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Halo nevus

MedGen UID:
141636
•Concept ID:
C0474824
•
Neoplastic Process
Synonyms: Halo nevi; Leukoderma acquisitum centrifugum of Sutton
SNOMED CT: Halo nevus (78325005); Halo nevus (398028009); Sutton's nevus (398028009)
 
Monarch Initiative: MONDO:0006778
OMIM®: 234300

Definition

A melanocytic nevus characterized by circumferential depigmentation. It is usually associated with a brisk lymphocytic infiltrate. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHalo nevus

Professional guidelines

PubMed

The role of reflectance confocal microscopy in the diagnosis and management of pigmentary disorders: A review.
Farabi B, Khan S, Jamgochian M, Atak MF, Jain M, Rao BK
J Cosmet Dermatol 2023 Dec;22(12):3213-3222. Epub 2023 Sep 27 doi: 10.1111/jocd.15827. PMID: 37759421
Management of resistant halo nevi.
Awad SS, Abdel Aziz RT, Mohammed SS
J Cosmet Laser Ther 2019;21(2):118-121. Epub 2018 May 9 doi: 10.1080/14764172.2018.1469772. PMID: 29741410
Treatment of halo nevus with a 308-nm excimer laser: a pilot study.
Mulekar SV, Issa AA, Eisa AA
J Cosmet Laser Ther 2007 Dec;9(4):245-8. doi: 10.1080/14764170701658229. PMID: 18236244

Recent clinical studies

Etiology

Aberrant expression of HMB45 and negative PRAME expression in halo nevi.
Ruby KN, Li Z, Yan S
J Cutan Pathol 2021 Apr;48(4):519-525. Epub 2020 Nov 25 doi: 10.1111/cup.13916. PMID: 33184871
Autoimmune diseases in Turner syndrome: an overview.
De Sanctis V, Khater D
Acta Biomed 2019 Sep 6;90(3):341-344. doi: 10.23750/abm.v90i3.8737. PMID: 31580326Free PMC Article
Association of halo nevus/i and vitiligo in childhood: a retrospective observational study.
Patrizi A, Bentivogli M, Raone B, Dondi A, Tabanelli M, Neri I
J Eur Acad Dermatol Venereol 2013 Feb;27(2):e148-52. Epub 2012 Mar 15 doi: 10.1111/j.1468-3083.2012.04504.x. PMID: 22416855
Inverse halo nevus.
Gupta S, Gupta S, Mahendra A, Gupta S
Dermatol Surg 2006 Jun;32(6):871-2. doi: 10.1111/j.1524-4725.2006.32180.x. PMID: 16792661
Halo nevus or halo phenomenon? A study of 142 cases.
Mooney MA, Barr RJ, Buxton MG
J Cutan Pathol 1995 Aug;22(4):342-8. doi: 10.1111/j.1600-0560.1995.tb01417.x. PMID: 7499574

Diagnosis

The role of reflectance confocal microscopy in the diagnosis and management of pigmentary disorders: A review.
Farabi B, Khan S, Jamgochian M, Atak MF, Jain M, Rao BK
J Cosmet Dermatol 2023 Dec;22(12):3213-3222. Epub 2023 Sep 27 doi: 10.1111/jocd.15827. PMID: 37759421
Agminated Halo Nevus: A Novel Presentation.
Hassab-El-Naby HMM, Rageh MA
Am J Dermatopathol 2023 Jun 1;45(6):388-390. Epub 2023 Mar 20 doi: 10.1097/DAD.0000000000002417. PMID: 36939134
Aberrant expression of HMB45 and negative PRAME expression in halo nevi.
Ruby KN, Li Z, Yan S
J Cutan Pathol 2021 Apr;48(4):519-525. Epub 2020 Nov 25 doi: 10.1111/cup.13916. PMID: 33184871
Non-lymphoid lesions that may mimic cutaneous hematopoietic neoplasms histologically.
Wick MR, Santa Cruz DJ, Gru AA
Semin Diagn Pathol 2017 Jan;34(1):99-107. Epub 2016 Nov 29 doi: 10.1053/j.semdp.2016.11.008. PMID: 27979335
Vitiligo: a review of the published work.
Yaghoobi R, Omidian M, Bagherani N
J Dermatol 2011 May;38(5):419-31. doi: 10.1111/j.1346-8138.2010.01139.x. PMID: 21667529

Therapy

Multiple Halo Nevi Induced by Intense Sun Exposure.
Loesch AJ, Kleinerman R, Lau G
J Drugs Dermatol 2023 Dec 1;22(12):e31-e32. doi: 10.36849/JDD.6792. PMID: 38051850
"Halo nevi" and UV radiation.
Pustisek N, Sikanić-Dugić N, Hirsl-Hećej V, Domljan ML
Coll Antropol 2010 Apr;34 Suppl 2:295-7. PMID: 21305746
Treatment of halo nevus with a 308-nm excimer laser: a pilot study.
Mulekar SV, Issa AA, Eisa AA
J Cosmet Laser Ther 2007 Dec;9(4):245-8. doi: 10.1080/14764170701658229. PMID: 18236244
Inverse halo nevus.
Gupta S, Gupta S, Mahendra A, Gupta S
Dermatol Surg 2006 Jun;32(6):871-2. doi: 10.1111/j.1524-4725.2006.32180.x. PMID: 16792661
Halo nevus, rather than vitiligo, is a typical dermatologic finding of turner's syndrome: clinical, genetic, and immunogenetic study in 72 patients.
Brazzelli V, Larizza D, Martinetti M, Martinoli S, Calcaterra V, De Silvestri A, Pandolfi R, Borroni G
J Am Acad Dermatol 2004 Sep;51(3):354-8. doi: 10.1016/j.jaad.2003.11.082. PMID: 15337976

Prognosis

Differences in the immune microenvironment between improved and non-improved cases of vitiligo after halo nevus excision.
Kano S, Nakamura M, Nojiri Y, Magara T, Yoshimitsu M, Kato H, Morita A
J Dermatol Sci 2023 Mar;109(3):136-142. Epub 2023 Mar 21 doi: 10.1016/j.jdermsci.2023.03.004. PMID: 36966028
Halo naevi with associated vitiligo-like depigmentations: pathogenetic hypothesis.
van Geel N, Speeckaert R, Lambert J, Mollet I, De Keyser S, De Schepper S, Brochez L
J Eur Acad Dermatol Venereol 2012 Jun;26(6):755-61. Epub 2011 Jun 23 doi: 10.1111/j.1468-3083.2011.04160.x. PMID: 21696452
Vitiligo: a review of the published work.
Yaghoobi R, Omidian M, Bagherani N
J Dermatol 2011 May;38(5):419-31. doi: 10.1111/j.1346-8138.2010.01139.x. PMID: 21667529
Prognostic value and clinical significance of halo naevi regarding vitiligo.
van Geel N, Vandenhaute S, Speeckaert R, Brochez L, Mollet I, De Cooman L, Lambert J
Br J Dermatol 2011 Apr;164(4):743-9. Epub 2011 Mar 16 doi: 10.1111/j.1365-2133.2010.10154.x. PMID: 21114480
Inverse halo nevus.
Gupta S, Gupta S, Mahendra A, Gupta S
Dermatol Surg 2006 Jun;32(6):871-2. doi: 10.1111/j.1524-4725.2006.32180.x. PMID: 16792661

Clinical prediction guides

Differences in the immune microenvironment between improved and non-improved cases of vitiligo after halo nevus excision.
Kano S, Nakamura M, Nojiri Y, Magara T, Yoshimitsu M, Kato H, Morita A
J Dermatol Sci 2023 Mar;109(3):136-142. Epub 2023 Mar 21 doi: 10.1016/j.jdermsci.2023.03.004. PMID: 36966028
Aberrant expression of HMB45 and negative PRAME expression in halo nevi.
Ruby KN, Li Z, Yan S
J Cutan Pathol 2021 Apr;48(4):519-525. Epub 2020 Nov 25 doi: 10.1111/cup.13916. PMID: 33184871
Association of halo nevus/i and vitiligo in childhood: a retrospective observational study.
Patrizi A, Bentivogli M, Raone B, Dondi A, Tabanelli M, Neri I
J Eur Acad Dermatol Venereol 2013 Feb;27(2):e148-52. Epub 2012 Mar 15 doi: 10.1111/j.1468-3083.2012.04504.x. PMID: 22416855
Prognostic value and clinical significance of halo naevi regarding vitiligo.
van Geel N, Vandenhaute S, Speeckaert R, Brochez L, Mollet I, De Cooman L, Lambert J
Br J Dermatol 2011 Apr;164(4):743-9. Epub 2011 Mar 16 doi: 10.1111/j.1365-2133.2010.10154.x. PMID: 21114480
The immune response in halo nevi.
Zeff RA, Freitag A, Grin CM, Grant-Kels JM
J Am Acad Dermatol 1997 Oct;37(4):620-4. doi: 10.1016/s0190-9622(97)70181-6. PMID: 9344203

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