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Middle cerebral artery infarction

MedGen UID:
152845
Concept ID:
C0740392
Disease or Syndrome
Synonyms: Cerebral Infarction, Middle Cerebral Artery; Infarct, MCA; Infarction, Middle Cerebral Artery; Infarcts, MCA; MCA Infarct; MCA Infarction; MCA Infarcts; Middle Cerebral Artery Circulation Infarction; Middle Cerebral Artery Infarction; Middle Cerebral Artery Stroke; Stroke, Middle Cerebral Artery
 
HPO: HP:0033762
Monarch Initiative: MONDO:0006857

Definition

Acute onset neurological deficits such as weakness, dizziness, numbness, issues with speech, or visual changes related to sudden impairment of blood flow to a part of the brain due to occlusion or rupture of the middle cerebral artery to the brain. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMiddle cerebral artery infarction

Professional guidelines

PubMed

Guo W, Li N, Xu J, Ma J, Li S, Ren C, Chen J, Duan J, Ma Q, Song H, Zhao W, Ji X
Curr Neurovasc Res 2023;20(2):254-260. doi: 10.2174/1567202620666230710114443. PMID: 37431897
Mohan Rajwani K, Crocker M, Moynihan B
Br J Neurosurg 2017 Aug;31(4):401-409. Epub 2017 Jun 12 doi: 10.1080/02688697.2017.1329518. PMID: 28604106
Heiss WD
Cerebrovasc Dis 2016;41(1-2):1-7. Epub 2015 Nov 19 doi: 10.1159/000441627. PMID: 26581023

Recent clinical studies

Etiology

Moughal S, Trippier S, Al-Mousa A, Hainsworth AH, Pereira AC, Minhas PS, Shtaya A
J Neurol 2022 Jan;269(1):149-158. Epub 2020 Dec 19 doi: 10.1007/s00415-020-10358-9. PMID: 33340332Free PMC Article
Das S, Mitchell P, Ross N, Whitfield PC
World Neurosurg 2019 Mar;123:8-16. Epub 2018 Nov 27 doi: 10.1016/j.wneu.2018.11.176. PMID: 30500591
Giossi A, Volonghi I, Del Zotto E, Costa P, Padovani A, Pezzini A
Front Neurol Neurosci 2012;30:154-7. Epub 2012 Feb 14 doi: 10.1159/000333628. PMID: 22377885
Wartenberg KE
Curr Opin Crit Care 2012 Apr;18(2):152-63. doi: 10.1097/MCC.0b013e32835075c5. PMID: 22322256
Hofmeijer J, Kappelle LJ, Algra A, Amelink GJ, van Gijn J, van der Worp HB; HAMLET investigators
Lancet Neurol 2009 Apr;8(4):326-33. Epub 2009 Mar 5 doi: 10.1016/S1474-4422(09)70047-X. PMID: 19269254

Diagnosis

Godoy D, Piñero G, Cruz-Flores S, Alcalá Cerra G, Rabinstein A
Neurologia 2016 Jun;31(5):332-43. Epub 2013 Apr 17 doi: 10.1016/j.nrl.2013.02.009. PMID: 23601756
Neugebauer H, Jüttler E
Int J Stroke 2014 Jun;9(4):460-7. Epub 2014 Apr 11 doi: 10.1111/ijs.12211. PMID: 24725828
González Delgado M, Bogousslavsky J
Front Neurol Neurosci 2012;30:111-4. Epub 2012 Feb 14 doi: 10.1159/000333604. PMID: 22377875
Wartenberg KE
Curr Opin Crit Care 2012 Apr;18(2):152-63. doi: 10.1097/MCC.0b013e32835075c5. PMID: 22322256
Treadwell SD, Thanvi B
Postgrad Med J 2010 Apr;86(1014):235-42. doi: 10.1136/pgmj.2009.094292. PMID: 20354047

Therapy

Albers GW, Jumaa M, Purdon B, Zaidi SF, Streib C, Shuaib A, Sangha N, Kim M, Froehler MT, Schwartz NE, Clark WM, Kircher CE, Yang M, Massaro L, Lu XY, Rippon GA, Broderick JP, Butcher K, Lansberg MG, Liebeskind DS, Nouh A, Schwamm LH, Campbell BCV; TIMELESS Investigators
N Engl J Med 2024 Feb 22;390(8):701-711. Epub 2024 Feb 8 doi: 10.1056/NEJMoa2310392. PMID: 38329148
Ma Y, Wang T, Wang H, Amin-Hanjani S, Tong X, Wang J, Tong Z, Kuai D, Cai Y, Ren J, Wang D, Duan L, Maimaitili A, Hang C, Yu J, Bai X, Powers WJ, Derdeyn CP, Wu Y, Ling F, Gu Y, Jiao L; CMOSS Investigators
JAMA 2023 Aug 22;330(8):704-714. doi: 10.1001/jama.2023.13390. PMID: 37606672Free PMC Article
Treadwell SD, Thanvi B
Postgrad Med J 2010 Apr;86(1014):235-42. doi: 10.1136/pgmj.2009.094292. PMID: 20354047
Särkämö T, Tervaniemi M, Laitinen S, Forsblom A, Soinila S, Mikkonen M, Autti T, Silvennoinen HM, Erkkilä J, Laine M, Peretz I, Hietanen M
Brain 2008 Mar;131(Pt 3):866-76. doi: 10.1093/brain/awn013. PMID: 18287122
Vahedi K, Hofmeijer J, Juettler E, Vicaut E, George B, Algra A, Amelink GJ, Schmiedeck P, Schwab S, Rothwell PM, Bousser MG, van der Worp HB, Hacke W; DECIMAL, DESTINY, and HAMLET investigators
Lancet Neurol 2007 Mar;6(3):215-22. doi: 10.1016/S1474-4422(07)70036-4. PMID: 17303527

Prognosis

Tracol C, Vannier S, Hurel C, Tuffier S, Eugene F, Le Reste PJ
Rev Neurol (Paris) 2020 Sep;176(7-8):619-625. Epub 2020 Jul 2 doi: 10.1016/j.neurol.2020.01.352. PMID: 32624178
Guanci MM
Crit Care Nurs Clin North Am 2020 Mar;32(1):51-66. Epub 2019 Dec 23 doi: 10.1016/j.cnc.2019.11.003. PMID: 32014161
Rahme R, Zuccarello M, Kleindorfer D, Adeoye OM, Ringer AJ
J Neurosurg 2012 Oct;117(4):749-54. Epub 2012 Aug 24 doi: 10.3171/2012.6.JNS111140. PMID: 22920962
Wartenberg KE
Curr Opin Crit Care 2012 Apr;18(2):152-63. doi: 10.1097/MCC.0b013e32835075c5. PMID: 22322256
Huttner HB, Schwab S
Lancet Neurol 2009 Oct;8(10):949-58. doi: 10.1016/S1474-4422(09)70224-8. PMID: 19747656

Clinical prediction guides

Xu X, Zhang G, Jia Z, Zhao L, Cao Y, Shi H, Zhang L, Li Z, Yang P, Zhang Y, Ye X, Lou M, Yin C, Jiang C, Liu S, Liu J; DIRECT-MT Investigators
Eur Radiol 2023 Jan;33(1):135-143. Epub 2022 Jul 18 doi: 10.1007/s00330-022-09013-w. PMID: 35849176
Tracol C, Vannier S, Hurel C, Tuffier S, Eugene F, Le Reste PJ
Rev Neurol (Paris) 2020 Sep;176(7-8):619-625. Epub 2020 Jul 2 doi: 10.1016/j.neurol.2020.01.352. PMID: 32624178
Rahme R, Zuccarello M, Kleindorfer D, Adeoye OM, Ringer AJ
J Neurosurg 2012 Oct;117(4):749-54. Epub 2012 Aug 24 doi: 10.3171/2012.6.JNS111140. PMID: 22920962
Huttner HB, Schwab S
Lancet Neurol 2009 Oct;8(10):949-58. doi: 10.1016/S1474-4422(09)70224-8. PMID: 19747656
Hofmeijer J, Kappelle LJ, Algra A, Amelink GJ, van Gijn J, van der Worp HB; HAMLET investigators
Lancet Neurol 2009 Apr;8(4):326-33. Epub 2009 Mar 5 doi: 10.1016/S1474-4422(09)70047-X. PMID: 19269254

Recent systematic reviews

Desai R, Mondal A, Prasad A, Vyas A, Jain A, Rupareliya C, Shah M, Paul T, Kumar G, Sachdeva R
Curr Probl Cardiol 2023 Oct;48(10):101814. Epub 2023 May 18 doi: 10.1016/j.cpcardiol.2023.101814. PMID: 37209804Free PMC Article
Pillai P, Mitchell PJ, Phan TG, Ma H, Yan B
Cerebrovasc Dis 2023;52(3):353-362. Epub 2022 Nov 24 doi: 10.1159/000526873. PMID: 36423598Free PMC Article
Das S, Mitchell P, Ross N, Whitfield PC
World Neurosurg 2019 Mar;123:8-16. Epub 2018 Nov 27 doi: 10.1016/j.wneu.2018.11.176. PMID: 30500591
Chen CJ, Wang C, Buell TJ, Ding D, Raper DM, Ironside N, Paisan GM, Starke RM, Southerland AM, Liu K, Worrall BB
World Neurosurg 2017 Nov;107:684-691. Epub 2017 Aug 24 doi: 10.1016/j.wneu.2017.08.108. PMID: 28844911
Rahme R, Zuccarello M, Kleindorfer D, Adeoye OM, Ringer AJ
J Neurosurg 2012 Oct;117(4):749-54. Epub 2012 Aug 24 doi: 10.3171/2012.6.JNS111140. PMID: 22920962

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