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Preterm premature rupture of membranes(PPROM)

MedGen UID:
147582
•Concept ID:
C0729264
•
Pathologic Function
Synonyms: PPROM; Preterm premature rupture of the membranes
SNOMED CT: PPROM - Preterm premature rupture of membranes (312974005); Preterm premature rupture of membranes (312974005)
 
Gene (location): SERPINH1 (11q13.5)
 
HPO: HP:6000310
Monarch Initiative: MONDO:0012511
OMIM®: 610504

Definition

Preterm premature rupture of the membranes (PPROM) is defined as rupture of membranes before 37 weeks of gestation, which occurs in approximately 3% of all pregnancies and accounts for about one-third of spontaneous preterm births (ACOG Practice Bulletin, 1998). Srinivas and Macones (2005) reviewed the pathophysiology of PPROM and noted that familial clustering and ethnic differences in the incidence of PPROM suggest possible genetic influences. [from OMIM]

Clinical features

From HPO
Premature rupture of membranes
MedGen UID:
8826
•Concept ID:
C0015944
•
Pathologic Function
Premature rupture of membranes (PROM) is a condition which occurs in pregnancy when the amniotic sac ruptures more than an hour before the onset of labor.
See: Feature record | Search on this feature

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPreterm premature rupture of membranes

Professional guidelines

PubMed

Guideline No. 430: Diagnosis and management of preterm prelabour rupture of membranes.
Ronzoni S, Boucoiran I, Yudin MH, Coolen J, Pylypjuk C, Melamed N, Holden AC, Smith G, Barrett J
J Obstet Gynaecol Can 2022 Nov;44(11):1193-1208.e1. Epub 2022 Oct 2 doi: 10.1016/j.jogc.2022.08.014. PMID: 36410937
Mid-trimester preterm premature rupture of membranes (PPROM): etiology, diagnosis, classification, international recommendations of treatment options and outcome.
Tchirikov M, Schlabritz-Loutsevitch N, Maher J, Buchmann J, Naberezhnev Y, Winarno AS, Seliger G
J Perinat Med 2018 Jul 26;46(5):465-488. doi: 10.1515/jpm-2017-0027. PMID: 28710882
Practice Bulletin No. 172: Premature Rupture of Membranes.
American College of Obstetricians and Gynecologists’ Committee on Practice Bulletins—Obstetrics
Obstet Gynecol 2016 Oct;128(4):e165-77. doi: 10.1097/AOG.0000000000001712. PMID: 27661655

Recent clinical studies

Etiology

Efficacy of prophylactic antibiotics for preterm premature rupture of membranes: a systematic review and network meta-analysis.
Lin LL, Hung JN, Shiu SI, Su YH, Chen WC, Tseng JJ
Am J Obstet Gynecol MFM 2023 Jul;5(7):100978. Epub 2023 Apr 23 doi: 10.1016/j.ajogmf.2023.100978. PMID: 37094635
Preterm premature rupture of membranes.
Fulová Veronika, Pilka Radovan
Ceska Gynekol 2023;88(1):27-32. doi: 10.48095/cccg202327. PMID: 36858971
Antibiotic prophylaxis in preterm premature rupture of membranes at 24-31 weeks' gestation: Perinatal and 2-year outcomes in the EPIPAGE-2 cohort.
Lorthe E, Letouzey M, Torchin H, Foix L'Helias L, Gras-Le Guen C, Benhammou V, Boileau P, Charlier C, Kayem G; EPIPAGE-2 Obstetric Writing Group
BJOG 2022 Aug;129(9):1560-1573. Epub 2022 Jan 13 doi: 10.1111/1471-0528.17081. PMID: 34954867Free PMC Article
Risk factors associated with preterm premature rupture of membranes (PPROM).
Lee WL, Chang WH, Wang PH
Taiwan J Obstet Gynecol 2021 Sep;60(5):805-806. doi: 10.1016/j.tjog.2021.07.004. PMID: 34507652
Preterm premature rupture of membranes (PPROM).
Skupski D
J Perinat Med 2019 Jul 26;47(5):491-492. doi: 10.1515/jpm-2019-0163. PMID: 31112509

Diagnosis

Efficacy of prophylactic antibiotics for preterm premature rupture of membranes: a systematic review and network meta-analysis.
Lin LL, Hung JN, Shiu SI, Su YH, Chen WC, Tseng JJ
Am J Obstet Gynecol MFM 2023 Jul;5(7):100978. Epub 2023 Apr 23 doi: 10.1016/j.ajogmf.2023.100978. PMID: 37094635
Guideline No. 430: Diagnosis and management of preterm prelabour rupture of membranes.
Ronzoni S, Boucoiran I, Yudin MH, Coolen J, Pylypjuk C, Melamed N, Holden AC, Smith G, Barrett J
J Obstet Gynaecol Can 2022 Nov;44(11):1193-1208.e1. Epub 2022 Oct 2 doi: 10.1016/j.jogc.2022.08.014. PMID: 36410937
Periviable Premature Rupture of Membranes.
Gibson KS, Brackney K
Obstet Gynecol Clin North Am 2020 Dec;47(4):633-651. Epub 2020 Oct 7 doi: 10.1016/j.ogc.2020.08.007. PMID: 33121650
Predictors of preterm birth.
Ville Y, Rozenberg P
Best Pract Res Clin Obstet Gynaecol 2018 Oct;52:23-32. Epub 2018 Jul 7 doi: 10.1016/j.bpobgyn.2018.05.002. PMID: 30309793
Mid-trimester preterm premature rupture of membranes (PPROM): etiology, diagnosis, classification, international recommendations of treatment options and outcome.
Tchirikov M, Schlabritz-Loutsevitch N, Maher J, Buchmann J, Naberezhnev Y, Winarno AS, Seliger G
J Perinat Med 2018 Jul 26;46(5):465-488. doi: 10.1515/jpm-2017-0027. PMID: 28710882

Therapy

Guideline No. 430: Diagnosis and management of preterm prelabour rupture of membranes.
Ronzoni S, Boucoiran I, Yudin MH, Coolen J, Pylypjuk C, Melamed N, Holden AC, Smith G, Barrett J
J Obstet Gynaecol Can 2022 Nov;44(11):1193-1208.e1. Epub 2022 Oct 2 doi: 10.1016/j.jogc.2022.08.014. PMID: 36410937
Periviable Premature Rupture of Membranes.
Gibson KS, Brackney K
Obstet Gynecol Clin North Am 2020 Dec;47(4):633-651. Epub 2020 Oct 7 doi: 10.1016/j.ogc.2020.08.007. PMID: 33121650
Vaginal Microbiome in Preterm Rupture of Membranes.
Bennett PR, Brown RG, MacIntyre DA
Obstet Gynecol Clin North Am 2020 Dec;47(4):503-521. doi: 10.1016/j.ogc.2020.08.001. PMID: 33121642
Predictors of preterm birth.
Ville Y, Rozenberg P
Best Pract Res Clin Obstet Gynaecol 2018 Oct;52:23-32. Epub 2018 Jul 7 doi: 10.1016/j.bpobgyn.2018.05.002. PMID: 30309793
Preterm premature rupture of membranes.
Meller CH, Carducci ME, Ceriani Cernadas JM, Otaño L
Arch Argent Pediatr 2018 Aug 1;116(4):e575-e581. doi: 10.5546/aap.2018.eng.e575. PMID: 30016035

Prognosis

Biomarkers for Pregnancy Latency Prediction after Preterm Premature Rupture of Membranes-A Systematic Review.
Feduniw S, Pruc M, Ciebiera M, Zeber-Lubecka N, Massalska D, Zgliczynska M, Pawlowska A, Szarpak L
Int J Mol Sci 2023 Apr 28;24(9) doi: 10.3390/ijms24098027. PMID: 37175733Free PMC Article
Risk Factors for Neonatal/Maternal Morbidity and Mortality in African American Women with Placental Abruption.
Elkafrawi D, Sisti G, Araji S, Khoury A, Miller J, Rodriguez Echevarria B
Medicina (Kaunas) 2020 Apr 13;56(4) doi: 10.3390/medicina56040174. PMID: 32295061Free PMC Article
Predictors of preterm birth.
Ville Y, Rozenberg P
Best Pract Res Clin Obstet Gynaecol 2018 Oct;52:23-32. Epub 2018 Jul 7 doi: 10.1016/j.bpobgyn.2018.05.002. PMID: 30309793
Mid-trimester preterm premature rupture of membranes (PPROM): etiology, diagnosis, classification, international recommendations of treatment options and outcome.
Tchirikov M, Schlabritz-Loutsevitch N, Maher J, Buchmann J, Naberezhnev Y, Winarno AS, Seliger G
J Perinat Med 2018 Jul 26;46(5):465-488. doi: 10.1515/jpm-2017-0027. PMID: 28710882
Abruption-associated prematurity.
Han CS, Schatz F, Lockwood CJ
Clin Perinatol 2011 Sep;38(3):407-21. doi: 10.1016/j.clp.2011.06.001. PMID: 21890016Free PMC Article

Clinical prediction guides

Biomarkers for Pregnancy Latency Prediction after Preterm Premature Rupture of Membranes-A Systematic Review.
Feduniw S, Pruc M, Ciebiera M, Zeber-Lubecka N, Massalska D, Zgliczynska M, Pawlowska A, Szarpak L
Int J Mol Sci 2023 Apr 28;24(9) doi: 10.3390/ijms24098027. PMID: 37175733Free PMC Article
Guideline No. 430: Diagnosis and management of preterm prelabour rupture of membranes.
Ronzoni S, Boucoiran I, Yudin MH, Coolen J, Pylypjuk C, Melamed N, Holden AC, Smith G, Barrett J
J Obstet Gynaecol Can 2022 Nov;44(11):1193-1208.e1. Epub 2022 Oct 2 doi: 10.1016/j.jogc.2022.08.014. PMID: 36410937
Predictors of preterm birth.
Ville Y, Rozenberg P
Best Pract Res Clin Obstet Gynaecol 2018 Oct;52:23-32. Epub 2018 Jul 7 doi: 10.1016/j.bpobgyn.2018.05.002. PMID: 30309793
Mid-trimester preterm premature rupture of membranes (PPROM): etiology, diagnosis, classification, international recommendations of treatment options and outcome.
Tchirikov M, Schlabritz-Loutsevitch N, Maher J, Buchmann J, Naberezhnev Y, Winarno AS, Seliger G
J Perinat Med 2018 Jul 26;46(5):465-488. doi: 10.1515/jpm-2017-0027. PMID: 28710882
Ureaplasma urealyticum, Mycoplasma hominis and adverse pregnancy outcomes.
Capoccia R, Greub G, Baud D
Curr Opin Infect Dis 2013 Jun;26(3):231-40. doi: 10.1097/QCO.0b013e328360db58. PMID: 23587772

Recent systematic reviews

Vaginal probiotics as an adjunct to antibiotic prophylaxis in the management of preterm premature rupture of membranes: A systematic review and meta-analysis of randomized controlled trials.
Baradwan S, AlSghan R, Sabban H, Khadawardi K, Abdelrahman Mohamed Ali Z, Felemban LHA, Khamis Galal S, Ragab Rashed A, Salah Elsayed T, Mohammed Ibrahim E, Abdelghaffar Moustafa A, Mohamed Abdelhakim A, Abdelaziz A, Abdelgawad Magdy H, ElHodiby ME
Eur J Obstet Gynecol Reprod Biol 2023 Dec;291:112-119. Epub 2023 Oct 12 doi: 10.1016/j.ejogrb.2023.10.011. PMID: 37862929
Combined vaginal progesterone and cervical cerclage in the prevention of preterm birth: a systematic review and meta-analysis.
Aubin AM, McAuliffe L, Williams K, Issah A, Diacci R, McAuliffe JE, Sabdia S, Phung J, Wang CA, Pennell CE
Am J Obstet Gynecol MFM 2023 Aug;5(8):101024. Epub 2023 May 20 doi: 10.1016/j.ajogmf.2023.101024. PMID: 37211087
Biomarkers for Pregnancy Latency Prediction after Preterm Premature Rupture of Membranes-A Systematic Review.
Feduniw S, Pruc M, Ciebiera M, Zeber-Lubecka N, Massalska D, Zgliczynska M, Pawlowska A, Szarpak L
Int J Mol Sci 2023 Apr 28;24(9) doi: 10.3390/ijms24098027. PMID: 37175733Free PMC Article
Efficacy of prophylactic antibiotics for preterm premature rupture of membranes: a systematic review and network meta-analysis.
Lin LL, Hung JN, Shiu SI, Su YH, Chen WC, Tseng JJ
Am J Obstet Gynecol MFM 2023 Jul;5(7):100978. Epub 2023 Apr 23 doi: 10.1016/j.ajogmf.2023.100978. PMID: 37094635
Evaluating Progestogens for Preventing Preterm birth International Collaborative (EPPPIC): meta-analysis of individual participant data from randomised controlled trials.
EPPPIC Group
Lancet 2021 Mar 27;397(10280):1183-1194. doi: 10.1016/S0140-6736(21)00217-8. PMID: 33773630

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