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Gait Disorders, Neurologic

MedGen UID:
148400
•Concept ID:
C0751830
•
Disease or Syndrome
Synonyms: Ambulation Disorder, Neurologic; Ambulation Disorders, Neurologic; Gait Disorder, Neurologic; Gait Dysfunction, Neurologic; Gait Dysfunctions, Neurologic; Locomotion Disorder, Neurologic; Locomotion Disorders, Neurologic; Neurologic Ambulation Disorder; Neurologic Ambulation Disorders; Neurologic Gait Disorder; Neurologic Gait Disorders; Neurologic Gait Dysfunction; Neurologic Gait Dysfunctions; Neurologic Locomotion Disorder; Neurologic Locomotion Disorders

Definition

Gait abnormalities that are a manifestation of nervous system dysfunction. These conditions may be caused by a wide variety of disorders which affect motor control, sensory feedback, and muscle strength including: CENTRAL NERVOUS SYSTEM DISEASES; PERIPHERAL NERVOUS SYSTEM DISEASES; NEUROMUSCULAR DISEASES; or MUSCULAR DISEASES. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGait Disorders, Neurologic

Professional guidelines

PubMed

Office management of gait disorders in the elderly.
Lam R
Can Fam Physician 2011 Jul;57(7):765-70. PMID: 21753097Free PMC Article

Recent clinical studies

Etiology

Effects of conventional physical therapy with and without proprioceptive neuromuscular facilitation on balance, gait, and function in patients with Parkinson's disease.
Mazhar T, Jameel A, Sharif F, Asghar M
J Pak Med Assoc 2023 Jun;73(6):1280-1283. doi: 10.47391/JPMA.6710. PMID: 37427630
Freezing of gait in Parkinson's disease: pathophysiology, risk factors and treatments.
Gao C, Liu J, Tan Y, Chen S
Transl Neurodegener 2020;9:12. Epub 2020 Apr 15 doi: 10.1186/s40035-020-00191-5. PMID: 32322387Free PMC Article
Gait and dementia.
Cohen JA, Verghese J
Handb Clin Neurol 2019;167:419-427. doi: 10.1016/B978-0-12-804766-8.00022-4. PMID: 31753146
Instrumental or Physical-Exercise Rehabilitation of Balance Improves Both Balance and Gait in Parkinson's Disease.
Giardini M, Nardone A, Godi M, Guglielmetti S, Arcolin I, Pisano F, Schieppati M
Neural Plast 2018;2018:5614242. Epub 2018 Mar 7 doi: 10.1155/2018/5614242. PMID: 29706993Free PMC Article
Gait Disorders.
Baker JM
Am J Med 2018 Jun;131(6):602-607. Epub 2017 Dec 27 doi: 10.1016/j.amjmed.2017.11.051. PMID: 29288631

Diagnosis

Neurological gait assessment.
Mermelstein S, Barbosa P, Kaski D
Pract Neurol 2024 Jan 23;24(1):11-21. doi: 10.1136/pn-2023-003917. PMID: 38135498
Gait Disorders.
Baker JM
Am J Med 2018 Jun;131(6):602-607. Epub 2017 Dec 27 doi: 10.1016/j.amjmed.2017.11.051. PMID: 29288631
Gait disorders in adults and the elderly : A clinical guide.
Pirker W, Katzenschlager R
Wien Klin Wochenschr 2017 Feb;129(3-4):81-95. Epub 2016 Oct 21 doi: 10.1007/s00508-016-1096-4. PMID: 27770207Free PMC Article
Toe walking: causes, epidemiology, assessment, and treatment.
Ruzbarsky JJ, Scher D, Dodwell E
Curr Opin Pediatr 2016 Feb;28(1):40-6. doi: 10.1097/MOP.0000000000000302. PMID: 26709689
Gait disorders.
Jankovic J
Neurol Clin 2015 Feb;33(1):249-68. doi: 10.1016/j.ncl.2014.09.007. PMID: 25432732

Therapy

The effects of lower extremity cross-training on gait and balance in stroke patients: a double-blinded randomized controlled trial.
Park C, Son H, Yeo B
Eur J Phys Rehabil Med 2021 Feb;57(1):4-12. Epub 2020 Sep 6 doi: 10.23736/S1973-9087.20.06183-3. PMID: 32891079
The effects of dual task gait and balance training in Parkinson's disease: a systematic review.
De Freitas TB MS, PT, Leite PHW BS, Doná F PhD, PT, Pompeu JE PhD, PT, Swarowsky A PhD, PT, Torriani-Pasin C PhD, PT
Physiother Theory Pract 2020 Oct;36(10):1088-1096. Epub 2018 Dec 3 doi: 10.1080/09593985.2018.1551455. PMID: 30501424
Clinical effects of robot-assisted gait training and treadmill training for Parkinson's disease. A randomized controlled trial.
Capecci M, Pournajaf S, Galafate D, Sale P, Le Pera D, Goffredo M, De Pandis MF, Andrenelli E, Pennacchioni M, Ceravolo MG, Franceschini M
Ann Phys Rehabil Med 2019 Sep;62(5):303-312. Epub 2019 Aug 1 doi: 10.1016/j.rehab.2019.06.016. PMID: 31377382
Effect of Cerebellar Stimulation on Gait and Balance Recovery in Patients With Hemiparetic Stroke: A Randomized Clinical Trial.
Koch G, Bonnì S, Casula EP, Iosa M, Paolucci S, Pellicciari MC, Cinnera AM, Ponzo V, Maiella M, Picazio S, Sallustio F, Caltagirone C
JAMA Neurol 2019 Feb 1;76(2):170-178. doi: 10.1001/jamaneurol.2018.3639. PMID: 30476999Free PMC Article
Music interventions for acquired brain injury.
Magee WL, Clark I, Tamplin J, Bradt J
Cochrane Database Syst Rev 2017 Jan 20;1(1):CD006787. doi: 10.1002/14651858.CD006787.pub3. PMID: 28103638Free PMC Article

Prognosis

Gait and dementia.
Cohen JA, Verghese J
Handb Clin Neurol 2019;167:419-427. doi: 10.1016/B978-0-12-804766-8.00022-4. PMID: 31753146
The TWIST Algorithm Predicts Time to Walking Independently After Stroke.
Smith MC, Barber PA, Stinear CM
Neurorehabil Neural Repair 2017 Oct-Nov;31(10-11):955-964. Epub 2017 Nov 1 doi: 10.1177/1545968317736820. PMID: 29090654
Gait analysis: clinical facts.
Baker R, Esquenazi A, Benedetti MG, Desloovere K
Eur J Phys Rehabil Med 2016 Aug;52(4):560-74. PMID: 27618499
Gait disturbances in patients with stroke.
Balaban B, Tok F
PM R 2014 Jul;6(7):635-42. Epub 2014 Jan 19 doi: 10.1016/j.pmrj.2013.12.017. PMID: 24451335
Foot drop: where, why and what to do?
Stewart JD
Pract Neurol 2008 Jun;8(3):158-69. doi: 10.1136/jnnp.2008.149393. PMID: 18502948

Clinical prediction guides

Gait profile score and gait variable scores in spina bifida.
Fusagawa H, Fujita H, Matsuyama T, Himuro N, Teramoto A, Yamashita T, Selber P
J Pediatr Orthop B 2022 Mar 1;31(2):e251-e257. doi: 10.1097/BPB.0000000000000877. PMID: 34028379
Prediction of Independent Walking in People Who Are Nonambulatory Early After Stroke: A Systematic Review.
Preston E, Ada L, Stanton R, Mahendran N, Dean CM
Stroke 2021 Oct;52(10):3217-3224. Epub 2021 Jul 9 doi: 10.1161/STROKEAHA.120.032345. PMID: 34238016
The TWIST Algorithm Predicts Time to Walking Independently After Stroke.
Smith MC, Barber PA, Stinear CM
Neurorehabil Neural Repair 2017 Oct-Nov;31(10-11):955-964. Epub 2017 Nov 1 doi: 10.1177/1545968317736820. PMID: 29090654
Measurement instruments to assess posture, gait, and balance in Parkinson's disease: Critique and recommendations.
Bloem BR, Marinus J, Almeida Q, Dibble L, Nieuwboer A, Post B, Ruzicka E, Goetz C, Stebbins G, Martinez-Martin P, Schrag A; Movement Disorders Society Rating Scales Committee
Mov Disord 2016 Sep;31(9):1342-55. Epub 2016 Mar 4 doi: 10.1002/mds.26572. PMID: 26945525
Poor Gait Performance and Prediction of Dementia: Results From a Meta-Analysis.
Beauchet O, Annweiler C, Callisaya ML, De Cock AM, Helbostad JL, Kressig RW, Srikanth V, Steinmetz JP, Blumen HM, Verghese J, Allali G
J Am Med Dir Assoc 2016 Jun 1;17(6):482-90. Epub 2016 Feb 4 doi: 10.1016/j.jamda.2015.12.092. PMID: 26852960Free PMC Article

Recent systematic reviews

Treatment of knee hyperextension in post-stroke gait. A systematic review.
Geerars M, Minnaar-van der Feen N, Huisstede BMA
Gait Posture 2022 Jan;91:137-148. Epub 2021 Aug 24 doi: 10.1016/j.gaitpost.2021.08.016. PMID: 34695721
Robotic-assisted gait rehabilitation following stroke: a systematic review of current guidelines and practical clinical recommendations.
Calabrò RS, Sorrentino G, Cassio A, Mazzoli D, Andrenelli E, Bizzarini E, Campanini I, Carmignano SM, Cerulli S, Chisari C, Colombo V, Dalise S, Fundarò C, Gazzotti V, Mazzoleni D, Mazzucchelli M, Melegari C, Merlo A, Stampacchia G, Boldrini P, Mazzoleni S, Posteraro F, Benanti P, Castelli E, Draicchio F, Falabella V, Galeri S, Gimigliano F, Grigioni M, Mazzon S, Molteni F, Morone G, Petrarca M, Picelli A, Senatore M, Turchetti G, Bonaiuti D; Italian Consensus Conference on Robotics in Neurorehabilitation (CICERONE)
Eur J Phys Rehabil Med 2021 Jun;57(3):460-471. Epub 2021 May 5 doi: 10.23736/S1973-9087.21.06887-8. PMID: 33947828
Functional electrical stimulation of the peroneal nerve improves post-stroke gait speed when combined with physiotherapy. A systematic review and meta-analysis.
Jaqueline da Cunha M, Rech KD, Salazar AP, Pagnussat AS
Ann Phys Rehabil Med 2021 Jan;64(1):101388. Epub 2020 May 24 doi: 10.1016/j.rehab.2020.03.012. PMID: 32376404
Physical Therapy for Freezing of Gait and Gait Impairments in Parkinson Disease: A Systematic Review.
Rutz DG, Benninger DH
PM R 2020 Nov;12(11):1140-1156. Epub 2020 May 19 doi: 10.1002/pmrj.12337. PMID: 31994842
Toe walking: causes, epidemiology, assessment, and treatment.
Ruzbarsky JJ, Scher D, Dodwell E
Curr Opin Pediatr 2016 Feb;28(1):40-6. doi: 10.1097/MOP.0000000000000302. PMID: 26709689

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