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Ameloblastoma

MedGen UID:: 1457
•Concept ID:: C0002448
•: Neoplastic Process

Synonym:	Ameloblastomas
SNOMED CT:	Adamantinoma (20462008); Ameloblastoma (20462008)
Modes of inheritance:	Not genetically inherited MedGen UID: 988794 •Concept ID: CN307044 • Finding Source: Orphanet clinical entity without genetic inheritance. See: This record Not genetically inherited (Orphanet)

HPO:	HP:0034515
Monarch Initiative:	MONDO:0017795
Orphanet:	ORPHA314419

Definition

Ameloblastoma is a benign odontogenic tumor generally present in the jaw bone. The tumor originates from the residual epithelium of the tooth germ, epithelium of odontogenic cysts stratified squamous epithelium and epithelium of the enamel organ. [from HPO]

Term Hierarchy

GTR
MeSH
Orphanet

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVAmeloblastoma

Mouth disorder
- Mouth disorder
  - Mouth disorder
    - Mouth disorder
      - Disorder of teeth AND/OR supporting structures
        Odontogenic neoplasm
        Ameloblastoma
        Benign Ameloblastoma
        Desmoplastic ameloblastoma
        Extraosseous/Peripheral Ameloblastoma
        Metastasizing Ameloblastoma
        Solid/Multicystic Ameloblastoma
        Follicular Ameloblastoma
        Acanthomatous Ameloblastoma
        Basal Cell Ameloblastoma
        Granular Cell Ameloblastoma
        Plexiform ameloblastoma
        Unicystic Ameloblastoma

Follow this link to review classifications for Ameloblastoma in Orphanet.

Professional guidelines

PubMed

Treatment efficacy and prognosis of pulmonary metastasizing ameloblastoma: a systematic review.

Yang X, Zhou K, Tao Y, Ge S, Shang W, Song K
Int J Oral Maxillofac Surg 2022 May;51(5):579-590. Epub 2021 Aug 27 doi: 10.1016/j.ijom.2021.07.016. PMID: 34462177

Radical vs conservative treatment of intraosseous ameloblastoma: Systematic review and meta-analysis.

Hendra FN, Natsir Kalla DS, Van Cann EM, de Vet HCW, Helder MN, Forouzanfar T
Oral Dis 2019 Oct;25(7):1683-1696. Epub 2019 Jan 1 doi: 10.1111/odi.13014. PMID: 30548549

Ameloblastoma: current etiopathological concepts and management.

Effiom OA, Ogundana OM, Akinshipo AO, Akintoye SO
Oral Dis 2018 Apr;24(3):307-316. Epub 2017 Mar 9 doi: 10.1111/odi.12646. PMID: 28142213

See all (50)

Recent clinical studies

Etiology

DNA damage and repair scenario in ameloblastoma.

Toprani SM
Oral Oncol 2020 Sep;108:104804. Epub 2020 May 28 doi: 10.1016/j.oraloncology.2020.104804. PMID: 32474390

Odontogenic Tumors.

Rajendra Santosh AB, Ogle OE
Dent Clin North Am 2020 Jan;64(1):121-138. Epub 2019 Oct 18 doi: 10.1016/j.cden.2019.08.008. PMID: 31735223

Radical vs conservative treatment of intraosseous ameloblastoma: Systematic review and meta-analysis.

Hendra FN, Natsir Kalla DS, Van Cann EM, de Vet HCW, Helder MN, Forouzanfar T
Oral Dis 2019 Oct;25(7):1683-1696. Epub 2019 Jan 1 doi: 10.1111/odi.13014. PMID: 30548549

Ameloblastoma.

Mendenhall WM, Werning JW, Fernandes R, Malyapa RS, Mendenhall NP
Am J Clin Oncol 2007 Dec;30(6):645-8. doi: 10.1097/COC.0b013e3181573e59. PMID: 18091060

Ameloblastoma in children.

Ord RA, Blanchaert RH Jr, Nikitakis NG, Sauk JJ
J Oral Maxillofac Surg 2002 Jul;60(7):762-70; discussion, 770-1. doi: 10.1053/joms.2002.33242. PMID: 12089689

See all (813)

Diagnosis

Pediatric Odontogenic Tumors.

Liu Y, Smith MH, Patel PB, Bilodeau EA
Pediatr Dev Pathol 2023 Nov-Dec;26(6):583-595. Epub 2023 Nov 30 doi: 10.1177/10935266231200115. PMID: 38032744

Papilliferous Keratoameloblastoma: Systematic review.

Sachdev SS, Chettiankandy TJ, Adhane YB, Sardar MA, Trimukhe A, Jain R
Sultan Qaboos Univ Med J 2023 Aug;23(3):288-296. Epub 2023 Aug 28 doi: 10.18295/squmj.5.2023.021. PMID: 37655071 Free PMC Article

Ameloblastoma-Clinical, radiological, and therapeutic findings.

Kreppel M, Zöller J
Oral Dis 2018 Mar;24(1-2):63-66. doi: 10.1111/odi.12702. PMID: 29480593

Ameloblastoma: current etiopathological concepts and management.

Effiom OA, Ogundana OM, Akinshipo AO, Akintoye SO
Oral Dis 2018 Apr;24(3):307-316. Epub 2017 Mar 9 doi: 10.1111/odi.12646. PMID: 28142213

Ameloblastoma.

Mendenhall WM, Werning JW, Fernandes R, Malyapa RS, Mendenhall NP
Am J Clin Oncol 2007 Dec;30(6):645-8. doi: 10.1097/COC.0b013e3181573e59. PMID: 18091060

See all (1290)

Therapy

BRAF inhibitors in BRAF V600E-mutated ameloblastoma: systematic review of rare cases in the literature.

Ebeling M, Scheurer M, Sakkas A, Pietzka S, Schramm A, Wilde F
Med Oncol 2023 Apr 28;40(6):163. doi: 10.1007/s12032-023-01993-z. PMID: 37115331 Free PMC Article

Effectiveness of molecular-targeted chemotherapy in ameloblastomas: A systematic review.

Yoithapprabhunath TR, Srichinthu KK, Gupta D, Singh D, Pasupuleti S, Nirmal RM
Indian J Dent Res 2022 Jul-Sep;33(3):323-331. doi: 10.4103/ijdr.ijdr_456_22. PMID: 36656197

Prevalence and Epidemiological Profile of Ameloblastoma in India: A Systematic Review and Meta-Analyses.

Thuckanaickenpalayam Ragunathan Y, Keniyan Kumar S, Janardhanam D, Ravi A, Santhanam V, Ramdas MN
Asian Pac J Cancer Prev 2022 Nov 1;23(11):3601-3610. doi: 10.31557/APJCP.2022.23.11.3601. PMID: 36444570 Free PMC Article

RANK, RANKL, and OPG in Dentigerous Cyst, Odontogenic Keratocyst, and Ameloblastoma: A Meta-Analysis.

Lima IFP, Matos FR, Bernardino ÍM, Santana ITS, Vieira WA, Blumenberg C, Siqueira WL, Paranhos LR
Braz Dent J 2021 Jan-Feb;32(1):16-25. doi: 10.1590/0103-6440202103387. PMID: 33913997

Ameloblastomas of the mandible and maxilla.

Petrovic ID, Migliacci J, Ganly I, Patel S, Xu B, Ghossein R, Huryn J, Shah J
Ear Nose Throat J 2018 Jul;97(7):E26-E32. doi: 10.1177/014556131809700704. PMID: 30036443 Free PMC Article

See all (159)

Prognosis

Ameloblastoma: A succinct review of the classification, genetic understanding and novel molecular targeted therapies.

Shi HA, Ng CWB, Kwa CT, Sim QXC
Surgeon 2021 Aug;19(4):238-243. Epub 2020 Jul 22 doi: 10.1016/j.surge.2020.06.009. PMID: 32712102

Ameloblastoma-Clinical, radiological, and therapeutic findings.

Kreppel M, Zöller J
Oral Dis 2018 Mar;24(1-2):63-66. doi: 10.1111/odi.12702. PMID: 29480593

Reconnoitre ameloblastic carcinoma: A prognostic update.

Saluja TS, Hosalkar R
Oral Oncol 2018 Feb;77:118-124. Epub 2018 Jan 4 doi: 10.1016/j.oraloncology.2017.12.018. PMID: 29362117

Odontogenic Cysts and Neoplasms.

Bilodeau EA, Collins BM
Surg Pathol Clin 2017 Mar;10(1):177-222. Epub 2016 Dec 29 doi: 10.1016/j.path.2016.10.006. PMID: 28153133

Immunohistochemical biomarkers in ameloblastomas.

do Canto AM, Rozatto JR, Schussel JL, de Freitas RR, Hasséus B, Braz-Silva PH
Acta Odontol Scand 2016 Nov;74(8):585-590. Epub 2016 Aug 30 doi: 10.1080/00016357.2016.1224918. PMID: 27571891

See all (569)

Clinical prediction guides

Clinical and pathomorphological aspects of odontogenic tumors.

Gültekin SE, Büttner R
Pathologie (Heidelb) 2022 Aug;43(Suppl 1):86-93. Epub 2022 Nov 8 doi: 10.1007/s00292-022-01150-9. PMID: 36346463

Adenoid ameloblastoma harbors beta-catenin mutations.

Bastos VC, Coura BP, Guimarães LM, Fernandes BG, Chan AC, Vargas PA, Bastos-Rodrigues L, De Marco LA, Hellstein J, Thavaraj S, Wright JM, Odell EW, Gomez RS, Gomes CC
Mod Pathol 2022 Nov;35(11):1562-1569. Epub 2022 Jul 15 doi: 10.1038/s41379-022-01125-4. PMID: 35840721

Ameloblastoma: A succinct review of the classification, genetic understanding and novel molecular targeted therapies.

Shi HA, Ng CWB, Kwa CT, Sim QXC
Surgeon 2021 Aug;19(4):238-243. Epub 2020 Jul 22 doi: 10.1016/j.surge.2020.06.009. PMID: 32712102

SOX2 and BCL-2 Expressions in Odontogenic Keratocyst and Ameloblastoma.

Silva BS, Silva LR, Lima KL, Dos Santos AC, Oliveira AC, Dezzen-Gomide AC, Batista AC, Yamamoto-Silva FP
Med Oral Patol Oral Cir Bucal 2020 Mar 1;25(2):e283-e290. doi: 10.4317/medoral.23348. PMID: 31967981 Free PMC Article

EGFR is not amplified in ameloblastoma.

Costa V, Fregnani ER, Fonseca FP, Abreu Alves F, Pinto CAL, Kaminagakura E
Oral Surg Oral Med Oral Pathol Oral Radiol 2018 May;125(5):454-458. Epub 2018 Mar 6 doi: 10.1016/j.oooo.2018.02.014. PMID: 29602688

See all (496)

Recent systematic reviews

Papilliferous Keratoameloblastoma: Systematic review.

Adenoid Ameloblastoma with Dentinoid: A systematic review.

Sachdev SS, Chettiankandy TJ, Sardar MA, Adhane Y, Shah AM, Grace AE
Sultan Qaboos Univ Med J 2022 Aug;22(3):325-338. Epub 2022 Aug 25 doi: 10.18295/squmj.9.2021.127. PMID: 36072074 Free PMC Article

Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Odontogenic and Maxillofacial Bone Tumours.

Vered M, Wright JM
Head Neck Pathol 2022 Mar;16(1):63-75. Epub 2022 Mar 21 doi: 10.1007/s12105-021-01404-7. PMID: 35312978 Free PMC Article

Radical vs conservative treatment of intraosseous ameloblastoma: Systematic review and meta-analysis.

Hendra FN, Natsir Kalla DS, Van Cann EM, de Vet HCW, Helder MN, Forouzanfar T
Oral Dis 2019 Oct;25(7):1683-1696. Epub 2019 Jan 1 doi: 10.1111/odi.13014. PMID: 30548549

Frequency of odontogenic cysts and tumors: a systematic review.

Johnson NR, Gannon OM, Savage NW, Batstone MD
J Investig Clin Dent 2014 Feb;5(1):9-14. Epub 2013 Jun 14 doi: 10.1111/jicd.12044. PMID: 23766099

See all (53)

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Ameloblastoma

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

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Table of contents

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Practice guidelines

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Reviews

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