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Schizophrenia Spectrum and Other Psychotic Disorders

MedGen UID:
141907
•Concept ID:
C0525046
•
Mental or Behavioral Dysfunction
Synonym: Schizophrenia and Disorders with Psychotic Features

Definition

Marked disorders of thought (delusions, hallucinations, or other thought disorder accompanied by disordered affect or behavior), and deterioration from a previous level of functioning. Individuals have one o more of the following symptoms: delusions, hallucinations, and disorganized speech. (from DSM-5) [from MeSH]

Professional guidelines

PubMed

What is the Link Between Substance-Induced Psychosis and Primary Psychotic Disorders?
Vassos E
Am J Psychiatry 2023 Jun 1;180(6):404-406. doi: 10.1176/appi.ajp.20230298. PMID: 37259511
Dementia Is More Than Memory Loss: Neuropsychiatric Symptoms of Dementia and Their Nonpharmacological and Pharmacological Management.
Tampi RR, Jeste DV
Am J Psychiatry 2022 Aug;179(8):528-543. doi: 10.1176/appi.ajp.20220508. PMID: 35921394
Depression and Schizophrenia: Sleep, Medical Risk Factors, Biomarkers, and Treatment.
Kalin NH
Am J Psychiatry 2021 Oct 1;178(10):881-884. doi: 10.1176/appi.ajp.2021.21080824. PMID: 34592847

Recent clinical studies

Etiology

Transition From Substance-Induced Psychosis to Schizophrenia Spectrum Disorder or Bipolar Disorder.
Rognli EB, Heiberg IH, Jacobsen BK, Høye A, Bramness JG
Am J Psychiatry 2023 Jun 1;180(6):437-444. Epub 2023 May 3 doi: 10.1176/appi.ajp.22010076. PMID: 37132221
Schizophrenia Imaging Signatures and Their Associations With Cognition, Psychopathology, and Genetics in the General Population.
Chand GB, Singhal P, Dwyer DB, Wen J, Erus G, Doshi J, Srinivasan D, Mamourian E, Varol E, Sotiras A, Hwang G, Dazzan P, Kahn RS, Schnack HG, Zanetti MV, Meisenzahl E, Busatto GF, Crespo-Facorro B, Pantelis C, Wood SJ, Zhuo C, Shinohara RT, Shou H, Fan Y, Koutsouleris N, Kaczkurkin AN, Moore TM, Verma A, Calkins ME, Gur RE, Gur RC, Ritchie MD, Satterthwaite TD, Wolf DH, Davatzikos C
Am J Psychiatry 2022 Sep;179(9):650-660. Epub 2022 Apr 12 doi: 10.1176/appi.ajp.21070686. PMID: 35410495Free PMC Article
Anticholinergic Medication Burden-Associated Cognitive Impairment in Schizophrenia.
Joshi YB, Thomas ML, Braff DL, Green MF, Gur RC, Gur RE, Nuechterlein KH, Stone WS, Greenwood TA, Lazzeroni LC, MacDonald LR, Molina JL, Nungaray JA, Radant AD, Silverman JM, Sprock J, Sugar CA, Tsuang DW, Tsuang MT, Turetsky BI, Swerdlow NR, Light GA
Am J Psychiatry 2021 Sep 1;178(9):838-847. Epub 2021 May 14 doi: 10.1176/appi.ajp.2020.20081212. PMID: 33985348Free PMC Article
Neuroimaging Biomarkers in Schizophrenia.
Kraguljac NV, McDonald WM, Widge AS, Rodriguez CI, Tohen M, Nemeroff CB
Am J Psychiatry 2021 Jun;178(6):509-521. Epub 2021 Jan 5 doi: 10.1176/appi.ajp.2020.20030340. PMID: 33397140Free PMC Article
Schizophrenia spectrum and other psychotic disorders.
Lewine R, Hart M
Handb Clin Neurol 2020;175:315-333. doi: 10.1016/B978-0-444-64123-6.00022-9. PMID: 33008535

Diagnosis

Schizophrenia Imaging Signatures and Their Associations With Cognition, Psychopathology, and Genetics in the General Population.
Chand GB, Singhal P, Dwyer DB, Wen J, Erus G, Doshi J, Srinivasan D, Mamourian E, Varol E, Sotiras A, Hwang G, Dazzan P, Kahn RS, Schnack HG, Zanetti MV, Meisenzahl E, Busatto GF, Crespo-Facorro B, Pantelis C, Wood SJ, Zhuo C, Shinohara RT, Shou H, Fan Y, Koutsouleris N, Kaczkurkin AN, Moore TM, Verma A, Calkins ME, Gur RE, Gur RC, Ritchie MD, Satterthwaite TD, Wolf DH, Davatzikos C
Am J Psychiatry 2022 Sep;179(9):650-660. Epub 2022 Apr 12 doi: 10.1176/appi.ajp.21070686. PMID: 35410495Free PMC Article
Anticholinergic Medication Burden-Associated Cognitive Impairment in Schizophrenia.
Joshi YB, Thomas ML, Braff DL, Green MF, Gur RC, Gur RE, Nuechterlein KH, Stone WS, Greenwood TA, Lazzeroni LC, MacDonald LR, Molina JL, Nungaray JA, Radant AD, Silverman JM, Sprock J, Sugar CA, Tsuang DW, Tsuang MT, Turetsky BI, Swerdlow NR, Light GA
Am J Psychiatry 2021 Sep 1;178(9):838-847. Epub 2021 May 14 doi: 10.1176/appi.ajp.2020.20081212. PMID: 33985348Free PMC Article
Sleep Abnormalities in Schizophrenia: State of the Art and Next Steps.
Ferrarelli F
Am J Psychiatry 2021 Oct 1;178(10):903-913. Epub 2021 Mar 17 doi: 10.1176/appi.ajp.2020.20070968. PMID: 33726524Free PMC Article
Neuroimaging Biomarkers in Schizophrenia.
Kraguljac NV, McDonald WM, Widge AS, Rodriguez CI, Tohen M, Nemeroff CB
Am J Psychiatry 2021 Jun;178(6):509-521. Epub 2021 Jan 5 doi: 10.1176/appi.ajp.2020.20030340. PMID: 33397140Free PMC Article
Schizophrenia spectrum and other psychotic disorders.
Lewine R, Hart M
Handb Clin Neurol 2020;175:315-333. doi: 10.1016/B978-0-444-64123-6.00022-9. PMID: 33008535

Therapy

Safety of Antipsychotic Polypharmacy Versus Monotherapy in a Nationwide Cohort of 61,889 Patients With Schizophrenia.
Taipale H, Tanskanen A, Tiihonen J
Am J Psychiatry 2023 May 1;180(5):377-385. Epub 2023 Mar 22 doi: 10.1176/appi.ajp.20220446. PMID: 36945825
Technology and Mental Health: State of the Art for Assessment and Treatment.
Harvey PD, Depp CA, Rizzo AA, Strauss GP, Spelber D, Carpenter LL, Kalin NH, Krystal JH, McDonald WM, Nemeroff CB, Rodriguez CI, Widge AS, Torous J
Am J Psychiatry 2022 Dec 1;179(12):897-914. Epub 2022 Oct 6 doi: 10.1176/appi.ajp.21121254. PMID: 36200275
Dementia Is More Than Memory Loss: Neuropsychiatric Symptoms of Dementia and Their Nonpharmacological and Pharmacological Management.
Tampi RR, Jeste DV
Am J Psychiatry 2022 Aug;179(8):528-543. doi: 10.1176/appi.ajp.20220508. PMID: 35921394
Muscarinic Acetylcholine Receptor Agonists as Novel Treatments for Schizophrenia.
Paul SM, Yohn SE, Popiolek M, Miller AC, Felder CC
Am J Psychiatry 2022 Sep;179(9):611-627. Epub 2022 Jun 27 doi: 10.1176/appi.ajp.21101083. PMID: 35758639
Anticholinergic Medication Burden-Associated Cognitive Impairment in Schizophrenia.
Joshi YB, Thomas ML, Braff DL, Green MF, Gur RC, Gur RE, Nuechterlein KH, Stone WS, Greenwood TA, Lazzeroni LC, MacDonald LR, Molina JL, Nungaray JA, Radant AD, Silverman JM, Sprock J, Sugar CA, Tsuang DW, Tsuang MT, Turetsky BI, Swerdlow NR, Light GA
Am J Psychiatry 2021 Sep 1;178(9):838-847. Epub 2021 May 14 doi: 10.1176/appi.ajp.2020.20081212. PMID: 33985348Free PMC Article

Prognosis

Polygenic Scores and Onset of Major Mood or Psychotic Disorders Among Offspring of Affected Parents.
Zwicker A, Fullerton JM, Mullins N, Rice F, Hafeman DM, van Haren NEM, Setiaman N, Merranko JA, Goldstein BI, Ferrera AG, Stapp EK, de la Serna E, Moreno D, Sugranyes G, Herrero SM, Roberts G, Toma C, Schofield PR, Edenberg HJ, Wilcox HC, McInnis MG, Powell V, Propper L, Denovan-Wright E, Rouleau G, Castro-Fornieles J, Hillegers MHJ, Birmaher B, Thapar A, Mitchell PB, Lewis CM, Alda M, Nurnberger JI, Uher R
Am J Psychiatry 2023 Apr 1;180(4):285-293. Epub 2023 Feb 22 doi: 10.1176/appi.ajp.20220476. PMID: 36856707
Sleep Abnormalities in Schizophrenia: State of the Art and Next Steps.
Ferrarelli F
Am J Psychiatry 2021 Oct 1;178(10):903-913. Epub 2021 Mar 17 doi: 10.1176/appi.ajp.2020.20070968. PMID: 33726524Free PMC Article
Neuroimaging Biomarkers in Schizophrenia.
Kraguljac NV, McDonald WM, Widge AS, Rodriguez CI, Tohen M, Nemeroff CB
Am J Psychiatry 2021 Jun;178(6):509-521. Epub 2021 Jan 5 doi: 10.1176/appi.ajp.2020.20030340. PMID: 33397140Free PMC Article
Schizophrenia spectrum and other psychotic disorders.
Lewine R, Hart M
Handb Clin Neurol 2020;175:315-333. doi: 10.1016/B978-0-444-64123-6.00022-9. PMID: 33008535
Self-disorders in Early Stages of the Schizophrenia Spectrum.
Valle R, Perales A
Rev Colomb Psiquiatr (Engl Ed) 2019 Oct-Dec;48(4):244-251. Epub 2018 Mar 20 doi: 10.1016/j.rcp.2018.02.003. PMID: 31779875

Clinical prediction guides

Schizophrenia Imaging Signatures and Their Associations With Cognition, Psychopathology, and Genetics in the General Population.
Chand GB, Singhal P, Dwyer DB, Wen J, Erus G, Doshi J, Srinivasan D, Mamourian E, Varol E, Sotiras A, Hwang G, Dazzan P, Kahn RS, Schnack HG, Zanetti MV, Meisenzahl E, Busatto GF, Crespo-Facorro B, Pantelis C, Wood SJ, Zhuo C, Shinohara RT, Shou H, Fan Y, Koutsouleris N, Kaczkurkin AN, Moore TM, Verma A, Calkins ME, Gur RE, Gur RC, Ritchie MD, Satterthwaite TD, Wolf DH, Davatzikos C
Am J Psychiatry 2022 Sep;179(9):650-660. Epub 2022 Apr 12 doi: 10.1176/appi.ajp.21070686. PMID: 35410495Free PMC Article
Anticholinergic Medication Burden-Associated Cognitive Impairment in Schizophrenia.
Joshi YB, Thomas ML, Braff DL, Green MF, Gur RC, Gur RE, Nuechterlein KH, Stone WS, Greenwood TA, Lazzeroni LC, MacDonald LR, Molina JL, Nungaray JA, Radant AD, Silverman JM, Sprock J, Sugar CA, Tsuang DW, Tsuang MT, Turetsky BI, Swerdlow NR, Light GA
Am J Psychiatry 2021 Sep 1;178(9):838-847. Epub 2021 May 14 doi: 10.1176/appi.ajp.2020.20081212. PMID: 33985348Free PMC Article
Sleep Abnormalities in Schizophrenia: State of the Art and Next Steps.
Ferrarelli F
Am J Psychiatry 2021 Oct 1;178(10):903-913. Epub 2021 Mar 17 doi: 10.1176/appi.ajp.2020.20070968. PMID: 33726524Free PMC Article
Neuroimaging Biomarkers in Schizophrenia.
Kraguljac NV, McDonald WM, Widge AS, Rodriguez CI, Tohen M, Nemeroff CB
Am J Psychiatry 2021 Jun;178(6):509-521. Epub 2021 Jan 5 doi: 10.1176/appi.ajp.2020.20030340. PMID: 33397140Free PMC Article
Self-disorders in Early Stages of the Schizophrenia Spectrum.
Valle R, Perales A
Rev Colomb Psiquiatr (Engl Ed) 2019 Oct-Dec;48(4):244-251. Epub 2018 Mar 20 doi: 10.1016/j.rcp.2018.02.003. PMID: 31779875

Recent systematic reviews

The relationship between sleep and suicidality in schizophrenia spectrum and other psychotic disorders: A systematic review.
Rogers E, Gresswell M, Durrant S
Schizophr Res 2023 Nov;261:291-303. Epub 2023 Oct 23 doi: 10.1016/j.schres.2023.10.010. PMID: 37879227
Peer-facilitated interventions for improving the physical health of people with schizophrenia spectrum disorders: systematic review and meta-analysis.
Coles A, Maksyutynska K, Knezevic D, Agarwal SM, Strudwick G, Dunbar JA, Druss B, Selby P, Banfield M, Hahn MK, Castle D
Med J Aust 2022 Oct 2;217 Suppl 7:S22-S28. doi: 10.5694/mja2.51693. PMID: 36183320
The role of alcohol intake in the pharmacogenetics of treatment with clozapine.
Monroy-Jaramillo N, Martínez-Magaña JJ, Pérez-Aldana BE, Ortega-Vázquez A, Montalvo-Ortiz J, López-López M
Pharmacogenomics 2022 Apr;23(6):371-392. Epub 2022 Mar 21 doi: 10.2217/pgs-2022-0006. PMID: 35311547
Care Management for Serious Mental Illness: A Systematic Review and Meta-Analysis.
Lim CT, Caan MP, Kim CH, Chow CM, Leff HS, Tepper MC
Psychiatr Serv 2022 Feb 1;73(2):180-187. Epub 2021 Jul 13 doi: 10.1176/appi.ps.202000473. PMID: 34253036
Adiposity in schizophrenia: A systematic review and meta-analysis.
Smith E, Singh R, Lee J, Colucci L, Graff-Guerrero A, Remington G, Hahn M, Agarwal SM
Acta Psychiatr Scand 2021 Dec;144(6):524-536. Epub 2021 Sep 16 doi: 10.1111/acps.13365. PMID: 34458979

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