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Ovarian serous tumor

MedGen UID:
141653
Concept ID:
C0476122
Neoplastic Process
Synonyms: Ovarian Serous Neoplasm; ovarian serous neoplasm; Ovarian Serous Tumor; ovarian serous tumor; Serous Neoplasm of Ovary; serous neoplasm of ovary; Serous Neoplasm of the Ovary; serous neoplasm of the ovary; Serous Tumor of Ovary; serous tumor of ovary; Serous Tumor of the Ovary; serous tumor of the ovary; serous tumour of ovary; serous tumour of the ovary
 
Monarch Initiative: MONDO:0037255

Definition

A benign, borderline, or malignant epithelial tumor of the ovary characterized by the presence of neoplastic epithelial cells that, in well differentiated tumors, resemble the epithelial cells of the fallopian tube and, in poorly differentiated tumors, show anaplastic features. Approximately thirty to fifty percent of the tumors are bilateral. Grossly, the better differentiated tumors consist of cystic masses, usually unilocular, containing a clear but sometimes viscous fluid. Papillary formations are often present. The more malignant tumors tend to be solid and invasive, with areas of necrosis and hemorrhage. [from NCI]

Professional guidelines

PubMed

Cathcart AM, Nezhat FR, Emerson J, Pejovic T, Nezhat CH, Nezhat CR
Am J Obstet Gynecol 2023 Jun;228(6):601-612. Epub 2022 Nov 19 doi: 10.1016/j.ajog.2022.11.1291. PMID: 36410423
Armstrong DK, Alvarez RD, Bakkum-Gamez JN, Barroilhet L, Behbakht K, Berchuck A, Chen LM, Cristea M, DeRosa M, Eisenhauer EL, Gershenson DM, Gray HJ, Grisham R, Hakam A, Jain A, Karam A, Konecny GE, Leath CA, Liu J, Mahdi H, Martin L, Matei D, McHale M, McLean K, Miller DS, O'Malley DM, Percac-Lima S, Ratner E, Remmenga SW, Vargas R, Werner TL, Zsiros E, Burns JL, Engh AM
J Natl Compr Canc Netw 2021 Feb 2;19(2):191-226. doi: 10.6004/jnccn.2021.0007. PMID: 33545690
Gershenson DM
Best Pract Res Clin Obstet Gynaecol 2017 May;41:49-59. Epub 2016 Oct 3 doi: 10.1016/j.bpobgyn.2016.09.012. PMID: 27780698

Recent clinical studies

Etiology

Kluz T, Bogaczyk A, Wita-Popów B, Habało P, Kluz-Barłowska M
Medicina (Kaunas) 2023 Oct 15;59(10) doi: 10.3390/medicina59101833. PMID: 37893550Free PMC Article
Zhou F, Lv B, Dong L, Wan F, Qin J, Huang L
Int J Clin Exp Pathol 2014;7(7):4448-53. Epub 2014 Jun 15 PMID: 25120832Free PMC Article
Deavers MT, Gershenson DM, Tortolero-Luna G, Malpica A, Lu KH, Silva EG
Am J Surg Pathol 2002 Sep;26(9):1129-41. doi: 10.1097/00000478-200209000-00003. PMID: 12218569
Tresukosol D, Kudelka AP, Edwards CL, Silva EG, Kanojia M, Kavanagh JJ
J Reprod Med 1996 May;41(5):363-6. PMID: 8725765
Yanai-Inbar I, Siriaunkgul S, Silverberg SG
Int J Gynecol Pathol 1995 Apr;14(2):107-13. doi: 10.1097/00004347-199504000-00003. PMID: 8601521

Diagnosis

Kluz T, Bogaczyk A, Wita-Popów B, Habało P, Kluz-Barłowska M
Medicina (Kaunas) 2023 Oct 15;59(10) doi: 10.3390/medicina59101833. PMID: 37893550Free PMC Article
Porcelli F, Verri M, De Santis S, Crescenzi A, Bianchi A, Felici AC, Sotgiu G, Romano S, Orsini M
Spectrochim Acta A Mol Biomol Spectrosc 2023 Oct 5;298:122792. Epub 2023 May 1 doi: 10.1016/j.saa.2023.122792. PMID: 37156176
Wolsky RJ, Price MA, Zaloudek CJ, Rabban JT
Int J Gynecol Pathol 2018 May;37(3):262-274. doi: 10.1097/PGP.0000000000000410. PMID: 28700429
Tanwar PS, Mohapatra G, Chiang S, Engler DA, Zhang L, Kaneko-Tarui T, Ohguchi Y, Birrer MJ, Teixeira JM
Carcinogenesis 2014 Mar;35(3):546-53. Epub 2013 Oct 29 doi: 10.1093/carcin/bgt357. PMID: 24170201Free PMC Article
Deavers MT, Gershenson DM, Tortolero-Luna G, Malpica A, Lu KH, Silva EG
Am J Surg Pathol 2002 Sep;26(9):1129-41. doi: 10.1097/00000478-200209000-00003. PMID: 12218569

Therapy

Grin L, Namazov A, Gemer O
J Obstet Gynaecol Res 2019 Jun;45(6):1205-1208. Epub 2019 Apr 5 doi: 10.1111/jog.13963. PMID: 30950130
Wolsky RJ, Price MA, Zaloudek CJ, Rabban JT
Int J Gynecol Pathol 2018 May;37(3):262-274. doi: 10.1097/PGP.0000000000000410. PMID: 28700429
Tresukosol D, Kudelka AP, Edwards CL, Silva EG, Kanojia M, Kavanagh JJ
J Reprod Med 1996 May;41(5):363-6. PMID: 8725765
Yanai-Inbar I, Siriaunkgul S, Silverberg SG
Int J Gynecol Pathol 1995 Apr;14(2):107-13. doi: 10.1097/00004347-199504000-00003. PMID: 8601521

Prognosis

Porcelli F, Verri M, De Santis S, Crescenzi A, Bianchi A, Felici AC, Sotgiu G, Romano S, Orsini M
Spectrochim Acta A Mol Biomol Spectrosc 2023 Oct 5;298:122792. Epub 2023 May 1 doi: 10.1016/j.saa.2023.122792. PMID: 37156176
Grin L, Namazov A, Gemer O
J Obstet Gynaecol Res 2019 Jun;45(6):1205-1208. Epub 2019 Apr 5 doi: 10.1111/jog.13963. PMID: 30950130
Liu F, Zhang G, Lv S, Wen X, Liu P
J Cell Biochem 2019 Aug;120(8):12618-12627. Epub 2019 Mar 4 doi: 10.1002/jcb.28528. PMID: 30834603
Tanwar PS, Mohapatra G, Chiang S, Engler DA, Zhang L, Kaneko-Tarui T, Ohguchi Y, Birrer MJ, Teixeira JM
Carcinogenesis 2014 Mar;35(3):546-53. Epub 2013 Oct 29 doi: 10.1093/carcin/bgt357. PMID: 24170201Free PMC Article
Deavers MT, Gershenson DM, Tortolero-Luna G, Malpica A, Lu KH, Silva EG
Am J Surg Pathol 2002 Sep;26(9):1129-41. doi: 10.1097/00000478-200209000-00003. PMID: 12218569

Clinical prediction guides

Porcelli F, Verri M, De Santis S, Crescenzi A, Bianchi A, Felici AC, Sotgiu G, Romano S, Orsini M
Spectrochim Acta A Mol Biomol Spectrosc 2023 Oct 5;298:122792. Epub 2023 May 1 doi: 10.1016/j.saa.2023.122792. PMID: 37156176
Deavers MT, Gershenson DM, Tortolero-Luna G, Malpica A, Lu KH, Silva EG
Am J Surg Pathol 2002 Sep;26(9):1129-41. doi: 10.1097/00000478-200209000-00003. PMID: 12218569

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