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Atypical angina

MedGen UID:
149267
•Concept ID:
C0741026
•
Disease or Syndrome
Synonym: Atypical Angina
SNOMED CT: Atypical angina (371807002)

Definition

Angina pectoris which does not have associated classical symptoms of chest pain. Symptoms may include weakness, nausea, or sweating. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAtypical angina

Professional guidelines

PubMed

Time to standardize and broaden the criteria of acute coronary syndrome symptom presentations in women.
Canto JG, Canto EA, Goldberg RJ
Can J Cardiol 2014 Jul;30(7):721-8. Epub 2013 Oct 25 doi: 10.1016/j.cjca.2013.10.015. PMID: 24530216
The clinical utility of gene expression testing on the diagnostic evaluation of patients presenting to the cardiologist with symptoms of suspected obstructive coronary artery disease: results from the IMPACT (Investigation of a Molecular Personalized Coronary Gene Expression Test on Cardiology Practice Pattern) trial.
McPherson JA, Davis K, Yau M, Beineke P, Rosenberg S, Monane M, Fredi JL
Crit Pathw Cardiol 2013 Jun;12(2):37-42. doi: 10.1097/HPC.0b013e3182822bd0. PMID: 23680805
Stratification for noninvasive coronary angiography: patient preselection considering atypical angina pectoris, conventional cardiovascular risk assessment, and calcium scoring.
Langer C, Wiemer M, Peterschröder A, Franzke K, Mellwig KP, van Buuren F, Koester-Eiserfunke W, Butz T, Diekmann J, Horstkotte D
Eur J Cardiovasc Prev Rehabil 2009 Apr;16(2):201-9. doi: 10.1097/HJR.0b013e32832776de. PMID: 19305353

Recent clinical studies

Etiology

Effects of percutaneous coronary intervention on dyspnea in stable coronary artery disease.
Wester M, Koll F, Luedde M, Langer C, Resch M, Luchner A, Müller K, Zeman F, Koller M, Maier LS, Sossalla S
Clin Res Cardiol 2023 Sep;112(9):1194-1203. Epub 2022 Sep 13 doi: 10.1007/s00392-022-02107-x. PMID: 36100700Free PMC Article
Health-related qualify of life, angina type and coronary artery disease in patients with stable chest pain.
Rieckmann N, Neumann K, Feger S, Ibes P, Napp A, Preuß D, Dreger H, Feuchtner G, Plank F, Suchánek V, Veselka J, Engstrøm T, Kofoed KF, Schröder S, Zelesny T, Gutberlet M, Woinke M, Maurovich-Horvat P, Merkely B, Donnelly P, Ball P, Dodd JD, Hensey M, Loi B, Saba L, Francone M, Mancone M, Berzina M, Erglis A, Vaitiekiene A, Zajanckauskiene L, Harań T, Suckiel MI, Faria R, Gama-Ribeiro V, Benedek I, Rodean I, Adjić F, Čemerlić Adjić N, Rodriguez-Palomares J, Garcia Del Blanco B, Brooksbank K, Collison D, Davis G, Thwaite E, Knuuti J, Saraste A, Kępka C, Kruk M, Benedek T, Ratiu M, Neskovic AN, Vidakovic R, Diez I, Lecumberri I, Fisher M, Ruzsics B, Hollingworth W, Gutiérrez-Ibarluzea I, Dewey M, Müller-Nordhorn J
Health Qual Life Outcomes 2020 May 14;18(1):140. doi: 10.1186/s12955-020-01312-4. PMID: 32410687Free PMC Article
The importance of characteristics of angina symptoms for the prediction of coronary artery disease in a cohort of stable patients in the modern era.
Nakas G, Bechlioulis A, Marini A, Vakalis K, Bougiakli M, Giannitsi S, Nikolaou K, Antoniadou EI, Kotsia A, Gartzonika K, Chasiotis G, Bairaktari E, Katsouras CS, Triantis G, Sionis D, Michalis LK, Naka KK
Hellenic J Cardiol 2019 Jul-Aug;60(4):241-246. Epub 2018 Jun 8 doi: 10.1016/j.hjc.2018.06.003. PMID: 29890282
Typical angina is associated with greater coronary endothelial dysfunction but not abnormal vasodilatory reserve.
AlBadri A, Leong D, Bairey Merz CN, Wei J, Handberg EM, Shufelt CL, Mehta PK, Nelson MD, Thomson LE, Berman DS, Shaw LJ, Cook-Wiens G, Pepine CJ
Clin Cardiol 2017 Oct;40(10):886-891. Epub 2017 Jun 12 doi: 10.1002/clc.22740. PMID: 28605043Free PMC Article
Time to standardize and broaden the criteria of acute coronary syndrome symptom presentations in women.
Canto JG, Canto EA, Goldberg RJ
Can J Cardiol 2014 Jul;30(7):721-8. Epub 2013 Oct 25 doi: 10.1016/j.cjca.2013.10.015. PMID: 24530216

Diagnosis

Effects of percutaneous coronary intervention on dyspnea in stable coronary artery disease.
Wester M, Koll F, Luedde M, Langer C, Resch M, Luchner A, Müller K, Zeman F, Koller M, Maier LS, Sossalla S
Clin Res Cardiol 2023 Sep;112(9):1194-1203. Epub 2022 Sep 13 doi: 10.1007/s00392-022-02107-x. PMID: 36100700Free PMC Article
Sex differentiation with regard to coronary artery disease.
Papakonstantinou NA, Stamou MI, Baikoussis NG, Goudevenos J, Apostolakis E
J Cardiol 2013 Jul;62(1):4-11. Epub 2013 May 1 doi: 10.1016/j.jjcc.2013.03.001. PMID: 23642501
Atypical angina.
Gimeno JR, Iñigo LA, López-Palop R, Valdés Chavarri M
Lancet 2000 Jun 3;355(9219):1966. doi: 10.1016/s0140-6736(00)02329-1. PMID: 10859043
The diagnosis of nonanginal chest pain.
Constant J
Keio J Med 1990 Sep;39(3):187-92. doi: 10.2302/kjm.39.187. PMID: 2255129
Atypical angina.
Br Med J 1971 Jan 9;1(5740):62. PMID: 5539170Free PMC Article

Therapy

Effects of percutaneous coronary intervention on dyspnea in stable coronary artery disease.
Wester M, Koll F, Luedde M, Langer C, Resch M, Luchner A, Müller K, Zeman F, Koller M, Maier LS, Sossalla S
Clin Res Cardiol 2023 Sep;112(9):1194-1203. Epub 2022 Sep 13 doi: 10.1007/s00392-022-02107-x. PMID: 36100700Free PMC Article
Detection of relevant extracardiac findings on coronary computed tomography angiography vs. invasive coronary angiography.
Laskowski D, Feger S, Bosserdt M, Zimmermann E, Mohamed M, Kendziora B, Rief M, Dreger H, Estrella M, Dewey M
Eur Radiol 2022 Jan;32(1):122-131. Epub 2021 Jun 15 doi: 10.1007/s00330-021-07967-x. PMID: 34129067Free PMC Article
Health-related qualify of life, angina type and coronary artery disease in patients with stable chest pain.
Rieckmann N, Neumann K, Feger S, Ibes P, Napp A, Preuß D, Dreger H, Feuchtner G, Plank F, Suchánek V, Veselka J, Engstrøm T, Kofoed KF, Schröder S, Zelesny T, Gutberlet M, Woinke M, Maurovich-Horvat P, Merkely B, Donnelly P, Ball P, Dodd JD, Hensey M, Loi B, Saba L, Francone M, Mancone M, Berzina M, Erglis A, Vaitiekiene A, Zajanckauskiene L, Harań T, Suckiel MI, Faria R, Gama-Ribeiro V, Benedek I, Rodean I, Adjić F, Čemerlić Adjić N, Rodriguez-Palomares J, Garcia Del Blanco B, Brooksbank K, Collison D, Davis G, Thwaite E, Knuuti J, Saraste A, Kępka C, Kruk M, Benedek T, Ratiu M, Neskovic AN, Vidakovic R, Diez I, Lecumberri I, Fisher M, Ruzsics B, Hollingworth W, Gutiérrez-Ibarluzea I, Dewey M, Müller-Nordhorn J
Health Qual Life Outcomes 2020 May 14;18(1):140. doi: 10.1186/s12955-020-01312-4. PMID: 32410687Free PMC Article
Ranolazine Reduces Angina in Women with Ischemic Heart Disease: Results of an Open-Label, Multicenter Trial.
Mehta PK, Sharma S, Minissian M, Harsch MR, Martinson M, Nyman JA, Shaw LJ, Bairey Merz CN, Wenger NK
J Womens Health (Larchmt) 2019 May;28(5):573-582. Epub 2019 Mar 19 doi: 10.1089/jwh.2018.7019. PMID: 30888919Free PMC Article
Typical angina is associated with greater coronary endothelial dysfunction but not abnormal vasodilatory reserve.
AlBadri A, Leong D, Bairey Merz CN, Wei J, Handberg EM, Shufelt CL, Mehta PK, Nelson MD, Thomson LE, Berman DS, Shaw LJ, Cook-Wiens G, Pepine CJ
Clin Cardiol 2017 Oct;40(10):886-891. Epub 2017 Jun 12 doi: 10.1002/clc.22740. PMID: 28605043Free PMC Article

Prognosis

Effects of percutaneous coronary intervention on dyspnea in stable coronary artery disease.
Wester M, Koll F, Luedde M, Langer C, Resch M, Luchner A, Müller K, Zeman F, Koller M, Maier LS, Sossalla S
Clin Res Cardiol 2023 Sep;112(9):1194-1203. Epub 2022 Sep 13 doi: 10.1007/s00392-022-02107-x. PMID: 36100700Free PMC Article
Typical angina is associated with greater coronary endothelial dysfunction but not abnormal vasodilatory reserve.
AlBadri A, Leong D, Bairey Merz CN, Wei J, Handberg EM, Shufelt CL, Mehta PK, Nelson MD, Thomson LE, Berman DS, Shaw LJ, Cook-Wiens G, Pepine CJ
Clin Cardiol 2017 Oct;40(10):886-891. Epub 2017 Jun 12 doi: 10.1002/clc.22740. PMID: 28605043Free PMC Article
Sex differentiation with regard to coronary artery disease.
Papakonstantinou NA, Stamou MI, Baikoussis NG, Goudevenos J, Apostolakis E
J Cardiol 2013 Jul;62(1):4-11. Epub 2013 May 1 doi: 10.1016/j.jjcc.2013.03.001. PMID: 23642501
Mitral valve prolapse, panic disorder, and chest pain.
Alpert MA, Mukerji V, Sabeti M, Russell JL, Beitman BD
Med Clin North Am 1991 Sep;75(5):1119-33. doi: 10.1016/s0025-7125(16)30402-3. PMID: 1895809
Panic disorder in cardiology patients.
Beitman BD, Mukerji V, Alpert M, Peters JC
Psychiatr Med 1990;8(2):67-81. PMID: 2185503

Clinical prediction guides

Effects of percutaneous coronary intervention on dyspnea in stable coronary artery disease.
Wester M, Koll F, Luedde M, Langer C, Resch M, Luchner A, Müller K, Zeman F, Koller M, Maier LS, Sossalla S
Clin Res Cardiol 2023 Sep;112(9):1194-1203. Epub 2022 Sep 13 doi: 10.1007/s00392-022-02107-x. PMID: 36100700Free PMC Article
Detection of relevant extracardiac findings on coronary computed tomography angiography vs. invasive coronary angiography.
Laskowski D, Feger S, Bosserdt M, Zimmermann E, Mohamed M, Kendziora B, Rief M, Dreger H, Estrella M, Dewey M
Eur Radiol 2022 Jan;32(1):122-131. Epub 2021 Jun 15 doi: 10.1007/s00330-021-07967-x. PMID: 34129067Free PMC Article
Ranolazine Reduces Angina in Women with Ischemic Heart Disease: Results of an Open-Label, Multicenter Trial.
Mehta PK, Sharma S, Minissian M, Harsch MR, Martinson M, Nyman JA, Shaw LJ, Bairey Merz CN, Wenger NK
J Womens Health (Larchmt) 2019 May;28(5):573-582. Epub 2019 Mar 19 doi: 10.1089/jwh.2018.7019. PMID: 30888919Free PMC Article
The importance of characteristics of angina symptoms for the prediction of coronary artery disease in a cohort of stable patients in the modern era.
Nakas G, Bechlioulis A, Marini A, Vakalis K, Bougiakli M, Giannitsi S, Nikolaou K, Antoniadou EI, Kotsia A, Gartzonika K, Chasiotis G, Bairaktari E, Katsouras CS, Triantis G, Sionis D, Michalis LK, Naka KK
Hellenic J Cardiol 2019 Jul-Aug;60(4):241-246. Epub 2018 Jun 8 doi: 10.1016/j.hjc.2018.06.003. PMID: 29890282
Mitral valve prolapse, panic disorder, and chest pain.
Alpert MA, Mukerji V, Sabeti M, Russell JL, Beitman BD
Med Clin North Am 1991 Sep;75(5):1119-33. doi: 10.1016/s0025-7125(16)30402-3. PMID: 1895809

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