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Ophthalmia neonatorum

MedGen UID:
14489
•Concept ID:
C0029076
•
Disease or Syndrome
Synonyms: gonococcal conjunctivitis (neonatorum); gonococcal ophthalmia neonatorum; Neonatal Conjunctivitis; Neonatal conjunctivitis; neonatal conjunctivitis; Ophthalmia Neonatorum; ophthalmia neonatorum
SNOMED CT: Ophthalmia neonatorum (34298002); Neonatal conjunctivitis (34298002)
 
Monarch Initiative: MONDO:0004854

Definition

Inflammation of the conjunctiva in a newborn due to chemical or infectious causes. Aseptic conjunctivitis is often related to the use of prophylactic medications for infectious conjunctivitis. Septic conjunctivitis is related to perinatal exposure to microorganisms. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOphthalmia neonatorum

Professional guidelines

PubMed

Management of Extraocular Infections.
Muthiah S, Radhakrishnan N
Indian J Pediatr 2017 Dec;84(12):945-952. Epub 2017 Jul 14 doi: 10.1007/s12098-017-2409-y. PMID: 28707045
Ophthalmia neonatorum treatment and prophylaxis: IPOSC global study.
Zloto O, Gharaibeh A, Mezer E, Stankovic B, Isenberg S, Wygnanski-Jaffe T
Graefes Arch Clin Exp Ophthalmol 2016 Mar;254(3):577-82. Epub 2016 Jan 26 doi: 10.1007/s00417-016-3274-5. PMID: 26810921
Neonatal chlamydial infections: prevention and treatment.
Zar HJ
Paediatr Drugs 2005;7(2):103-10. doi: 10.2165/00148581-200507020-00003. PMID: 15871630

Recent clinical studies

Etiology

Antibiotic prophylaxis for ophthalmia neonatorum in Italy: results from a national survey and the Italian intersociety new position statements.
Mondì V, Tzialla C, Aversa S, Merazzi D, Martinelli S, Araimo G, Massenzi L, Cavallaro G, Gagliardi L, Piersigilli F, Giuffrè M, Lozzi S, Manzoni P, Mosca F, Cetin I, Trojano V, Valensise H, Colacurci N, Orfeo L, Auriti C
Ital J Pediatr 2023 Sep 11;49(1):117. doi: 10.1186/s13052-023-01507-7. PMID: 37697419Free PMC Article
Severe ophthalmia neonatorum in Southwest China: a 5-year review of demographics, microbiological results, and risk factors.
Tang XJ, He JT, Liu Q, Chen XK, Chen L
Int Ophthalmol 2022 Jul;42(7):2185-2193. Epub 2022 Jan 15 doi: 10.1007/s10792-022-02218-4. PMID: 35032274
Ophthalmia neonatorum: what kind of prophylaxis?
Zuppa AA, D'Andrea V, Catenazzi P, Scorrano A, Romagnoli C
J Matern Fetal Neonatal Med 2011 Jun;24(6):769-73. doi: 10.3109/14767058.2010.531326. PMID: 21534852
Ophthalmia neonatorum.
Gul SS, Jamal M, Khan N
J Coll Physicians Surg Pak 2010 Sep;20(9):595-8. PMID: 20810051
Gonorrhea.
Spence MR
Clin Obstet Gynecol 1983 Mar;26(1):111-24. doi: 10.1097/00003081-198303000-00016. PMID: 6404578

Diagnosis

Case series and literature review of chlamydial ophthalmia neonatorum in Botswana.
Yang K, Babalola CM, Mussa A, Ryan R, Wynn A, Simon S, Bame B, Morroni C, Klausner JD
Int J STD AIDS 2023 Oct;34(12):860-868. Epub 2023 Jun 20 doi: 10.1177/09564624231173028. PMID: 37338101
Ophthalmia Neonatorum.
Tan AK
N Engl J Med 2019 Jan 10;380(2):e2. doi: 10.1056/NEJMicm1808613. PMID: 30625059
Management of Extraocular Infections.
Muthiah S, Radhakrishnan N
Indian J Pediatr 2017 Dec;84(12):945-952. Epub 2017 Jul 14 doi: 10.1007/s12098-017-2409-y. PMID: 28707045
Ophthalmia neonatorum.
Gul SS, Jamal M, Khan N
J Coll Physicians Surg Pak 2010 Sep;20(9):595-8. PMID: 20810051
Gonorrhea.
Spence MR
Clin Obstet Gynecol 1983 Mar;26(1):111-24. doi: 10.1097/00003081-198303000-00016. PMID: 6404578

Therapy

Gonococcal infection: An unresolved problem.
Barberá MJ, Serra-Pladevall J
Enferm Infecc Microbiol Clin (Engl Ed) 2019 Aug-Sep;37(7):458-466. Epub 2019 Feb 4 doi: 10.1016/j.eimc.2018.12.008. PMID: 30732970
The use of povidone-iodine in ophthalmology.
Grzybowski A, Kanclerz P, Myers WG
Curr Opin Ophthalmol 2018 Jan;29(1):19-32. doi: 10.1097/ICU.0000000000000437. PMID: 28984794
Silver nitrate prophylaxis.
Schneider G
Can Med Assoc J 1984 Aug 1;131(3):193-6. PMID: 6378348Free PMC Article
Gonorrhea.
Spence MR
Clin Obstet Gynecol 1983 Mar;26(1):111-24. doi: 10.1097/00003081-198303000-00016. PMID: 6404578
Ophthalmia neonatorum.
Friendly DS
Pediatr Clin North Am 1983 Dec;30(6):1033-42. doi: 10.1016/s0031-3955(16)34500-x. PMID: 6359042

Prognosis

Case series and literature review of chlamydial ophthalmia neonatorum in Botswana.
Yang K, Babalola CM, Mussa A, Ryan R, Wynn A, Simon S, Bame B, Morroni C, Klausner JD
Int J STD AIDS 2023 Oct;34(12):860-868. Epub 2023 Jun 20 doi: 10.1177/09564624231173028. PMID: 37338101
Management of Extraocular Infections.
Muthiah S, Radhakrishnan N
Indian J Pediatr 2017 Dec;84(12):945-952. Epub 2017 Jul 14 doi: 10.1007/s12098-017-2409-y. PMID: 28707045
Ophthalmia neonatorum treatment and prophylaxis: IPOSC global study.
Zloto O, Gharaibeh A, Mezer E, Stankovic B, Isenberg S, Wygnanski-Jaffe T
Graefes Arch Clin Exp Ophthalmol 2016 Mar;254(3):577-82. Epub 2016 Jan 26 doi: 10.1007/s00417-016-3274-5. PMID: 26810921
Neonatal chlamydial infections: prevention and treatment.
Zar HJ
Paediatr Drugs 2005;7(2):103-10. doi: 10.2165/00148581-200507020-00003. PMID: 15871630
Ophthalmia neonatorum.
O'Hara MA
Pediatr Clin North Am 1993 Aug;40(4):715-25. PMID: 8345961

Clinical prediction guides

Is Ophthalmia Neonatorum Associated With Invasive Bacterial Infection? A Single-Center Retrospective Study.
St-Onge-St-Hilaire A, Boutin A, Gravel J
Pediatr Emerg Care 2023 Nov 1;39(11):858-862. Epub 2023 Oct 11 doi: 10.1097/PEC.0000000000003066. PMID: 37820378
Ophthalmia Neonatorum, Helen Keller, and the Social Dimensions of Eye Disease.
Harman LE, Margo CE
Cornea 2023 Dec 1;42(12):1601-1604. Epub 2023 Jul 6 doi: 10.1097/ICO.0000000000003332. PMID: 37410593
Case series and literature review of chlamydial ophthalmia neonatorum in Botswana.
Yang K, Babalola CM, Mussa A, Ryan R, Wynn A, Simon S, Bame B, Morroni C, Klausner JD
Int J STD AIDS 2023 Oct;34(12):860-868. Epub 2023 Jun 20 doi: 10.1177/09564624231173028. PMID: 37338101
Ophthalmia neonatorum.
Gul SS, Jamal M, Khan N
J Coll Physicians Surg Pak 2010 Sep;20(9):595-8. PMID: 20810051
A five-year study in Iran of ophthalmia neonatorum: prevalence and etiology.
Amini E, Ghasemi M, Daneshjou K
Med Sci Monit 2008 Feb;14(2):CR90-96. PMID: 18227767

Recent systematic reviews

Adverse pregnancy and neonatal outcomes associated with Neisseria gonorrhoeae: systematic review and meta-analysis.
Vallely LM, Egli-Gany D, Wand H, Pomat WS, Homer CSE, Guy R, Silver B, Rumbold AR, Kaldor JM, Vallely AJ, Low N
Sex Transm Infect 2021 Mar;97(2):104-111. Epub 2021 Jan 12 doi: 10.1136/sextrans-2020-054653. PMID: 33436505Free PMC Article
Interventions for preventing ophthalmia neonatorum.
Kapoor VS, Evans JR, Vedula SS
Cochrane Database Syst Rev 2020 Sep 21;9(9):CD001862. doi: 10.1002/14651858.CD001862.pub4. PMID: 32959365Free PMC Article
Antibiotics for treating gonorrhoea in pregnancy.
Comunián-Carrasco G, Peña-Martí GE, Martí-Carvajal AJ
Cochrane Database Syst Rev 2018 Feb 21;2(2):CD011167. doi: 10.1002/14651858.CD011167.pub2. PMID: 29465747Free PMC Article
A meta-analysis of the efficacy of ocular prophylactic agents used for the prevention of gonococcal and chlamydial ophthalmia neonatorum.
Darling EK, McDonald H
J Midwifery Womens Health 2010 Jul-Aug;55(4):319-27. doi: 10.1016/j.jmwh.2009.09.003. PMID: 20630358
Antibiotics for gonorrhoea in pregnancy.
Brocklehurst P
Cochrane Database Syst Rev 2002;(2):CD000098. doi: 10.1002/14651858.CD000098. PMID: 12076381

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