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Phlebotomus fever

MedGen UID:
14597
•Concept ID:
C0030372
•
Disease or Syndrome
Synonyms: Pappataci Fever; Pappataci Fevers; Phlebotomus Fever; Phlebotomus Fevers; Sandfly Fever; Sandfly Fevers
SNOMED CT: Sandfly-borne phleboviral disease (407476002); Pappataci (407476002); Sandfly fever (407476002); Phlebotomus fever (407476002); Pappataci fever (407476002)
 
Monarch Initiative: MONDO:0005913

Definition

Influenza-like febrile viral disease caused by several members of the bunyaviridae family and transmitted mostly by the bloodsucking sandfly Phlebotomus papatasii. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPhlebotomus fever

Professional guidelines

PubMed

Increased Prevalence of Severe Fever with Thrombocytopenia Syndrome in Eastern China Clustered with Multiple Genotypes and Reasserted Virus during 2010-2015.
Li Z, Hu J, Cui L, Hong Y, Liu J, Li P, Guo X, Liu W, Wang X, Qi X, Wu B, Feng Z, Shen A, Liu X, Zhao H, Tan W, Zhou J, Xing Z, Bao C
Sci Rep 2017 Jul 26;7(1):6503. doi: 10.1038/s41598-017-06853-1. PMID: 28747674Free PMC Article
Ongoing activity of Toscana virus genotype A and West Nile virus lineage 1 strains in Turkey: a clinical and field survey.
Ocal M, Orsten S, Inkaya AC, Yetim E, Acar NP, Alp S, Kasap OE, Gunay F, Arsava EM, Alten B, Ozkul A, Us D, Niedrig M, Ergunay K
Zoonoses Public Health 2014 Nov;61(7):480-91. Epub 2013 Dec 19 doi: 10.1111/zph.12096. PMID: 25285941

Recent clinical studies

Etiology

Severe Fever with Thrombocytopenia Syndrome, Japan, 2013-2017.
Kobayashi Y, Kato H, Yamagishi T, Shimada T, Matsui T, Yoshikawa T, Kurosu T, Shimojima M, Morikawa S, Hasegawa H, Saijo M, Oishi K; SFTS Epidemiological Research Group Japan
Emerg Infect Dis 2020 Apr;26(4):692-699. doi: 10.3201/eid2604.191011. PMID: 32186502Free PMC Article
Calcium channel blockers reduce severe fever with thrombocytopenia syndrome virus (SFTSV) related fatality.
Li H, Zhang LK, Li SF, Zhang SF, Wan WW, Zhang YL, Xin QL, Dai K, Hu YY, Wang ZB, Zhu XT, Fang YJ, Cui N, Zhang PH, Yuan C, Lu QB, Bai JY, Deng F, Xiao GF, Liu W, Peng K
Cell Res 2019 Sep;29(9):739-753. Epub 2019 Aug 23 doi: 10.1038/s41422-019-0214-z. PMID: 31444469Free PMC Article
Severe fever with thrombocytopenia syndrome-associated encephalopathy/encephalitis.
Park SY, Kwon JS, Kim JY, Kim SM, Jang YR, Kim MC, Cho OH, Kim T, Chong YP, Lee SO, Choi SH, Kim YS, Woo JH, Kim SH
Clin Microbiol Infect 2018 Apr;24(4):432.e1-432.e4. Epub 2017 Sep 9 doi: 10.1016/j.cmi.2017.09.002. PMID: 28899841
Meta-analysis of the clinical and laboratory parameters of SFTS patients in China.
Liu MM, Lei XY, Yu XJ
Virol J 2016 Nov 29;13(1):198. doi: 10.1186/s12985-016-0661-9. PMID: 27899121Free PMC Article
Epidemiological, clinical and laboratory aspects of sandfly fever.
Dionisio D, Esperti F, Vivarelli A, Valassina M
Curr Opin Infect Dis 2003 Oct;16(5):383-8. doi: 10.1097/00001432-200310000-00003. PMID: 14501989

Diagnosis

Sandfly-Borne Phleboviruses in Portugal: Four and Still Counting.
Amaro F, Zé-Zé L, Alves MJ
Viruses 2022 Aug 13;14(8) doi: 10.3390/v14081768. PMID: 36016390Free PMC Article
Current status of Severe Fever with Thrombocytopenia Syndrome vaccine development.
Reece LM, Beasley DW, Milligan GN, Sarathy VV, Barrett AD
Curr Opin Virol 2018 Apr;29:72-78. Epub 2018 Apr 9 doi: 10.1016/j.coviro.2018.03.005. PMID: 29642053
Of phlebotomines (sandflies) and viruses: a comprehensive perspective on a complex situation.
Ayhan N, Charrel RN
Curr Opin Insect Sci 2017 Aug;22:117-124. Epub 2017 Jun 27 doi: 10.1016/j.cois.2017.05.019. PMID: 28805633
Novel and emergent sandfly-borne phleboviruses in Asia Minor: a systematic review.
Ergunay K, Ayhan N, Charrel RN
Rev Med Virol 2017 Mar;27(2) Epub 2016 Aug 17 doi: 10.1002/rmv.1898. PMID: 27531681
A Mediterranean arbovirus: the Toscana virus.
Valassina M, Cusi MG, Valensin PE
J Neurovirol 2003 Dec;9(6):577-83. doi: 10.1080/13550280390247678. PMID: 14602570

Therapy

Calcium channel blockers reduce severe fever with thrombocytopenia syndrome virus (SFTSV) related fatality.
Li H, Zhang LK, Li SF, Zhang SF, Wan WW, Zhang YL, Xin QL, Dai K, Hu YY, Wang ZB, Zhu XT, Fang YJ, Cui N, Zhang PH, Yuan C, Lu QB, Bai JY, Deng F, Xiao GF, Liu W, Peng K
Cell Res 2019 Sep;29(9):739-753. Epub 2019 Aug 23 doi: 10.1038/s41422-019-0214-z. PMID: 31444469Free PMC Article
Reactive plasmacytosis mimicking multiple myeloma associated with SFTS virus infection: a report of two cases and literature review.
Zhang J, Yan X, Li Y, Gao R, Wang P, Mo W
BMC Infect Dis 2018 Oct 22;18(1):528. doi: 10.1186/s12879-018-3431-z. PMID: 30348099Free PMC Article
A Pediatric Case of Severe Fever with Thrombocytopenia Syndrome in Korea.
Song TY, Yang EM, Kim CJ
J Korean Med Sci 2017 Apr;32(4):704-707. doi: 10.3346/jkms.2017.32.4.704. PMID: 28244301Free PMC Article
Common adverse events associated with ribavirin therapy for Severe Fever with Thrombocytopenia Syndrome.
Lu QB, Zhang SY, Cui N, Hu JG, Fan YD, Guo CT, Qin SL, Yang ZD, Wang LY, Wang HY, Zhang XA, Liu W, Cao WC
Antiviral Res 2015 Jul;119:19-22. Epub 2015 Apr 16 doi: 10.1016/j.antiviral.2015.04.006. PMID: 25892251
Case-fatality ratio and effectiveness of ribavirin therapy among hospitalized patients in china who had severe fever with thrombocytopenia syndrome.
Liu W, Lu QB, Cui N, Li H, Wang LY, Liu K, Yang ZD, Wang BJ, Wang HY, Zhang YY, Zhuang L, Hu CY, Yuan C, Fan XJ, Wang Z, Zhang L, Zhang XA, Walker DH, Cao WC
Clin Infect Dis 2013 Nov;57(9):1292-9. Epub 2013 Aug 20 doi: 10.1093/cid/cit530. PMID: 23965284

Prognosis

Severe fever with thrombocytopenia syndrome: a systematic review and meta-analysis of epidemiology, clinical signs, routine laboratory diagnosis, risk factors, and outcomes.
He Z, Wang B, Li Y, Du Y, Ma H, Li X, Guo W, Xu B, Huang X
BMC Infect Dis 2020 Aug 5;20(1):575. doi: 10.1186/s12879-020-05303-0. PMID: 32758175Free PMC Article
Serial analysis of cytokine and chemokine profiles and viral load in severe fever with thrombocytopenia syndrome: Case report and review of literature.
Fujikawa K, Koga T, Honda T, Uchida T, Okamoto M, Endo Y, Mihara T, Kondo A, Shimada S, Hayasaka D, Morita K, Mizokami A, Kawakami A
Medicine (Baltimore) 2019 Oct;98(42):e17571. doi: 10.1097/MD.0000000000017571. PMID: 31626125Free PMC Article
Sandflies and sandfly-borne infections of humans in Central Europe in the light of climate change.
Aspöck H, Gerersdorfer T, Formayer H, Walochnik J
Wien Klin Wochenschr 2008;120(19-20 Suppl 4):24-9. doi: 10.1007/s00508-008-1072-8. PMID: 19066768
Epidemiological, clinical and laboratory aspects of sandfly fever.
Dionisio D, Esperti F, Vivarelli A, Valassina M
Curr Opin Infect Dis 2003 Oct;16(5):383-8. doi: 10.1097/00001432-200310000-00003. PMID: 14501989
Sandfly fever viruses in Italy.
Nicoletti L, Ciufolini MG, Verani P
Arch Virol Suppl 1996;11:41-7. doi: 10.1007/978-3-7091-7482-1_5. PMID: 8800804

Clinical prediction guides

Serial analysis of cytokine and chemokine profiles and viral load in severe fever with thrombocytopenia syndrome: Case report and review of literature.
Fujikawa K, Koga T, Honda T, Uchida T, Okamoto M, Endo Y, Mihara T, Kondo A, Shimada S, Hayasaka D, Morita K, Mizokami A, Kawakami A
Medicine (Baltimore) 2019 Oct;98(42):e17571. doi: 10.1097/MD.0000000000017571. PMID: 31626125Free PMC Article
Analysis of clinical features and early warning indicators of death from severe fever with thrombocytopenia syndrome.
Xu X, Sun Z, Liu J, Zhang J, Liu T, Mu X, Jiang M
Int J Infect Dis 2018 Aug;73:43-48. Epub 2018 May 30 doi: 10.1016/j.ijid.2018.05.013. PMID: 29859247
Clinical and laboratory findings of a sandfly fever Turkey Virus outbreak in Ankara.
Kocak Tufan Z, Weidmann M, Bulut C, Kinikli S, Hufert FT, Dobler G, Demiroz AP
J Infect 2011 Nov;63(5):375-81. Epub 2011 Jul 29 doi: 10.1016/j.jinf.2011.07.011. PMID: 21824495
Epidemiological, clinical and laboratory aspects of sandfly fever.
Dionisio D, Esperti F, Vivarelli A, Valassina M
Curr Opin Infect Dis 2003 Oct;16(5):383-8. doi: 10.1097/00001432-200310000-00003. PMID: 14501989
Sandfly fever viruses in Italy.
Nicoletti L, Ciufolini MG, Verani P
Arch Virol Suppl 1996;11:41-7. doi: 10.1007/978-3-7091-7482-1_5. PMID: 8800804

Recent systematic reviews

Severe fever with thrombocytopenia syndrome: a systematic review and meta-analysis of epidemiology, clinical signs, routine laboratory diagnosis, risk factors, and outcomes.
He Z, Wang B, Li Y, Du Y, Ma H, Li X, Guo W, Xu B, Huang X
BMC Infect Dis 2020 Aug 5;20(1):575. doi: 10.1186/s12879-020-05303-0. PMID: 32758175Free PMC Article
Novel and emergent sandfly-borne phleboviruses in Asia Minor: a systematic review.
Ergunay K, Ayhan N, Charrel RN
Rev Med Virol 2017 Mar;27(2) Epub 2016 Aug 17 doi: 10.1002/rmv.1898. PMID: 27531681

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