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Myelophthisic anemia

MedGen UID:
1529
•Concept ID:
C0002890
•
Disease or Syndrome
Synonyms: Anemia, Leukoerythroblastic; Anemia, Myelophthisic; Anemias, Leukoerythroblastic; Anemias, Myelophthisic; Leukoerythroblastic Anemia; Leukoerythroblastic Anemias; Myelophthisic Anemia; Myelophthisic Anemias
SNOMED CT: Myelophthisic anemia (2694001); Anemia associated with marrow infiltration (2694001); Leukoerythroblastic anemia (2694001); Leukoerythroblastosis (2694001)
 
Monarch Initiative: MONDO:0005868

Definition

A laboratory test result indicating an abnormal amount of circulating nucleated red blood cells and immature red blood cells. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMyelophthisic anemia

Professional guidelines

PubMed

Myelophthisic anemia as terminal stage of polycythemia vera; protracted x-ray treatment followed by a myelosclerotic syndrome.
ROSELSEN E, OHLSEN S
Acta Med Scand 1952 Mar 19;142(4):239-48. doi: 10.1111/j.0954-6820.1952.tb13861.x. PMID: 14932790

Recent clinical studies

Etiology

Access to Palliative Care Services and Clinical Outcomes of Patients With Solid Malignancy-Associated Myelophthisis in a Resource-Limited Setting.
Vargas-Serafin C, Acosta-Medina AA, Teran-De-la-Sancha K, Delgado-de-la-Mora J, Bourlon MT, Bourlon C
Am J Hosp Palliat Care 2021 Aug;38(8):932-937. Epub 2020 Nov 9 doi: 10.1177/1049909120969963. PMID: 33161730
Case of metastatic basal cell carcinoma to bone marrow, resulting in myelophthisic anemia.
Pham CM, Syed AA, Siddiqui HA, Keller RA, Kowalewski C
Am J Dermatopathol 2013 Apr;35(2):e34-6. doi: 10.1097/DAD.0b013e3182761362. PMID: 23147353
Leukoerythroblastic anemia in metastatic prostate cancer. Clinical and prognostic significance in patients with hormone-refractory disease.
Shamdas GJ, Ahmann FR, Matzner MB, Ritchie JM
Cancer 1993 Jun 1;71(11):3594-600. doi: 10.1002/1097-0142(19930601)71:11<3594::aid-cncr2820711121>3.0.co;2-o. PMID: 8490908
Osteopetrosis. Current clinical considerations.
Shapiro F
Clin Orthop Relat Res 1993 Sep;(294):34-44. PMID: 8358940
Normoblasts in peripheral blood of Nigerians: their clinical significance.
Okpara RA
J Natl Med Assoc 1985 Nov;77(11):899-903. PMID: 4078915Free PMC Article

Diagnosis

An elderly man with hemolysis and myelophthisic anemia.
Horn R, Maiti A, Cherian SV
Eur J Intern Med 2018 Feb;48:e7-e8. Epub 2017 Jul 8 doi: 10.1016/j.ejim.2017.07.004. PMID: 28697949
Osteopetrosis. Current clinical considerations.
Shapiro F
Clin Orthop Relat Res 1993 Sep;(294):34-44. PMID: 8358940
Anemia and cancer.
Steinberg D
CA Cancer J Clin 1989 Sep-Oct;39(5):296-304. doi: 10.3322/canjclin.39.5.296. PMID: 2513101
Anemia in cancer.
Zucker S
Cancer Invest 1985;3(3):249-60. doi: 10.3109/07357908509039786. PMID: 3891030
Differential diagnosis of anemia and cancer.
Leite C, Hoogstraten B
CA Cancer J Clin 1977 Mar-Apr;27(2):88-99. doi: 10.3322/canjclin.27.2.88. PMID: 402990

Therapy

An elderly man with hemolysis and myelophthisic anemia.
Horn R, Maiti A, Cherian SV
Eur J Intern Med 2018 Feb;48:e7-e8. Epub 2017 Jul 8 doi: 10.1016/j.ejim.2017.07.004. PMID: 28697949
Osteopetrosis. Current clinical considerations.
Shapiro F
Clin Orthop Relat Res 1993 Sep;(294):34-44. PMID: 8358940
Myelofibrosis in neuroblastoma.
Labotka RJ, Morgan ER
Med Pediatr Oncol 1982;10(1):21-6. doi: 10.1002/mpo.2950100105. PMID: 7062895
Differential diagnosis of anemia and cancer.
Leite C, Hoogstraten B
CA Cancer J Clin 1977 Mar-Apr;27(2):88-99. doi: 10.3322/canjclin.27.2.88. PMID: 402990
Presentation of case.
RAMOS AJ
J Am Med Assoc 1956 May 5;161(1):60-1. doi: 10.1001/jama.1956.62970010012016. PMID: 13306602

Prognosis

Microangiopathic hemolytic anemia and leukoerythroblastic blood film heralding bone marrow metastatic gastroesophageal adenocarcinoma.
Rauh MJ, Al Habeeb A, Chang H
Pathol Res Pract 2011 Feb 15;207(2):121-3. Epub 2010 Aug 5 doi: 10.1016/j.prp.2010.07.003. PMID: 20691546
Osteopetrosis. Current clinical considerations.
Shapiro F
Clin Orthop Relat Res 1993 Sep;(294):34-44. PMID: 8358940
Anemia in cancer.
Zucker S
Cancer Invest 1985;3(3):249-60. doi: 10.3109/07357908509039786. PMID: 3891030
Leukoerythroblastosis and cancer frequency, prognosis, and physiopathologic significance.
Delsol G, Guiu-Godfrin B, Guiu M, Pris J, Corberand J, Fabre J
Cancer 1979 Sep;44(3):1009-13. doi: 10.1002/1097-0142(197909)44:3<1009::aid-cncr2820440331>3.0.co;2-j. PMID: 476585
Neurological complications of osteopetrosis.
Amacher AL
Childs Brain 1977;3(5):257-64. doi: 10.1159/000119676. PMID: 902509

Clinical prediction guides

Case of metastatic basal cell carcinoma to bone marrow, resulting in myelophthisic anemia.
Pham CM, Syed AA, Siddiqui HA, Keller RA, Kowalewski C
Am J Dermatopathol 2013 Apr;35(2):e34-6. doi: 10.1097/DAD.0b013e3182761362. PMID: 23147353
Microangiopathic hemolytic anemia and leukoerythroblastic blood film heralding bone marrow metastatic gastroesophageal adenocarcinoma.
Rauh MJ, Al Habeeb A, Chang H
Pathol Res Pract 2011 Feb 15;207(2):121-3. Epub 2010 Aug 5 doi: 10.1016/j.prp.2010.07.003. PMID: 20691546
Osteopetrosis: a rare cause of anemia--review of literature.
Saluja S, Bhandari S, Aggarwal S, Kapoor S
Indian J Pathol Microbiol 2009 Jul-Sep;52(3):363-7. doi: 10.4103/0377-4929.54995. PMID: 19679962
Premature labor and leukoerythroblastosis in a newborn with parvovirus B19 infection.
Gulen H, Basarir F, Hakan N, Ciftdogan DY, Tansug N, Onag A
Haematologica 2005 Nov;90 Suppl:ECR38. PMID: 16266929
Granulocytic fragments in sepsis.
Krauss JS, Dover RK, Khankhanian NK, Tom GD
Mod Pathol 1989 Jul;2(4):301-5. PMID: 2762286

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