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Metastatic Malignant Neoplasm in the Pharynx

MedGen UID:
146891
•Concept ID:
C0684963
•
Neoplastic Process
Synonyms: Metastasis to the Pharynx; Metastatic malignant neoplasm of pharynx; Metastatic malignant neoplasm to pharynx; Metastatic Malignant Neoplasm to the Pharynx; Metastatic Neoplasm to the Pharynx; Metastatic Tumor to the Pharynx; Secondary malignant neoplasm of pharynx
SNOMED CT: Secondary malignant neoplasm of pharynx (94488007); Metastatic malignant neoplasm to pharynx (94488007); Metastatic malignant neoplasm of pharynx (94488007)

Definition

A malignant neoplasm that has spread to the pharynx from another anatomic site. [from NCI]

Professional guidelines

PubMed

Treatment Options for Hypopharyngeal Cancer.
Eckel HE, Bradley PJ
Adv Otorhinolaryngol 2019;83:47-53. Epub 2019 Feb 12 doi: 10.1159/000492308. PMID: 30943512
Clinical Practice Guideline: Evaluation of the Neck Mass in Adults.
Pynnonen MA, Gillespie MB, Roman B, Rosenfeld RM, Tunkel DE, Bontempo L, Brook I, Chick DA, Colandrea M, Finestone SA, Fowler JC, Griffith CC, Henson Z, Levine C, Mehta V, Salama A, Scharpf J, Shatzkes DR, Stern WB, Youngerman JS, Corrigan MD
Otolaryngol Head Neck Surg 2017 Sep;157(2_suppl):S1-S30. doi: 10.1177/0194599817722550. PMID: 28891406
Diagnosis and Treatment of Nasopharyngeal Carcinoma in Children and Adolescents - Recommendations of the GPOH-NPC Study Group.
Kontny U, Franzen S, Behrends U, Bührlen M, Christiansen H, Delecluse H, Eble M, Feuchtinger T, Gademann G, Granzen B, Kratz CP, Lassay L, Leuschner I, Mottaghy FM, Schmitt C, Staatz G, Timmermann B, Vorwerk P, Wilop S, Wolff HA, Mertens R
Klin Padiatr 2016 Apr;228(3):105-12. Epub 2016 May 2 doi: 10.1055/s-0041-111180. PMID: 27135270

Recent clinical studies

Etiology

Swallowing Exercise During Head and Neck Cancer Treatment: Results of a Randomized Trial.
Hajdú SF, Wessel I, Dalton SO, Eskildsen SJ, Johansen C
Dysphagia 2022 Aug;37(4):749-762. Epub 2021 Jun 11 doi: 10.1007/s00455-021-10320-5. PMID: 34117531Free PMC Article
Perineural Invasion and Perineural Tumor Spread in Head and Neck Cancer.
Bakst RL, Glastonbury CM, Parvathaneni U, Katabi N, Hu KS, Yom SS
Int J Radiat Oncol Biol Phys 2019 Apr 1;103(5):1109-1124. Epub 2018 Dec 15 doi: 10.1016/j.ijrobp.2018.12.009. PMID: 30562546
Clinical Practice Guideline: Evaluation of the Neck Mass in Adults.
Pynnonen MA, Gillespie MB, Roman B, Rosenfeld RM, Tunkel DE, Bontempo L, Brook I, Chick DA, Colandrea M, Finestone SA, Fowler JC, Griffith CC, Henson Z, Levine C, Mehta V, Salama A, Scharpf J, Shatzkes DR, Stern WB, Youngerman JS, Corrigan MD
Otolaryngol Head Neck Surg 2017 Sep;157(2_suppl):S1-S30. doi: 10.1177/0194599817722550. PMID: 28891406
Lymph node staging.
Vogl T, Bisdas S
Top Magn Reson Imaging 2007 Aug;18(4):303-16. doi: 10.1097/RMR.0b013e3181570c5b. PMID: 17893595
Misonidazole neuropathy.
Paulson OB, Melgaard B, Hansen HS, Kamieniecka Z, Køhler O, Hansen JM, Pedersen AG, Tang X, Trojaborg W
Acta Neurol Scand Suppl 1984;100:133-6. PMID: 6091392

Diagnosis

Swallowing Exercise During Head and Neck Cancer Treatment: Results of a Randomized Trial.
Hajdú SF, Wessel I, Dalton SO, Eskildsen SJ, Johansen C
Dysphagia 2022 Aug;37(4):749-762. Epub 2021 Jun 11 doi: 10.1007/s00455-021-10320-5. PMID: 34117531Free PMC Article
Head and neck squamous cell carcinoma.
Johnson DE, Burtness B, Leemans CR, Lui VWY, Bauman JE, Grandis JR
Nat Rev Dis Primers 2020 Nov 26;6(1):92. doi: 10.1038/s41572-020-00224-3. PMID: 33243986Free PMC Article
Treatment Options for Hypopharyngeal Cancer.
Eckel HE, Bradley PJ
Adv Otorhinolaryngol 2019;83:47-53. Epub 2019 Feb 12 doi: 10.1159/000492308. PMID: 30943512
Clinical Practice Guideline: Evaluation of the Neck Mass in Adults.
Pynnonen MA, Gillespie MB, Roman B, Rosenfeld RM, Tunkel DE, Bontempo L, Brook I, Chick DA, Colandrea M, Finestone SA, Fowler JC, Griffith CC, Henson Z, Levine C, Mehta V, Salama A, Scharpf J, Shatzkes DR, Stern WB, Youngerman JS, Corrigan MD
Otolaryngol Head Neck Surg 2017 Sep;157(2_suppl):S1-S30. doi: 10.1177/0194599817722550. PMID: 28891406
Otorhinolaryngology manifestations secondary to oral sex.
Fernández-López C, Morales-Angulo C
Acta Otorrinolaringol Esp (Engl Ed) 2017 May-Jun;68(3):169-180. Epub 2016 Oct 25 doi: 10.1016/j.otorri.2016.04.003. PMID: 27793330

Therapy

Swallowing Exercise During Head and Neck Cancer Treatment: Results of a Randomized Trial.
Hajdú SF, Wessel I, Dalton SO, Eskildsen SJ, Johansen C
Dysphagia 2022 Aug;37(4):749-762. Epub 2021 Jun 11 doi: 10.1007/s00455-021-10320-5. PMID: 34117531Free PMC Article
Head and neck squamous cell carcinoma.
Johnson DE, Burtness B, Leemans CR, Lui VWY, Bauman JE, Grandis JR
Nat Rev Dis Primers 2020 Nov 26;6(1):92. doi: 10.1038/s41572-020-00224-3. PMID: 33243986Free PMC Article
Pharyngeal metastasis following living-donor liver transplantation for hepatocellular carcinoma: a case report and literature review.
Tohyama T, Sakamoto K, Tamura K, Nakamura T, Watanabe J, Wakisaka H, Takada Y
World J Surg Oncol 2020 May 28;18(1):109. doi: 10.1186/s12957-020-01873-0. PMID: 32466780Free PMC Article
Targeting interferon signaling and CTLA-4 enhance the therapeutic efficacy of anti-PD-1 immunotherapy in preclinical model of HPV(+) oral cancer.
Dorta-Estremera S, Hegde VL, Slay RB, Sun R, Yanamandra AV, Nicholas C, Nookala S, Sierra G, Curran MA, Sastry KJ
J Immunother Cancer 2019 Sep 18;7(1):252. doi: 10.1186/s40425-019-0728-4. PMID: 31533840Free PMC Article
Treatment Options for Hypopharyngeal Cancer.
Eckel HE, Bradley PJ
Adv Otorhinolaryngol 2019;83:47-53. Epub 2019 Feb 12 doi: 10.1159/000492308. PMID: 30943512

Prognosis

Secondary organizing pneumonia after recovery of mild COVID-19 infection.
Golbets E, Kaplan A, Shafat T, Yagel Y, Jotkowitz A, Awesat J, Barski L
J Med Virol 2022 Jan;94(1):417-423. Epub 2021 Oct 5 doi: 10.1002/jmv.27360. PMID: 34581458Free PMC Article
Head and neck squamous cell carcinoma.
Johnson DE, Burtness B, Leemans CR, Lui VWY, Bauman JE, Grandis JR
Nat Rev Dis Primers 2020 Nov 26;6(1):92. doi: 10.1038/s41572-020-00224-3. PMID: 33243986Free PMC Article
Pharyngeal metastasis following living-donor liver transplantation for hepatocellular carcinoma: a case report and literature review.
Tohyama T, Sakamoto K, Tamura K, Nakamura T, Watanabe J, Wakisaka H, Takada Y
World J Surg Oncol 2020 May 28;18(1):109. doi: 10.1186/s12957-020-01873-0. PMID: 32466780Free PMC Article
Perineural Invasion and Perineural Tumor Spread in Head and Neck Cancer.
Bakst RL, Glastonbury CM, Parvathaneni U, Katabi N, Hu KS, Yom SS
Int J Radiat Oncol Biol Phys 2019 Apr 1;103(5):1109-1124. Epub 2018 Dec 15 doi: 10.1016/j.ijrobp.2018.12.009. PMID: 30562546
Clinical Practice Guideline: Evaluation of the Neck Mass in Adults.
Pynnonen MA, Gillespie MB, Roman B, Rosenfeld RM, Tunkel DE, Bontempo L, Brook I, Chick DA, Colandrea M, Finestone SA, Fowler JC, Griffith CC, Henson Z, Levine C, Mehta V, Salama A, Scharpf J, Shatzkes DR, Stern WB, Youngerman JS, Corrigan MD
Otolaryngol Head Neck Surg 2017 Sep;157(2_suppl):S1-S30. doi: 10.1177/0194599817722550. PMID: 28891406

Clinical prediction guides

Swallowing Exercise During Head and Neck Cancer Treatment: Results of a Randomized Trial.
Hajdú SF, Wessel I, Dalton SO, Eskildsen SJ, Johansen C
Dysphagia 2022 Aug;37(4):749-762. Epub 2021 Jun 11 doi: 10.1007/s00455-021-10320-5. PMID: 34117531Free PMC Article
Head and neck squamous cell carcinoma.
Johnson DE, Burtness B, Leemans CR, Lui VWY, Bauman JE, Grandis JR
Nat Rev Dis Primers 2020 Nov 26;6(1):92. doi: 10.1038/s41572-020-00224-3. PMID: 33243986Free PMC Article
Pharyngeal metastasis following living-donor liver transplantation for hepatocellular carcinoma: a case report and literature review.
Tohyama T, Sakamoto K, Tamura K, Nakamura T, Watanabe J, Wakisaka H, Takada Y
World J Surg Oncol 2020 May 28;18(1):109. doi: 10.1186/s12957-020-01873-0. PMID: 32466780Free PMC Article
Targeting interferon signaling and CTLA-4 enhance the therapeutic efficacy of anti-PD-1 immunotherapy in preclinical model of HPV(+) oral cancer.
Dorta-Estremera S, Hegde VL, Slay RB, Sun R, Yanamandra AV, Nicholas C, Nookala S, Sierra G, Curran MA, Sastry KJ
J Immunother Cancer 2019 Sep 18;7(1):252. doi: 10.1186/s40425-019-0728-4. PMID: 31533840Free PMC Article
Lymph node staging.
Vogl T, Bisdas S
Top Magn Reson Imaging 2007 Aug;18(4):303-16. doi: 10.1097/RMR.0b013e3181570c5b. PMID: 17893595

Recent systematic reviews

Tonsillectomy as Prevention of Tonsil and Base of Tongue Cancer: Systematic Review and Meta-analysis on the Immuno-Oncological Effect of One Among the Most Common Surgeries in the World.
Virgilio E, Bonfili D, Bettoni S, Vona L, Mercuri J, D'Agostino F, Baldinu M, Salvemini C, Montali F, Costi R
Anticancer Res 2023 Sep;43(9):3881-3889. doi: 10.21873/anticanres.16575. PMID: 37648322
Role of palatine tonsillectomy in the diagnostic workup of head and neck squamous cell carcinoma of unknown primary origin: A systematic review and meta-analysis.
Di Maio P, Iocca O, De Virgilio A, Ferreli F, Cristalli G, Pellini R, Golusinski P, Ricci G, Spriano G
Head Neck 2019 Apr;41(4):1112-1121. Epub 2018 Dec 21 doi: 10.1002/hed.25522. PMID: 30575162
Systematic review and meta-analyses of intensity-modulated radiation therapy versus conventional two-dimensional and/or or three-dimensional radiotherapy in curative-intent management of head and neck squamous cell carcinoma.
Gupta T, Kannan S, Ghosh-Laskar S, Agarwal JP
PLoS One 2018;13(7):e0200137. Epub 2018 Jul 6 doi: 10.1371/journal.pone.0200137. PMID: 29979726Free PMC Article
Solitary splenic metastasis from nasopharyngeal carcinoma: a case report and systematic review of the literature.
Genova P, Brunetti F, Bequignon E, Landi F, Lizzi V, Esposito F, Charpy C, Calderaro J, Azoulay D, de'Angelis N
World J Surg Oncol 2016 Jul 15;14(1):184. doi: 10.1186/s12957-016-0941-2. PMID: 27422630Free PMC Article
Management of retropharyngeal node metastases from thyroid carcinoma.
Hartl DM, Leboulleux S, Vélayoudom-Céphise FL, Mirghani H, Déandréis D, Schlumberger M
World J Surg 2015 May;39(5):1274-81. doi: 10.1007/s00268-015-2947-2. PMID: 25585526

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