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Cardiomegaly due to hypertension

MedGen UID:
151958
•Concept ID:
C0694541
•
Disease or Syndrome
Synonyms: Hypertensive cardiomegaly; Hypertensive Cardiomegaly
SNOMED CT: Cardiomegaly due to hypertension (275516004); Hypertensive cardiomegaly (275516004)

Definition

Abnormal enlargement of the heart resulting from long-standing hypertension. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCardiomegaly due to hypertension

Professional guidelines

PubMed

Clinical Risk Score to Predict Pathogenic Genotypes in Patients With Dilated Cardiomyopathy.
Escobar-Lopez L, Ochoa JP, Royuela A, Verdonschot JAJ, Dal Ferro M, Espinosa MA, Sabater-Molina M, Gallego-Delgado M, Larrañaga-Moreira JM, Garcia-Pinilla JM, Basurte-Elorz MT, Rodríguez-Palomares JF, Climent V, Bermudez-Jimenez FJ, Mogollón-Jiménez MV, Lopez J, Peña-Peña ML, Garcia-Alvarez A, López-Abel B, Ripoll-Vera T, Palomino-Doza J, Bayes-Genis A, Brugada R, Idiazabal U, Mirelis JG, Dominguez F, Henkens MTHM, Krapels IPC, Brunner HG, Paldino A, Zaffalon D, Mestroni L, Sinagra G, Heymans SRB, Merlo M, Garcia-Pavia P
J Am Coll Cardiol 2022 Sep 20;80(12):1115-1126. doi: 10.1016/j.jacc.2022.06.040. PMID: 36109106
Efficacy of echocardiography for differential diagnosis of left ventricular hypertrophy: special focus on speckle-tracking longitudinal strain.
Tanaka H
J Echocardiogr 2021 Jun;19(2):71-79. Epub 2021 Jan 18 doi: 10.1007/s12574-020-00508-3. PMID: 33460030Free PMC Article
Hypertension Canada's 2020 Comprehensive Guidelines for the Prevention, Diagnosis, Risk Assessment, and Treatment of Hypertension in Adults and Children.
Rabi DM, McBrien KA, Sapir-Pichhadze R, Nakhla M, Ahmed SB, Dumanski SM, Butalia S, Leung AA, Harris KC, Cloutier L, Zarnke KB, Ruzicka M, Hiremath S, Feldman RD, Tobe SW, Campbell TS, Bacon SL, Nerenberg KA, Dresser GK, Fournier A, Burgess E, Lindsay P, Rabkin SW, Prebtani APH, Grover S, Honos G, Alfonsi JE, Arcand J, Audibert F, Benoit G, Bittman J, Bolli P, Côté AM, Dionne J, Don-Wauchope A, Edwards C, Firoz T, Gabor JY, Gilbert RE, Grégoire JC, Gryn SE, Gupta M, Hannah-Shmouni F, Hegele RA, Herman RJ, Hill MD, Howlett JG, Hundemer GL, Jones C, Kaczorowski J, Khan NA, Kuyper LM, Lamarre-Cliche M, Lavoie KL, Leiter LA, Lewanczuk R, Logan AG, Magee LA, Mangat BK, McFarlane PA, McLean D, Michaud A, Milot A, Moe GW, Penner SB, Pipe A, Poppe AY, Rey E, Roerecke M, Schiffrin EL, Selby P, Sharma M, Shoamanesh A, Sivapalan P, Townsend RR, Tran K, Trudeau L, Tsuyuki RT, Vallée M, Woo V, Bell AD, Daskalopoulou SS
Can J Cardiol 2020 May;36(5):596-624. doi: 10.1016/j.cjca.2020.02.086. PMID: 32389335

Recent clinical studies

Etiology

Hyperhomocysteinemia Promotes Cardiac Hypertrophy in Hypertension.
Deng Y, Li Z, An X, Fan R, Wang Y, Li J, Yang X, Liao J, Xia Y
Oxid Med Cell Longev 2022;2022:1486157. Epub 2022 Aug 22 doi: 10.1155/2022/1486157. PMID: 36046692Free PMC Article
Comprehensive bioinformatics analysis identifies LAPTM5 as a potential blood biomarker for hypertensive patients with left ventricular hypertrophy.
Li T, Wang W, Gan W, Lv S, Zeng Z, Hou Y, Yan Z, Zhang R, Yang M
Aging (Albany NY) 2022 Feb 14;14(3):1508-1528. doi: 10.18632/aging.203894. PMID: 35157609Free PMC Article
Hypertensive heart disease.
Diamond JA, Phillips RA
Hypertens Res 2005 Mar;28(3):191-202. doi: 10.1291/hypres.28.191. PMID: 16097361
Dippers versus non-dippers.
Verdecchia P, Schillaci G, Porcellati C
J Hypertens Suppl 1991 Dec;9(8):S42-4. PMID: 1839037
Heart and hypertension.
Fogari R, Zoppi A
Am J Hypertens 1989 Feb;2(2 Pt 2):16S-23S. doi: 10.1093/ajh/2.2.16s. PMID: 2522004

Diagnosis

Phenotyping the hypertensive heart.
Tadic M, Cuspidi C, Marwick TH
Eur Heart J 2022 Oct 11;43(38):3794-3810. doi: 10.1093/eurheartj/ehac393. PMID: 35869979
Comprehensive bioinformatics analysis identifies LAPTM5 as a potential blood biomarker for hypertensive patients with left ventricular hypertrophy.
Li T, Wang W, Gan W, Lv S, Zeng Z, Hou Y, Yan Z, Zhang R, Yang M
Aging (Albany NY) 2022 Feb 14;14(3):1508-1528. doi: 10.18632/aging.203894. PMID: 35157609Free PMC Article
Pharmacotherapy for hypertension-induced left ventricular hypertrophy.
Leache L, Gutiérrez-Valencia M, Finizola RM, Infante E, Finizola B, Pardo Pardo J, Flores Y, Granero R, Arai KJ
Cochrane Database Syst Rev 2021 Oct 10;10(10):CD012039. doi: 10.1002/14651858.CD012039.pub3. PMID: 34628642Free PMC Article
Hypertension, left ventricular hypertrophy, and sudden cardiac death.
Shenasa M, Shenasa H
Int J Cardiol 2017 Jun 15;237:60-63. Epub 2017 Mar 3 doi: 10.1016/j.ijcard.2017.03.002. PMID: 28285801
Myocardial remodeling in hypertension.
Nadruz W
J Hum Hypertens 2015 Jan;29(1):1-6. Epub 2014 May 8 doi: 10.1038/jhh.2014.36. PMID: 24804791

Therapy

Pharmacotherapy for hypertension-induced left ventricular hypertrophy.
Leache L, Gutiérrez-Valencia M, Finizola RM, Infante E, Finizola B, Pardo Pardo J, Flores Y, Granero R, Arai KJ
Cochrane Database Syst Rev 2021 Oct 10;10(10):CD012039. doi: 10.1002/14651858.CD012039.pub3. PMID: 34628642Free PMC Article
Is Left Ventricular Hypertrophy a Valid Therapeutic Target?
Brooks JE, Soliman EZ, Upadhya B
Curr Hypertens Rep 2019 May 20;21(6):47. doi: 10.1007/s11906-019-0952-9. PMID: 31111289
Hypertension and the heart.
Mancia G, Scopelliti F, Grassi G
Semin Cardiothorac Vasc Anesth 2006 Sep;10(3):198-202. doi: 10.1177/1089253206291315. PMID: 16959750
Hypertensive heart disease.
Diamond JA, Phillips RA
Hypertens Res 2005 Mar;28(3):191-202. doi: 10.1291/hypres.28.191. PMID: 16097361
Hypertension and the elderly.
Potter JF
Br Med Bull 1994 Apr;50(2):408-19. doi: 10.1093/oxfordjournals.bmb.a072900. PMID: 8205466

Prognosis

Hypertension, left ventricular hypertrophy, and sudden cardiac death.
Shenasa M, Shenasa H
Int J Cardiol 2017 Jun 15;237:60-63. Epub 2017 Mar 3 doi: 10.1016/j.ijcard.2017.03.002. PMID: 28285801
Myocardial remodeling in hypertension.
Nadruz W
J Hum Hypertens 2015 Jan;29(1):1-6. Epub 2014 May 8 doi: 10.1038/jhh.2014.36. PMID: 24804791
Hypertension and the heart.
Schmieder RE, Messerli FH
J Hum Hypertens 2000 Oct-Nov;14(10-11):597-604. doi: 10.1038/sj.jhh.1001044. PMID: 11095153
Hypertension and the heart.
Susic D, Frohlich ED
Curr Hypertens Rep 2000 Dec;2(6):565-9. doi: 10.1007/s11906-996-0042-7. PMID: 11062603
Dippers versus non-dippers.
Verdecchia P, Schillaci G, Porcellati C
J Hypertens Suppl 1991 Dec;9(8):S42-4. PMID: 1839037

Clinical prediction guides

Hypertension, left ventricular hypertrophy, and sudden cardiac death.
Shenasa M, Shenasa H
Int J Cardiol 2017 Jun 15;237:60-63. Epub 2017 Mar 3 doi: 10.1016/j.ijcard.2017.03.002. PMID: 28285801
Myocardial remodeling in hypertension.
Nadruz W
J Hum Hypertens 2015 Jan;29(1):1-6. Epub 2014 May 8 doi: 10.1038/jhh.2014.36. PMID: 24804791
Cardiac hypertrophy and hypertension.
Agabiti-Rosei E, Muiesan ML
Curr Opin Nephrol Hypertens 1998 Mar;7(2):211-6. doi: 10.1097/00041552-199803000-00011. PMID: 9529625
Cardiac baroreflexes and hypertension.
Head GA
Clin Exp Pharmacol Physiol 1994 Oct;21(10):791-802. doi: 10.1111/j.1440-1681.1994.tb02448.x. PMID: 7867230
Heart and hypertension.
Fogari R, Zoppi A
Am J Hypertens 1989 Feb;2(2 Pt 2):16S-23S. doi: 10.1093/ajh/2.2.16s. PMID: 2522004

Recent systematic reviews

COVID-19 Infection and Myocarditis: A State-of-the-Art Systematic Review.
Jaiswal V, Sarfraz Z, Sarfraz A, Mukherjee D, Batra N, Hitawala G, Yaqoob S, Patel A, Agarwala P, Ruchika, Sarfraz M, Bano S, Azeem N, Naz S, Jaiswal A, Sharma P, Chaudhary G
J Prim Care Community Health 2021 Jan-Dec;12:21501327211056800. doi: 10.1177/21501327211056800. PMID: 34854348Free PMC Article
Pharmacotherapy for hypertension-induced left ventricular hypertrophy.
Leache L, Gutiérrez-Valencia M, Finizola RM, Infante E, Finizola B, Pardo Pardo J, Flores Y, Granero R, Arai KJ
Cochrane Database Syst Rev 2021 Oct 10;10(10):CD012039. doi: 10.1002/14651858.CD012039.pub3. PMID: 34628642Free PMC Article
Blood pressure and hypertension in athletes: a systematic review.
Berge HM, Isern CB, Berge E
Br J Sports Med 2015 Jun;49(11):716-23. Epub 2015 Jan 28 doi: 10.1136/bjsports-2014-093976. PMID: 25631543
Untreated Masked Hypertension and Subclinical Cardiac Damage: A Systematic Review and Meta-analysis.
Cuspidi C, Sala C, Tadic M, Rescaldani M, Grassi G, Mancia G
Am J Hypertens 2015 Jun;28(6):806-13. Epub 2014 Dec 1 doi: 10.1093/ajh/hpu231. PMID: 25468808
Masked hypertension: a systematic review.
Bobrie G, Clerson P, Ménard J, Postel-Vinay N, Chatellier G, Plouin PF
J Hypertens 2008 Sep;26(9):1715-25. doi: 10.1097/HJH.0b013e3282fbcedf. PMID: 18698202

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