche M, Liu W, Li H, You C, Yang M, Ma L
Acta Neurochir (Wien) 2021 Apr;163(4):1167-1179. Epub 2021 Jan 11 doi: 10.1007/s00701-020-04697-9. PMID: 33427988
Acute compartment syndrome: Cause, diagnosis, and new viewpoint.
Guo J, Yin Y, Jin L, Zhang R, Hou Z, Zhang Y
Medicine (Baltimore) 2019 Jul;98(27):e16260. doi: 10.1097/MD.0000000000016260. PMID: 31277147Free PMC Article

Recent systematic reviews

Negative pressure wound therapy for surgical wounds healing by primary closure.
Norman G, Shi C, Goh EL, Murphy EM, Reid A, Chiverton L, Stankiewicz M, Dumville JC
Cochrane Database Syst Rev 2022 Apr 26;4(4):CD009261. doi: 10.1002/14651858.CD009261.pub7. PMID: 35471497Free PMC Article
Surgical Interventions for Patients With Vitiligo: A Systematic Review and Meta-analysis.
Ju HJ, Bae JM, Lee RW, Kim SH, Parsad D, Pourang A, Hamzavi I, Shourick J, Ezzedine K
JAMA Dermatol 2021 Mar 1;157(3):307-316. doi: 10.1001/jamadermatol.2020.5756. PMID: 33595599Free PMC Article
Negative pressure wound therapy for surgical wounds healing by primary closure.
Norman G, Goh EL, Dumville JC, Shi C, Liu Z, Chiverton L, Stankiewicz M, Reid A
Cochrane Database Syst Rev 2020 Jun 15;6(6):CD009261. doi: 10.1002/14651858.CD009261.pub6. PMID: 32542647Free PMC Article
A Systematic Review of Drug-Induced Pemphigoid.
Verheyden MJ, Bilgic A, Murrell DF
Acta Derm Venereol 2020 Aug 17;100(15):adv00224. doi: 10.2340/00015555-3457. PMID: 32176310Free PMC Article
A Systematic Review and Meta-Analysis of Treatment and Outcome of Blister-Like Aneurysms.
Peschillo S, Cannizzaro D, Caporlingua A, Missori P
AJNR Am J Neuroradiol 2016 May;37(5):856-61. Epub 2015 Dec 3 doi: 10.3174/ajnr.A4606. PMID: 26635287Free PMC Article

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