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Benign Stromal Tumor

MedGen UID:
141637
•Concept ID:
C0474833
•
Neoplastic Process
Synonym: Benign stromal tumor
SNOMED CT: Benign stromal tumor (447644002)

Definition

A benign neoplasm composed of mesenchymal stromal cells without evidence of cellular atypia. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBenign Stromal Tumor

Professional guidelines

PubMed

ACG Clinical Guideline: Diagnosis and Management of Gastrointestinal Subepithelial Lesions.
Jacobson BC, Bhatt A, Greer KB, Lee LS, Park WG, Sauer BG, Shami VM
Am J Gastroenterol 2023 Jan 1;118(1):46-58. Epub 2022 Sep 6 doi: 10.14309/ajg.0000000000002100. PMID: 36602835
Endoscopic management of subepithelial lesions including neuroendocrine neoplasms: European Society of Gastrointestinal Endoscopy (ESGE) Guideline.
Deprez PH, Moons LMG, OʼToole D, Gincul R, Seicean A, Pimentel-Nunes P, Fernández-Esparrach G, Polkowski M, Vieth M, Borbath I, Moreels TG, Nieveen van Dijkum E, Blay JY, van Hooft JE
Endoscopy 2022 Apr;54(4):412-429. Epub 2022 Feb 18 doi: 10.1055/a-1751-5742. PMID: 35180797
Current clinical management of gastrointestinal stromal tumor.
Akahoshi K, Oya M, Koga T, Shiratsuchi Y
World J Gastroenterol 2018 Jul 14;24(26):2806-2817. doi: 10.3748/wjg.v24.i26.2806. PMID: 30018476Free PMC Article

Recent clinical studies

Etiology

Fine needle aspiration cytology presentation of a cellular variant of breast myofibroblastoma. Report of a case with immunohistochemical studies.
Schmitt FC, AC Mera A
Acta Cytol 1998 May-Jun;42(3):721-4. doi: 10.1159/000331833. PMID: 9622694
Pancreas-sparing duodenectomy for infra-ampullary duodenal pathology.
Maher MM, Yeo CJ, Lillemoe KD, Roberts JR, Cameron JL
Am J Surg 1996 Jan;171(1):62-7. doi: 10.1016/S0002-9610(99)80075-0. PMID: 8554153

Diagnosis

Mammary-type Myofibroblastoma with Leiomyomatous Differentiation: A Rare Variant with Potential Pitfalls.
Strait AM, Bridge JA, Iafrate AJ, Li MM, Xu F, Tsongalis GJ, Linos K
Int J Surg Pathol 2022 Apr;30(2):200-206. Epub 2021 Aug 2 doi: 10.1177/10668969211031309. PMID: 34338561
Hemangioblastoma-like Clear Cell Stromal Tumor of the Lung: A Clinicopathologic and Immunohistochemical Study of 5 Cases.
Lindholm KE, Moran CA
Am J Surg Pathol 2020 Jun;44(6):771-775. doi: 10.1097/PAS.0000000000001429. PMID: 31913155
Clinicopathological Characteristics of Mitotically-active Cellular Fibroma of the Ovary: A Single-institutional Experience.
Kim JY, Na K, Kim HS
Anticancer Res 2017 May;37(5):2557-2564. doi: 10.21873/anticanres.11599. PMID: 28476827
Mammary myofibroblastoma with extensive myxoedematous stromal changes: a potential diagnostic pitfall.
Magro G, Salvatorelli L, Spadola S, Angelico G
Pathol Res Pract 2014 Dec;210(12):1106-11. Epub 2014 Aug 19 doi: 10.1016/j.prp.2014.08.004. PMID: 25242026
Bronchogenic cyst of the stomach masquerading as benign stromal tumor.
Song SY, Noh JH, Lee SJ, Son HJ
Pathol Int 2005 Feb;55(2):87-91. doi: 10.1111/j.1440-1827.2005.01788.x. PMID: 15693855

Therapy

Fine needle aspiration cytology presentation of a cellular variant of breast myofibroblastoma. Report of a case with immunohistochemical studies.
Schmitt FC, AC Mera A
Acta Cytol 1998 May-Jun;42(3):721-4. doi: 10.1159/000331833. PMID: 9622694

Clinical prediction guides

Clinicopathological Characteristics of Mitotically-active Cellular Fibroma of the Ovary: A Single-institutional Experience.
Kim JY, Na K, Kim HS
Anticancer Res 2017 May;37(5):2557-2564. doi: 10.21873/anticanres.11599. PMID: 28476827
Fine needle aspiration cytology presentation of a cellular variant of breast myofibroblastoma. Report of a case with immunohistochemical studies.
Schmitt FC, AC Mera A
Acta Cytol 1998 May-Jun;42(3):721-4. doi: 10.1159/000331833. PMID: 9622694
Myofibroblastoma of the breast revisited: an etiologic association with androgens?
Morgan MB, Pitha JV
Hum Pathol 1998 Apr;29(4):347-51. doi: 10.1016/s0046-8177(98)90114-9. PMID: 9563783

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