U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Osteitis fibrosa

MedGen UID:
14529
•Concept ID:
C0029405
•
Disease or Syndrome
Synonyms: Osteitis Fibrosa Cystica; Recklinghausen Disease of Bone; Recklinghausen Disease, Bone; Recklinghausen's Disease of Bone; Recklinghausens Disease, Bone
SNOMED CT: von Recklinghausen's bone disease (84727000); Osteitis fibrosa cystica generalisata (84727000); Fibro-osteoclasia (84727000); Von Recklinghausen's disease of bone (84727000); Fibrous osteodystrophy (84727000); Osteodystrophia fibrosa (84727000); Osteitis fibrosa cystica (84727000)
 
Monarch Initiative: MONDO:0005890

Definition

A disorder that is characterized by bone cysts and fractures, resulting from hyperparathyroidism. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOsteitis fibrosa

Professional guidelines

PubMed

Old and New Drugs for the Management of Bone Disorders in CKD.
Komaba H, Ketteler M, Cunningham J, Fukagawa M
Calcif Tissue Int 2021 Apr;108(4):486-495. Epub 2021 Jan 2 doi: 10.1007/s00223-020-00788-y. PMID: 33386480
Parathyroid carcinoma: etiology, diagnosis, and treatment.
Okamoto T, Iihara M, Obara T, Tsukada T
World J Surg 2009 Nov;33(11):2343-54. doi: 10.1007/s00268-009-9999-0. PMID: 19350316
Diagnosis and management of bone disorders in chronic renal failure and dialyzed patients.
Tzamaloukas AH
Med Clin North Am 1990 Jul;74(4):961-74. doi: 10.1016/s0025-7125(16)30529-6. PMID: 2195265

Recent clinical studies

Etiology

Diabetes and Bone Involvement in Primary Hyperparathyroidism: Literature Review and Our Personal Experience.
Castellano E, Attanasio R, Boriano A, Borretta V, Tassone F, Borretta G
Front Endocrinol (Lausanne) 2021;12:665984. Epub 2021 Apr 19 doi: 10.3389/fendo.2021.665984. PMID: 33953702Free PMC Article
Old and New Drugs for the Management of Bone Disorders in CKD.
Komaba H, Ketteler M, Cunningham J, Fukagawa M
Calcif Tissue Int 2021 Apr;108(4):486-495. Epub 2021 Jan 2 doi: 10.1007/s00223-020-00788-y. PMID: 33386480
Skeletal abnormalities in Hypoparathyroidism and in Primary Hyperparathyroidism.
Silva BC, Bilezikian JP
Rev Endocr Metab Disord 2021 Dec;22(4):789-802. Epub 2020 Nov 16 doi: 10.1007/s11154-020-09614-0. PMID: 33200346
Osteitis fibrosa cystica.
Arbault A, Ornetti P, Laroche D, Pottecher P
Joint Bone Spine 2017 Mar;84(2):229. Epub 2016 May 26 doi: 10.1016/j.jbspin.2016.02.027. PMID: 27238197
Hyperparathyroidism.
Tonini G, Tatò L, Rigon F, Radetti G, De Sanctis C, De Sanctis V, Buzi F, Bozzola M, Bona G, Bernasconi S
Minerva Pediatr 2004 Feb;56(1):125-31. PMID: 15249924

Diagnosis

Variable Bone Phenotypes in Patients with Pseudohypoparathyroidism.
Wang Y, Lu C, Chen X
Curr Osteoporos Rep 2023 Jun;21(3):311-321. Epub 2023 Apr 4 doi: 10.1007/s11914-023-00787-6. PMID: 37014531
Sporadic Primary Hyperparathyroidism.
Kim SJ, Shoback DM
Endocrinol Metab Clin North Am 2021 Dec;50(4):609-628. doi: 10.1016/j.ecl.2021.07.006. PMID: 34774237
Hyperparathyroidism and Bone Health.
Bandeira F, Cassibba S
Curr Rheumatol Rep 2015 Jul;17(7):48. doi: 10.1007/s11926-015-0523-2. PMID: 26105042
Asymptomatic primary hyperparathyroidism.
Silverberg SJ, Walker MD, Bilezikian JP
J Clin Densitom 2013 Jan-Mar;16(1):14-21. doi: 10.1016/j.jocd.2012.11.005. PMID: 23374736Free PMC Article
Hyperparathyroidism.
Tonini G, Tatò L, Rigon F, Radetti G, De Sanctis C, De Sanctis V, Buzi F, Bozzola M, Bona G, Bernasconi S
Minerva Pediatr 2004 Feb;56(1):125-31. PMID: 15249924

Therapy

Sporadic Primary Hyperparathyroidism.
Kim SJ, Shoback DM
Endocrinol Metab Clin North Am 2021 Dec;50(4):609-628. doi: 10.1016/j.ecl.2021.07.006. PMID: 34774237
Skeletal abnormalities in Hypoparathyroidism and in Primary Hyperparathyroidism.
Silva BC, Bilezikian JP
Rev Endocr Metab Disord 2021 Dec;22(4):789-802. Epub 2020 Nov 16 doi: 10.1007/s11154-020-09614-0. PMID: 33200346
Osteitis Fibrosa Cystica.
Ramon A, Berthod PE
N Engl J Med 2020 Mar 12;382(11):e15. doi: 10.1056/NEJMicm1907828. PMID: 32160666
Osteitis fibrosa cystica.
Arbault A, Ornetti P, Laroche D, Pottecher P
Joint Bone Spine 2017 Mar;84(2):229. Epub 2016 May 26 doi: 10.1016/j.jbspin.2016.02.027. PMID: 27238197
Asymptomatic primary hyperparathyroidism.
Silverberg SJ, Walker MD, Bilezikian JP
J Clin Densitom 2013 Jan-Mar;16(1):14-21. doi: 10.1016/j.jocd.2012.11.005. PMID: 23374736Free PMC Article

Prognosis

Diabetes and Bone Involvement in Primary Hyperparathyroidism: Literature Review and Our Personal Experience.
Castellano E, Attanasio R, Boriano A, Borretta V, Tassone F, Borretta G
Front Endocrinol (Lausanne) 2021;12:665984. Epub 2021 Apr 19 doi: 10.3389/fendo.2021.665984. PMID: 33953702Free PMC Article
The use of bone turnover markers in chronic kidney disease-mineral and bone disorders.
Chiang C
Nephrology (Carlton) 2017 Mar;22 Suppl 2:11-13. doi: 10.1111/nep.13014. PMID: 28429547
Skeletal lesions in primary hyperparathyroidism.
Yang Q, Sun P, Li J, Yang Z, Li X, Li Z, Yan J, Li K, Wang L
Am J Med Sci 2015 Apr;349(4):321-7. doi: 10.1097/MAJ.0000000000000441. PMID: 25798829
Parathyroid carcinoma: etiology, diagnosis, and treatment.
Okamoto T, Iihara M, Obara T, Tsukada T
World J Surg 2009 Nov;33(11):2343-54. doi: 10.1007/s00268-009-9999-0. PMID: 19350316
The role of metabolic acidosis in the pathogenesis of renal osteodystrophy.
Kraut JA
Adv Ren Replace Ther 1995 Jan;2(1):40-51. doi: 10.1016/s1073-4449(12)80070-7. PMID: 7614335

Clinical prediction guides

Skeletal abnormalities in Hypoparathyroidism and in Primary Hyperparathyroidism.
Silva BC, Bilezikian JP
Rev Endocr Metab Disord 2021 Dec;22(4):789-802. Epub 2020 Nov 16 doi: 10.1007/s11154-020-09614-0. PMID: 33200346
Vitamin D and Clinical Outcomes in Dialysis.
Parikh C, Gutgarts V, Eisenberg E, Melamed ML
Semin Dial 2015 Nov-Dec;28(6):604-9. Epub 2015 Oct 1 doi: 10.1111/sdi.12446. PMID: 26424141Free PMC Article
Hyperparathyroidism and Bone Health.
Bandeira F, Cassibba S
Curr Rheumatol Rep 2015 Jul;17(7):48. doi: 10.1007/s11926-015-0523-2. PMID: 26105042
Nontraditional manifestations of primary hyperparathyroidism.
Walker MD, Rubin M, Silverberg SJ
J Clin Densitom 2013 Jan-Mar;16(1):40-7. doi: 10.1016/j.jocd.2012.11.008. PMID: 23374740Free PMC Article
Asymptomatic primary hyperparathyroidism.
Silverberg SJ, Walker MD, Bilezikian JP
J Clin Densitom 2013 Jan-Mar;16(1):14-21. doi: 10.1016/j.jocd.2012.11.005. PMID: 23374736Free PMC Article

Recent systematic reviews

Pathological Fracture of the Tibia as a First Sign of Hyperparathyroidism - A Case Report and Systematic Review of the Current Literature.
Keiler A, Dammerer D, Liebensteiner M, Schmitz K, Kaiser P, Wurm A
Anticancer Res 2021 Jun;41(6):3083-3089. doi: 10.21873/anticanres.15092. PMID: 34083301
Systematic review of oral manifestations related to hyperparathyroidism.
Palla B, Burian E, Fliefel R, Otto S
Clin Oral Investig 2018 Jan;22(1):1-27. Epub 2017 Jun 14 doi: 10.1007/s00784-017-2124-0. PMID: 28616750
Hyperparathyroidism Diagnosed Due to Brown Tumors of the Jaw: A Case Report and Literature Review.
Brabyn P, Capote A, Belloti M, Zylberberg I
J Oral Maxillofac Surg 2017 Oct;75(10):2162-2169. Epub 2017 Mar 20 doi: 10.1016/j.joms.2017.03.013. PMID: 28412266
Facial disfigurement due to osteitis fibrosa cystica or brown tumor from secondary hyperparathyroidism in patients on dialysis: A systematic review and an illustrative case report.
Baracaldo RM, Bao D, Iampornpipopchai P, Fogel J, Rubinstein S
Hemodial Int 2015 Oct;19(4):583-92. Epub 2015 Mar 31 doi: 10.1111/hdi.12298. PMID: 25828738
Calcimimetics for secondary hyperparathyroidism in chronic kidney disease patients.
Strippoli GF, Tong A, Palmer SC, Elder G, Craig JC
Cochrane Database Syst Rev 2006 Oct 18;(4):CD006254. doi: 10.1002/14651858.CD006254. PMID: 17054287

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • MeSH
      Related Medical Subject Headings
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...