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Amnionitis

MedGen UID:
1490
•Concept ID:
C0002631
•
Disease or Syndrome
Synonym: Amnionitides
SNOMED CT: Amniotic cavity infection (10573002); Infection of amniotic cavity (10573002); Amnionitis (10573002)
 
Monarch Initiative: MONDO:0020710

Definition

Inflammation of the amnion. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAmnionitis

Professional guidelines

PubMed

The antibiotic treatment of PPROM study: systemic maternal and fetal markers and perinatal outcomes.
Mercer BM, Crouse DT, Goldenberg RL, Miodovnik M, Mapp DC, Meis PJ, Dombrowski MP; Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network
Am J Obstet Gynecol 2012 Feb;206(2):145.e1-9. Epub 2011 Sep 8 doi: 10.1016/j.ajog.2011.08.028. PMID: 22000668Free PMC Article
Premature rupture of the membranes: management controversies.
Kennedy KA, Clark SL
Clin Perinatol 1992 Jun;19(2):385-97. PMID: 1617882
Prenatal diagnosis of thalassemia and hemoglobinopathies in Thailand: experience from 100 pregnancies.
Fucharoen S, Winichagoon P, Thonglairoam V, Siriboon W, Siritanaratkul N, Kanokpongsakdi S, Vantanasiri C
Southeast Asian J Trop Med Public Health 1991 Mar;22(1):16-29. PMID: 1948258

Recent clinical studies

Etiology

Maternal Origins of Neonatal Infections: What Do Obstetrician-Gynecologist Should/Could Do?
Germano C, Messina A, Massaro A, Attini R, Leo L, Manzoni P, Masturzo B
Am J Perinatol 2022 Dec;39(S 01):S31-S41. Epub 2022 Dec 19 doi: 10.1055/s-0042-1758858. PMID: 36535368
Impact of maternal obesity on the risk of preterm delivery: insights into pathogenic mechanisms.
Tersigni C, Neri C, D'Ippolito S, Garofalo S, Martino C, Lanzone A, Scambia G, Di Simone N
J Matern Fetal Neonatal Med 2022 Aug;35(16):3216-3221. Epub 2020 Sep 17 doi: 10.1080/14767058.2020.1817370. PMID: 32942918
Refractory uterine atony: still a problem after all these years.
Balki M, Wong CA
Int J Obstet Anesth 2021 Nov;48:103207. Epub 2021 Jul 21 doi: 10.1016/j.ijoa.2021.103207. PMID: 34391025
Pathological staging of chorioamnionitis contributes to complications in preterm infants.
Miao J, Ren Z, Rao Y, Xia X, Wang J, Xu F, Zhang X, Yang J
Ital J Pediatr 2020 Sep 11;46(1):127. doi: 10.1186/s13052-020-00895-4. PMID: 32917243Free PMC Article
The role of anaerobic bacteria in bacteremia.
Brook I
Anaerobe 2010 Jun;16(3):183-9. Epub 2009 Dec 16 doi: 10.1016/j.anaerobe.2009.12.001. PMID: 20025984

Diagnosis

Pathological staging of chorioamnionitis contributes to complications in preterm infants.
Miao J, Ren Z, Rao Y, Xia X, Wang J, Xu F, Zhang X, Yang J
Ital J Pediatr 2020 Sep 11;46(1):127. doi: 10.1186/s13052-020-00895-4. PMID: 32917243Free PMC Article
Role of the infections in recurrent spontaneous abortion.
Nigro G, Mazzocco M, Mattia E, Di Renzo GC, Carta G, Anceschi MM
J Matern Fetal Neonatal Med 2011 Aug;24(8):983-9. Epub 2011 Jan 24 doi: 10.3109/14767058.2010.547963. PMID: 21261443
Streptococcus pneumoniae infections in the neonate.
Hoffman JA, Mason EO, Schutze GE, Tan TQ, Barson WJ, Givner LB, Wald ER, Bradley JS, Yogev R, Kaplan SL
Pediatrics 2003 Nov;112(5):1095-102. doi: 10.1542/peds.112.5.1095. PMID: 14595052
Fetal breathing movements within 24 hours of delivery in prematurity are related to histologic and clinical evidence of amnionitis.
Sherer DM, Spong CY, Salafia CM
Am J Perinatol 1997 Jul;14(6):337-40. doi: 10.1055/s-2007-994156. PMID: 9217954
Bacterial vaginosis.
Sobel JD
Br J Clin Pract Suppl 1990 Sep;71:65-9. PMID: 2091736

Therapy

Maternal Origins of Neonatal Infections: What Do Obstetrician-Gynecologist Should/Could Do?
Germano C, Messina A, Massaro A, Attini R, Leo L, Manzoni P, Masturzo B
Am J Perinatol 2022 Dec;39(S 01):S31-S41. Epub 2022 Dec 19 doi: 10.1055/s-0042-1758858. PMID: 36535368
Refractory uterine atony: still a problem after all these years.
Balki M, Wong CA
Int J Obstet Anesth 2021 Nov;48:103207. Epub 2021 Jul 21 doi: 10.1016/j.ijoa.2021.103207. PMID: 34391025
Pregnancy-related pharmacokinetics and antimicrobial prophylaxis during fetal surgery, cefazolin and clindamycin as examples.
Allegaert K, Muller AE, Russo F, Schoenmakers S, Deprest J, Koch BCP
Prenat Diagn 2020 Aug;40(9):1178-1184. Epub 2020 Jun 14 doi: 10.1002/pd.5753. PMID: 32441341
Antenatal steroids and neonatal outcome after chorioamnionitis: a meta-analysis.
Been JV, Degraeuwe PL, Kramer BW, Zimmermann LJ
BJOG 2011 Jan;118(2):113-22. Epub 2010 Nov 4 doi: 10.1111/j.1471-0528.2010.02751.x. PMID: 21054759
Amnioinfusion for preterm rupture of membranes.
Hofmeyr GJ
Cochrane Database Syst Rev 2000;(2):CD000942. doi: 10.1002/14651858.CD000942. PMID: 10796224

Prognosis

Refractory uterine atony: still a problem after all these years.
Balki M, Wong CA
Int J Obstet Anesth 2021 Nov;48:103207. Epub 2021 Jul 21 doi: 10.1016/j.ijoa.2021.103207. PMID: 34391025
An elevated maternal serum C-reactive protein in the context of intra-amniotic inflammation is an indicator that the development of amnionitis, an intense fetal and AF inflammatory response are likely in patients with preterm labor: clinical implications.
Park CW, Yoon BH, Park JS, Jun JK
J Matern Fetal Neonatal Med 2013 Jun;26(9):847-53. doi: 10.3109/14767058.2013.783806. PMID: 23484918
The role of anaerobic bacteria in bacteremia.
Brook I
Anaerobe 2010 Jun;16(3):183-9. Epub 2009 Dec 16 doi: 10.1016/j.anaerobe.2009.12.001. PMID: 20025984
Streptococcus pneumoniae infections in the neonate.
Hoffman JA, Mason EO, Schutze GE, Tan TQ, Barson WJ, Givner LB, Wald ER, Bradley JS, Yogev R, Kaplan SL
Pediatrics 2003 Nov;112(5):1095-102. doi: 10.1542/peds.112.5.1095. PMID: 14595052
Fetal breathing movements within 24 hours of delivery in prematurity are related to histologic and clinical evidence of amnionitis.
Sherer DM, Spong CY, Salafia CM
Am J Perinatol 1997 Jul;14(6):337-40. doi: 10.1055/s-2007-994156. PMID: 9217954

Clinical prediction guides

Refractory uterine atony: still a problem after all these years.
Balki M, Wong CA
Int J Obstet Anesth 2021 Nov;48:103207. Epub 2021 Jul 21 doi: 10.1016/j.ijoa.2021.103207. PMID: 34391025
An elevated maternal serum C-reactive protein in the context of intra-amniotic inflammation is an indicator that the development of amnionitis, an intense fetal and AF inflammatory response are likely in patients with preterm labor: clinical implications.
Park CW, Yoon BH, Park JS, Jun JK
J Matern Fetal Neonatal Med 2013 Jun;26(9):847-53. doi: 10.3109/14767058.2013.783806. PMID: 23484918
Antenatal steroids and neonatal outcome after chorioamnionitis: a meta-analysis.
Been JV, Degraeuwe PL, Kramer BW, Zimmermann LJ
BJOG 2011 Jan;118(2):113-22. Epub 2010 Nov 4 doi: 10.1111/j.1471-0528.2010.02751.x. PMID: 21054759
Streptococcus pneumoniae infections in the neonate.
Hoffman JA, Mason EO, Schutze GE, Tan TQ, Barson WJ, Givner LB, Wald ER, Bradley JS, Yogev R, Kaplan SL
Pediatrics 2003 Nov;112(5):1095-102. doi: 10.1542/peds.112.5.1095. PMID: 14595052
Fetal breathing movements within 24 hours of delivery in prematurity are related to histologic and clinical evidence of amnionitis.
Sherer DM, Spong CY, Salafia CM
Am J Perinatol 1997 Jul;14(6):337-40. doi: 10.1055/s-2007-994156. PMID: 9217954

Recent systematic reviews

Prevalence of Urinary Tract Infection and Its Associated Factors among Pregnant Women in Ethiopia: A Systematic Review and Meta-Analysis.
Getaneh T, Negesse A, Dessie G, Desta M, Tigabu A
Biomed Res Int 2021;2021:6551526. Epub 2021 Dec 1 doi: 10.1155/2021/6551526. PMID: 34901276Free PMC Article
Antenatal steroids and neonatal outcome after chorioamnionitis: a meta-analysis.
Been JV, Degraeuwe PL, Kramer BW, Zimmermann LJ
BJOG 2011 Jan;118(2):113-22. Epub 2010 Nov 4 doi: 10.1111/j.1471-0528.2010.02751.x. PMID: 21054759
Amnioinfusion for preterm rupture of membranes.
Hofmeyr GJ
Cochrane Database Syst Rev 2000;(2):CD000942. doi: 10.1002/14651858.CD000942. PMID: 10796224
Amnioinfusion for umbilical cord compression in labour.
Hofmeyr GJ
Cochrane Database Syst Rev 2000;(2):CD000013. doi: 10.1002/14651858.CD000013. PMID: 10796084

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