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Skin hemangioma

MedGen UID:
151951
•Concept ID:
C0687140
•
Neoplastic Process
Synonyms: Angioma of Skin; angioma of skin; Angioma of the Skin; angioma of the skin; angiomatous naevus of skin; Hemangioma of skin; Hemangioma of Skin; hemangioma of skin; Hemangioma of the Skin; hemangioma of the skin; hemangioma of zone of skin; Skin Angioma; skin angioma; Skin Hemangioma; skin hemangioma; zone of skin hemangioma
SNOMED CT: Hemangioma of skin (93471006)
 
Monarch Initiative: MONDO:0003110

Definition

A hemangioma arising from the skin. [from NCI]

Professional guidelines

PubMed

Radium treatment for hemangioma in early childhood. Reconstruction and dosimetry of treatments, 1920-1959.
Lundell M, Fürst CJ, Hedlund B, Holm LE
Acta Oncol 1990;29(5):551-6. doi: 10.3109/02841869009090049. PMID: 2206564

Recent clinical studies

Etiology

Radiation-induced genomic instability in breast carcinomas of the Swedish hemangioma cohort.
Biermann J, Langen B, Nemes S, Holmberg E, Parris TZ, Werner Rönnerman E, Engqvist H, Kovács A, Helou K, Karlsson P
Genes Chromosomes Cancer 2019 Sep;58(9):627-635. Epub 2019 Apr 12 doi: 10.1002/gcc.22757. PMID: 30938900
Continuous low-dose-rate radiation of radionuclide phosphorus-32 for hemangiomas.
Shi CB, Yuan B, Lu JR, Xu JL, Yang WD, Deng JL, Wang J
Cancer Biother Radiopharm 2012 Apr;27(3):198-203. Epub 2012 Feb 24 doi: 10.1089/cbr.2011.0995. PMID: 22364418
Radiotherapy as a risk factor for malignant melanoma after childhood skin hemangioma.
Haddy N, Mousannif A, Paoletti C, Dondon MG, Shamsaldin A, Doyon F, Avril MF, Fragu P, Labbé M, Lefkopoulos D, Chavaudra J, Robert C, Diallo I, de Vathaire F
Melanoma Res 2012 Feb;22(1):77-85. doi: 10.1097/CMR.0b013e32834dcff1. PMID: 22082956
Breast cancer following radiotherapy for a hemangioma during childhood.
Haddy N, Dondon MG, Paoletti C, Rubino C, Mousannif A, Shamsaldin A, Doyon F, Labbé M, Robert C, Avril MF, Demars R, Molinie F, Lefkopoulos D, Diallo I, de Vathaire F
Cancer Causes Control 2010 Nov;21(11):1807-16. Epub 2010 Jul 7 doi: 10.1007/s10552-010-9607-5. PMID: 20607383
Thyroid adenomas and carcinomas following radiotherapy for a hemangioma during infancy.
Haddy N, Andriamboavonjy T, Paoletti C, Dondon MG, Mousannif A, Shamsaldin A, Doyon F, Labbé M, Robert C, Avril MF, Fragu P, Eschwege F, Chavaudra J, Schvartz C, Lefkopoulos D, Schlumberger M, Diallo I, de Vathaire F
Radiother Oncol 2009 Nov;93(2):377-82. Epub 2009 Jun 8 doi: 10.1016/j.radonc.2009.05.011. PMID: 19515442

Diagnosis

Radiotherapy as a risk factor for malignant melanoma after childhood skin hemangioma.
Haddy N, Mousannif A, Paoletti C, Dondon MG, Shamsaldin A, Doyon F, Avril MF, Fragu P, Labbé M, Lefkopoulos D, Chavaudra J, Robert C, Diallo I, de Vathaire F
Melanoma Res 2012 Feb;22(1):77-85. doi: 10.1097/CMR.0b013e32834dcff1. PMID: 22082956
The impact of reproductive factors on breast cancer risk--the feasibility of using Swedish population-based registers to account for the effect of confounding in cohort studies.
Holmberg E, Anderson H, Lundell M, Karlsson P
Cancer Causes Control 2005 Apr;16(3):235-43. doi: 10.1007/s10552-004-3363-3. PMID: 15947875
Hepatic hemangioendothelioma in children: analysis of thirteen cases.
Chen CC, Kong MS, Yang CP, Hung IJ
Acta Paediatr Taiwan 2003 Jan-Feb;44(1):8-13. PMID: 12800377
Breast cancer risk after radiotherapy in infancy: a pooled analysis of two Swedish cohorts of 17,202 infants.
Lundell M, Mattsson A, Karlsson P, Holmberg E, Gustafsson A, Holm LE
Radiat Res 1999 May;151(5):626-32. PMID: 10319736
Intracranial tumors after radium treatment for skin hemangioma during infancy--a cohort and case-control study.
Karlsson P, Holmberg E, Lundberg LM, Nordborg C, Wallgren A
Radiat Res 1997 Aug;148(2):161-7. PMID: 9254735

Therapy

Radiation-induced genomic instability in breast carcinomas of the Swedish hemangioma cohort.
Biermann J, Langen B, Nemes S, Holmberg E, Parris TZ, Werner Rönnerman E, Engqvist H, Kovács A, Helou K, Karlsson P
Genes Chromosomes Cancer 2019 Sep;58(9):627-635. Epub 2019 Apr 12 doi: 10.1002/gcc.22757. PMID: 30938900
The expression and function of miR-424 in infantile skin hemangioma and its mechanism.
Yang L, Dai J, Li F, Cheng H, Yan D, Ruan Q
Sci Rep 2017 Sep 19;7(1):11846. doi: 10.1038/s41598-017-10674-7. PMID: 28928430Free PMC Article
Radiotherapy as a risk factor for malignant melanoma after childhood skin hemangioma.
Haddy N, Mousannif A, Paoletti C, Dondon MG, Shamsaldin A, Doyon F, Avril MF, Fragu P, Labbé M, Lefkopoulos D, Chavaudra J, Robert C, Diallo I, de Vathaire F
Melanoma Res 2012 Feb;22(1):77-85. doi: 10.1097/CMR.0b013e32834dcff1. PMID: 22082956
Breast cancer following radiotherapy for a hemangioma during childhood.
Haddy N, Dondon MG, Paoletti C, Rubino C, Mousannif A, Shamsaldin A, Doyon F, Labbé M, Robert C, Avril MF, Demars R, Molinie F, Lefkopoulos D, Diallo I, de Vathaire F
Cancer Causes Control 2010 Nov;21(11):1807-16. Epub 2010 Jul 7 doi: 10.1007/s10552-010-9607-5. PMID: 20607383
Thyroid adenomas and carcinomas following radiotherapy for a hemangioma during infancy.
Haddy N, Andriamboavonjy T, Paoletti C, Dondon MG, Mousannif A, Shamsaldin A, Doyon F, Labbé M, Robert C, Avril MF, Fragu P, Eschwege F, Chavaudra J, Schvartz C, Lefkopoulos D, Schlumberger M, Diallo I, de Vathaire F
Radiother Oncol 2009 Nov;93(2):377-82. Epub 2009 Jun 8 doi: 10.1016/j.radonc.2009.05.011. PMID: 19515442

Prognosis

Activation of Hedgehog Signaling in Aggressive Hepatic Hemangioma in Newborns and Infants.
Wendling-Keim D, Vokuhl C, Walz C, Rieder L, Grantzow R, VON Schweinitz D, Kappler R, Berger M
Anticancer Res 2019 May;39(5):2351-2360. doi: 10.21873/anticanres.13352. PMID: 31092427
Radiation-induced genomic instability in breast carcinomas of the Swedish hemangioma cohort.
Biermann J, Langen B, Nemes S, Holmberg E, Parris TZ, Werner Rönnerman E, Engqvist H, Kovács A, Helou K, Karlsson P
Genes Chromosomes Cancer 2019 Sep;58(9):627-635. Epub 2019 Apr 12 doi: 10.1002/gcc.22757. PMID: 30938900
Continuous low-dose-rate radiation of radionuclide phosphorus-32 for hemangiomas.
Shi CB, Yuan B, Lu JR, Xu JL, Yang WD, Deng JL, Wang J
Cancer Biother Radiopharm 2012 Apr;27(3):198-203. Epub 2012 Feb 24 doi: 10.1089/cbr.2011.0995. PMID: 22364418
Breast cancer following radiotherapy for a hemangioma during childhood.
Haddy N, Dondon MG, Paoletti C, Rubino C, Mousannif A, Shamsaldin A, Doyon F, Labbé M, Robert C, Avril MF, Demars R, Molinie F, Lefkopoulos D, Diallo I, de Vathaire F
Cancer Causes Control 2010 Nov;21(11):1807-16. Epub 2010 Jul 7 doi: 10.1007/s10552-010-9607-5. PMID: 20607383
Cancer mortality after radiotherapy for a skin hemangioma during childhood.
Dondon MG, de Vathaire F, Shamsaldin A, Doyon F, Diallo I, Ligot L, Paoletti C, Labbé M, Abbas M, Chavaudra J, Avril MF, Fragu P, Eschwège F
Radiother Oncol 2004 Jul;72(1):87-93. doi: 10.1016/j.radonc.2004.03.011. PMID: 15236880

Clinical prediction guides

Radiation-induced genomic instability in breast carcinomas of the Swedish hemangioma cohort.
Biermann J, Langen B, Nemes S, Holmberg E, Parris TZ, Werner Rönnerman E, Engqvist H, Kovács A, Helou K, Karlsson P
Genes Chromosomes Cancer 2019 Sep;58(9):627-635. Epub 2019 Apr 12 doi: 10.1002/gcc.22757. PMID: 30938900
Retrospective cohort study and biobanking of patients treated for hemangioma in childhood - telomeres as biomarker of aging and radiation exposure.
Frenzel M, Ricoul M, Benadjaoud MA, Bellamy M, Lenain A, Haddy N, Diallo I, Mateus C, de Vathaire F, Sabatier L
Int J Radiat Biol 2017 Oct;93(10):1040-1053. Epub 2017 Jun 26 doi: 10.1080/09553002.2017.1337278. PMID: 28649877
Radiotherapy as a risk factor for malignant melanoma after childhood skin hemangioma.
Haddy N, Mousannif A, Paoletti C, Dondon MG, Shamsaldin A, Doyon F, Avril MF, Fragu P, Labbé M, Lefkopoulos D, Chavaudra J, Robert C, Diallo I, de Vathaire F
Melanoma Res 2012 Feb;22(1):77-85. doi: 10.1097/CMR.0b013e32834dcff1. PMID: 22082956
Cancer mortality after radiotherapy for a skin hemangioma during childhood.
Dondon MG, de Vathaire F, Shamsaldin A, Doyon F, Diallo I, Ligot L, Paoletti C, Labbé M, Abbas M, Chavaudra J, Avril MF, Fragu P, Eschwège F
Radiother Oncol 2004 Jul;72(1):87-93. doi: 10.1016/j.radonc.2004.03.011. PMID: 15236880
Cancer incidence after radiotherapy for skin hemangioma: a retrospective cohort study in Sweden.
Fürst CJ, Lundell M, Holm LE, Silfverswärd C
J Natl Cancer Inst 1988 Nov 2;80(17):1387-92. doi: 10.1093/jnci/80.17.1387. PMID: 3172265

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