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Burning mouth syndrome

MedGen UID:
14254
•Concept ID:
C0006430
•
Disease or Syndrome
Synonyms: Burning Mouth Syndrome; Burning Mouth Syndromes; Mouth Syndrome, Burning; Mouth Syndromes, Burning; Syndrome, Burning Mouth; Syndromes, Burning Mouth
SNOMED CT: Burning mouth syndrome (399165002); Orodynia (399165002); Stomatopyrosis (399165002); BMS - burning mouth syndrome (399165002)
 
Monarch Initiative: MONDO:0006687
Orphanet: ORPHA353253

Definition

A rare neurologic disease characterized by an unremitting bilateral symmetrical burning sensation of the oral mucosa without clinical evidence of causative lesions. It most frequently occurs in postmenopausal women and typically affects the tongue, less often the palate, lips, or buccal mucosa. It is often associated with dysgeusia and xerostomia. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBurning mouth syndrome

Professional guidelines

PubMed

Management of Burning Mouth Syndrome.
Thakkar J, Dym H
Dent Clin North Am 2024 Jan;68(1):113-119. Epub 2023 Aug 29 doi: 10.1016/j.cden.2023.07.007. PMID: 37951628
Hyposalivation and Xerostomia and Burning Mouth Syndrome: Medical Management.
Thakkar JP, Lane CJ
Oral Maxillofac Surg Clin North Am 2022 Feb;34(1):135-146. Epub 2021 Sep 29 doi: 10.1016/j.coms.2021.08.002. PMID: 34598858
A systematic review of treatment for patients with burning mouth syndrome.
Tan HL, Smith JG, Hoffmann J, Renton T
Cephalalgia 2022 Feb;42(2):128-161. Epub 2021 Aug 18 doi: 10.1177/03331024211036152. PMID: 34404247Free PMC Article

Recent clinical studies

Etiology

Treatments for Burning Mouth Syndrome: A Network Meta-analysis.
Alvarenga-Brant R, Costa FO, Mattos-Pereira G, Esteves-Lima RP, Belém FV, Lai H, Ge L, Gomez RS, Martins CC
J Dent Res 2023 Feb;102(2):135-145. Epub 2022 Oct 8 doi: 10.1177/00220345221130025. PMID: 36214096
Not only limbs in atypical restless legs syndrome.
Turrini A, Raggi A, Calandra-Buonaura G, Martinelli P, Ferri R, Provini F
Sleep Med Rev 2018 Apr;38:50-55. Epub 2017 Apr 4 doi: 10.1016/j.smrv.2017.03.007. PMID: 28559087
Spectrum of orocutaneous disease associations: Genodermatoses and inflammatory conditions.
Wilder EG, Frieder J, Sulhan S, Michel P, Cizenski JD, Wright JM, Menter MA
J Am Acad Dermatol 2017 Nov;77(5):809-830. doi: 10.1016/j.jaad.2017.02.017. PMID: 29029902
The alpha-herpesviridae in dermatology : Varicella zoster virus.
El Hayderi L, Rübben A, Nikkels AF
Hautarzt 2017 Dec;68(Suppl 1):6-10. doi: 10.1007/s00105-016-3920-1. PMID: 28197697
Pain at midlife.
Rousseau ME, Gottlieb SF
J Midwifery Womens Health 2004 Nov-Dec;49(6):529-38. doi: 10.1016/j.jmwh.2004.08.026. PMID: 15544982

Diagnosis

Persistent Idiopathic Dentoalveolar Pain: Is It a Central Pain Disorder?
Heir GM, Ananthan S, Kalladka M, Kuchukulla M, Renton T
Dent Clin North Am 2023 Jan;67(1):71-83. Epub 2022 Oct 27 doi: 10.1016/j.cden.2022.07.006. PMID: 36404082
Burning Mouth Syndrome.
Khawaja SN, Alaswaiti OF, Scrivani SJ
Dent Clin North Am 2023 Jan;67(1):49-60. Epub 2022 Oct 27 doi: 10.1016/j.cden.2022.07.004. PMID: 36404080
Sore Mouth.
Chaubal TV, Bapat R
Am J Med 2021 Apr;134(4):e270. Epub 2020 Sep 28 doi: 10.1016/j.amjmed.2020.08.031. PMID: 32997980
Burning Mouth Syndrome.
Klein B, Thoppay JR, De Rossi SS, Ciarrocca K
Dermatol Clin 2020 Oct;38(4):477-483. Epub 2020 Aug 10 doi: 10.1016/j.det.2020.05.008. PMID: 32892856
Burning Mouth Syndrome.
Bender SD
Dent Clin North Am 2018 Oct;62(4):585-596. Epub 2018 Jul 27 doi: 10.1016/j.cden.2018.05.006. PMID: 30189984

Therapy

A systematic review of treatment for patients with burning mouth syndrome.
Tan HL, Smith JG, Hoffmann J, Renton T
Cephalalgia 2022 Feb;42(2):128-161. Epub 2021 Aug 18 doi: 10.1177/03331024211036152. PMID: 34404247Free PMC Article
Sore Mouth.
Chaubal TV, Bapat R
Am J Med 2021 Apr;134(4):e270. Epub 2020 Sep 28 doi: 10.1016/j.amjmed.2020.08.031. PMID: 32997980
Burning mouth syndrome: a systematic review of treatments.
Liu YF, Kim Y, Yoo T, Han P, Inman JC
Oral Dis 2018 Apr;24(3):325-334. Epub 2017 Mar 30 doi: 10.1111/odi.12660. PMID: 28247977
The alpha-herpesviridae in dermatology : Varicella zoster virus.
El Hayderi L, Rübben A, Nikkels AF
Hautarzt 2017 Dec;68(Suppl 1):6-10. doi: 10.1007/s00105-016-3920-1. PMID: 28197697
Burning mouth syndrome: a review and update.
Silvestre FJ, Silvestre-Rangil J, López-Jornet P
Rev Neurol 2015 May 16;60(10):457-63. PMID: 25952601

Prognosis

Tactile hallucinations in dementia with Lewy bodies.
Ukai K
Psychogeriatrics 2019 Sep;19(5):435-439. Epub 2019 Feb 7 doi: 10.1111/psyg.12407. PMID: 30734409
Spectrum of orocutaneous disease associations: Genodermatoses and inflammatory conditions.
Wilder EG, Frieder J, Sulhan S, Michel P, Cizenski JD, Wright JM, Menter MA
J Am Acad Dermatol 2017 Nov;77(5):809-830. doi: 10.1016/j.jaad.2017.02.017. PMID: 29029902
Cerebellopontine angle mass mimicking lingual nerve injury after dental implant placement: a case report.
Momota Y, Kani K, Takano H, Azuma M
Aust Dent J 2015 Sep;60(3):412-5. doi: 10.1111/adj.12224. PMID: 25280059
Burning mouth syndrome.
Gurvits GE, Tan A
World J Gastroenterol 2013 Feb 7;19(5):665-72. doi: 10.3748/wjg.v19.i5.665. PMID: 23429751Free PMC Article
Studies on the relationship between electrogustometry and sour taste perception.
Ellegård EK, Goldsmith D, Hay KD, Stillman JA, Morton RP
Auris Nasus Larynx 2007 Dec;34(4):477-80. Epub 2007 Apr 27 doi: 10.1016/j.anl.2007.03.004. PMID: 17467215

Clinical prediction guides

A systematic review of treatment for patients with burning mouth syndrome.
Tan HL, Smith JG, Hoffmann J, Renton T
Cephalalgia 2022 Feb;42(2):128-161. Epub 2021 Aug 18 doi: 10.1177/03331024211036152. PMID: 34404247Free PMC Article
Psychological Interventions for Persistent Orofacial Pain.
Barker S, Urbanek M, Penlington C
Prim Dent J 2019 Feb 19;7(4):30-35. PMID: 30835664
Burning mouth syndrome.
Gurvits GE, Tan A
World J Gastroenterol 2013 Feb 7;19(5):665-72. doi: 10.3748/wjg.v19.i5.665. PMID: 23429751Free PMC Article
Oral microcirculation observed in vivo by videocapillaroscopy: a review.
Scardina GA, Ruggieri A, Messina P
J Oral Sci 2009 Mar;51(1):1-10. doi: 10.2334/josnusd.51.1. PMID: 19325194
Oral manifestations and dental treatment in menopause.
Frutos R, Rodríguez S, Miralles-Jorda L, Machuca G
Med Oral 2002 Jan-Feb;7(1):26-30, 31-5. PMID: 11788806

Recent systematic reviews

Treatments for Burning Mouth Syndrome: A Network Meta-analysis.
Alvarenga-Brant R, Costa FO, Mattos-Pereira G, Esteves-Lima RP, Belém FV, Lai H, Ge L, Gomez RS, Martins CC
J Dent Res 2023 Feb;102(2):135-145. Epub 2022 Oct 8 doi: 10.1177/00220345221130025. PMID: 36214096
A systematic review of treatment for patients with burning mouth syndrome.
Tan HL, Smith JG, Hoffmann J, Renton T
Cephalalgia 2022 Feb;42(2):128-161. Epub 2021 Aug 18 doi: 10.1177/03331024211036152. PMID: 34404247Free PMC Article
Burning mouth syndrome: a systematic review of treatments.
Liu YF, Kim Y, Yoo T, Han P, Inman JC
Oral Dis 2018 Apr;24(3):325-334. Epub 2017 Mar 30 doi: 10.1111/odi.12660. PMID: 28247977
WITHDRAWN: Psychosocial interventions for the management of chronic orofacial pain.
Aggarwal VR, Lovell K, Peters S, Javidi H, Joughin A, Goldthorpe J
Cochrane Database Syst Rev 2015 Dec 17;2015(12):CD008456. doi: 10.1002/14651858.CD008456.pub3. PMID: 26678041Free PMC Article
Management of xerostomia and other complications of Sjögren's syndrome.
Pinto A
Oral Maxillofac Surg Clin North Am 2014 Feb;26(1):63-73. doi: 10.1016/j.coms.2013.09.010. PMID: 24287194

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