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Malignant Urinary Tract Neoplasm

MedGen UID:
148343
•Concept ID:
C0751571
•
Neoplastic Process
Synonyms: Cancer of the Urinary Tract; Cancer of Urinary Tract; Cancer, Urinary Tract; Cancer, Urologic; Cancer, Urological; Cancers, Urinary Tract; Cancers, Urologic; Cancers, Urological; Urinary Tract Cancer; Urinary Tract Cancers; Urologic Cancer; Urologic Cancers; Urological Cancer; Urological Cancers
SNOMED CT: Malignant tumor of urinary tract proper (363517008); Malignant tumor of urinary tract (363517008)

Definition

A primary or metastatic malignant neoplasm involving the urinary tract. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMalignant Urinary Tract Neoplasm

Professional guidelines

PubMed

Current best practice for bladder cancer: a narrative review of diagnostics and treatments.
Compérat E, Amin MB, Cathomas R, Choudhury A, De Santis M, Kamat A, Stenzl A, Thoeny HC, Witjes JA
Lancet 2022 Nov 12;400(10364):1712-1721. Epub 2022 Sep 26 doi: 10.1016/S0140-6736(22)01188-6. PMID: 36174585
Renal cell carcinoma: an overview of the epidemiology, diagnosis, and treatment.
Bahadoram S, Davoodi M, Hassanzadeh S, Bahadoram M, Barahman M, Mafakher L
G Ital Nefrol 2022 Jun 20;39(3) PMID: 35819037
Bladder Cancer: Diagnosis and Treatment.
DeGeorge KC, Holt HR, Hodges SC
Am Fam Physician 2017 Oct 15;96(8):507-514. PMID: 29094888

Recent clinical studies

Etiology

What Is the Significance of Variant Histology in Urothelial Carcinoma?
Lobo N, Shariat SF, Guo CC, Fernandez MI, Kassouf W, Choudhury A, Gao J, Williams SB, Galsky MD, Taylor JA 3rd, Roupret M, Kamat AM
Eur Urol Focus 2020 Jul 15;6(4):653-663. Epub 2019 Sep 15 doi: 10.1016/j.euf.2019.09.003. PMID: 31530497
Hematuria.
Peterson LM, Reed HS
Prim Care 2019 Jun;46(2):265-273. Epub 2019 Apr 1 doi: 10.1016/j.pop.2019.02.008. PMID: 31030828
Updates in the Eighth Edition of the Tumor-Node-Metastasis Staging Classification for Urologic Cancers.
Paner GP, Stadler WM, Hansel DE, Montironi R, Lin DW, Amin MB
Eur Urol 2018 Apr;73(4):560-569. Epub 2018 Jan 9 doi: 10.1016/j.eururo.2017.12.018. PMID: 29325693
Epidemiology of urothelial carcinoma.
Miyazaki J, Nishiyama H
Int J Urol 2017 Oct;24(10):730-734. Epub 2017 May 21 doi: 10.1111/iju.13376. PMID: 28543959
Treatment of patients with metastatic urothelial cancer "unfit" for Cisplatin-based chemotherapy.
Galsky MD, Hahn NM, Rosenberg J, Sonpavde G, Hutson T, Oh WK, Dreicer R, Vogelzang N, Sternberg CN, Bajorin DF, Bellmunt J
J Clin Oncol 2011 Jun 10;29(17):2432-8. Epub 2011 May 9 doi: 10.1200/JCO.2011.34.8433. PMID: 21555688

Diagnosis

What Is the Significance of Variant Histology in Urothelial Carcinoma?
Lobo N, Shariat SF, Guo CC, Fernandez MI, Kassouf W, Choudhury A, Gao J, Williams SB, Galsky MD, Taylor JA 3rd, Roupret M, Kamat AM
Eur Urol Focus 2020 Jul 15;6(4):653-663. Epub 2019 Sep 15 doi: 10.1016/j.euf.2019.09.003. PMID: 31530497
Epigenetics of Urological Cancers.
Schulz WA, Sørensen KD
Int J Mol Sci 2019 Sep 26;20(19) doi: 10.3390/ijms20194775. PMID: 31561442Free PMC Article
Hematuria.
Peterson LM, Reed HS
Prim Care 2019 Jun;46(2):265-273. Epub 2019 Apr 1 doi: 10.1016/j.pop.2019.02.008. PMID: 31030828
Updates in the Eighth Edition of the Tumor-Node-Metastasis Staging Classification for Urologic Cancers.
Paner GP, Stadler WM, Hansel DE, Montironi R, Lin DW, Amin MB
Eur Urol 2018 Apr;73(4):560-569. Epub 2018 Jan 9 doi: 10.1016/j.eururo.2017.12.018. PMID: 29325693
Epidemiology of urothelial carcinoma.
Miyazaki J, Nishiyama H
Int J Urol 2017 Oct;24(10):730-734. Epub 2017 May 21 doi: 10.1111/iju.13376. PMID: 28543959

Therapy

Efficacy of enfortumab vedotin in advanced urothelial cancer: Analysis from the Urothelial Cancer Network to Investigate Therapeutic Experiences (UNITE) study.
Koshkin VS, Henderson N, James M, Natesan D, Freeman D, Nizam A, Su CT, Khaki AR, Osterman CK, Glover MJ, Chiang R, Makrakis D, Talukder R, Lemke E, Olsen TA, Jain J, Jang A, Ali A, Jindal T, Chou J, Friedlander TW, Hoimes C, Basu A, Zakharia Y, Barata PC, Bilen MA, Emamekhoo H, Davis NB, Shah SA, Milowsky MI, Gupta S, Campbell MT, Grivas P, Sonpavde GP, Kilari D, Alva AS
Cancer 2022 Mar 15;128(6):1194-1205. Epub 2021 Dec 9 doi: 10.1002/cncr.34057. PMID: 34882781
Enfortumab Vedotin in Previously Treated Advanced Urothelial Carcinoma.
Powles T, Rosenberg JE, Sonpavde GP, Loriot Y, Durán I, Lee JL, Matsubara N, Vulsteke C, Castellano D, Wu C, Campbell M, Matsangou M, Petrylak DP
N Engl J Med 2021 Mar 25;384(12):1125-1135. Epub 2021 Feb 12 doi: 10.1056/NEJMoa2035807. PMID: 33577729Free PMC Article
KEYNOTE-676: Phase III study of BCG and pembrolizumab for persistent/recurrent high-risk NMIBC.
Kamat AM, Shore N, Hahn N, Alanee S, Nishiyama H, Shariat S, Nam K, Kapadia E, Frenkl T, Steinberg G
Future Oncol 2020 Apr;16(10):507-516. Epub 2020 Mar 12 doi: 10.2217/fon-2019-0817. PMID: 32162533
Epidemiology of urothelial carcinoma.
Miyazaki J, Nishiyama H
Int J Urol 2017 Oct;24(10):730-734. Epub 2017 May 21 doi: 10.1111/iju.13376. PMID: 28543959
Treatment of patients with metastatic urothelial cancer "unfit" for Cisplatin-based chemotherapy.
Galsky MD, Hahn NM, Rosenberg J, Sonpavde G, Hutson T, Oh WK, Dreicer R, Vogelzang N, Sternberg CN, Bajorin DF, Bellmunt J
J Clin Oncol 2011 Jun 10;29(17):2432-8. Epub 2011 May 9 doi: 10.1200/JCO.2011.34.8433. PMID: 21555688

Prognosis

Adverse Events of Immune Checkpoint Inhibitors Therapy for Urologic Cancer Patients in Clinical Trials: A Collaborative Systematic Review and Meta-analysis.
Wu Z, Chen Q, Qu L, Li M, Wang L, Mir MC, Carbonara U, Pandolfo SD, Black PC, Paul AK, Di Lorenzo G, Porpiglia F, Mari A, Necchi A, Rouprêt M, Psutka SP, Autorino R
Eur Urol 2022 Apr;81(4):414-425. Epub 2022 Jan 31 doi: 10.1016/j.eururo.2022.01.028. PMID: 35101302
Epigenetics of Urological Cancers.
Schulz WA, Sørensen KD
Int J Mol Sci 2019 Sep 26;20(19) doi: 10.3390/ijms20194775. PMID: 31561442Free PMC Article
Advanced urothelial cancer: a radiology update.
Alessandrino F, Ghaith O, Williams K, Sonpavde GP, Silverman SG, Shinagare AB
Abdom Radiol (NY) 2019 Dec;44(12):3858-3873. doi: 10.1007/s00261-019-02148-3. PMID: 31363813
Randomized phase III KEYNOTE-045 trial of pembrolizumab versus paclitaxel, docetaxel, or vinflunine in recurrent advanced urothelial cancer: results of >2 years of follow-up.
Fradet Y, Bellmunt J, Vaughn DJ, Lee JL, Fong L, Vogelzang NJ, Climent MA, Petrylak DP, Choueiri TK, Necchi A, Gerritsen W, Gurney H, Quinn DI, Culine S, Sternberg CN, Nam K, Frenkl TL, Perini RF, de Wit R, Bajorin DF
Ann Oncol 2019 Jun 1;30(6):970-976. doi: 10.1093/annonc/mdz127. PMID: 31050707Free PMC Article
Nivolumab in metastatic urothelial carcinoma after platinum therapy (CheckMate 275): a multicentre, single-arm, phase 2 trial.
Sharma P, Retz M, Siefker-Radtke A, Baron A, Necchi A, Bedke J, Plimack ER, Vaena D, Grimm MO, Bracarda S, Arranz JÁ, Pal S, Ohyama C, Saci A, Qu X, Lambert A, Krishnan S, Azrilevich A, Galsky MD
Lancet Oncol 2017 Mar;18(3):312-322. Epub 2017 Jan 26 doi: 10.1016/S1470-2045(17)30065-7. PMID: 28131785

Clinical prediction guides

Clinical staging of upper urinary tract urothelial carcinoma for T staging: Review and pictorial essay.
Honda Y, Nakamura Y, Teishima J, Goto K, Higaki T, Narita K, Akagi M, Terada H, Kaichi Y, Fujii S, Hayashi T, Matsubara A, Sentani K, Yasui W, Iida M, Awai K
Int J Urol 2019 Nov;26(11):1024-1032. Epub 2019 Aug 4 doi: 10.1111/iju.14068. PMID: 31379021
Multiparametric Magnetic Resonance Imaging for Bladder Cancer: Development of VI-RADS (Vesical Imaging-Reporting And Data System).
Panebianco V, Narumi Y, Altun E, Bochner BH, Efstathiou JA, Hafeez S, Huddart R, Kennish S, Lerner S, Montironi R, Muglia VF, Salomon G, Thomas S, Vargas HA, Witjes JA, Takeuchi M, Barentsz J, Catto JWF
Eur Urol 2018 Sep;74(3):294-306. Epub 2018 May 10 doi: 10.1016/j.eururo.2018.04.029. PMID: 29755006Free PMC Article
Urinary extracellular vesicle biomarkers in urological cancers: From discovery towards clinical implementation.
Dhondt B, Van Deun J, Vermaerke S, de Marco A, Lumen N, De Wever O, Hendrix A
Int J Biochem Cell Biol 2018 Jun;99:236-256. Epub 2018 Apr 11 doi: 10.1016/j.biocel.2018.04.009. PMID: 29654900
Asymptomatic Microscopic Hematuria in Women.
Female Pelvic Med Reconstr Surg 2017 Jul/Aug;23(4):228-231. doi: 10.1097/SPV.0000000000000432. PMID: 28650895
Nephrogenic adenoma.
Amin W, Parwani AV
Pathol Res Pract 2010 Oct 15;206(10):659-62. Epub 2010 Jul 8 doi: 10.1016/j.prp.2010.06.001. PMID: 20619548

Recent systematic reviews

Epidemiology of Bladder Cancer in 2023: A Systematic Review of Risk Factors.
Jubber I, Ong S, Bukavina L, Black PC, Compérat E, Kamat AM, Kiemeney L, Lawrentschuk N, Lerner SP, Meeks JJ, Moch H, Necchi A, Panebianco V, Sridhar SS, Znaor A, Catto JWF, Cumberbatch MG
Eur Urol 2023 Aug;84(2):176-190. Epub 2023 May 16 doi: 10.1016/j.eururo.2023.03.029. PMID: 37198015
Epidemiology of Renal Cell Carcinoma: 2022 Update.
Bukavina L, Bensalah K, Bray F, Carlo M, Challacombe B, Karam JA, Kassouf W, Mitchell T, Montironi R, O'Brien T, Panebianco V, Scelo G, Shuch B, van Poppel H, Blosser CD, Psutka SP
Eur Urol 2022 Nov;82(5):529-542. Epub 2022 Sep 10 doi: 10.1016/j.eururo.2022.08.019. PMID: 36100483
Air pollution exposure and bladder, kidney and urinary tract cancer risk: A systematic review.
Zare Sakhvidi MJ, Lequy E, Goldberg M, Jacquemin B
Environ Pollut 2020 Dec;267:115328. Epub 2020 Aug 20 doi: 10.1016/j.envpol.2020.115328. PMID: 32871482
Diagnosis and Treatment of Non-Muscle Invasive Bladder Cancer: AUA/SUO Guideline.
Chang SS, Boorjian SA, Chou R, Clark PE, Daneshmand S, Konety BR, Pruthi R, Quale DZ, Ritch CR, Seigne JD, Skinner EC, Smith ND, McKiernan JM
J Urol 2016 Oct;196(4):1021-9. Epub 2016 Jun 16 doi: 10.1016/j.juro.2016.06.049. PMID: 27317986
Management of Renal Masses and Localized Renal Cancer: Systematic Review and Meta-Analysis.
Pierorazio PM, Johnson MH, Patel HD, Sozio SM, Sharma R, Iyoha E, Bass EB, Allaf ME
J Urol 2016 Oct;196(4):989-99. Epub 2016 May 6 doi: 10.1016/j.juro.2016.04.081. PMID: 27157369Free PMC Article

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