U.S. flag

An official website of the United States government


Send to:

Choose Destination

Single naris

MedGen UID:
Concept ID:
Congenital Abnormality
Synonyms: Single nares; Single nostril
SNOMED CT: Single naris (95266003)
HPO: HP:0009932


The presence of only a single nostril. [from HPO]

Term Hierarchy

Conditions with this feature

Holoprosencephaly 9
MedGen UID:
Concept ID:
Disease or Syndrome
Holoprosencephaly-9 refers to a disorder characterized by a wide phenotypic spectrum of brain developmental defects, with or without overt forebrain cleavage abnormalities. It usually includes midline craniofacial anomalies involving the first branchial arch and/or orbits, pituitary hypoplasia with panhypopituitarism, and postaxial polydactyly. The disorder shows incomplete penetrance and variable expressivity (summary by Roessler et al., 2003 and Bertolacini et al., 2012). For general phenotypic information and a discussion of genetic heterogeneity of holoprosencephaly, see HPE1 (236100).
Holoprosencephaly 3
MedGen UID:
Concept ID:
Disease or Syndrome
Any holoprosencephaly in which the cause of the disease is a mutation in the SHH gene.
Joubert syndrome 21
MedGen UID:
Concept ID:
Disease or Syndrome
Classic Joubert syndrome (JS) is characterized by three primary findings: A distinctive cerebellar and brain stem malformation called the molar tooth sign (MTS). Hypotonia. Developmental delays. Often these findings are accompanied by episodic tachypnea or apnea and/or atypical eye movements. In general, the breathing abnormalities improve with age, truncal ataxia develops over time, and acquisition of gross motor milestones is delayed. Cognitive abilities are variable, ranging from severe intellectual disability to normal. Additional findings can include retinal dystrophy, renal disease, ocular colobomas, occipital encephalocele, hepatic fibrosis, polydactyly, oral hamartomas, and endocrine abnormalities. Both intra- and interfamilial variation are seen.
Tetraamelia syndrome 1
MedGen UID:
Concept ID:
Disease or Syndrome
Tetraamelia syndrome-1 (TETAMS1) is characterized by complete limb agenesis without defects of scapulae or clavicles. Other features include bilateral cleft lip/palate, diaphragmatic defect with bilobar right lung, renal and adrenal agenesis, pelvic hypoplasia, and urogenital defects (Niemann et al., 2004). Genetic Heterogeneity of tetraamelia syndrome Tetraamelia syndrome-2 (TETAMS2; 618021) is caused by mutation in the RSPO2 gene (610575) on chromosome 8q23.

Recent clinical studies


Afrin M, Chowdhury TI, Shams KL
Mymensingh Med J 2020 Oct;29(4):1010-1014. PMID: 33116110


Miller JL, Ashford JW, Archer SM, Rudy AC, Wermeling DP
Pharmacotherapy 2008 Jul;28(7):875-82. doi: 10.1592/phco.28.7.875. PMID: 18576902

Supplemental Content

Table of contents

    Clinical resources

    Consumer resources

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...