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Brain infarction

MedGen UID:
148426
Concept ID:
C0751955
Disease or Syndrome
Synonyms: Brain Infarct; Brain Infarction; Brain Infarctions; Brain Infarcts; Infarct, Brain; Infarction, Brain; Infarctions, Brain; Infarcts, Brain
 
Monarch Initiative: MONDO:0005394

Definition

Tissue necrosis in any area of the brain, including the cerebral hemispheres, the cerebellum, and the brain stem. Brain infarction is the result of a cascade of events initiated by inadequate blood flow through the brain that is followed by hypoxia and hypoglycemia in brain tissue. Damage may be temporary, permanent, selective or pan-necrosis. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBrain infarction

Professional guidelines

PubMed

Thimukonda Jegadeesan J, Baldia M, Basu B
Acta Biomater 2022 Dec;154:63-82. Epub 2022 Oct 19 doi: 10.1016/j.actbio.2022.10.030. PMID: 36272686
Na DG, Sohn CH, Kim EY
Korean J Radiol 2015 Mar-Apr;16(2):372-90. Epub 2015 Feb 27 doi: 10.3348/kjr.2015.16.2.372. PMID: 25741200Free PMC Article
O'Shea TM
Clin Obstet Gynecol 2008 Dec;51(4):816-28. doi: 10.1097/GRF.0b013e3181870ba7. PMID: 18981805Free PMC Article

Recent clinical studies

Etiology

Schattner A
Am J Med 2022 Jan;135(1):12-14. Epub 2021 Sep 8 doi: 10.1016/j.amjmed.2021.07.044. PMID: 34508701
de Havenon A, Meyer C, McNally JS, Alexander M, Chung L
Curr Atheroscler Rep 2019 Jul 27;21(10):39. doi: 10.1007/s11883-019-0799-1. PMID: 31350593Free PMC Article
Abdelrasoul AA, Elsebaie NA, Gamaleldin OA, Khalifa MH, Razek AAKA
J Comput Assist Tomogr 2019 May/Jun;43(3):443-451. doi: 10.1097/RCT.0000000000000865. PMID: 31082950
Gonçalves B, Turon R, Mendes A, Melo N, Lacerda P, Brasil P, Bozza FA, Kurtz P, Righy C
World Neurosurg 2018 Jul;115:e292-e298. Epub 2018 Apr 13 doi: 10.1016/j.wneu.2018.04.037. PMID: 29660554
Gupta A, Giambrone AE, Gialdini G, Finn C, Delgado D, Gutierrez J, Wright C, Beiser AS, Seshadri S, Pandya A, Kamel H
Stroke 2016 Mar;47(3):719-25. doi: 10.1161/STROKEAHA.115.011889. PMID: 26888534Free PMC Article

Diagnosis

Sui B, Gao P
J Int Med Res 2020 Jan;48(1):300060518802530. doi: 10.1177/0300060518802530. PMID: 31997680Free PMC Article
Welgampola MS, Young AS, Pogson JM, Bradshaw AP, Halmagyi GM
Pract Neurol 2019 Dec;19(6):492-501. Epub 2019 Jul 20 doi: 10.1136/practneurol-2019-002199. PMID: 31326945
Wu L, Wu W, Tali ET, Yuh WT
Neuroimaging Clin N Am 2018 Nov;28(4):599-609. doi: 10.1016/j.nic.2018.06.013. PMID: 30322596
Gonçalves B, Turon R, Mendes A, Melo N, Lacerda P, Brasil P, Bozza FA, Kurtz P, Righy C
World Neurosurg 2018 Jul;115:e292-e298. Epub 2018 Apr 13 doi: 10.1016/j.wneu.2018.04.037. PMID: 29660554
MILLIKAN C, KETY SS, FISHER CM, PAGE IH, SAHS A, ROSE AS
Neurology 1956 Aug;6(8):580-93. doi: 10.1212/wnl.6.8.580. PMID: 13348821

Therapy

Mistry EA, Hart KW, Davis LT, Gao Y, Prestigiacomo CJ, Mittal S, Mehta T, LaFever H, Harker P, Wilson-Perez HE, Beasley KA, Krothapalli N, Lippincott E, Stefek H, Froehler M, Chitale R, Fusco M, Grossman A, Shirani P, Smith M, Jaffa MN, Yeatts SD, Albers GW, Wanderer JP, Tolles J, Lindsell CJ, Lewis RJ, Bernard GR, Khatri P
JAMA 2023 Sep 5;330(9):821-831. doi: 10.1001/jama.2023.14330. PMID: 37668620Free PMC Article
Bilski AE, Aparicio HJ, Gutierrez J, de Leeuw FE, Hilkens NA
Stroke 2023 Jul;54(7):1954-1959. Epub 2023 May 16 doi: 10.1161/STROKEAHA.122.040444. PMID: 37191009Free PMC Article
Søndergaard L, Kasner SE, Rhodes JF, Andersen G, Iversen HK, Nielsen-Kudsk JE, Settergren M, Sjöstrand C, Roine RO, Hildick-Smith D, Spence JD, Thomassen L; Gore REDUCE Clinical Study Investigators
N Engl J Med 2017 Sep 14;377(11):1033-1042. doi: 10.1056/NEJMoa1707404. PMID: 28902580
Nidorf SM, Eikelboom JW, Budgeon CA, Thompson PL
J Am Coll Cardiol 2013 Jan 29;61(4):404-410. Epub 2012 Dec 19 doi: 10.1016/j.jacc.2012.10.027. PMID: 23265346
Chabriat H, Joutel A, Dichgans M, Tournier-Lasserve E, Bousser MG
Lancet Neurol 2009 Jul;8(7):643-53. doi: 10.1016/S1474-4422(09)70127-9. PMID: 19539236

Prognosis

Schattner A
Am J Med 2022 Jan;135(1):12-14. Epub 2021 Sep 8 doi: 10.1016/j.amjmed.2021.07.044. PMID: 34508701
Naganuma T, Takemoto Y
Contrib Nephrol 2018;196:22-26. Epub 2018 Jul 24 doi: 10.1159/000485692. PMID: 30041200
Gonçalves B, Turon R, Mendes A, Melo N, Lacerda P, Brasil P, Bozza FA, Kurtz P, Righy C
World Neurosurg 2018 Jul;115:e292-e298. Epub 2018 Apr 13 doi: 10.1016/j.wneu.2018.04.037. PMID: 29660554
Nidorf SM, Eikelboom JW, Budgeon CA, Thompson PL
J Am Coll Cardiol 2013 Jan 29;61(4):404-410. Epub 2012 Dec 19 doi: 10.1016/j.jacc.2012.10.027. PMID: 23265346
Lastilla M
Clin Exp Hypertens 2006 Apr-May;28(3-4):205-15. doi: 10.1080/10641960600549082. PMID: 16833026

Clinical prediction guides

Mistry EA, Hart KW, Davis LT, Gao Y, Prestigiacomo CJ, Mittal S, Mehta T, LaFever H, Harker P, Wilson-Perez HE, Beasley KA, Krothapalli N, Lippincott E, Stefek H, Froehler M, Chitale R, Fusco M, Grossman A, Shirani P, Smith M, Jaffa MN, Yeatts SD, Albers GW, Wanderer JP, Tolles J, Lindsell CJ, Lewis RJ, Bernard GR, Khatri P
JAMA 2023 Sep 5;330(9):821-831. doi: 10.1001/jama.2023.14330. PMID: 37668620Free PMC Article
Chang K, Huang CH, Chen TC, Lin CY, Lu PL, Chen YH
J Microbiol Immunol Infect 2021 Oct;54(5):885-892. Epub 2021 Mar 31 doi: 10.1016/j.jmii.2021.03.009. PMID: 33840603
Ito A, Iwata S, Tamura S, Kim AT, Nonin S, Ishikawa S, Ito A, Izumiya Y, Abe T, Shibata T, Yoshiyama M
Cerebrovasc Dis Extra 2020;10(3):116-123. Epub 2020 Oct 8 doi: 10.1159/000510438. PMID: 33032286Free PMC Article
Hahne K, Mönnig G, Samol A
Vasc Health Risk Manag 2016;12:65-74. Epub 2016 Mar 7 doi: 10.2147/VHRM.S81807. PMID: 27022272Free PMC Article
Arsava EM, Kim GM, Oliveira-Filho J, Gungor L, Noh HJ, Lordelo Mde J, Avery R, Maier IL, Ay H
JAMA Neurol 2016 Apr;73(4):396-401. doi: 10.1001/jamaneurol.2015.4949. PMID: 26926383

Recent systematic reviews

Gerstenecker A, Norling AM, Jacob A, Lazar RM
Neuropsychol Rev 2023 Jun;33(2):474-491. Epub 2022 Jul 8 doi: 10.1007/s11065-022-09548-1. PMID: 35804216
Debette S, Schilling S, Duperron MG, Larsson SC, Markus HS
JAMA Neurol 2019 Jan 1;76(1):81-94. doi: 10.1001/jamaneurol.2018.3122. PMID: 30422209Free PMC Article
Gonçalves B, Turon R, Mendes A, Melo N, Lacerda P, Brasil P, Bozza FA, Kurtz P, Righy C
World Neurosurg 2018 Jul;115:e292-e298. Epub 2018 Apr 13 doi: 10.1016/j.wneu.2018.04.037. PMID: 29660554
Gupta A, Giambrone AE, Gialdini G, Finn C, Delgado D, Gutierrez J, Wright C, Beiser AS, Seshadri S, Pandya A, Kamel H
Stroke 2016 Mar;47(3):719-25. doi: 10.1161/STROKEAHA.115.011889. PMID: 26888534Free PMC Article
Prabhakaran S, Ruff I, Bernstein RA
JAMA 2015 Apr 14;313(14):1451-62. doi: 10.1001/jama.2015.3058. PMID: 25871671

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