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Benign gastrointestinal tract tumors

MedGen UID:
141680
•Concept ID:
C0497538
•
Neoplastic Process
Synonyms: alimentary part of gastrointestinal system benign neoplasm; Benign Digestive System Neoplasm; benign digestive system neoplasm; Benign Digestive System Tumor; benign digestive system tumor; Benign Gastrointestinal Neoplasm; benign gastrointestinal neoplasm; Benign Gastrointestinal System Tumor; benign gastrointestinal system tumor; Benign gastrointestinal tract tumours; Benign Gastrointestinal Tumor; benign gastrointestinal tumor; Benign GI Neoplasm; benign GI neoplasm; Benign GI System Neoplasm; benign GI system neoplasm; Benign GI System Tumor; benign GI system tumor; Benign GI tract tumors; Benign GI tract tumours; Benign GI Tumor; benign GI tumor; Benign Neoplasm of Digestive System; benign neoplasm of digestive system; Benign Neoplasm of Gastrointestinal System; benign neoplasm of gastrointestinal system; Benign neoplasm of gastrointestinal tract; Benign Neoplasm of the Digestive System; benign neoplasm of the digestive system; Benign Tumor of Digestive System; benign tumor of digestive system; Benign Tumor of Gastrointestinal System; benign tumor of gastrointestinal system; Benign tumor of gastrointestinal tract; Benign Tumor of GI System; benign tumor of GI system; Benign Tumor of the Digestive System; benign tumor of the digestive system; Benign Tumor of the Gastrointestinal System; benign tumor of the gastrointestinal system; Benign Tumor of the GI System; benign tumor of the GI system; gastrointestinal system benign neoplasm; Non-cancerous GI tumors; Non-cancerous GI tumours
SNOMED CT: Benign neoplasm of gastrointestinal tract (92118007); Benign tumor of gastrointestinal tract (92118007)
 
HPO: HP:0006719
Monarch Initiative: MONDO:0000385

Definition

A non-metastasizing neoplasm arising from any part of the digestive system. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBenign gastrointestinal tract tumors

Conditions with this feature

Muir-Torré syndrome
MedGen UID:
231157
•Concept ID:
C1321489
•
Neoplastic Process
Lynch syndrome is characterized by an increased risk for colorectal cancer (CRC) and cancers of the endometrium, ovary, stomach, small bowel, urinary tract, biliary tract, brain (usually glioblastoma), skin (sebaceous adenomas, sebaceous carcinomas, and keratoacanthomas), pancreas, and prostate. Cancer risks and age of onset vary depending on the associated gene. Several other cancer types have been reported to occur in individuals with Lynch syndrome (e.g., breast, sarcomas, adrenocortical carcinoma). However, the data are not sufficient to demonstrate that the risk of developing these cancers is increased in individuals with Lynch syndrome.
See: Condition Record
Muir-Torré syndrome

Professional guidelines

PubMed

Management of Mucoceles, Sialoceles, and Ranulas.
Bowers EMR, Schaitkin B
Otolaryngol Clin North Am 2021 Jun;54(3):543-551. doi: 10.1016/j.otc.2021.03.002. PMID: 34024482
Current clinical management of gastrointestinal stromal tumor.
Akahoshi K, Oya M, Koga T, Shiratsuchi Y
World J Gastroenterol 2018 Jul 14;24(26):2806-2817. doi: 10.3748/wjg.v24.i26.2806. PMID: 30018476Free PMC Article
Management of post-hepatectomy complications.
Jin S, Fu Q, Wuyun G, Wuyun T
World J Gastroenterol 2013 Nov 28;19(44):7983-91. doi: 10.3748/wjg.v19.i44.7983. PMID: 24307791Free PMC Article

Recent clinical studies

Etiology

Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Salivary Glands.
Skálová A, Hyrcza MD, Leivo I
Head Neck Pathol 2022 Mar;16(1):40-53. Epub 2022 Mar 21 doi: 10.1007/s12105-022-01420-1. PMID: 35312980Free PMC Article
Endoscopic management of subepithelial lesions including neuroendocrine neoplasms: European Society of Gastrointestinal Endoscopy (ESGE) Guideline.
Deprez PH, Moons LMG, OʼToole D, Gincul R, Seicean A, Pimentel-Nunes P, Fernández-Esparrach G, Polkowski M, Vieth M, Borbath I, Moreels TG, Nieveen van Dijkum E, Blay JY, van Hooft JE
Endoscopy 2022 Apr;54(4):412-429. Epub 2022 Feb 18 doi: 10.1055/a-1751-5742. PMID: 35180797
T- and NK-cell lymphoproliferative disorders of the gastrointestinal tract: review and update.
van Vliet C, Spagnolo DV
Pathology 2020 Jan;52(1):128-141. Epub 2019 Nov 11 doi: 10.1016/j.pathol.2019.10.001. PMID: 31727264
Benign oral mucosal lesions: Clinical and pathological findings.
Maymone MBC, Greer RO, Burdine LK, Dao-Cheng A, Venkatesh S, Sahitya PC, Maymone AC, Kesecker J, Vashi NA
J Am Acad Dermatol 2019 Jul;81(1):43-56. Epub 2018 Nov 14 doi: 10.1016/j.jaad.2018.09.061. PMID: 30447312
Gastrointestinal stromal tumour.
Joensuu H, Hohenberger P, Corless CL
Lancet 2013 Sep 14;382(9896):973-83. Epub 2013 Apr 24 doi: 10.1016/S0140-6736(13)60106-3. PMID: 23623056

Diagnosis

Endoscopic management of subepithelial lesions including neuroendocrine neoplasms: European Society of Gastrointestinal Endoscopy (ESGE) Guideline.
Deprez PH, Moons LMG, OʼToole D, Gincul R, Seicean A, Pimentel-Nunes P, Fernández-Esparrach G, Polkowski M, Vieth M, Borbath I, Moreels TG, Nieveen van Dijkum E, Blay JY, van Hooft JE
Endoscopy 2022 Apr;54(4):412-429. Epub 2022 Feb 18 doi: 10.1055/a-1751-5742. PMID: 35180797
The Microbiome and Gynecologic Cancer: Current Evidence and Future Opportunities.
Chambers LM, Bussies P, Vargas R, Esakov E, Tewari S, Reizes O, Michener C
Curr Oncol Rep 2021 Jun 14;23(8):92. doi: 10.1007/s11912-021-01079-x. PMID: 34125319
T- and NK-cell lymphoproliferative disorders of the gastrointestinal tract: review and update.
van Vliet C, Spagnolo DV
Pathology 2020 Jan;52(1):128-141. Epub 2019 Nov 11 doi: 10.1016/j.pathol.2019.10.001. PMID: 31727264
Current clinical management of gastrointestinal stromal tumor.
Akahoshi K, Oya M, Koga T, Shiratsuchi Y
World J Gastroenterol 2018 Jul 14;24(26):2806-2817. doi: 10.3748/wjg.v24.i26.2806. PMID: 30018476Free PMC Article
Gastrointestinal stromal tumour.
Joensuu H, Hohenberger P, Corless CL
Lancet 2013 Sep 14;382(9896):973-83. Epub 2013 Apr 24 doi: 10.1016/S0140-6736(13)60106-3. PMID: 23623056

Therapy

Laparoscopic versus open pancreatoduodenectomy for pancreatic or periampullary tumours: a multicentre, open-label, randomised controlled trial.
Wang M, Li D, Chen R, Huang X, Li J, Liu Y, Liu J, Cheng W, Chen X, Zhao W, Li J, Tan Z, Huang H, Li D, Zhu F, Qin T, Ma J, Yu G, Zhou B, Zheng S, Tang Y, Han W, Meng L, Ke J, Feng F, Chen B, Yin X, Chen W, Ma H, Xu J, Liu Y, Lin R, Dong Y, Yu Y, Liu J, Zhang H, Qin R; Minimally Invasive Treatment Group in the Pancreatic Disease Branch of China's International Exchange and Promotion Association for Medicine and Healthcare (MITG-P-CPAM)
Lancet Gastroenterol Hepatol 2021 Jun;6(6):438-447. Epub 2021 Apr 27 doi: 10.1016/S2468-1253(21)00054-6. PMID: 33915091
Surgical treatment strategy in Warthin tumor of the parotid gland.
Lee DH, Yoon TM, Lee JK, Lim SC
Braz J Otorhinolaryngol 2019 Sep-Oct;85(5):546-550. Epub 2018 May 16 doi: 10.1016/j.bjorl.2018.04.004. PMID: 29807810Free PMC Article
Current clinical management of gastrointestinal stromal tumor.
Akahoshi K, Oya M, Koga T, Shiratsuchi Y
World J Gastroenterol 2018 Jul 14;24(26):2806-2817. doi: 10.3748/wjg.v24.i26.2806. PMID: 30018476Free PMC Article
Gastrointestinal stromal tumour.
Joensuu H, Hohenberger P, Corless CL
Lancet 2013 Sep 14;382(9896):973-83. Epub 2013 Apr 24 doi: 10.1016/S0140-6736(13)60106-3. PMID: 23623056
Major and minor salivary gland tumors.
Guzzo M, Locati LD, Prott FJ, Gatta G, McGurk M, Licitra L
Crit Rev Oncol Hematol 2010 May;74(2):134-48. Epub 2009 Nov 24 doi: 10.1016/j.critrevonc.2009.10.004. PMID: 19939701

Prognosis

T- and NK-cell lymphoproliferative disorders of the gastrointestinal tract: review and update.
van Vliet C, Spagnolo DV
Pathology 2020 Jan;52(1):128-141. Epub 2019 Nov 11 doi: 10.1016/j.pathol.2019.10.001. PMID: 31727264
Current clinical management of gastrointestinal stromal tumor.
Akahoshi K, Oya M, Koga T, Shiratsuchi Y
World J Gastroenterol 2018 Jul 14;24(26):2806-2817. doi: 10.3748/wjg.v24.i26.2806. PMID: 30018476Free PMC Article
Retrorectal tumors.
Bullard Dunn K
Surg Clin North Am 2010 Feb;90(1):163-71, Table of Contents. doi: 10.1016/j.suc.2009.09.009. PMID: 20109640
Major and minor salivary gland tumors.
Guzzo M, Locati LD, Prott FJ, Gatta G, McGurk M, Licitra L
Crit Rev Oncol Hematol 2010 May;74(2):134-48. Epub 2009 Nov 24 doi: 10.1016/j.critrevonc.2009.10.004. PMID: 19939701
Carcinoid tumors.
Pasieka JL
Surg Clin North Am 2009 Oct;89(5):1123-37. doi: 10.1016/j.suc.2009.06.008. PMID: 19836488

Clinical prediction guides

Analysis of the Clinical Relevance of Histological Classification of Benign Epithelial Salivary Gland Tumours.
Hellquist H, Paiva-Correia A, Vander Poorten V, Quer M, Hernandez-Prera JC, Andreasen S, Zbären P, Skalova A, Rinaldo A, Ferlito A
Adv Ther 2019 Aug;36(8):1950-1974. Epub 2019 Jun 17 doi: 10.1007/s12325-019-01007-3. PMID: 31209701Free PMC Article
Evaluation: Imaging Studies.
Kontzialis M, Glastonbury CM, Aygun N
Adv Otorhinolaryngol 2016;78:25-38. Epub 2016 Apr 12 doi: 10.1159/000442122. PMID: 27093072
SMALL INTESTINAL TUMORS.
Bozhkov V, Magjov R, Chernopolsky P, Arnaudov P, Plachkov I, Ivanov T
Khirurgiia (Sofiia) 2015;81(2):4-8. PMID: 26668984
Benign esophageal lesions: endoscopic and pathologic features.
Tsai SJ, Lin CC, Chang CW, Hung CY, Shieh TY, Wang HY, Shih SC, Chen MJ
World J Gastroenterol 2015 Jan 28;21(4):1091-8. doi: 10.3748/wjg.v21.i4.1091. PMID: 25632181Free PMC Article
Gastrointestinal stromal tumors: epidemiology, clinical picture, diagnosis, prognosis and treatment.
Cichoz-Lach H, Kasztelan-Szczerbińska B, Słomka M
Pol Arch Med Wewn 2008 Apr;118(4):216-21. PMID: 18575421

Recent systematic reviews

Surgical interventions for management of benign parotid tumors: Systematic review and network meta-analysis.
Mashrah MA, Al-Sharani HM, Al-Aroomi MA, Abdelrehem A, Aldhohrah T, Wang L
Head Neck 2021 Nov;43(11):3631-3645. Epub 2021 Jul 20 doi: 10.1002/hed.26813. PMID: 34288212
Management options for chronic anal fissure: a systematic review of randomised controlled trials.
Boland PA, Kelly ME, Donlon NE, Bolger JC, Larkin JO, Mehigan BJ, McCormick PH
Int J Colorectal Dis 2020 Oct;35(10):1807-1815. Epub 2020 Jul 25 doi: 10.1007/s00384-020-03699-4. PMID: 32712929
Body mass index and complications following major gastrointestinal surgery: a prospective, international cohort study and meta-analysis.
EuroSurg Collaborative
Colorectal Dis 2018 Aug;20(8):O215-O225. Epub 2018 Jul 9 doi: 10.1111/codi.14292. PMID: 29897171
Intraoperative use of ICG fluorescence imaging to reduce the risk of anastomotic leakage in colorectal surgery: a systematic review and meta-analysis.
Blanco-Colino R, Espin-Basany E
Tech Coloproctol 2018 Jan;22(1):15-23. Epub 2017 Dec 11 doi: 10.1007/s10151-017-1731-8. PMID: 29230591
Cowden syndrome and the PTEN hamartoma tumor syndrome: systematic review and revised diagnostic criteria.
Pilarski R, Burt R, Kohlman W, Pho L, Shannon KM, Swisher E
J Natl Cancer Inst 2013 Nov 6;105(21):1607-16. Epub 2013 Oct 17 doi: 10.1093/jnci/djt277. PMID: 24136893

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