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Burning mouth syndrome

MedGen UID:
14254
•Concept ID:
C0006430
•
Disease or Syndrome
Synonyms: Burning Mouth Syndrome; Burning Mouth Syndromes; Mouth Syndrome, Burning; Mouth Syndromes, Burning; Syndrome, Burning Mouth; Syndromes, Burning Mouth
SNOMED CT: Burning mouth syndrome (399165002); Orodynia (399165002); Stomatopyrosis (399165002); BMS - burning mouth syndrome (399165002)
 
Monarch Initiative: MONDO:0006687
Orphanet: ORPHA353253

Definition

A rare neurologic disease characterized by an unremitting bilateral symmetrical burning sensation of the oral mucosa without clinical evidence of causative lesions. It most frequently occurs in postmenopausal women and typically affects the tongue, less often the palate, lips, or buccal mucosa. It is often associated with dysgeusia and xerostomia. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBurning mouth syndrome

Professional guidelines

PubMed

A systematic review of treatment for patients with burning mouth syndrome.
Tan HL, Smith JG, Hoffmann J, Renton T
Cephalalgia 2022 Feb;42(2):128-161. Epub 2021 Aug 18 doi: 10.1177/03331024211036152. PMID: 34404247Free PMC Article
Pharmacological and non-pharmacological management of burning mouth syndrome: A systematic review.
Reyad AA, Mishriky R, Girgis E
Dent Med Probl 2020 Jul-Sep;57(3):295-304. doi: 10.17219/dmp/120991. PMID: 33113291
Differential diagnosis of facial pain and guidelines for management.
Zakrzewska JM
Br J Anaesth 2013 Jul;111(1):95-104. doi: 10.1093/bja/aet125. PMID: 23794651

Recent clinical studies

Etiology

Treatments for Burning Mouth Syndrome: A Network Meta-analysis.
Alvarenga-Brant R, Costa FO, Mattos-Pereira G, Esteves-Lima RP, Belém FV, Lai H, Ge L, Gomez RS, Martins CC
J Dent Res 2023 Feb;102(2):135-145. Epub 2022 Oct 8 doi: 10.1177/00220345221130025. PMID: 36214096
Burning Mouth Syndrome Etiology: A Narrative Review.
Russo M, Crafa P, Guglielmetti S, Franzoni L, Fiore W, Di Mario F
J Gastrointestin Liver Dis 2022 Jun 12;31(2):223-228. doi: 10.15403/jgld-4245. PMID: 35574619
Burning mouth syndrome and associated factors: A case-control retrospective study.
Chimenos-Küstner E, de Luca-Monasterios F, Schemel-Suárez M, Rodríguez de Rivera-Campillo ME, Pérez-Pérez AM, López-López J
Med Clin (Barc) 2017 Feb 23;148(4):153-157. Epub 2016 Nov 18 doi: 10.1016/j.medcli.2016.09.046. PMID: 27871766
Interventions for treating burning mouth syndrome.
McMillan R, Forssell H, Buchanan JA, Glenny AM, Weldon JC, Zakrzewska JM
Cochrane Database Syst Rev 2016 Nov 18;11(11):CD002779. doi: 10.1002/14651858.CD002779.pub3. PMID: 27855478Free PMC Article
Black hairy tongue syndrome.
Gurvits GE, Tan A
World J Gastroenterol 2014 Aug 21;20(31):10845-50. doi: 10.3748/wjg.v20.i31.10845. PMID: 25152586Free PMC Article

Diagnosis

Burning Mouth Syndrome.
Khawaja SN, Alaswaiti OF, Scrivani SJ
Dent Clin North Am 2023 Jan;67(1):49-60. Epub 2022 Oct 27 doi: 10.1016/j.cden.2022.07.004. PMID: 36404080
Burning mouth syndrome: a review of therapeutic approach.
Nosratzehi T
J Complement Integr Med 2021 Dec 9;19(1):83-90. doi: 10.1515/jcim-2021-0434. PMID: 34881535
Burning Mouth Syndrome.
Klein B, Thoppay JR, De Rossi SS, Ciarrocca K
Dermatol Clin 2020 Oct;38(4):477-483. Epub 2020 Aug 10 doi: 10.1016/j.det.2020.05.008. PMID: 32892856
Burning Mouth Syndrome.
Bender SD
Dent Clin North Am 2018 Oct;62(4):585-596. Epub 2018 Jul 27 doi: 10.1016/j.cden.2018.05.006. PMID: 30189984
Burning mouth syndrome: a review and update.
Silvestre FJ, Silvestre-Rangil J, López-Jornet P
Rev Neurol 2015 May 16;60(10):457-63. PMID: 25952601

Therapy

A systematic review of treatment for patients with burning mouth syndrome.
Tan HL, Smith JG, Hoffmann J, Renton T
Cephalalgia 2022 Feb;42(2):128-161. Epub 2021 Aug 18 doi: 10.1177/03331024211036152. PMID: 34404247Free PMC Article
Burning mouth syndrome: a review of therapeutic approach.
Nosratzehi T
J Complement Integr Med 2021 Dec 9;19(1):83-90. doi: 10.1515/jcim-2021-0434. PMID: 34881535
Burning mouth syndrome: a systematic review of treatments.
Liu YF, Kim Y, Yoo T, Han P, Inman JC
Oral Dis 2018 Apr;24(3):325-334. Epub 2017 Mar 30 doi: 10.1111/odi.12660. PMID: 28247977
Burning mouth syndrome: a review and update.
Silvestre FJ, Silvestre-Rangil J, López-Jornet P
Rev Neurol 2015 May 16;60(10):457-63. PMID: 25952601
Neuropathic pain after dental treatment.
Tınastepe N, Oral K
Agri 2013;25(1):1-6. doi: 10.5505/agri.2013.55477. PMID: 23588863

Prognosis

Acute and Chronic Pain from Facial Skin and Oral Mucosa: Unique Neurobiology and Challenging Treatment.
Chung MK, Wang S, Oh SL, Kim YS
Int J Mol Sci 2021 May 28;22(11) doi: 10.3390/ijms22115810. PMID: 34071720Free PMC Article
Black hairy tongue syndrome.
Gurvits GE, Tan A
World J Gastroenterol 2014 Aug 21;20(31):10845-50. doi: 10.3748/wjg.v20.i31.10845. PMID: 25152586Free PMC Article
Burning mouth syndrome.
Gurvits GE, Tan A
World J Gastroenterol 2013 Feb 7;19(5):665-72. doi: 10.3748/wjg.v19.i5.665. PMID: 23429751Free PMC Article
Burning mouth syndrome.
Nasri-Heir C
Alpha Omegan 2012 Winter;105(3-4):76-81. PMID: 23589947
Burning mouth syndrome.
Grinspan D, Fernández Blanco G, Allevato MA, Stengel FM
Int J Dermatol 1995 Jul;34(7):483-7. doi: 10.1111/j.1365-4362.1995.tb00617.x. PMID: 7591412

Clinical prediction guides

Non-drug pain relievers active on non-opioid pain mechanisms.
Marchesi N, Govoni S, Allegri M
Pain Pract 2022 Feb;22(2):255-275. Epub 2021 Sep 18 doi: 10.1111/papr.13073. PMID: 34498362
A systematic review of treatment for patients with burning mouth syndrome.
Tan HL, Smith JG, Hoffmann J, Renton T
Cephalalgia 2022 Feb;42(2):128-161. Epub 2021 Aug 18 doi: 10.1177/03331024211036152. PMID: 34404247Free PMC Article
Black hairy tongue syndrome.
Gurvits GE, Tan A
World J Gastroenterol 2014 Aug 21;20(31):10845-50. doi: 10.3748/wjg.v20.i31.10845. PMID: 25152586Free PMC Article
Burning mouth syndrome.
Gurvits GE, Tan A
World J Gastroenterol 2013 Feb 7;19(5):665-72. doi: 10.3748/wjg.v19.i5.665. PMID: 23429751Free PMC Article
Burning mouth syndrome.
Buchanan JA, Zakrzewska JM
BMJ Clin Evid 2010 Jul 19;2010 PMID: 21418666Free PMC Article

Recent systematic reviews

Treatments for Burning Mouth Syndrome: A Network Meta-analysis.
Alvarenga-Brant R, Costa FO, Mattos-Pereira G, Esteves-Lima RP, Belém FV, Lai H, Ge L, Gomez RS, Martins CC
J Dent Res 2023 Feb;102(2):135-145. Epub 2022 Oct 8 doi: 10.1177/00220345221130025. PMID: 36214096
A systematic review of treatment for patients with burning mouth syndrome.
Tan HL, Smith JG, Hoffmann J, Renton T
Cephalalgia 2022 Feb;42(2):128-161. Epub 2021 Aug 18 doi: 10.1177/03331024211036152. PMID: 34404247Free PMC Article
Pharmacological and non-pharmacological management of burning mouth syndrome: A systematic review.
Reyad AA, Mishriky R, Girgis E
Dent Med Probl 2020 Jul-Sep;57(3):295-304. doi: 10.17219/dmp/120991. PMID: 33113291
Burning mouth syndrome: a systematic review of treatments.
Liu YF, Kim Y, Yoo T, Han P, Inman JC
Oral Dis 2018 Apr;24(3):325-334. Epub 2017 Mar 30 doi: 10.1111/odi.12660. PMID: 28247977
Interventions for treating burning mouth syndrome.
McMillan R, Forssell H, Buchanan JA, Glenny AM, Weldon JC, Zakrzewska JM
Cochrane Database Syst Rev 2016 Nov 18;11(11):CD002779. doi: 10.1002/14651858.CD002779.pub3. PMID: 27855478Free PMC Article

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