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Nephrosclerosis

MedGen UID:
14330
Concept ID:
C0027719
Disease or Syndrome
Synonym: Nephroscleroses
SNOMED CT: Renal sclerosis (32916005); Nephrosclerosis (32916005); Interstitial arteriosclerotic nephritis (32916005); Chronic arteriosclerotic nephritis (32916005); Arteriosclerosis of kidney (32916005); Renal arteriosclerosis (32916005)
 
HPO: HP:0009741
Monarch Initiative: MONDO:0006044

Definition

Nephrosclerosis refers to thickening or scarring ("sclerosis") resulting from damage to the renal arterioles, also referred to as arteriosclerosis of the kidney arteries. [from HPO]

Conditions with this feature

LADD syndrome 1
MedGen UID:
1824096
Concept ID:
C5774323
Disease or Syndrome
Lacrimoauriculodentodigital syndrome-1 (LADD1) is a multiple congenital anomaly disorder mainly affecting lacrimal glands and ducts, salivary glands and ducts, ears, teeth, and distal limb segments (summary by Rohmann et al., 2006). Genetic Heterogeneity of Lacrimoauriculodentodigital Syndrome LADD syndrome-2 (LADD2; 620192) is caused by mutation in the FGFR3 gene (134934) on chromosome 4p16, and LADD syndrome-3 (LADD3; 620193) is caused by mutation in the FGF10 gene, an FGFR ligand, on chromosome 5p12.

Professional guidelines

PubMed

Elewa U, Sandri AM, Rizza SA, Fervenza FC
Nephron Clin Pract 2011;118(4):c346-54; discussion c354. Epub 2011 Feb 3 doi: 10.1159/000323666. PMID: 21293158
Xie Y, Chen X
Am J Nephrol 2008;28(1):1-7. Epub 2007 Sep 20 doi: 10.1159/000108755. PMID: 17890852
Meyrier A
Kidney Int 2006 Apr;69(8):1308-12. doi: 10.1038/sj.ki.5000263. PMID: 16614719

Recent clinical studies

Etiology

Tsukamoto S, Uehara T, Azushima K, Wakui H, Tamura K
J Am Heart Assoc 2023 Apr 18;12(8):e029565. Epub 2023 Apr 17 doi: 10.1161/JAHA.122.029565. PMID: 37066800Free PMC Article
Kitai Y, Nangaku M, Yanagita M
Contrib Nephrol 2021;199:266-273. Epub 2021 Aug 3 doi: 10.1159/000517708. PMID: 34343996
Hommos MS, Glassock RJ, Rule AD
J Am Soc Nephrol 2017 Oct;28(10):2838-2844. Epub 2017 Aug 8 doi: 10.1681/ASN.2017040421. PMID: 28790143Free PMC Article
Silva Junior GB, Bentes AC, Daher EF, Matos SM
J Bras Nefrol 2017 Mar;39(1):65-69. doi: 10.5935/0101-2800.20170011. PMID: 28355395
Denic A, Glassock RJ, Rule AD
Adv Chronic Kidney Dis 2016 Jan;23(1):19-28. doi: 10.1053/j.ackd.2015.08.004. PMID: 26709059Free PMC Article

Diagnosis

Heras Benito M
Hipertens Riesgo Vasc 2023 Apr-Jun;40(2):98-103. Epub 2022 Aug 30 doi: 10.1016/j.hipert.2022.07.004. PMID: 36050216
Henriksen KJ, Chang A
Semin Nephrol 2020 Jan;40(1):69-75. doi: 10.1016/j.semnephrol.2019.12.008. PMID: 32130968
O'Sullivan ED, Hughes J, Ferenbach DA
J Am Soc Nephrol 2017 Feb;28(2):407-420. Epub 2016 Nov 15 doi: 10.1681/ASN.2015121308. PMID: 28143966Free PMC Article
Denic A, Glassock RJ, Rule AD
Adv Chronic Kidney Dis 2016 Jan;23(1):19-28. doi: 10.1053/j.ackd.2015.08.004. PMID: 26709059Free PMC Article
Freedman BI, Cohen AH
Nat Rev Nephrol 2016 Jan;12(1):27-36. Epub 2015 Nov 10 doi: 10.1038/nrneph.2015.172. PMID: 26553514

Therapy

Tsukamoto S, Uehara T, Azushima K, Wakui H, Tamura K
J Am Heart Assoc 2023 Apr 18;12(8):e029565. Epub 2023 Apr 17 doi: 10.1161/JAHA.122.029565. PMID: 37066800Free PMC Article
Costantino VV, Gil Lorenzo AF, Bocanegra V, Vallés PG
Cells 2021 Nov 12;10(11) doi: 10.3390/cells10113146. PMID: 34831368Free PMC Article
Wright JT Jr, Bakris G, Greene T, Agodoa LY, Appel LJ, Charleston J, Cheek D, Douglas-Baltimore JG, Gassman J, Glassock R, Hebert L, Jamerson K, Lewis J, Phillips RA, Toto RD, Middleton JP, Rostand SG; African American Study of Kidney Disease and Hypertension Study Group
JAMA 2002 Nov 20;288(19):2421-31. doi: 10.1001/jama.288.19.2421. PMID: 12435255
Ritz E, Nowicki M, Fliser D, Hörner D, Klimm HP
Kidney Int Suppl 1994 Nov;47:S76-80. PMID: 7869676
Weir MR, Wolfsthal SD
Prim Care 1991 Sep;18(3):525-44. PMID: 1946786

Prognosis

d'Izarny-Gargas T, Isnard P, Boudhabhay I, Buob D, Moktefi A, Linster C, Hummel A, Esteve E, Audard V, Lazareth H, Maroun N, Hertig A, Gosset C, Jouzel C, Permal S, Domenger C, Kosmider O, Rabant M, Karras A, Duong Van Huyen JP
Kidney Int 2023 Dec;104(6):1206-1218. Epub 2023 Sep 26 doi: 10.1016/j.kint.2023.09.010. PMID: 37769965
Fang Y, Gong AY, Haller ST, Dworkin LD, Liu Z, Gong R
Ageing Res Rev 2020 Nov;63:101151. Epub 2020 Aug 22 doi: 10.1016/j.arr.2020.101151. PMID: 32835891Free PMC Article
Meyrier A
Nephrol Dial Transplant 2015 Nov;30(11):1833-41. Epub 2014 Dec 8 doi: 10.1093/ndt/gfu366. PMID: 25488894
Ritz E, Nowicki M, Fliser D, Hörner D, Klimm HP
Kidney Int Suppl 1994 Nov;47:S76-80. PMID: 7869676
Schmieder RE, Messerli FH
Med Clin North Am 1987 Sep;71(5):991-1001. doi: 10.1016/s0025-7125(16)30822-7. PMID: 3306213

Clinical prediction guides

Kitai Y, Nangaku M, Yanagita M
Contrib Nephrol 2021;199:266-273. Epub 2021 Aug 3 doi: 10.1159/000517708. PMID: 34343996
O'Sullivan ED, Hughes J, Ferenbach DA
J Am Soc Nephrol 2017 Feb;28(2):407-420. Epub 2016 Nov 15 doi: 10.1681/ASN.2015121308. PMID: 28143966Free PMC Article
Meyrier A
Nephrol Dial Transplant 2015 Nov;30(11):1833-41. Epub 2014 Dec 8 doi: 10.1093/ndt/gfu366. PMID: 25488894
Wright JT Jr, Bakris G, Greene T, Agodoa LY, Appel LJ, Charleston J, Cheek D, Douglas-Baltimore JG, Gassman J, Glassock R, Hebert L, Jamerson K, Lewis J, Phillips RA, Toto RD, Middleton JP, Rostand SG; African American Study of Kidney Disease and Hypertension Study Group
JAMA 2002 Nov 20;288(19):2421-31. doi: 10.1001/jama.288.19.2421. PMID: 12435255
Schmieder RE, Messerli FH
Med Clin North Am 1987 Sep;71(5):991-1001. doi: 10.1016/s0025-7125(16)30822-7. PMID: 3306213

Recent systematic reviews

Wang CJ, Wetmore JB, Crary GS, Kasiske BL
Am J Transplant 2015 Jul;15(7):1903-14. Epub 2015 Mar 13 doi: 10.1111/ajt.13213. PMID: 25772854

Supplemental Content

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