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Benign neoplasm of placenta

MedGen UID:
146350
•Concept ID:
C0686274
•
Neoplastic Process
Synonyms: Benign Neoplasm of Placenta; benign neoplasm of placenta; Benign Neoplasm of the Placenta; benign neoplasm of the placenta; Benign Placenta Neoplasm; benign placenta neoplasm; Benign Placenta Tumor; benign placenta tumor; benign placenta tumour; Benign Placental Neoplasm; benign placental neoplasm; Benign Placental Tumor; benign placental tumor; benign placental tumour; Benign Tumor of Placenta; benign tumor of placenta; Benign Tumor of the Placenta; benign tumor of the placenta; benign tumour of placenta; benign tumour of the placenta; placenta benign neoplasm; Placental Neoplasms, Benign; placental neoplasms, benign
SNOMED CT: Benign neoplasm of placenta (92297008)
 
Monarch Initiative: MONDO:0021498

Definition

A neoplasm that arises from the placenta and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBenign neoplasm of placenta

Professional guidelines

PubMed

Diagnosis and management of gestational trophoblastic disease: 2021 update.
Ngan HYS, Seckl MJ, Berkowitz RS, Xiang Y, Golfier F, Sekharan PK, Lurain JR, Massuger L
Int J Gynaecol Obstet 2021 Oct;155 Suppl 1(Suppl 1):86-93. doi: 10.1002/ijgo.13877. PMID: 34669197Free PMC Article
Treatment of gestational trophoblastic disease in the 2020s.
Clark JJ, Slater S, Seckl MJ
Curr Opin Obstet Gynecol 2021 Feb 1;33(1):7-12. doi: 10.1097/GCO.0000000000000674. PMID: 33337613Free PMC Article
Management and treatment of deep vein thrombosis in special populations.
Boon GJAM, Van Dam LF, Klok FA, Huisman MV
Expert Rev Hematol 2018 Sep;11(9):685-695. Epub 2018 Jul 25 doi: 10.1080/17474086.2018.1502082. PMID: 30016119

Recent clinical studies

Etiology

Advances in diagnostics and management of gestational trophoblastic disease.
Lukinovic N, Malovrh EP, Takac I, Sobocan M, Knez J
Radiol Oncol 2022 Dec 1;56(4):430-439. Epub 2022 Oct 27 doi: 10.2478/raon-2022-0038. PMID: 36286620Free PMC Article
Uterine Fibroids and Pregnancy: How Do They Affect Each Other?
Coutinho LM, Assis WA, Spagnuolo-Souza A, Reis FM
Reprod Sci 2022 Aug;29(8):2145-2151. Epub 2021 Jun 17 doi: 10.1007/s43032-021-00656-6. PMID: 34142343
Pathology of gestational trophoblastic disease (GTD).
Kaur B
Best Pract Res Clin Obstet Gynaecol 2021 Jul;74:3-28. Epub 2021 Mar 31 doi: 10.1016/j.bpobgyn.2021.02.005. PMID: 34219021
Treatment of gestational trophoblastic disease in the 2020s.
Clark JJ, Slater S, Seckl MJ
Curr Opin Obstet Gynecol 2021 Feb 1;33(1):7-12. doi: 10.1097/GCO.0000000000000674. PMID: 33337613Free PMC Article
Autophagy in the physiological endometrium and cancer.
Devis-Jauregui L, Eritja N, Davis ML, Matias-Guiu X, Llobet-Navàs D
Autophagy 2021 May;17(5):1077-1095. Epub 2020 May 13 doi: 10.1080/15548627.2020.1752548. PMID: 32401642Free PMC Article

Diagnosis

Advances in diagnostics and management of gestational trophoblastic disease.
Lukinovic N, Malovrh EP, Takac I, Sobocan M, Knez J
Radiol Oncol 2022 Dec 1;56(4):430-439. Epub 2022 Oct 27 doi: 10.2478/raon-2022-0038. PMID: 36286620Free PMC Article
Amino acid transporter LAT1 (SLC7A5) as a molecular target for cancer diagnosis and therapeutics.
Kanai Y
Pharmacol Ther 2022 Feb;230:107964. Epub 2021 Aug 12 doi: 10.1016/j.pharmthera.2021.107964. PMID: 34390745
Uterine Fibroids and Pregnancy: How Do They Affect Each Other?
Coutinho LM, Assis WA, Spagnuolo-Souza A, Reis FM
Reprod Sci 2022 Aug;29(8):2145-2151. Epub 2021 Jun 17 doi: 10.1007/s43032-021-00656-6. PMID: 34142343
Pathology of gestational trophoblastic disease (GTD).
Kaur B
Best Pract Res Clin Obstet Gynaecol 2021 Jul;74:3-28. Epub 2021 Mar 31 doi: 10.1016/j.bpobgyn.2021.02.005. PMID: 34219021
Gestational Trophoblastic Tumors: A Timely Review of Diagnostic Pathology.
Hui P
Arch Pathol Lab Med 2019 Jan;143(1):65-74. Epub 2018 Nov 8 doi: 10.5858/arpa.2018-0234-RA. PMID: 30407075

Therapy

Amino acid transporter LAT1 (SLC7A5) as a molecular target for cancer diagnosis and therapeutics.
Kanai Y
Pharmacol Ther 2022 Feb;230:107964. Epub 2021 Aug 12 doi: 10.1016/j.pharmthera.2021.107964. PMID: 34390745
Uterine Fibroids and Pregnancy: How Do They Affect Each Other?
Coutinho LM, Assis WA, Spagnuolo-Souza A, Reis FM
Reprod Sci 2022 Aug;29(8):2145-2151. Epub 2021 Jun 17 doi: 10.1007/s43032-021-00656-6. PMID: 34142343
Diagnosis and management of gestational trophoblastic disease: 2021 update.
Ngan HYS, Seckl MJ, Berkowitz RS, Xiang Y, Golfier F, Sekharan PK, Lurain JR, Massuger L
Int J Gynaecol Obstet 2021 Oct;155 Suppl 1(Suppl 1):86-93. doi: 10.1002/ijgo.13877. PMID: 34669197Free PMC Article
Difficult caesarean section: A literature review.
Visconti F, Quaresima P, Rania E, Palumbo AR, Micieli M, Zullo F, Venturella R, Di Carlo C
Eur J Obstet Gynecol Reprod Biol 2020 Mar;246:72-78. Epub 2020 Jan 7 doi: 10.1016/j.ejogrb.2019.12.026. PMID: 31962259
Management and treatment of deep vein thrombosis in special populations.
Boon GJAM, Van Dam LF, Klok FA, Huisman MV
Expert Rev Hematol 2018 Sep;11(9):685-695. Epub 2018 Jul 25 doi: 10.1080/17474086.2018.1502082. PMID: 30016119

Prognosis

Amino acid transporter LAT1 (SLC7A5) as a molecular target for cancer diagnosis and therapeutics.
Kanai Y
Pharmacol Ther 2022 Feb;230:107964. Epub 2021 Aug 12 doi: 10.1016/j.pharmthera.2021.107964. PMID: 34390745
Pathology of gestational trophoblastic disease (GTD).
Kaur B
Best Pract Res Clin Obstet Gynaecol 2021 Jul;74:3-28. Epub 2021 Mar 31 doi: 10.1016/j.bpobgyn.2021.02.005. PMID: 34219021
Treatment of gestational trophoblastic disease in the 2020s.
Clark JJ, Slater S, Seckl MJ
Curr Opin Obstet Gynecol 2021 Feb 1;33(1):7-12. doi: 10.1097/GCO.0000000000000674. PMID: 33337613Free PMC Article
Growth/Differentiation Factor-15 (GDF-15): From Biomarker to Novel Targetable Immune Checkpoint.
Wischhusen J, Melero I, Fridman WH
Front Immunol 2020;11:951. Epub 2020 May 19 doi: 10.3389/fimmu.2020.00951. PMID: 32508832Free PMC Article
Placental chorioangioma: literature review.
Fan M, Skupski DW
J Perinat Med 2014 May;42(3):273-9. doi: 10.1515/jpm-2013-0170. PMID: 24334427

Clinical prediction guides

Hydatidiform mole.
Daumová M, Hadravská Š, Putzová M
Cesk Patol 2023 Summer;59(2):50-54. PMID: 37468322
Gestational trophoblastic neoplasia: Novelties and challenges.
Silva ALMD, Monteiro KDN, Sun SY, Borbely AU
Placenta 2021 Dec;116:38-42. Epub 2021 Feb 25 doi: 10.1016/j.placenta.2021.02.013. PMID: 33685753
Growth/Differentiation Factor-15 (GDF-15): From Biomarker to Novel Targetable Immune Checkpoint.
Wischhusen J, Melero I, Fridman WH
Front Immunol 2020;11:951. Epub 2020 May 19 doi: 10.3389/fimmu.2020.00951. PMID: 32508832Free PMC Article
Breast cancer, placenta and pregnancy.
Froehlich K, Schmidt A, Heger JI, Al-Kawlani B, Aberl CA, Jeschke U, Loibl S, Markert UR
Eur J Cancer 2019 Jul;115:68-78. Epub 2019 May 20 doi: 10.1016/j.ejca.2019.03.021. PMID: 31121525
The trophoblast model of cancer.
Ross CA
Nutr Cancer 2015;67(1):61-7. Epub 2014 Nov 5 doi: 10.1080/01635581.2014.956257. PMID: 25372465

Recent systematic reviews

Maternal and fetal outcomes of intraplacental choriocarcinoma complicated by fetomaternal hemorrhage: a systematic review.
Stabile G, Gentile RM, Carlucci S, Stampalija T, Biffi S, Oletto G, Guido M, Bruno M
J Matern Fetal Neonatal Med 2023 Dec;36(2):2285238. Epub 2023 Nov 27 doi: 10.1080/14767058.2023.2285238. PMID: 38010764
Reproductive and Obstetric Outcomes after UAE, HIFU, and TFA of Uterine Fibroids: Systematic Review and Meta-Analysis.
Akhatova A, Aimagambetova G, Bapayeva G, Laganà AS, Chiantera V, Oppelt P, Sarria-Santamera A, Terzic M
Int J Environ Res Public Health 2023 Mar 2;20(5) doi: 10.3390/ijerph20054480. PMID: 36901489Free PMC Article
Systematic review of fetal and placental metastases among pregnant patients with cancer.
Khazzaka A, Rassy E, Sleiman Z, Boussios S, Pavlidis N
Cancer Treat Rev 2022 Mar;104:102356. Epub 2022 Feb 11 doi: 10.1016/j.ctrv.2022.102356. PMID: 35182890
Radiofrequency Ablation of Uterine Myomas and Pregnancy Outcomes: An Updated Review of the Literature.
Polin M, Hur HC
J Minim Invasive Gynecol 2022 Jun;29(6):709-715. Epub 2022 Feb 2 doi: 10.1016/j.jmig.2022.01.015. PMID: 35123041
Systematic review of reproductive outcomes after High Intensity Focused Ultrasound treatment of uterine fibroids.
Anneveldt KJ, van 't Oever HJ, Nijholt IM, Dijkstra JR, Hehenkamp WJ, Veersema S, Huirne JAF, Schutte JM, Boomsma MF
Eur J Radiol 2021 Aug;141:109801. Epub 2021 May 27 doi: 10.1016/j.ejrad.2021.109801. PMID: 34116454

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