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Metastatic Malignant Neoplasm in the Pharynx

MedGen UID:
146891
•Concept ID:
C0684963
•
Neoplastic Process
Synonyms: Metastasis to the Pharynx; Metastatic malignant neoplasm of pharynx; Metastatic malignant neoplasm to pharynx; Metastatic Malignant Neoplasm to the Pharynx; Metastatic Neoplasm to the Pharynx; Metastatic Tumor to the Pharynx; Secondary malignant neoplasm of pharynx
SNOMED CT: Secondary malignant neoplasm of pharynx (94488007); Metastatic malignant neoplasm to pharynx (94488007); Metastatic malignant neoplasm of pharynx (94488007)

Definition

A malignant neoplasm that has spread to the pharynx from another anatomic site. [from NCI]

Professional guidelines

PubMed

Treatment Options for Hypopharyngeal Cancer.
Eckel HE, Bradley PJ
Adv Otorhinolaryngol 2019;83:47-53. Epub 2019 Feb 12 doi: 10.1159/000492308. PMID: 30943512
Clinical Practice Guideline: Evaluation of the Neck Mass in Adults.
Pynnonen MA, Gillespie MB, Roman B, Rosenfeld RM, Tunkel DE, Bontempo L, Brook I, Chick DA, Colandrea M, Finestone SA, Fowler JC, Griffith CC, Henson Z, Levine C, Mehta V, Salama A, Scharpf J, Shatzkes DR, Stern WB, Youngerman JS, Corrigan MD
Otolaryngol Head Neck Surg 2017 Sep;157(2_suppl):S1-S30. doi: 10.1177/0194599817722550. PMID: 28891406
Metastatic retropharyngeal lymph nodes in nasopharyngeal carcinoma: imaging criteria.
Sharma M, Bartlett E, Yu E
Expert Rev Anticancer Ther 2010 Nov;10(11):1703-6. doi: 10.1586/era.10.159. PMID: 21080798

Recent clinical studies

Etiology

Role of chemotherapy in patients with nasopharynx carcinoma treated with radiotherapy (MAC-NPC): an updated individual patient data network meta-analysis.
Petit C, Lee A, Ma J, Lacas B, Ng WT, Chan ATC, Hong RL, Chen MY, Chen L, Li WF, Huang PY, Tan T, Ngan RKC, Zhu G, Mai HQ, Hui EP, Fountzilas G, Zhang L, Carmel A, Kwong DLW, Moon J, Bourhis J, Auperin A, Pignon JP, Blanchard P; MAC-NPC Collaborative Group
Lancet Oncol 2023 Jun;24(6):611-623. doi: 10.1016/S1470-2045(23)00163-8. PMID: 37269842
Swallowing Exercise During Head and Neck Cancer Treatment: Results of a Randomized Trial.
Hajdú SF, Wessel I, Dalton SO, Eskildsen SJ, Johansen C
Dysphagia 2022 Aug;37(4):749-762. Epub 2021 Jun 11 doi: 10.1007/s00455-021-10320-5. PMID: 34117531Free PMC Article
Perineural Invasion and Perineural Tumor Spread in Head and Neck Cancer.
Bakst RL, Glastonbury CM, Parvathaneni U, Katabi N, Hu KS, Yom SS
Int J Radiat Oncol Biol Phys 2019 Apr 1;103(5):1109-1124. Epub 2018 Dec 15 doi: 10.1016/j.ijrobp.2018.12.009. PMID: 30562546
Clinical Practice Guideline: Evaluation of the Neck Mass in Adults.
Pynnonen MA, Gillespie MB, Roman B, Rosenfeld RM, Tunkel DE, Bontempo L, Brook I, Chick DA, Colandrea M, Finestone SA, Fowler JC, Griffith CC, Henson Z, Levine C, Mehta V, Salama A, Scharpf J, Shatzkes DR, Stern WB, Youngerman JS, Corrigan MD
Otolaryngol Head Neck Surg 2017 Sep;157(2_suppl):S1-S30. doi: 10.1177/0194599817722550. PMID: 28891406
Lymph node staging.
Vogl T, Bisdas S
Top Magn Reson Imaging 2007 Aug;18(4):303-16. doi: 10.1097/RMR.0b013e3181570c5b. PMID: 17893595

Diagnosis

Swallowing Exercise During Head and Neck Cancer Treatment: Results of a Randomized Trial.
Hajdú SF, Wessel I, Dalton SO, Eskildsen SJ, Johansen C
Dysphagia 2022 Aug;37(4):749-762. Epub 2021 Jun 11 doi: 10.1007/s00455-021-10320-5. PMID: 34117531Free PMC Article
Head and neck squamous cell carcinoma.
Johnson DE, Burtness B, Leemans CR, Lui VWY, Bauman JE, Grandis JR
Nat Rev Dis Primers 2020 Nov 26;6(1):92. doi: 10.1038/s41572-020-00224-3. PMID: 33243986Free PMC Article
Treatment Options for Hypopharyngeal Cancer.
Eckel HE, Bradley PJ
Adv Otorhinolaryngol 2019;83:47-53. Epub 2019 Feb 12 doi: 10.1159/000492308. PMID: 30943512
Clinical Practice Guideline: Evaluation of the Neck Mass in Adults.
Pynnonen MA, Gillespie MB, Roman B, Rosenfeld RM, Tunkel DE, Bontempo L, Brook I, Chick DA, Colandrea M, Finestone SA, Fowler JC, Griffith CC, Henson Z, Levine C, Mehta V, Salama A, Scharpf J, Shatzkes DR, Stern WB, Youngerman JS, Corrigan MD
Otolaryngol Head Neck Surg 2017 Sep;157(2_suppl):S1-S30. doi: 10.1177/0194599817722550. PMID: 28891406
Lymph node staging.
Vogl T, Bisdas S
Top Magn Reson Imaging 2007 Aug;18(4):303-16. doi: 10.1097/RMR.0b013e3181570c5b. PMID: 17893595

Therapy

Role of chemotherapy in patients with nasopharynx carcinoma treated with radiotherapy (MAC-NPC): an updated individual patient data network meta-analysis.
Petit C, Lee A, Ma J, Lacas B, Ng WT, Chan ATC, Hong RL, Chen MY, Chen L, Li WF, Huang PY, Tan T, Ngan RKC, Zhu G, Mai HQ, Hui EP, Fountzilas G, Zhang L, Carmel A, Kwong DLW, Moon J, Bourhis J, Auperin A, Pignon JP, Blanchard P; MAC-NPC Collaborative Group
Lancet Oncol 2023 Jun;24(6):611-623. doi: 10.1016/S1470-2045(23)00163-8. PMID: 37269842
Swallowing Exercise During Head and Neck Cancer Treatment: Results of a Randomized Trial.
Hajdú SF, Wessel I, Dalton SO, Eskildsen SJ, Johansen C
Dysphagia 2022 Aug;37(4):749-762. Epub 2021 Jun 11 doi: 10.1007/s00455-021-10320-5. PMID: 34117531Free PMC Article
Head and neck squamous cell carcinoma.
Johnson DE, Burtness B, Leemans CR, Lui VWY, Bauman JE, Grandis JR
Nat Rev Dis Primers 2020 Nov 26;6(1):92. doi: 10.1038/s41572-020-00224-3. PMID: 33243986Free PMC Article
Treatment Options for Hypopharyngeal Cancer.
Eckel HE, Bradley PJ
Adv Otorhinolaryngol 2019;83:47-53. Epub 2019 Feb 12 doi: 10.1159/000492308. PMID: 30943512
Juvenile nasopharyngeal angiofibroma.
Blount A, Riley KO, Woodworth BA
Otolaryngol Clin North Am 2011 Aug;44(4):989-1004, ix. doi: 10.1016/j.otc.2011.06.003. PMID: 21819885

Prognosis

The prognosis of HPV-associated metastatic pharyngeal patients by primary and distant site.
Wang J, Tian Y, Huang H, Huang D, Liu Y, Tian Y, Zhu G, Zhang X, Ferris RL
Oral Oncol 2022 Feb;125:105675. Epub 2021 Dec 27 doi: 10.1016/j.oraloncology.2021.105675. PMID: 34968864
Head and neck squamous cell carcinoma.
Johnson DE, Burtness B, Leemans CR, Lui VWY, Bauman JE, Grandis JR
Nat Rev Dis Primers 2020 Nov 26;6(1):92. doi: 10.1038/s41572-020-00224-3. PMID: 33243986Free PMC Article
Perineural Invasion and Perineural Tumor Spread in Head and Neck Cancer.
Bakst RL, Glastonbury CM, Parvathaneni U, Katabi N, Hu KS, Yom SS
Int J Radiat Oncol Biol Phys 2019 Apr 1;103(5):1109-1124. Epub 2018 Dec 15 doi: 10.1016/j.ijrobp.2018.12.009. PMID: 30562546
Clinical Practice Guideline: Evaluation of the Neck Mass in Adults.
Pynnonen MA, Gillespie MB, Roman B, Rosenfeld RM, Tunkel DE, Bontempo L, Brook I, Chick DA, Colandrea M, Finestone SA, Fowler JC, Griffith CC, Henson Z, Levine C, Mehta V, Salama A, Scharpf J, Shatzkes DR, Stern WB, Youngerman JS, Corrigan MD
Otolaryngol Head Neck Surg 2017 Sep;157(2_suppl):S1-S30. doi: 10.1177/0194599817722550. PMID: 28891406
Lymph node staging.
Vogl T, Bisdas S
Top Magn Reson Imaging 2007 Aug;18(4):303-16. doi: 10.1097/RMR.0b013e3181570c5b. PMID: 17893595

Clinical prediction guides

Tonsillectomy as Prevention of Tonsil and Base of Tongue Cancer: Systematic Review and Meta-analysis on the Immuno-Oncological Effect of One Among the Most Common Surgeries in the World.
Virgilio E, Bonfili D, Bettoni S, Vona L, Mercuri J, D'Agostino F, Baldinu M, Salvemini C, Montali F, Costi R
Anticancer Res 2023 Sep;43(9):3881-3889. doi: 10.21873/anticanres.16575. PMID: 37648322
Role of chemotherapy in patients with nasopharynx carcinoma treated with radiotherapy (MAC-NPC): an updated individual patient data network meta-analysis.
Petit C, Lee A, Ma J, Lacas B, Ng WT, Chan ATC, Hong RL, Chen MY, Chen L, Li WF, Huang PY, Tan T, Ngan RKC, Zhu G, Mai HQ, Hui EP, Fountzilas G, Zhang L, Carmel A, Kwong DLW, Moon J, Bourhis J, Auperin A, Pignon JP, Blanchard P; MAC-NPC Collaborative Group
Lancet Oncol 2023 Jun;24(6):611-623. doi: 10.1016/S1470-2045(23)00163-8. PMID: 37269842
Swallowing Exercise During Head and Neck Cancer Treatment: Results of a Randomized Trial.
Hajdú SF, Wessel I, Dalton SO, Eskildsen SJ, Johansen C
Dysphagia 2022 Aug;37(4):749-762. Epub 2021 Jun 11 doi: 10.1007/s00455-021-10320-5. PMID: 34117531Free PMC Article
Head and neck squamous cell carcinoma.
Johnson DE, Burtness B, Leemans CR, Lui VWY, Bauman JE, Grandis JR
Nat Rev Dis Primers 2020 Nov 26;6(1):92. doi: 10.1038/s41572-020-00224-3. PMID: 33243986Free PMC Article
Lymph node staging.
Vogl T, Bisdas S
Top Magn Reson Imaging 2007 Aug;18(4):303-16. doi: 10.1097/RMR.0b013e3181570c5b. PMID: 17893595

Recent systematic reviews

Tonsillectomy as Prevention of Tonsil and Base of Tongue Cancer: Systematic Review and Meta-analysis on the Immuno-Oncological Effect of One Among the Most Common Surgeries in the World.
Virgilio E, Bonfili D, Bettoni S, Vona L, Mercuri J, D'Agostino F, Baldinu M, Salvemini C, Montali F, Costi R
Anticancer Res 2023 Sep;43(9):3881-3889. doi: 10.21873/anticanres.16575. PMID: 37648322
Association of Unilateral Radiotherapy With Contralateral Lymph Node Failure Among Patients With Squamous Cell Carcinoma of the Tonsil: A Systematic Review and Meta-analysis.
Razavian NB, D'Agostino RB Jr, Steber CR, Helis CA, Hughes RT
JAMA Netw Open 2023 Feb 1;6(2):e2255209. doi: 10.1001/jamanetworkopen.2022.55209. PMID: 36753275Free PMC Article
Transoral Robotic Surgical Proficiency Via Real-Time Tactile Collision Awareness System.
Mendelsohn AH, Kim C, Song J, Singh A, Le T, Abiri A, Berke GS, Geoghegan R
Laryngoscope 2020 Dec;130 Suppl 6:S1-S17. Epub 2020 Aug 31 doi: 10.1002/lary.29034. PMID: 32865822
Systematic review and meta-analyses of intensity-modulated radiation therapy versus conventional two-dimensional and/or or three-dimensional radiotherapy in curative-intent management of head and neck squamous cell carcinoma.
Gupta T, Kannan S, Ghosh-Laskar S, Agarwal JP
PLoS One 2018;13(7):e0200137. Epub 2018 Jul 6 doi: 10.1371/journal.pone.0200137. PMID: 29979726Free PMC Article
Solitary splenic metastasis from nasopharyngeal carcinoma: a case report and systematic review of the literature.
Genova P, Brunetti F, Bequignon E, Landi F, Lizzi V, Esposito F, Charpy C, Calderaro J, Azoulay D, de'Angelis N
World J Surg Oncol 2016 Jul 15;14(1):184. doi: 10.1186/s12957-016-0941-2. PMID: 27422630Free PMC Article

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