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Cardiomegaly due to hypertension

MedGen UID:
151958
•Concept ID:
C0694541
•
Disease or Syndrome
Synonyms: Hypertensive cardiomegaly; Hypertensive Cardiomegaly
SNOMED CT: Cardiomegaly due to hypertension (275516004); Hypertensive cardiomegaly (275516004)

Definition

Abnormal enlargement of the heart resulting from long-standing hypertension. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCardiomegaly due to hypertension

Professional guidelines

PubMed

Clinical Risk Score to Predict Pathogenic Genotypes in Patients With Dilated Cardiomyopathy.
Escobar-Lopez L, Ochoa JP, Royuela A, Verdonschot JAJ, Dal Ferro M, Espinosa MA, Sabater-Molina M, Gallego-Delgado M, Larrañaga-Moreira JM, Garcia-Pinilla JM, Basurte-Elorz MT, Rodríguez-Palomares JF, Climent V, Bermudez-Jimenez FJ, Mogollón-Jiménez MV, Lopez J, Peña-Peña ML, Garcia-Alvarez A, López-Abel B, Ripoll-Vera T, Palomino-Doza J, Bayes-Genis A, Brugada R, Idiazabal U, Mirelis JG, Dominguez F, Henkens MTHM, Krapels IPC, Brunner HG, Paldino A, Zaffalon D, Mestroni L, Sinagra G, Heymans SRB, Merlo M, Garcia-Pavia P
J Am Coll Cardiol 2022 Sep 20;80(12):1115-1126. doi: 10.1016/j.jacc.2022.06.040. PMID: 36109106Free PMC Article
Efficacy of echocardiography for differential diagnosis of left ventricular hypertrophy: special focus on speckle-tracking longitudinal strain.
Tanaka H
J Echocardiogr 2021 Jun;19(2):71-79. Epub 2021 Jan 18 doi: 10.1007/s12574-020-00508-3. PMID: 33460030Free PMC Article
Hypertension Canada's 2020 Comprehensive Guidelines for the Prevention, Diagnosis, Risk Assessment, and Treatment of Hypertension in Adults and Children.
Rabi DM, McBrien KA, Sapir-Pichhadze R, Nakhla M, Ahmed SB, Dumanski SM, Butalia S, Leung AA, Harris KC, Cloutier L, Zarnke KB, Ruzicka M, Hiremath S, Feldman RD, Tobe SW, Campbell TS, Bacon SL, Nerenberg KA, Dresser GK, Fournier A, Burgess E, Lindsay P, Rabkin SW, Prebtani APH, Grover S, Honos G, Alfonsi JE, Arcand J, Audibert F, Benoit G, Bittman J, Bolli P, Côté AM, Dionne J, Don-Wauchope A, Edwards C, Firoz T, Gabor JY, Gilbert RE, Grégoire JC, Gryn SE, Gupta M, Hannah-Shmouni F, Hegele RA, Herman RJ, Hill MD, Howlett JG, Hundemer GL, Jones C, Kaczorowski J, Khan NA, Kuyper LM, Lamarre-Cliche M, Lavoie KL, Leiter LA, Lewanczuk R, Logan AG, Magee LA, Mangat BK, McFarlane PA, McLean D, Michaud A, Milot A, Moe GW, Penner SB, Pipe A, Poppe AY, Rey E, Roerecke M, Schiffrin EL, Selby P, Sharma M, Shoamanesh A, Sivapalan P, Townsend RR, Tran K, Trudeau L, Tsuyuki RT, Vallée M, Woo V, Bell AD, Daskalopoulou SS
Can J Cardiol 2020 May;36(5):596-624. doi: 10.1016/j.cjca.2020.02.086. PMID: 32389335

Recent clinical studies

Etiology

Myocardial remodeling in hypertension.
Nadruz W
J Hum Hypertens 2015 Jan;29(1):1-6. Epub 2014 May 8 doi: 10.1038/jhh.2014.36. PMID: 24804791
Three 4-letter words of hypertension-related cardiac hypertrophy: TRPC, mTOR, and HDAC.
Kurdi M, Booz GW
J Mol Cell Cardiol 2011 Jun;50(6):964-71. Epub 2011 Feb 19 doi: 10.1016/j.yjmcc.2011.02.004. PMID: 21320507Free PMC Article
Hypertensive heart disease.
Diamond JA, Phillips RA
Hypertens Res 2005 Mar;28(3):191-202. doi: 10.1291/hypres.28.191. PMID: 16097361
Cardiac baroreflexes and hypertension.
Head GA
Clin Exp Pharmacol Physiol 1994 Oct;21(10):791-802. doi: 10.1111/j.1440-1681.1994.tb02448.x. PMID: 7867230
Heart and hypertension.
Fogari R, Zoppi A
Am J Hypertens 1989 Feb;2(2 Pt 2):16S-23S. doi: 10.1093/ajh/2.2.16s. PMID: 2522004

Diagnosis

MEF2 in cardiac hypertrophy in response to hypertension.
Cornwell JD, McDermott JC
Trends Cardiovasc Med 2023 May;33(4):204-212. Epub 2022 Jan 11 doi: 10.1016/j.tcm.2022.01.002. PMID: 35026393
Phenotyping the hypertensive heart.
Tadic M, Cuspidi C, Marwick TH
Eur Heart J 2022 Oct 11;43(38):3794-3810. doi: 10.1093/eurheartj/ehac393. PMID: 35869979
Personality traits and hypertension-mediated organ damage.
Popiołek L, Siga O, Dzieża-Grudnik A, Popiołek I, Moląg M, Królczyk J, Grodzicki T, Walczewska J, Rutkowski K
Psychiatr Pol 2019 Oct 30;53(5):1003-1020. doi: 10.12740/PP/108453. PMID: 31955182
Hypertension, left ventricular hypertrophy, and sudden cardiac death.
Shenasa M, Shenasa H
Int J Cardiol 2017 Jun 15;237:60-63. Epub 2017 Mar 3 doi: 10.1016/j.ijcard.2017.03.002. PMID: 28285801
Myocardial remodeling in hypertension.
Nadruz W
J Hum Hypertens 2015 Jan;29(1):1-6. Epub 2014 May 8 doi: 10.1038/jhh.2014.36. PMID: 24804791

Therapy

Pharmacotherapy for hypertension-induced left ventricular hypertrophy.
Leache L, Gutiérrez-Valencia M, Finizola RM, Infante E, Finizola B, Pardo Pardo J, Flores Y, Granero R, Arai KJ
Cochrane Database Syst Rev 2021 Oct 10;10(10):CD012039. doi: 10.1002/14651858.CD012039.pub3. PMID: 34628642Free PMC Article
Is Left Ventricular Hypertrophy a Valid Therapeutic Target?
Brooks JE, Soliman EZ, Upadhya B
Curr Hypertens Rep 2019 May 20;21(6):47. doi: 10.1007/s11906-019-0952-9. PMID: 31111289
Mineralocorticoid antagonism and cardiac hypertrophy.
Nagata K
Curr Hypertens Rep 2008 Jun;10(3):216-21. doi: 10.1007/s11906-008-0041-y. PMID: 18765093
Hypertensive heart disease.
Diamond JA, Phillips RA
Hypertens Res 2005 Mar;28(3):191-202. doi: 10.1291/hypres.28.191. PMID: 16097361
Obesity, hypertension, and the heart.
Thakur V, Richards R, Reisin E
Am J Med Sci 2001 Apr;321(4):242-8. doi: 10.1097/00000441-200104000-00005. PMID: 11307866

Prognosis

Level of Physical Activity, Left Ventricular Mass, Hypertension, and Prognosis.
Joseph G, Marott JL, Biering-Sørensen T, Johansen MN, Saevereid HA, Nielsen G, Schnohr P, Prescott E, Søgaard P, Mogelvang R
Hypertension 2020 Mar;75(3):693-701. Epub 2019 Dec 30 doi: 10.1161/HYPERTENSIONAHA.119.14287. PMID: 31884852
Personality traits and hypertension-mediated organ damage.
Popiołek L, Siga O, Dzieża-Grudnik A, Popiołek I, Moląg M, Królczyk J, Grodzicki T, Walczewska J, Rutkowski K
Psychiatr Pol 2019 Oct 30;53(5):1003-1020. doi: 10.12740/PP/108453. PMID: 31955182
Hypertension, left ventricular hypertrophy, and sudden cardiac death.
Shenasa M, Shenasa H
Int J Cardiol 2017 Jun 15;237:60-63. Epub 2017 Mar 3 doi: 10.1016/j.ijcard.2017.03.002. PMID: 28285801
Myocardial remodeling in hypertension.
Nadruz W
J Hum Hypertens 2015 Jan;29(1):1-6. Epub 2014 May 8 doi: 10.1038/jhh.2014.36. PMID: 24804791
Hypertension and the heart.
Susic D, Frohlich ED
Curr Hypertens Rep 2000 Dec;2(6):565-9. doi: 10.1007/s11906-996-0042-7. PMID: 11062603

Clinical prediction guides

Hypertension, left ventricular hypertrophy, and sudden cardiac death.
Shenasa M, Shenasa H
Int J Cardiol 2017 Jun 15;237:60-63. Epub 2017 Mar 3 doi: 10.1016/j.ijcard.2017.03.002. PMID: 28285801
The role of echocardiography in the evaluation of cardiac damage in hypertensive obese patient.
Crea P, Zito C, Cusmà Piccione M, Arcidiaco S, Todaro MC, Oreto L, Navarra G, Carerj S
High Blood Press Cardiovasc Prev 2015 Mar;22(1):23-7. Epub 2014 May 21 doi: 10.1007/s40292-014-0058-z. PMID: 24844198
Myocardial remodeling in hypertension.
Nadruz W
J Hum Hypertens 2015 Jan;29(1):1-6. Epub 2014 May 8 doi: 10.1038/jhh.2014.36. PMID: 24804791
Cardiac baroreflexes and hypertension.
Head GA
Clin Exp Pharmacol Physiol 1994 Oct;21(10):791-802. doi: 10.1111/j.1440-1681.1994.tb02448.x. PMID: 7867230
Heart and hypertension.
Fogari R, Zoppi A
Am J Hypertens 1989 Feb;2(2 Pt 2):16S-23S. doi: 10.1093/ajh/2.2.16s. PMID: 2522004

Recent systematic reviews

Prevalence of Pediatric Masked Hypertension and Risk of Subclinical Cardiovascular Outcomes: A Systematic Review and Meta-Analysis.
Chung J, Robinson C, Sheffield L, Paramanathan P, Yu A, Ewusie J, Sanger S, Mitsnefes M, Parekh RS, Sinha MD, Rodrigues M, Thabane L, Dionne J, Chanchlani R
Hypertension 2023 Nov;80(11):2280-2292. Epub 2023 Sep 22 doi: 10.1161/HYPERTENSIONAHA.123.20967. PMID: 37737026
Pharmacotherapy for hypertension-induced left ventricular hypertrophy.
Leache L, Gutiérrez-Valencia M, Finizola RM, Infante E, Finizola B, Pardo Pardo J, Flores Y, Granero R, Arai KJ
Cochrane Database Syst Rev 2021 Oct 10;10(10):CD012039. doi: 10.1002/14651858.CD012039.pub3. PMID: 34628642Free PMC Article
Blood pressure and hypertension in athletes: a systematic review.
Berge HM, Isern CB, Berge E
Br J Sports Med 2015 Jun;49(11):716-23. Epub 2015 Jan 28 doi: 10.1136/bjsports-2014-093976. PMID: 25631543
A systematic review and meta-analysis of cohort studies of echocardiographic findings in OSA children after adenotonsilectomy.
Weber SA, Pierri Carvalho R, Ridley G, Williams K, El Dib R
Int J Pediatr Otorhinolaryngol 2014 Oct;78(10):1571-8. Epub 2014 Jul 22 doi: 10.1016/j.ijporl.2014.07.021. PMID: 25108873
Masked hypertension: a systematic review.
Bobrie G, Clerson P, Ménard J, Postel-Vinay N, Chatellier G, Plouin PF
J Hypertens 2008 Sep;26(9):1715-25. doi: 10.1097/HJH.0b013e3282fbcedf. PMID: 18698202

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