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Pathological gambling

MedGen UID:
14632
•Concept ID:
C0030662
•
Mental or Behavioral Dysfunction
Synonyms: Addictive gambling behavior; Gambling, pathologic
SNOMED CT: Pathological gambling disorder (18085000); Gambling disorder (18085000); Compulsive gambling (18085000)
 
HPO: HP:5200334
Monarch Initiative: MONDO:0011662
OMIM®: 606349

Definition

Pathologic gambling is defined as a chronic and progressive failure to resist impulses to gamble accompanied by gambling behavior that compromises or damages personal, family, or vocational pursuits. The prevalence of pathologic gambling in the adult American population is estimated to be between 1 and 3% (review by Eisen et al., 1998). Comings et al. (2001) noted that some form of gambling is legal in all but 2 states in the U.S., and gambling on the Internet is available to anyone with a computer regardless of the local laws. They stated that as access to gambling has increased, there has been a corresponding increase in the frequency of addiction to gambling, known as pathologic gambling. [from OMIM]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPathological gambling

Professional guidelines

PubMed

Naltrexone: A Pan-Addiction Treatment?
Aboujaoude E, Salame WO
CNS Drugs 2016 Aug;30(8):719-33. doi: 10.1007/s40263-016-0373-0. PMID: 27401883
Gambling in Singapore: an overview of history, research, treatment and policy.
Winslow M, Cheok C, Subramaniam M
Addiction 2015 Sep;110(9):1383-7. Epub 2015 May 6 doi: 10.1111/add.12931. PMID: 25944124
Treatment of pathological gambling.
Leung KS, Cottler LB
Curr Opin Psychiatry 2009 Jan;22(1):69-74. doi: 10.1097/YCO.0b013e32831575d9. PMID: 19122538

Recent clinical studies

Etiology

Sex differences in addictive disorders.
Fattore L, Melis M, Fadda P, Fratta W
Front Neuroendocrinol 2014 Aug;35(3):272-84. Epub 2014 Apr 21 doi: 10.1016/j.yfrne.2014.04.003. PMID: 24769267
Pharmacological treatments in pathological gambling.
Grant JE, Odlaug BL, Schreiber LR
Br J Clin Pharmacol 2014 Feb;77(2):375-81. doi: 10.1111/j.1365-2125.2012.04457.x. PMID: 22979951Free PMC Article
Pathological gambling: a general overview.
Ashley LL, Boehlke KK
J Psychoactive Drugs 2012 Jan-Mar;44(1):27-37. doi: 10.1080/02791072.2012.662078. PMID: 22641963
A pathways model of problem and pathological gambling.
Blaszczynski A, Nower L
Addiction 2002 May;97(5):487-99. doi: 10.1046/j.1360-0443.2002.00015.x. PMID: 12033650
Pathological gambling.
Allcock CC
Aust N Z J Psychiatry 1986 Sep;20(3):259-65. doi: 10.3109/00048678609158874. PMID: 3541888

Diagnosis

Definition of Substance and Non-substance Addiction.
Zou Z, Wang H, d'Oleire Uquillas F, Wang X, Ding J, Chen H
Adv Exp Med Biol 2017;1010:21-41. doi: 10.1007/978-981-10-5562-1_2. PMID: 29098666
Behavioral addictions.
Robbins TW, Clark L
Curr Opin Neurobiol 2015 Feb;30:66-72. Epub 2014 Sep 26 doi: 10.1016/j.conb.2014.09.005. PMID: 25262209
Internet addiction: a systematic review of epidemiological research for the last decade.
Kuss DJ, Griffiths MD, Karila L, Billieux J
Curr Pharm Des 2014;20(25):4026-52. doi: 10.2174/13816128113199990617. PMID: 24001297
Neurobiology of gambling behaviors.
Potenza MN
Curr Opin Neurobiol 2013 Aug;23(4):660-7. Epub 2013 Mar 29 doi: 10.1016/j.conb.2013.03.004. PMID: 23541597Free PMC Article
Pathological gambling: prevalence, diagnosis, comorbidity, and intervention in Germany.
Erbas B, Buchner UG
Dtsch Arztebl Int 2012 Mar;109(10):173-9. Epub 2012 Mar 9 doi: 10.3238/arztebl.2012.0173. PMID: 22470406Free PMC Article

Therapy

Naltrexone: A Pan-Addiction Treatment?
Aboujaoude E, Salame WO
CNS Drugs 2016 Aug;30(8):719-33. doi: 10.1007/s40263-016-0373-0. PMID: 27401883
The Movement Disorder Society Evidence-Based Medicine Review Update: Treatments for the non-motor symptoms of Parkinson's disease.
Seppi K, Weintraub D, Coelho M, Perez-Lloret S, Fox SH, Katzenschlager R, Hametner EM, Poewe W, Rascol O, Goetz CG, Sampaio C
Mov Disord 2011 Oct;26 Suppl 3(0 3):S42-80. doi: 10.1002/mds.23884. PMID: 22021174Free PMC Article
Treatment of pathological gambling.
Leung KS, Cottler LB
Curr Opin Psychiatry 2009 Jan;22(1):69-74. doi: 10.1097/YCO.0b013e32831575d9. PMID: 19122538
Pathological gambling.
Hollander E, Buchalter AJ, DeCaria CM
Psychiatr Clin North Am 2000 Sep;23(3):629-42. doi: 10.1016/s0193-953x(05)70185-4. PMID: 10986732
Impulsivity.
Hollander E, Rosen J
J Psychopharmacol 2000;14(2 Suppl 1):S39-44. doi: 10.1177/02698811000142S106. PMID: 10888030

Prognosis

Similarities and Differences in Diagnostic Scales.
Xuan B, Li P, Yang L, Li M, Zhou J
Adv Exp Med Biol 2017;1010:133-168. doi: 10.1007/978-981-10-5562-1_8. PMID: 29098672
Similarities and Differences in Neuroimaging.
Sun YK, Sun Y, Lin X, Lu L, Shi J
Adv Exp Med Biol 2017;1010:73-89. doi: 10.1007/978-981-10-5562-1_5. PMID: 29098669
Gambling disorder: an integrative review of animal and human studies.
Nautiyal KM, Okuda M, Hen R, Blanco C
Ann N Y Acad Sci 2017 Apr;1394(1):106-127. doi: 10.1111/nyas.13356. PMID: 28486792Free PMC Article
Pathological gambling: a general overview.
Ashley LL, Boehlke KK
J Psychoactive Drugs 2012 Jan-Mar;44(1):27-37. doi: 10.1080/02791072.2012.662078. PMID: 22641963
Gambling disorders.
Hodgins DC, Stea JN, Grant JE
Lancet 2011 Nov 26;378(9806):1874-84. Epub 2011 May 18 doi: 10.1016/S0140-6736(10)62185-X. PMID: 21600645

Clinical prediction guides

Similarities and Differences in Diagnostic Scales.
Xuan B, Li P, Yang L, Li M, Zhou J
Adv Exp Med Biol 2017;1010:133-168. doi: 10.1007/978-981-10-5562-1_8. PMID: 29098672
Similarities and Differences in Neuroimaging.
Sun YK, Sun Y, Lin X, Lu L, Shi J
Adv Exp Med Biol 2017;1010:73-89. doi: 10.1007/978-981-10-5562-1_5. PMID: 29098669
Pathological gambling in Parkinson's disease: what are the risk factors and what is the role of impulsivity?
Heiden P, Heinz A, Romanczuk-Seiferth N
Eur J Neurosci 2017 Jan;45(1):67-72. Epub 2016 Oct 1 doi: 10.1111/ejn.13396. PMID: 27623191Free PMC Article
Pathological gambling subtypes.
Vachon DD, Bagby RM
Psychol Assess 2009 Dec;21(4):608-15. doi: 10.1037/a0016846. PMID: 19947793
Genetics of pathological gambling.
Ibáñez A, Blanco C, Perez de Castro I, Fernandez-Piqueras J, Sáiz-Ruiz J
J Gambl Stud 2003 Spring;19(1):11-22. doi: 10.1023/a:1021271029163. PMID: 12635538

Recent systematic reviews

Psychological intervention for gambling disorder: A systematic review and meta-analysis.
Eriksen JW, Fiskaali A, Zachariae R, Wellnitz KB, Oernboel E, Stenbro AW, Marcussen T, Petersen MW
J Behav Addict 2023 Oct 5;12(3):613-630. Epub 2023 Jul 14 doi: 10.1556/2006.2023.00034. PMID: 37450372Free PMC Article
Pathological Gambling and Motor Impulsivity: A Systematic Review with Meta-Analysis.
Chowdhury NS, Livesey EJ, Blaszczynski A, Harris JA
J Gambl Stud 2017 Dec;33(4):1213-1239. doi: 10.1007/s10899-017-9683-5. PMID: 28255940
Internet addiction: a systematic review of epidemiological research for the last decade.
Kuss DJ, Griffiths MD, Karila L, Billieux J
Curr Pharm Des 2014;20(25):4026-52. doi: 10.2174/13816128113199990617. PMID: 24001297
The genetics of problem and pathological gambling: a systematic review.
Gyollai A, Griffiths MD, Barta C, Vereczkei A, Urbán R, Kun B, Kökönyei G, Székely A, Sasvári-Székely M, Blum K, Demetrovics Z
Curr Pharm Des 2014;20(25):3993-9. doi: 10.2174/13816128113199990626. PMID: 24001288
Pathological gambling: a systematic review of biochemical, neuroimaging, and neuropsychological findings.
Conversano C, Marazziti D, Carmassi C, Baldini S, Barnabei G, Dell'Osso L
Harv Rev Psychiatry 2012 May-Jun;20(3):130-48. doi: 10.3109/10673229.2012.694318. PMID: 22716504

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