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Bowen disease of the skin

MedGen UID:
Concept ID:
Neoplastic Process
Synonym: Bowen's disease
SNOMED CT: BD - Bowen's disease (84999002); SCC - Intraepidermal squamous cell carcinoma - Bowen's type (84999002); Bowen's disease (84999002); Intraepidermal squamous cell carcinoma, Bowen's type (84999002); Bowen disease (84999002); Bowen's disease of skin (254656002)
Monarch Initiative: MONDO:0020761


A form of squamous cell carcinoma in situ. It is a distinct clinicopathological entity and arises from the skin or the mucocutaneous junction. It affects predominantly white males in their 6-8th decades of life. Exposed and non-exposed skin sites are equally affected. UV damage and ingestion of inorganic arsenic may play a role in the development of the disease. On the skin surface, it presents as a single or multiple erythematous, scaly, keratotic patches or plaques. The clinical entity of erythroplasia of Queyrat is regarded as Bowen disease of the penis and it presents as an asymptomatic, red, circumscribed plaque. Morphologically, Bowen disease is characterized by the presence of hyperkeratosis, parakeratosis, dyskeratosis, and acanthosis. The keratotic squamous cells are atypical and display hyperchromatism and abnormal mitotic figures. The dermoepidermal basement membrane is intact. Complete surgical removal of the lesion may be curative. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBowen disease of the skin

Professional guidelines


May PJ, Tong SYC, Steer AC, Currie BJ, Andrews RM, Carapetis JR, Bowen AC
Trop Med Int Health 2019 Mar;24(3):280-293. Epub 2019 Jan 28 doi: 10.1111/tmi.13198. PMID: 30582783Free PMC Article
Ozog DM, Rkein AM, Fabi SG, Gold MH, Goldman MP, Lowe NJ, Martin GM, Munavalli GS
Dermatol Surg 2016 Jul;42(7):804-27. doi: 10.1097/DSS.0000000000000800. PMID: 27336945
Edwards SK, Bunker CB, Ziller F, van der Meijden WI
Int J STD AIDS 2014 Aug;25(9):615-26. Epub 2014 May 14 doi: 10.1177/0956462414533099. PMID: 24828553

Recent clinical studies


Centeno JA, Mullick FG, Martinez L, Page NP, Gibb H, Longfellow D, Thompson C, Ladich ER
Environ Health Perspect 2002 Oct;110 Suppl 5(Suppl 5):883-6. doi: 10.1289/ehp.02110s5883. PMID: 12426152Free PMC Article

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