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Gastric carcinoma

MedGen UID:
147066
•Concept ID:
C0699791
•
Neoplastic Process
Synonyms: Adult stomach carcinoma; Stomach carcinoma
SNOMED CT: Carcinoma of stomach (372143007); Gastric carcinoma (372143007)
 
Monarch Initiative: MONDO:0004950

Definition

A malignant epithelial tumor of the stomach mucosa. The vast majority of gastric carcinomas are adenocarcinomas, arising from the gastric glandular epithelium. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
Follow this link to review classifications for Gastric carcinoma in Orphanet.

Professional guidelines

PubMed

Berberine for gastric cancer prevention and treatment: Multi-step actions on the Correa's cascade underlie its therapeutic effects.
Liu Q, Tang J, Chen S, Hu S, Shen C, Xiang J, Chen N, Wang J, Ma X, Zhang Y, Zeng J
Pharmacol Res 2022 Oct;184:106440. Epub 2022 Sep 13 doi: 10.1016/j.phrs.2022.106440. PMID: 36108874
Clinical relevance of Helicobacter pylori vacA and cagA genotypes in gastric carcinoma.
Ferreira RM, Machado JC, Figueiredo C
Best Pract Res Clin Gastroenterol 2014 Dec;28(6):1003-15. Epub 2014 Oct 2 doi: 10.1016/j.bpg.2014.09.004. PMID: 25439067
Japanese classification of gastric carcinoma: 3rd English edition.
Japanese Gastric Cancer Association
Gastric Cancer 2011 Jun;14(2):101-12. doi: 10.1007/s10120-011-0041-5. PMID: 21573743

Recent clinical studies

Etiology

Gastric microbial community profiling reveals a dysbiotic cancer-associated microbiota.
Ferreira RM, Pereira-Marques J, Pinto-Ribeiro I, Costa JL, Carneiro F, Machado JC, Figueiredo C
Gut 2018 Feb;67(2):226-236. Epub 2017 Nov 4 doi: 10.1136/gutjnl-2017-314205. PMID: 29102920Free PMC Article
Gastric carcinoma in canines and humans, a review.
Hugen S, Thomas RE, German AJ, Burgener IA, Mandigers PJJ
Vet Comp Oncol 2017 Sep;15(3):692-705. Epub 2016 Aug 22 doi: 10.1111/vco.12249. PMID: 27549077
Recent advances in proximal gastric carcinoma.
Huang Q, Sun Q, Fan XS, Zhou D, Zou XP
J Dig Dis 2016 Jul;17(7):421-32. doi: 10.1111/1751-2980.12355. PMID: 27129018
Helicobacter pylori virulence factors in development of gastric carcinoma.
Wang MY, Liu XF, Gao XZ
Future Microbiol 2015;10(9):1505-16. Epub 2015 Sep 7 doi: 10.2217/fmb.15.72. PMID: 26346770
Clinical relevance of Helicobacter pylori vacA and cagA genotypes in gastric carcinoma.
Ferreira RM, Machado JC, Figueiredo C
Best Pract Res Clin Gastroenterol 2014 Dec;28(6):1003-15. Epub 2014 Oct 2 doi: 10.1016/j.bpg.2014.09.004. PMID: 25439067

Diagnosis

Molecular Diagnostics in Esophageal and Gastric Neoplasms: 2018 Update.
Zulfiqar M, Bluth MH, Bhalla A
Clin Lab Med 2018 Jun;38(2):357-365. doi: 10.1016/j.cll.2018.02.009. PMID: 29776635
Gastric microbial community profiling reveals a dysbiotic cancer-associated microbiota.
Ferreira RM, Pereira-Marques J, Pinto-Ribeiro I, Costa JL, Carneiro F, Machado JC, Figueiredo C
Gut 2018 Feb;67(2):226-236. Epub 2017 Nov 4 doi: 10.1136/gutjnl-2017-314205. PMID: 29102920Free PMC Article
Gastric carcinoma in canines and humans, a review.
Hugen S, Thomas RE, German AJ, Burgener IA, Mandigers PJJ
Vet Comp Oncol 2017 Sep;15(3):692-705. Epub 2016 Aug 22 doi: 10.1111/vco.12249. PMID: 27549077
Gastric Carcinoma: Recent Trends in Diagnostic Biomarkers and Molecular Targeted Therapies.
Majeed W, Iftikhar A, Khaliq T, Aslam B, Muzaffar H, Atta K, Mahmood A, Waris S
Asian Pac J Cancer Prev 2016;17(7):3053-60. PMID: 27509928
THE TWO HISTOLOGICAL MAIN TYPES OF GASTRIC CARCINOMA: DIFFUSE AND SO-CALLED INTESTINAL-TYPE CARCINOMA. AN ATTEMPT AT A HISTO-CLINICAL CLASSIFICATION.
LAUREN P
Acta Pathol Microbiol Scand 1965;64:31-49. doi: 10.1111/apm.1965.64.1.31. PMID: 14320675

Therapy

Integrated Safety Analysis of Abrocitinib for the Treatment of Moderate-to-Severe Atopic Dermatitis From the Phase II and Phase III Clinical Trial Program.
Simpson EL, Silverberg JI, Nosbaum A, Winthrop KL, Guttman-Yassky E, Hoffmeister KM, Egeberg A, Valdez H, Zhang M, Farooqui SA, Romero W, Thorpe AJ, Rojo R, Johnson S
Am J Clin Dermatol 2021 Sep;22(5):693-707. Epub 2021 Aug 18 doi: 10.1007/s40257-021-00618-3. PMID: 34406619Free PMC Article
Vaccine Development for Epstein-Barr Virus.
Cohen JI
Adv Exp Med Biol 2018;1045:477-493. doi: 10.1007/978-981-10-7230-7_22. PMID: 29896681Free PMC Article
Gastric Carcinoma: Recent Trends in Diagnostic Biomarkers and Molecular Targeted Therapies.
Majeed W, Iftikhar A, Khaliq T, Aslam B, Muzaffar H, Atta K, Mahmood A, Waris S
Asian Pac J Cancer Prev 2016;17(7):3053-60. PMID: 27509928
Gastric carcinoma.
Phan AT, Ajani JA
Curr Oncol Rep 2004 May;6(3):192-8. doi: 10.1007/s11912-004-0049-7. PMID: 15066230
Gastric carcinoma.
Fuchs CS, Mayer RJ
N Engl J Med 1995 Jul 6;333(1):32-41. doi: 10.1056/NEJM199507063330107. PMID: 7776992

Prognosis

Recent advances in proximal gastric carcinoma.
Huang Q, Sun Q, Fan XS, Zhou D, Zou XP
J Dig Dis 2016 Jul;17(7):421-32. doi: 10.1111/1751-2980.12355. PMID: 27129018
Helicobacter pylori virulence factors in development of gastric carcinoma.
Wang MY, Liu XF, Gao XZ
Future Microbiol 2015;10(9):1505-16. Epub 2015 Sep 7 doi: 10.2217/fmb.15.72. PMID: 26346770
Clinicopathologic characteristics and prognosis of mucinous gastric carcinoma.
Zhang M, Zhu GY, Zhang HF, Gao HY, Han XF, Xue YW
J Surg Oncol 2010 Jul 1;102(1):64-7. doi: 10.1002/jso.21533. PMID: 20578080
Gastric carcinoma in young adults.
Kokkola A, Sipponen P
Hepatogastroenterology 2001 Nov-Dec;48(42):1552-5. PMID: 11813570
Gastric carcinoma.
Fuchs CS, Mayer RJ
N Engl J Med 1995 Jul 6;333(1):32-41. doi: 10.1056/NEJM199507063330107. PMID: 7776992

Clinical prediction guides

Identifying mitophagy-related genes as prognostic biomarkers and therapeutic targets of gastric carcinoma by integrated analysis of single-cell and bulk-RNA sequencing data.
Wang Z, Chen C, Ai J, Shu J, Ding Y, Wang W, Gao Y, Jia Y, Qin Y
Comput Biol Med 2023 Sep;163:107227. Epub 2023 Jul 3 doi: 10.1016/j.compbiomed.2023.107227. PMID: 37413850
Development and Validation of a Computed Tomography-Based Radiomics Signature to Predict Response to Neoadjuvant Chemotherapy for Locally Advanced Gastric Cancer.
Wang W, Peng Y, Feng X, Zhao Y, Seeruttun SR, Zhang J, Cheng Z, Li Y, Liu Z, Zhou Z
JAMA Netw Open 2021 Aug 2;4(8):e2121143. doi: 10.1001/jamanetworkopen.2021.21143. PMID: 34410397Free PMC Article
Assessment of Epinephrine and Norepinephrine in Gastric Carcinoma.
Mehedințeanu AM, Sfredel V, Stovicek PO, Schenker M, Târtea GC, Istrătoaie O, Ciurea AM, Vere CC
Int J Mol Sci 2021 Feb 18;22(4) doi: 10.3390/ijms22042042. PMID: 33670813Free PMC Article
Non-malignant Helicobacter pylori-Associated Diseases.
Falkeis-Veits C, Vieth M
Adv Exp Med Biol 2019;1149:121-134. doi: 10.1007/5584_2019_362. PMID: 31016630
Gastric microbial community profiling reveals a dysbiotic cancer-associated microbiota.
Ferreira RM, Pereira-Marques J, Pinto-Ribeiro I, Costa JL, Carneiro F, Machado JC, Figueiredo C
Gut 2018 Feb;67(2):226-236. Epub 2017 Nov 4 doi: 10.1136/gutjnl-2017-314205. PMID: 29102920Free PMC Article

Recent systematic reviews

Estimating the Global Burden of Epstein-Barr Virus-Associated Gastric Cancer: A Systematic Review and Meta-Analysis.
Hirabayashi M, Georges D, Clifford GM, de Martel C
Clin Gastroenterol Hepatol 2023 Apr;21(4):922-930.e21. Epub 2022 Aug 10 doi: 10.1016/j.cgh.2022.07.042. PMID: 35963539
Epirubicin-based compared with docetaxel-based chemotherapy for advanced gastric carcinoma: A systematic review and meta-analysis.
Petrioli R, Roviello G, Zanotti L, Roviello F, Polom K, Bottini A, Marano L, Francini E, Marrelli D, Generali D
Crit Rev Oncol Hematol 2016 Jun;102:82-8. Epub 2016 Apr 8 doi: 10.1016/j.critrevonc.2016.04.001. PMID: 27083592
Genetic variation and gastric cancer risk: a field synopsis and meta-analysis.
Mocellin S, Verdi D, Pooley KA, Nitti D
Gut 2015 Aug;64(8):1209-19. Epub 2015 Mar 2 doi: 10.1136/gutjnl-2015-309168. PMID: 25731870
Systematic review and meta-analysis on the association between IL-1B polymorphisms and cancer risk.
Xu J, Yin Z, Cao S, Gao W, Liu L, Yin Y, Liu P, Shu Y
PLoS One 2013;8(5):e63654. Epub 2013 May 21 doi: 10.1371/journal.pone.0063654. PMID: 23704929Free PMC Article
Interleukin-1B and interleukin-1 RN polymorphisms and gastric carcinoma risk: a meta-analysis.
Xue H, Lin B, Ni P, Xu H, Huang G
J Gastroenterol Hepatol 2010 Oct;25(10):1604-17. doi: 10.1111/j.1440-1746.2010.06428.x. PMID: 20880168

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