U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Carcinoma of colon(CRC)

MedGen UID:
147065
Concept ID:
C0699790
Neoplastic Process
Synonyms: Colon carcinoma; Colonic carcinoma; CRC
SNOMED CT: Carcinoma of colon (269533000)
 
Monarch Initiative: MONDO:0002032

Disease characteristics

Excerpted from the GeneReview: Lynch Syndrome
Lynch syndrome is characterized by an increased risk for colorectal cancer (CRC) and cancers of the endometrium, ovary, stomach, small bowel, urinary tract, biliary tract, brain (usually glioblastoma), skin (sebaceous adenomas, sebaceous carcinomas, and keratoacanthomas), pancreas, and prostate. Cancer risks and age of onset vary depending on the associated gene. Several other cancer types have been reported to occur in individuals with Lynch syndrome (e.g., breast, sarcomas, adrenocortical carcinoma). However, the data are not sufficient to demonstrate that the risk of developing these cancers is increased in individuals with Lynch syndrome. [from GeneReviews]
Authors:
Gregory Idos  |  Laura Valle   view full author information

Term Hierarchy

Professional guidelines

PubMed

Millán-Pérez Peña L, Martin PS, Herrera-Camacho I, Bandala C, Anaya-Ruiz M
Expert Opin Ther Pat 2020 May;30(5):307-311. Epub 2020 Feb 27 doi: 10.1080/13543776.2020.1732352. PMID: 32106724
Halle M, Schoenberg MH
Dtsch Arztebl Int 2009 Oct;106(44):722-7. Epub 2009 Oct 30 doi: 10.3238/arztebl.2009.0722. PMID: 19997551Free PMC Article
Beuers U, Kullak-Ublick GA, Pusl T, Rauws ER, Rust C
Clin Rev Allergy Immunol 2009 Feb;36(1):52-61. doi: 10.1007/s12016-008-8085-y. PMID: 18751930

Curated

Febbo PG, Ladanyi M, Aldape KD, De Marzo AM, Hammond ME, Hayes DF, Iafrate AJ, Kelley RK, Marcucci G, Ogino S, Pao W, Sgroi DC, Birkeland ML
J Natl Compr Canc Netw 2011 Nov;9 Suppl 5:S1-32; quiz S33. doi: 10.6004/jnccn.2011.0137. PMID: 22138009

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) Colon Cancer, 2023

UK NICE Guideline NG151, Colorectal cancer, 2021

Technology Assessment on Genetic Testing or Molecular Pathology Testing of Cancers with Unknown Primary Site to Determine Origin (ARCHIVED)

American College of Medical Genetics and Genomics Family History ACT Sheet, Colon Cancer (Asymptomatic), 2012

Suggested Reading

PubMed

Imperiale TF, Ransohoff DF, Itzkowitz SH
N Engl J Med 2014 Jul 10;371(2):187-8. doi: 10.1056/NEJMc1405215. PMID: 25006736

External

AMA/NCHPEG, 2012

Recent clinical studies

Etiology

Weng MT, Chao KH, Tung CC, Chang HC, Shih IL, Lin BR, Shieh MJ, Shun CT, Wong JM, Wei SC
BMC Gastroenterol 2022 Apr 8;22(1):173. doi: 10.1186/s12876-022-02258-1. PMID: 35395754Free PMC Article
Choi SJ, Kim HS, Ahn SJ, Jeong YM, Choi HY
Acta Radiol 2013 Jun;54(5):487-92. Epub 2013 Apr 30 doi: 10.1177/0284185113475923. PMID: 23436826
Masoomi H, Ziogas A, Lin BS, Barleben A, Mills S, Stamos MJ, Zell JA
Dis Colon Rectum 2012 May;55(5):509-14. doi: 10.1097/DCR.0b013e3182420953. PMID: 22513428Free PMC Article
Rajkumar D, Prakash A, Arya SV, Sinha AN
Indian J Gastroenterol 2001 Nov-Dec;20(6):241-2. PMID: 11817779
Consorti F, Lorenzotti A, Midiri G, Di Paola M
J Surg Oncol 2000 Feb;73(2):70-4. doi: 10.1002/(sici)1096-9098(200002)73:2<70::aid-jso3>3.0.co;2-j. PMID: 10694641

Diagnosis

Weng MT, Chao KH, Tung CC, Chang HC, Shih IL, Lin BR, Shieh MJ, Shun CT, Wong JM, Wei SC
BMC Gastroenterol 2022 Apr 8;22(1):173. doi: 10.1186/s12876-022-02258-1. PMID: 35395754Free PMC Article
Schizas D, Katsaros I, Mastoraki A, Karela NR, Zampetaki D, Lazaridis II, Tsapralis D, Theodoropoulos GE
J Invest Surg 2022 Jan;35(1):151-156. Epub 2020 Oct 6 doi: 10.1080/08941939.2020.1824044. PMID: 33021125
Masoomi H, Ziogas A, Lin BS, Barleben A, Mills S, Stamos MJ, Zell JA
Dis Colon Rectum 2012 May;55(5):509-14. doi: 10.1097/DCR.0b013e3182420953. PMID: 22513428Free PMC Article
Hamaloglu E, Yavuz B
Panminerva Med 1990 Jul-Sep;32(3):118-21. PMID: 2077478
Welch JP, Donaldson GA
Ann Surg 1974 Nov;180(5):734-40. doi: 10.1097/00000658-197411000-00005. PMID: 4423043Free PMC Article

Therapy

Seshadri M, Thalitaya MD, Simon T, Odelola C, Enow H
Psychiatr Danub 2017 Sep;29(Suppl 3):610-614. PMID: 28953839
Zvejnieks PA, Tellschow SR, Gudlaugsson EG, Markham N, Shroyer KR
Mol Cell Probes 1998 Aug;12(4):185-90. doi: 10.1006/mcpr.1998.0172. PMID: 9727193
Larson SM
Cancer Res 1990 Feb 1;50(3 Suppl):892s-898s. PMID: 2404583
Wanebo HJ, Llaneras M, Martin T, Kaiser D
Surg Gynecol Obstet 1989 Dec;169(6):479-87. PMID: 2683153
Shamsuddin AK, Bell HG, Petrucci JV, Trump BF
Pathol Res Pract 1980;167(2-4):374-9. doi: 10.1016/S0344-0338(80)80066-5. PMID: 7433244

Prognosis

Weng MT, Chao KH, Tung CC, Chang HC, Shih IL, Lin BR, Shieh MJ, Shun CT, Wong JM, Wei SC
BMC Gastroenterol 2022 Apr 8;22(1):173. doi: 10.1186/s12876-022-02258-1. PMID: 35395754Free PMC Article
Masoomi H, Ziogas A, Lin BS, Barleben A, Mills S, Stamos MJ, Zell JA
Dis Colon Rectum 2012 May;55(5):509-14. doi: 10.1097/DCR.0b013e3182420953. PMID: 22513428Free PMC Article
Consorti F, Lorenzotti A, Midiri G, Di Paola M
J Surg Oncol 2000 Feb;73(2):70-4. doi: 10.1002/(sici)1096-9098(200002)73:2<70::aid-jso3>3.0.co;2-j. PMID: 10694641
Paksoy M, Ipek T, Colak T, Cebeci H
Eur J Surg 1999 Jan;165(1):55-9. doi: 10.1080/110241599750007513. PMID: 10069635
Welch JP, Donaldson GA
Ann Surg 1974 Nov;180(5):734-40. doi: 10.1097/00000658-197411000-00005. PMID: 4423043Free PMC Article

Clinical prediction guides

Sun R, Liu Z, Han L, Yang Y, Wu F, Jiang Q, Zhang H, Ma R, Miao J, He K, Wang X, Zhou D, Huang C
FASEB J 2019 Apr;33(4):5411-5424. Epub 2019 Jan 30 doi: 10.1096/fj.201801798RR. PMID: 30698996
Choi SJ, Kim HS, Ahn SJ, Jeong YM, Choi HY
Acta Radiol 2013 Jun;54(5):487-92. Epub 2013 Apr 30 doi: 10.1177/0284185113475923. PMID: 23436826
Consorti F, Lorenzotti A, Midiri G, Di Paola M
J Surg Oncol 2000 Feb;73(2):70-4. doi: 10.1002/(sici)1096-9098(200002)73:2<70::aid-jso3>3.0.co;2-j. PMID: 10694641
Bhatavdekar J, Patel D, Ghosh N, Vora H, Shah N, Karelia N, Balar D, Chikhlikar P, Dave R
J Surg Oncol 1994 Apr;55(4):246-9. doi: 10.1002/jso.2930550409. PMID: 8159006
Larson SM
Cancer Res 1990 Feb 1;50(3 Suppl):892s-898s. PMID: 2404583

Recent systematic reviews

Schizas D, Katsaros I, Mastoraki A, Karela NR, Zampetaki D, Lazaridis II, Tsapralis D, Theodoropoulos GE
J Invest Surg 2022 Jan;35(1):151-156. Epub 2020 Oct 6 doi: 10.1080/08941939.2020.1824044. PMID: 33021125

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NCCN, 2023
      NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) Colon Cancer, 2023
    • NICE, 2021
      UK NICE Guideline NG151, Colorectal cancer, 2021
    • AHRQ, 2013
      Technology Assessment on Genetic Testing or Molecular Pathology Testing of Cancers with Unknown Primary Site to Determine Origin (ARCHIVED)
    • ACMG ACT, 2012
      American College of Medical Genetics and Genomics Family History ACT Sheet, Colon Cancer (Asymptomatic), 2012
    • NCCN, 2011
      NCCN Task Force report: Evaluating the clinical utility of tumor markers in oncology.

    Consumer resources

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...