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Cardiomegaly due to hypertension

MedGen UID:
151958
Concept ID:
C0694541
Disease or Syndrome
Synonyms: Hypertensive cardiomegaly; Hypertensive Cardiomegaly
SNOMED CT: Cardiomegaly due to hypertension (275516004); Hypertensive cardiomegaly (275516004)

Definition

Abnormal enlargement of the heart resulting from long-standing hypertension. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCardiomegaly due to hypertension

Professional guidelines

PubMed

Escobar-Lopez L, Ochoa JP, Royuela A, Verdonschot JAJ, Dal Ferro M, Espinosa MA, Sabater-Molina M, Gallego-Delgado M, Larrañaga-Moreira JM, Garcia-Pinilla JM, Basurte-Elorz MT, Rodríguez-Palomares JF, Climent V, Bermudez-Jimenez FJ, Mogollón-Jiménez MV, Lopez J, Peña-Peña ML, Garcia-Alvarez A, López-Abel B, Ripoll-Vera T, Palomino-Doza J, Bayes-Genis A, Brugada R, Idiazabal U, Mirelis JG, Dominguez F, Henkens MTHM, Krapels IPC, Brunner HG, Paldino A, Zaffalon D, Mestroni L, Sinagra G, Heymans SRB, Merlo M, Garcia-Pavia P
J Am Coll Cardiol 2022 Sep 20;80(12):1115-1126. doi: 10.1016/j.jacc.2022.06.040. PMID: 36109106Free PMC Article
Tanaka H
J Echocardiogr 2021 Jun;19(2):71-79. Epub 2021 Jan 18 doi: 10.1007/s12574-020-00508-3. PMID: 33460030Free PMC Article
Rabi DM, McBrien KA, Sapir-Pichhadze R, Nakhla M, Ahmed SB, Dumanski SM, Butalia S, Leung AA, Harris KC, Cloutier L, Zarnke KB, Ruzicka M, Hiremath S, Feldman RD, Tobe SW, Campbell TS, Bacon SL, Nerenberg KA, Dresser GK, Fournier A, Burgess E, Lindsay P, Rabkin SW, Prebtani APH, Grover S, Honos G, Alfonsi JE, Arcand J, Audibert F, Benoit G, Bittman J, Bolli P, Côté AM, Dionne J, Don-Wauchope A, Edwards C, Firoz T, Gabor JY, Gilbert RE, Grégoire JC, Gryn SE, Gupta M, Hannah-Shmouni F, Hegele RA, Herman RJ, Hill MD, Howlett JG, Hundemer GL, Jones C, Kaczorowski J, Khan NA, Kuyper LM, Lamarre-Cliche M, Lavoie KL, Leiter LA, Lewanczuk R, Logan AG, Magee LA, Mangat BK, McFarlane PA, McLean D, Michaud A, Milot A, Moe GW, Penner SB, Pipe A, Poppe AY, Rey E, Roerecke M, Schiffrin EL, Selby P, Sharma M, Shoamanesh A, Sivapalan P, Townsend RR, Tran K, Trudeau L, Tsuyuki RT, Vallée M, Woo V, Bell AD, Daskalopoulou SS
Can J Cardiol 2020 May;36(5):596-624. doi: 10.1016/j.cjca.2020.02.086. PMID: 32389335

Recent clinical studies

Etiology

Jia XY, Jiang DL, Jia XT, Fu LY, Tian H, Liu KL, Qi J, Kang YM, Yu XJ
Phytomedicine 2023 Sep;118:154951. Epub 2023 Jul 7 doi: 10.1016/j.phymed.2023.154951. PMID: 37453193
Elghazaly H, McCracken C, Szabo L, Malcolmson J, Manisty CH, Davies AH, Piechnik SK, Harvey NC, Neubauer S, Mohiddin SA, Petersen SE, Raisi-Estabragh Z
Eur Heart J Cardiovasc Imaging 2023 Sep 26;24(10):1352-1360. doi: 10.1093/ehjci/jead123. PMID: 37309807Free PMC Article
Nadruz W
J Hum Hypertens 2015 Jan;29(1):1-6. Epub 2014 May 8 doi: 10.1038/jhh.2014.36. PMID: 24804791
Diamond JA, Phillips RA
Hypertens Res 2005 Mar;28(3):191-202. doi: 10.1291/hypres.28.191. PMID: 16097361
Head GA
Clin Exp Pharmacol Physiol 1994 Oct;21(10):791-802. doi: 10.1111/j.1440-1681.1994.tb02448.x. PMID: 7867230

Diagnosis

Elghazaly H, McCracken C, Szabo L, Malcolmson J, Manisty CH, Davies AH, Piechnik SK, Harvey NC, Neubauer S, Mohiddin SA, Petersen SE, Raisi-Estabragh Z
Eur Heart J Cardiovasc Imaging 2023 Sep 26;24(10):1352-1360. doi: 10.1093/ehjci/jead123. PMID: 37309807Free PMC Article
Tadic M, Cuspidi C, Marwick TH
Eur Heart J 2022 Oct 11;43(38):3794-3810. doi: 10.1093/eurheartj/ehac393. PMID: 35869979
Shenasa M, Shenasa H
Int J Cardiol 2017 Jun 15;237:60-63. Epub 2017 Mar 3 doi: 10.1016/j.ijcard.2017.03.002. PMID: 28285801
Nadruz W
J Hum Hypertens 2015 Jan;29(1):1-6. Epub 2014 May 8 doi: 10.1038/jhh.2014.36. PMID: 24804791
Head GA
Clin Exp Pharmacol Physiol 1994 Oct;21(10):791-802. doi: 10.1111/j.1440-1681.1994.tb02448.x. PMID: 7867230

Therapy

Cuspidi C, Gherbesi E, Sala C, Tadic M
J Hum Hypertens 2023 Aug;37(8):626-633. Epub 2022 Aug 27 doi: 10.1038/s41371-022-00750-5. PMID: 36030347
Leache L, Gutiérrez-Valencia M, Finizola RM, Infante E, Finizola B, Pardo Pardo J, Flores Y, Granero R, Arai KJ
Cochrane Database Syst Rev 2021 Oct 10;10(10):CD012039. doi: 10.1002/14651858.CD012039.pub3. PMID: 34628642Free PMC Article
Cruickshank JM
Indian Heart J 2010 Mar-Apr;62(2):101-10. PMID: 21180298
Diamond JA, Phillips RA
Hypertens Res 2005 Mar;28(3):191-202. doi: 10.1291/hypres.28.191. PMID: 16097361
Thakur V, Richards R, Reisin E
Am J Med Sci 2001 Apr;321(4):242-8. doi: 10.1097/00000441-200104000-00005. PMID: 11307866

Prognosis

Popiołek L, Siga O, Dzieża-Grudnik A, Popiołek I, Moląg M, Królczyk J, Grodzicki T, Walczewska J, Rutkowski K
Psychiatr Pol 2019 Oct 30;53(5):1003-1020. doi: 10.12740/PP/108453. PMID: 31955182
Shenasa M, Shenasa H
Int J Cardiol 2017 Jun 15;237:60-63. Epub 2017 Mar 3 doi: 10.1016/j.ijcard.2017.03.002. PMID: 28285801
Nadruz W
J Hum Hypertens 2015 Jan;29(1):1-6. Epub 2014 May 8 doi: 10.1038/jhh.2014.36. PMID: 24804791
Bobrie G, Clerson P, Ménard J, Postel-Vinay N, Chatellier G, Plouin PF
J Hypertens 2008 Sep;26(9):1715-25. doi: 10.1097/HJH.0b013e3282fbcedf. PMID: 18698202
Verdecchia P, Schillaci G, Porcellati C
J Hypertens Suppl 1991 Dec;9(8):S42-4. PMID: 1839037

Clinical prediction guides

Shenasa M, Shenasa H
Int J Cardiol 2017 Jun 15;237:60-63. Epub 2017 Mar 3 doi: 10.1016/j.ijcard.2017.03.002. PMID: 28285801
Nadruz W
J Hum Hypertens 2015 Jan;29(1):1-6. Epub 2014 May 8 doi: 10.1038/jhh.2014.36. PMID: 24804791
Okeahialam B, Ohihoin E, Ajuluchukwu J
Ther Adv Cardiovasc Dis 2011 Apr;5(2):113-8. Epub 2011 Mar 7 doi: 10.1177/1753944711402119. PMID: 21383004
Head GA
Clin Exp Pharmacol Physiol 1994 Oct;21(10):791-802. doi: 10.1111/j.1440-1681.1994.tb02448.x. PMID: 7867230
Fogari R, Zoppi A
Am J Hypertens 1989 Feb;2(2 Pt 2):16S-23S. doi: 10.1093/ajh/2.2.16s. PMID: 2522004

Recent systematic reviews

Chung J, Robinson C, Sheffield L, Paramanathan P, Yu A, Ewusie J, Sanger S, Mitsnefes M, Parekh RS, Sinha MD, Rodrigues M, Thabane L, Dionne J, Chanchlani R
Hypertension 2023 Nov;80(11):2280-2292. Epub 2023 Sep 22 doi: 10.1161/HYPERTENSIONAHA.123.20967. PMID: 37737026
Goulas I, Evripidou K, Doundoulakis I, Kollios K, Nika T, Chainoglou A, Kotsis V, Stabouli S
J Hypertens 2023 May 1;41(5):699-707. Epub 2023 Mar 1 doi: 10.1097/HJH.0000000000003402. PMID: 36883474
Leache L, Gutiérrez-Valencia M, Finizola RM, Infante E, Finizola B, Pardo Pardo J, Flores Y, Granero R, Arai KJ
Cochrane Database Syst Rev 2021 Oct 10;10(10):CD012039. doi: 10.1002/14651858.CD012039.pub3. PMID: 34628642Free PMC Article
Berge HM, Isern CB, Berge E
Br J Sports Med 2015 Jun;49(11):716-23. Epub 2015 Jan 28 doi: 10.1136/bjsports-2014-093976. PMID: 25631543
Bobrie G, Clerson P, Ménard J, Postel-Vinay N, Chatellier G, Plouin PF
J Hypertens 2008 Sep;26(9):1715-25. doi: 10.1097/HJH.0b013e3282fbcedf. PMID: 18698202

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