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Benign neoplasm of epicardium

MedGen UID:
146342
•Concept ID:
C0685115
•
Neoplastic Process
Synonyms: Benign Epicardial Neoplasm; benign epicardial neoplasm; Benign Epicardial Tumor; benign epicardial tumor; benign epicardial tumour; Benign Neoplasm of Epicardium; benign neoplasm of epicardium; Benign Neoplasm of the Epicardium; benign neoplasm of the epicardium; Benign Tumor of Epicardium; benign tumor of epicardium; Benign Tumor of the Epicardium; benign tumor of the epicardium; benign tumour of epicardium; benign tumour of the epicardium; epicardium benign neoplasm
SNOMED CT: Benign neoplasm of epicardium (92087008)
 
Monarch Initiative: MONDO:0021508

Definition

A neoplasm that arises from the inner layer of pericardium and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBenign neoplasm of epicardium

Professional guidelines

PubMed

Current clinical management of primary cardiac sarcoma.
Siontis BL, Leja M, Chugh R
Expert Rev Anticancer Ther 2020 Jan;20(1):45-51. Epub 2020 Jan 9 doi: 10.1080/14737140.2020.1711738. PMID: 31914831
Management of neoplastic pericardial disease.
Zhang J, Zhang Q, Chen X, Zhang N
Herz 2020 Dec;45(Suppl 1):46-51. Epub 2019 Jul 11 doi: 10.1007/s00059-019-4833-4. PMID: 31297544
2015 ESC Guidelines for the diagnosis and management of pericardial diseases: The Task Force for the Diagnosis and Management of Pericardial Diseases of the European Society of Cardiology (ESC)Endorsed by: The European Association for Cardio-Thoracic Surgery (EACTS).
Adler Y, Charron P, Imazio M, Badano L, Barón-Esquivias G, Bogaert J, Brucato A, Gueret P, Klingel K, Lionis C, Maisch B, Mayosi B, Pavie A, Ristic AD, Sabaté Tenas M, Seferovic P, Swedberg K, Tomkowski W; ESC Scientific Document Group
Eur Heart J 2015 Nov 7;36(42):2921-2964. Epub 2015 Aug 29 doi: 10.1093/eurheartj/ehv318. PMID: 26320112Free PMC Article

Recent clinical studies

Etiology

Pericardial Mesotheliomas.
Arrossi AV
Adv Anat Pathol 2023 Jul 1;30(4):253-258. Epub 2023 Apr 27 doi: 10.1097/PAP.0000000000000399. PMID: 37104724
Extramedullary disease in multiple myeloma: a systematic literature review.
Bladé J, Beksac M, Caers J, Jurczyszyn A, von Lilienfeld-Toal M, Moreau P, Rasche L, Rosiñol L, Usmani SZ, Zamagni E, Richardson P
Blood Cancer J 2022 Mar 21;12(3):45. doi: 10.1038/s41408-022-00643-3. PMID: 35314675Free PMC Article
Mesothelial Cysts.
Karpathiou G, Casteillo F, Dridi M, Peoc'h M
Am J Clin Pathol 2021 May 18;155(6):853-862. doi: 10.1093/ajcp/aqaa189. PMID: 33258870
Radiation-Associated Pericardial Disease.
Szpakowski N, Desai MY
Curr Cardiol Rep 2019 Jul 27;21(9):97. doi: 10.1007/s11886-019-1192-y. PMID: 31352541
Polyserositis: a diagnostic challenge.
Losada I, González-Moreno J, Roda N, Ventayol L, Borjas Y, Domínguez FJ, Fernández-Baca V, García-Gasalla M, Payeras A
Intern Med J 2018 Aug;48(8):982-987. doi: 10.1111/imj.13966. PMID: 29761620

Diagnosis

Imaging of Pericardial Disease.
Kligerman S
Radiol Clin North Am 2019 Jan;57(1):179-199. doi: 10.1016/j.rcl.2018.09.001. PMID: 30454812
Congenital Abnormalities of the Pericardium.
Parmar YJ, Shah AB, Poon M, Kronzon I
Cardiol Clin 2017 Nov;35(4):601-614. doi: 10.1016/j.ccl.2017.07.012. PMID: 29025550
Neoplastic Pericardial Disease.
Maleszewski JJ, Anavekar NS
Cardiol Clin 2017 Nov;35(4):589-600. Epub 2017 Sep 6 doi: 10.1016/j.ccl.2017.07.011. PMID: 29025549
Primary pericardial tumors.
Restrepo CS, Vargas D, Ocazionez D, Martínez-Jiménez S, Betancourt Cuellar SL, Gutierrez FR
Radiographics 2013 Oct;33(6):1613-30. doi: 10.1148/rg.336135512. PMID: 24108554
Primary pericardial mesothelioma.
Eren NT, Akar AR
Curr Treat Options Oncol 2002 Oct;3(5):369-73. doi: 10.1007/s11864-002-0002-7. PMID: 12194802

Therapy

Pericardial Involvement in Cancer.
Chahine J, Shekhar S, Mahalwar G, Imazio M, Collier P, Klein A
Am J Cardiol 2021 Apr 15;145:151-159. Epub 2021 Jan 15 doi: 10.1016/j.amjcard.2020.12.092. PMID: 33460602
Pericardial Disease Associated with Malignancy.
Schusler R, Meyerson SL
Curr Cardiol Rep 2018 Aug 20;20(10):92. doi: 10.1007/s11886-018-1040-5. PMID: 30128844
Malignant pericardial effusion.
Burazor I, Imazio M, Markel G, Adler Y
Cardiology 2013;124(4):224-32. Epub 2013 Apr 5 doi: 10.1159/000348559. PMID: 23571453
Malignant mesothelioma.
Kao SC, Reid G, Lee K, Vardy J, Clarke S, van Zandwijk N
Intern Med J 2010 Nov;40(11):742-50. doi: 10.1111/j.1445-5994.2010.02223.x. PMID: 20298508
Radiation-related pericarditis.
Martin RG, Ruckdeschel JC, Chang P, Byhardt R, Bouchard RJ, Wiernik PH
Am J Cardiol 1975 Feb;35(2):216-20. doi: 10.1016/0002-9149(75)90004-1. PMID: 1119380

Prognosis

Multimodality Imaging for the Assessment of Pericardial Diseases.
Chetrit M, Xu B, Verma BR, Klein AL
Curr Cardiol Rep 2019 Apr 16;21(5):41. doi: 10.1007/s11886-019-1115-y. PMID: 30993456
Treatment and Outcomes of Primary Pericardial Mesothelioma: A Contemporary Review of 103 Published Cases.
McGehee E, Gerber DE, Reisch J, Dowell JE
Clin Lung Cancer 2019 Mar;20(2):e152-e157. Epub 2018 Nov 29 doi: 10.1016/j.cllc.2018.11.008. PMID: 30594459
Pericardial Disease Associated with Malignancy.
Schusler R, Meyerson SL
Curr Cardiol Rep 2018 Aug 20;20(10):92. doi: 10.1007/s11886-018-1040-5. PMID: 30128844
Primary pericardial tumors.
Restrepo CS, Vargas D, Ocazionez D, Martínez-Jiménez S, Betancourt Cuellar SL, Gutierrez FR
Radiographics 2013 Oct;33(6):1613-30. doi: 10.1148/rg.336135512. PMID: 24108554
Pericardial tumors.
Luk A, Ahn E, Vaideeswar P, Butany JW
Semin Diagn Pathol 2008 Feb;25(1):47-53. doi: 10.1053/j.semdp.2007.12.001. PMID: 18350922

Clinical prediction guides

Recurrent Tumor Suppressor Alterations in Primary Pericardial Mesothelioma.
Schaefer IM, Mariño-Enríquez A, Hammer MM, Padera RF, Sholl LM
Mod Pathol 2023 Sep;36(9):100237. Epub 2023 Jun 8 doi: 10.1016/j.modpat.2023.100237. PMID: 37295554Free PMC Article
Clinical Utility of [(18)F]FDG-PET /CT in Pericardial Disease.
Kim MS, Kim EK, Choi JY, Oh JK, Chang SA
Curr Cardiol Rep 2019 Aug 2;21(9):107. doi: 10.1007/s11886-019-1193-x. PMID: 31376028
Polyserositis: a diagnostic challenge.
Losada I, González-Moreno J, Roda N, Ventayol L, Borjas Y, Domínguez FJ, Fernández-Baca V, García-Gasalla M, Payeras A
Intern Med J 2018 Aug;48(8):982-987. doi: 10.1111/imj.13966. PMID: 29761620
Surgery in mesothelioma--where do we go after MARS?
Hiddinga BI, van Meerbeeck JP
J Thorac Oncol 2013 May;8(5):525-9. doi: 10.1097/JTO.0b013e31828353d7. PMID: 23407570
Malignant mesothelioma.
Kao SC, Reid G, Lee K, Vardy J, Clarke S, van Zandwijk N
Intern Med J 2010 Nov;40(11):742-50. doi: 10.1111/j.1445-5994.2010.02223.x. PMID: 20298508

Recent systematic reviews

A Systematic Review and Meta-Analysis of Prevalence and Outcomes of Cardiac Metastasis of Neuroendocrine Malignancies.
Hamza M, Manasrah N, Patel NN, Sattar Y, Patel B
Am J Cardiol 2023 May 1;194:86-92. Epub 2023 Mar 29 doi: 10.1016/j.amjcard.2023.02.011. PMID: 36996525
Extramedullary disease in multiple myeloma: a systematic literature review.
Bladé J, Beksac M, Caers J, Jurczyszyn A, von Lilienfeld-Toal M, Moreau P, Rasche L, Rosiñol L, Usmani SZ, Zamagni E, Richardson P
Blood Cancer J 2022 Mar 21;12(3):45. doi: 10.1038/s41408-022-00643-3. PMID: 35314675Free PMC Article
Prenatal management of fetal intrapericardial teratoma: a systematic review.
Nassr AA, Shazly SA, Morris SA, Ayres N, Espinoza J, Erfani H, Olutoye OA, Sexson SK, Olutoye OO, Fraser CD Jr, Belfort MA, Shamshirsaz AA
Prenat Diagn 2017 Sep;37(9):849-863. Epub 2017 Aug 7 doi: 10.1002/pd.5113. PMID: 28695637
Epidemiology of mesothelioma of the pericardium and tunica vaginalis testis.
Mezei G, Chang ET, Mowat FS, Moolgavkar SH
Ann Epidemiol 2017 May;27(5):348-359.e11. Epub 2017 Apr 14 doi: 10.1016/j.annepidem.2017.04.001. PMID: 28527639
Systematic review of percutaneous interventions for malignant pericardial effusion.
Virk SA, Chandrakumar D, Villanueva C, Wolfenden H, Liou K, Cao C
Heart 2015 Oct;101(20):1619-26. Epub 2015 Jul 15 doi: 10.1136/heartjnl-2015-307907. PMID: 26180077

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