U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Lupus erythematosus panniculitis

MedGen UID:
14589
•Concept ID:
C0030327
•
Disease or Syndrome
Synonyms: Lupus Erythematosus Panniculitides; Lupus Erythematosus Panniculitis; Lupus Erythematosus Profundus; Lupus Panniculitides; Lupus Panniculitis; Lupus Profundus; Panniculitides, Lupus; Panniculitides, Lupus Erythematosus; Panniculitis, Lupus; Panniculitis, Lupus Erythematosus
SNOMED CT: Lupus erythematosus profundus (15084002); Lupus panniculitis (239888002)
 
Monarch Initiative: MONDO:0019561
Orphanet: ORPHA90285

Definition

A rare form of chronic cutaneous lupus erythematosus characterized by recurrent, indurated, erythematous plaques and subcutaneous nodules with normal overlying epidermis, occurring predominantly on the face, upper arms, trunk, buttocks, and thighs. The lesions can ulcerate and lead to scarring. Histological findings include lobular lymphocytic panniculitis, hyaline fat necrosis, mucin deposition, and calcification. The condition may be associated with discoid or systemic lupus erythematosus. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLupus erythematosus panniculitis
Follow this link to review classifications for Lupus erythematosus panniculitis in Orphanet.

Professional guidelines

PubMed

Treatment of Childhood-Onset Lupus Erythematosus Panniculitis With Rituximab.
Correll CK, Miller DD, Maguiness SM
JAMA Dermatol 2020 May 1;156(5):566-569. doi: 10.1001/jamadermatol.2019.4984. PMID: 32049306Free PMC Article
Update on management of connective tissue panniculitides.
Braunstein I, Werth VP
Dermatol Ther 2012 Mar-Apr;25(2):173-82. doi: 10.1111/j.1529-8019.2012.01489.x. PMID: 22741936Free PMC Article

Recent clinical studies

Etiology

Subcutaneous panniculitis-like T-cell lymphoma, lupus erythematosus profundus, and overlapping cases: molecular characterization through the study of 208 genes.
Machan S, Rodríguez M, Alonso-Alonso R, Manso R, Pérez-Buira S, Borregón J, Rodríguez-Peralto JL, Cerroni L, Haro R, García C, García Toro E, Estrach T, García-Herrera A, Ferrer B, González-Cruz C, Segues N, Afonso-Martin JL, Peñate Y, Monteagudo C, Limeres-Gonzalez MÁ, González-Núñez MÁ, Torres MÁT, Cereceda L, Córdoba R, Piris MÁ, Requena L, María Rodríguez-Pinilla S
Leuk Lymphoma 2021 Sep;62(9):2130-2140. Epub 2021 May 8 doi: 10.1080/10428194.2021.1901098. PMID: 33966586
Treatment of Childhood-Onset Lupus Erythematosus Panniculitis With Rituximab.
Correll CK, Miller DD, Maguiness SM
JAMA Dermatol 2020 May 1;156(5):566-569. doi: 10.1001/jamadermatol.2019.4984. PMID: 32049306Free PMC Article
Panniculitides of particular interest to the rheumatologist.
Morita TCAB, Trés GFS, García MSC, Halpern I, Criado PR, de Carvalho JF
Adv Rheumatol 2019 Aug 1;59(1):35. doi: 10.1186/s42358-019-0077-5. PMID: 31370889
Panniculitis in childhood-onset systemic lupus erythematosus: a multicentric cohort study.
Verdier M, Anuardo P, Gormezano NWS, Romiti R, Campos LMA, Aikawa NE, Pereira RMR, Terreri MT, Magalhães CS, Ferreira JCOA, Silva MFC, Ferriani M, Sakamoto AP, Ferriani VPL, Centeville M, Sato J, Santos MC, Bonfá E, Silva CA
Adv Rheumatol 2019 Jan 18;59(1):3. doi: 10.1186/s42358-019-0049-9. PMID: 30658703
Lupus erythematosus panniculitis: clinicopathological, immunophenotypic, and molecular studies.
Park HS, Choi JW, Kim BK, Cho KH
Am J Dermatopathol 2010 Feb;32(1):24-30. doi: 10.1097/DAD.0b013e3181b4a5ec. PMID: 20098081

Diagnosis

Non-scarring alopecia of lupus erythematosus: A comprehensive review.
Perales A, Lipsker D, Cribier B, Lenormand C
Ann Dermatol Venereol 2023 Dec;150(4):260-269. Epub 2023 Aug 17 doi: 10.1016/j.annder.2023.04.002. PMID: 37598015
Panniculitides of particular interest to the rheumatologist.
Morita TCAB, Trés GFS, García MSC, Halpern I, Criado PR, de Carvalho JF
Adv Rheumatol 2019 Aug 1;59(1):35. doi: 10.1186/s42358-019-0077-5. PMID: 31370889
Panniculitis in childhood-onset systemic lupus erythematosus: a multicentric cohort study.
Verdier M, Anuardo P, Gormezano NWS, Romiti R, Campos LMA, Aikawa NE, Pereira RMR, Terreri MT, Magalhães CS, Ferreira JCOA, Silva MFC, Ferriani M, Sakamoto AP, Ferriani VPL, Centeville M, Sato J, Santos MC, Bonfá E, Silva CA
Adv Rheumatol 2019 Jan 18;59(1):3. doi: 10.1186/s42358-019-0049-9. PMID: 30658703
Lupus erythematosus panniculitis.
Fraga J, García-Díez A
Dermatol Clin 2008 Oct;26(4):453-63, vi. doi: 10.1016/j.det.2008.06.002. PMID: 18793977
Lupus erythematosus panniculitis.
Peters MS, Su WP
Med Clin North Am 1989 Sep;73(5):1113-26. doi: 10.1016/s0025-7125(16)30622-8. PMID: 2671535

Therapy

Centrifugal lipodystrophy on a spectrum with lupus erythematosus panniculitis in children and efficacy and safety of hydroxychloroquine: A clinicopathological study.
Xu Q, Qiu Y, Lu Z, Yu H, Ling B, Li Y, Gu Y, Yao Z
Dermatol Ther 2022 Nov;35(11):e15825. Epub 2022 Sep 27 doi: 10.1111/dth.15825. PMID: 36100983
Treatment of Childhood-Onset Lupus Erythematosus Panniculitis With Rituximab.
Correll CK, Miller DD, Maguiness SM
JAMA Dermatol 2020 May 1;156(5):566-569. doi: 10.1001/jamadermatol.2019.4984. PMID: 32049306Free PMC Article
Panniculitides of particular interest to the rheumatologist.
Morita TCAB, Trés GFS, García MSC, Halpern I, Criado PR, de Carvalho JF
Adv Rheumatol 2019 Aug 1;59(1):35. doi: 10.1186/s42358-019-0077-5. PMID: 31370889
Distinctive lupus panniculitis of scalp with linear alopecia along Blaschko's lines: a review of the literature.
Lueangarun S, Subpayasarn U, Tempark T
Int J Dermatol 2019 Feb;58(2):144-150. Epub 2018 Aug 3 doi: 10.1111/ijd.14155. PMID: 30074627
Lupus erythematosus panniculitis: clinicopathological, immunophenotypic, and molecular studies.
Park HS, Choi JW, Kim BK, Cho KH
Am J Dermatopathol 2010 Feb;32(1):24-30. doi: 10.1097/DAD.0b013e3181b4a5ec. PMID: 20098081

Prognosis

Centrifugal lipodystrophy on a spectrum with lupus erythematosus panniculitis in children and efficacy and safety of hydroxychloroquine: A clinicopathological study.
Xu Q, Qiu Y, Lu Z, Yu H, Ling B, Li Y, Gu Y, Yao Z
Dermatol Ther 2022 Nov;35(11):e15825. Epub 2022 Sep 27 doi: 10.1111/dth.15825. PMID: 36100983
Lupus Panniculitis as an Initial Manifestation of Systemic Lupus Erythematosus: A Case Report.
Zhao YK, Wang F, Chen WN, Xu R, Wang Z, Jiang YW, Luo DQ, Han JD
Medicine (Baltimore) 2016 Apr;95(16):e3429. doi: 10.1097/MD.0000000000003429. PMID: 27100438Free PMC Article
Lupus mastitis: a clinicopathologic review and addition of a case.
Summers TA Jr, Lehman MB, Barner R, Royer MC
Adv Anat Pathol 2009 Jan;16(1):56-61. doi: 10.1097/PAP.0b013e3181915ff7. PMID: 19098467
Cutaneous lupus erythematosus: a personal approach to management.
Callen JP
Australas J Dermatol 2006 Feb;47(1):13-27. doi: 10.1111/j.1440-0960.2006.00217.x. PMID: 16405478
Lupus erythematosus panniculitis.
Peters MS, Su WP
Med Clin North Am 1989 Sep;73(5):1113-26. doi: 10.1016/s0025-7125(16)30622-8. PMID: 2671535

Clinical prediction guides

Subcutaneous panniculitis-like T-cell lymphoma, lupus erythematosus profundus, and overlapping cases: molecular characterization through the study of 208 genes.
Machan S, Rodríguez M, Alonso-Alonso R, Manso R, Pérez-Buira S, Borregón J, Rodríguez-Peralto JL, Cerroni L, Haro R, García C, García Toro E, Estrach T, García-Herrera A, Ferrer B, González-Cruz C, Segues N, Afonso-Martin JL, Peñate Y, Monteagudo C, Limeres-Gonzalez MÁ, González-Núñez MÁ, Torres MÁT, Cereceda L, Córdoba R, Piris MÁ, Requena L, María Rodríguez-Pinilla S
Leuk Lymphoma 2021 Sep;62(9):2130-2140. Epub 2021 May 8 doi: 10.1080/10428194.2021.1901098. PMID: 33966586
Treatment of Childhood-Onset Lupus Erythematosus Panniculitis With Rituximab.
Correll CK, Miller DD, Maguiness SM
JAMA Dermatol 2020 May 1;156(5):566-569. doi: 10.1001/jamadermatol.2019.4984. PMID: 32049306Free PMC Article
Panniculitis in childhood-onset systemic lupus erythematosus: a multicentric cohort study.
Verdier M, Anuardo P, Gormezano NWS, Romiti R, Campos LMA, Aikawa NE, Pereira RMR, Terreri MT, Magalhães CS, Ferreira JCOA, Silva MFC, Ferriani M, Sakamoto AP, Ferriani VPL, Centeville M, Sato J, Santos MC, Bonfá E, Silva CA
Adv Rheumatol 2019 Jan 18;59(1):3. doi: 10.1186/s42358-019-0049-9. PMID: 30658703
Lupus erythematosus panniculitis in children and adolescents.
Guissa VR, Trudes G, Jesus AA, Aikawa NE, Romiti R, Silva CA
Acta Reumatol Port 2012 Jan-Mar;37(1):82-5. PMID: 22781517
Panniculitis: recent developments and observations.
White WL, Wieselthier JS, Hitchcock MG
Semin Cutan Med Surg 1996 Dec;15(4):278-99. doi: 10.1016/s1085-5629(96)80042-3. PMID: 9069596

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Reviews

    Related information

    • MeSH
      Related Medical Subject Headings
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...