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Paracoccidioidomycosis(PCM)

MedGen UID:
14601
Concept ID:
C0030409
Disease or Syndrome
Synonyms: Lobo disease; Lutz-Splendore-Almeida disease; Paracoccidioidal granuloma; PCM; South american blastomycosis
SNOMED CT: Paracoccidioidal granuloma (36866003); Mucocutaneous South American blastomycosis (36866003); Mucocutaneous-lymphangitic paracoccidioidomycosis (36866003); Paracoccidioidomycosis (59925007); South American blastomycosis (59925007); Infection by Blastomyces brasiliensis (59925007); Infection by Paracoccidioides brasiliensis (59925007); Brazilian blastomycosis (59925007); Lutz-Splendore-Almeida disease (59925007)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
Monarch Initiative: MONDO:0005894
Orphanet: ORPHA73260

Definition

A rare mycosis characterized by an acute form mostly occurring in children and young adults presenting with fever, weight loss, lymph node enlargement, hepatosplenomegaly, and bone marrow dysfunction, versus a chronic form which usually involves the lungs and mucosae of the upper respiratory tract, skin, lymph nodes, and adrenal glands, but may affect any part of the body. The most common sequelae are chronic respiratory insufficiency and Addison's disease. The infectious agent, <i>Paracoccidioides brasiliensis</i>, is a fungus limited to Latin America. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVParacoccidioidomycosis
Follow this link to review classifications for Paracoccidioidomycosis in Orphanet.

Professional guidelines

PubMed

Thompson GR 3rd, Le T, Chindamporn A, Kauffman CA, Alastruey-Izquierdo A, Ampel NM, Andes DR, Armstrong-James D, Ayanlowo O, Baddley JW, Barker BM, Lopes Bezerra L, Buitrago MJ, Chamani-Tabriz L, Chan JFW, Chayakulkeeree M, Cornely OA, Cunwei C, Gangneux JP, Govender NP, Hagen F, Hedayati MT, Hohl TM, Jouvion G, Kenyon C, Kibbler CC, Klimko N, Kong DCM, Krause R, Lee Lee L, Meintjes G, Miceli MH, Rath PM, Spec A, Queiroz-Telles F, Variava E, Verweij PE, Schwartz IS, Pasqualotto AC
Lancet Infect Dis 2021 Dec;21(12):e364-e374. Epub 2021 Aug 6 doi: 10.1016/S1473-3099(21)00191-2. PMID: 34364529Free PMC Article
Shikanai-Yasuda MA, Mendes RP, Colombo AL, Queiroz-Telles F, Kono ASG, Paniago AMM, Nathan A, Valle ACFD, Bagagli E, Benard G, Ferreira MS, Teixeira MM, Silva-Vergara ML, Pereira RM, Cavalcante RS, Hahn R, Durlacher RR, Khoury Z, Camargo ZP, Moretti ML, Martinez R
Rev Soc Bras Med Trop 2017 Sep-Oct;50(5):715-740. Epub 2017 Jul 12 doi: 10.1590/0037-8682-0230-2017. PMID: 28746570
Shikanai-Yasuda MA
Rev Inst Med Trop Sao Paulo 2015 Sep;57 Suppl 19(Suppl 19):31-7. doi: 10.1590/S0036-46652015000700007. PMID: 26465367Free PMC Article

Recent clinical studies

Therapy

Shikanai-Yasuda MA, Mendes RP, Colombo AL, Queiroz-Telles F, Kono ASG, Paniago AMM, Nathan A, Valle ACFD, Bagagli E, Benard G, Ferreira MS, Teixeira MM, Silva-Vergara ML, Pereira RM, Cavalcante RS, Hahn R, Durlacher RR, Khoury Z, Camargo ZP, Moretti ML, Martinez R
Rev Soc Bras Med Trop 2017 Sep-Oct;50(5):715-740. Epub 2017 Jul 12 doi: 10.1590/0037-8682-0230-2017. PMID: 28746570
Shikanai-Yasuda MA
Rev Inst Med Trop Sao Paulo 2015 Sep;57 Suppl 19(Suppl 19):31-7. doi: 10.1590/S0036-46652015000700007. PMID: 26465367Free PMC Article
Marques SA
Clin Dermatol 2012 Nov-Dec;30(6):610-5. doi: 10.1016/j.clindermatol.2012.01.006. PMID: 23068148
Travassos LR, Taborda CP
Hum Vaccin Immunother 2012 Oct;8(10):1450-3. Epub 2012 Aug 16 doi: 10.4161/hv.21283. PMID: 22894948Free PMC Article
Talhari S, Talhari C
Clin Dermatol 2012 Jul-Aug;30(4):420-4. doi: 10.1016/j.clindermatol.2011.09.014. PMID: 22682191

Prognosis

Thompson GR 3rd, Le T, Chindamporn A, Kauffman CA, Alastruey-Izquierdo A, Ampel NM, Andes DR, Armstrong-James D, Ayanlowo O, Baddley JW, Barker BM, Lopes Bezerra L, Buitrago MJ, Chamani-Tabriz L, Chan JFW, Chayakulkeeree M, Cornely OA, Cunwei C, Gangneux JP, Govender NP, Hagen F, Hedayati MT, Hohl TM, Jouvion G, Kenyon C, Kibbler CC, Klimko N, Kong DCM, Krause R, Lee Lee L, Meintjes G, Miceli MH, Rath PM, Spec A, Queiroz-Telles F, Variava E, Verweij PE, Schwartz IS, Pasqualotto AC
Lancet Infect Dis 2021 Dec;21(12):e364-e374. Epub 2021 Aug 6 doi: 10.1016/S1473-3099(21)00191-2. PMID: 34364529Free PMC Article
Queiroz-Telles F, Fahal AH, Falci DR, Caceres DH, Chiller T, Pasqualotto AC
Lancet Infect Dis 2017 Nov;17(11):e367-e377. Epub 2017 Jul 31 doi: 10.1016/S1473-3099(17)30306-7. PMID: 28774696
Shikanai-Yasuda MA
Rev Inst Med Trop Sao Paulo 2015 Sep;57 Suppl 19(Suppl 19):31-7. doi: 10.1590/S0036-46652015000700007. PMID: 26465367Free PMC Article
Talhari S, Talhari C
Clin Dermatol 2012 Jul-Aug;30(4):420-4. doi: 10.1016/j.clindermatol.2011.09.014. PMID: 22682191
Ameen M, Talhari C, Talhari S
Clin Exp Dermatol 2010 Aug;35(6):576-80. Epub 2009 Oct 23 doi: 10.1111/j.1365-2230.2009.03647.x. PMID: 19874328

Clinical prediction guides

Rodrigues AM, Hagen F, Puccia R, Hahn RC, de Camargo ZP
Mycopathologia 2023 Apr;188(1-2):129-133. Epub 2023 Jan 12 doi: 10.1007/s11046-022-00704-y. PMID: 36633737
Ramos-e-Silva M, Lima CM, Schechtman RC, Trope BM, Carneiro S
Clin Dermatol 2012 Nov-Dec;30(6):616-27. doi: 10.1016/j.clindermatol.2012.01.008. PMID: 23068149
Ferreira MS
Paediatr Respir Rev 2009 Dec;10(4):161-5. Epub 2009 Sep 25 doi: 10.1016/j.prrv.2009.08.001. PMID: 19879504
Shikanai-Yasuda MA, Conceição YM, Kono A, Rivitti E, Campos AF, Campos SV
Mycopathologia 2008 Apr-May;165(4-5):303-12. doi: 10.1007/s11046-007-9047-2. PMID: 18780466
Restrepo A, Benard G, de Castro CC, Agudelo CA, Tobón AM
Semin Respir Crit Care Med 2008 Apr;29(2):182-97. doi: 10.1055/s-2008-1063857. PMID: 18366000

Recent systematic reviews

Zerbato V, Di Bella S, Pol R, D'Aleo F, Angheben A, Farina C, Conte M, Luzzaro F; Gianluigi Lombardi on behalf of the AMCLI Mycology Committee, Luzzati R, Principe L
Mycopathologia 2023 Aug;188(4):307-334. Epub 2023 Jun 9 doi: 10.1007/s11046-023-00735-z. PMID: 37294504Free PMC Article
de Oliveira VF, Magri MMC, Levin AS, Silva GD
Mycoses 2023 Feb;66(2):168-175. Epub 2022 Sep 13 doi: 10.1111/myc.13525. PMID: 36062632
da Cruz ER, Forno AD, Pacheco SA, Bigarella LG, Ballotin VR, Salgado K, Freisbelen D, Michelin L, Soldera J
Braz J Infect Dis 2021 Jul-Aug;25(4):101605. Epub 2021 Aug 27 doi: 10.1016/j.bjid.2021.101605. PMID: 34461048Free PMC Article
Costa MC, de Carvalho MM, Sperandio FF, Ribeiro Junior NV, Hanemann JAC, Pigossi SC, de Carli ML
Mycoses 2021 Feb;64(2):108-122. Epub 2020 Oct 25 doi: 10.1111/myc.13194. PMID: 33031605
Menezes VM, Soares BG, Fontes CJ
Cochrane Database Syst Rev 2006 Apr 19;2006(2):CD004967. doi: 10.1002/14651858.CD004967.pub2. PMID: 16625617Free PMC Article

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