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Disorder of neck

MedGen UID:: 154322
•Concept ID:: C0558385
•: Disease or Syndrome

Synonyms:	Neck Disease; Neck Disorder
SNOMED CT:	Disorder of neck (118939000)

Definition

A non-neoplastic or neoplastic disorder that affects the anatomic structures of the neck region. This category includes disorders of the pharynx, larynx, thyroid gland, and parathyroid gland. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVDisorder of neck

Pathological Conditions, Signs and Symptoms
- Pathological process
  - Disease
    - Disorder by Site
      - Head and Neck Disorder
        Disorder of neck
        Disorder of parathyroid gland
        Hyperparathyroidism
        Hyperparathyroidism, transient neonatal
        Primary hyperparathyroidism
        Secondary hyperparathyroidism
        Tertiary hyperparathyroidism
        Hypoparathyroidism
        22q11 Deletion Syndrome
        Acquired Hypoparathyroidism
        Autoimmune hypoparathyroidism
        Autosomal dominant hypocalcemia 1
        Congenital hypoparathyroidism
        Hypoparathyroidism - X-linked
        Hypoparathyroidism, autosomal recessive
        Iatrogenic Hypoparathyroidism
        Primary Hypoparathyroidism
        Transient Neonatal Hypoparathyroidism
        Neoplasm of the parathyroid gland
        Benign neoplasm of parathyroid gland
        Malignant Parathyroid Gland Neoplasm
        Parathyroid carcinoma
        Parathyroid gland adenoma
        Non-Neoplastic Parathyroid Gland Disorder
        Parathyroid Gland Abscess
        Disorder of pharynx
        Dysphagia
        Dyskinesia of esophagus
        Esophageal dysphagia
        Impaired oral bolus formation
        Impaired oropharyngeal swallow response
        Neuromuscular dysphagia
        Oral-pharyngeal dysphagia
        Lemierre syndrome
        Nasopharyngeal disorder
        Nasopharyngeal Non-Neoplastic Disorder
        Nasopharyngitis
        Neoplasia of the nasopharynx
        Neoplasm of the pharynx
        Benign neoplasm of pharynx
        Hypopharyngeal Neoplasm
        Malignant Pharyngeal Neoplasm
        Neoplasm of oropharynx
        Non-Neoplastic Pharyngeal Disorder
        Epiglottitis
        Pharyngeal Mucositis
        Pharyngitis
        Velopharyngeal insufficiency
        Disorder of thyroid gland
        Euthyroid sick syndrome
        Goiter
        Congenital goiter
        Diffuse goiter
        Endemic goiter
        Euthyroid goiter
        Graves disease
        Hypothyroid Goiter
        Lingual goiter
        Nodular goiter
        Nontoxic goiter
        Plummer disease
        Substernal goiter
        Hyperthyroidism
        Acquired Hyperthyroidism
        Central Hyperthyroidism
        Congenital Hyperthyroidism
        Hyperthyroxinemia, familial dysalbuminemic
        Iodine-induced hyperthyroidism
        Primary Hyperthyroidism
        Thyroid crisis
        Thyrotoxicosis
        Thyrotoxicosis from ectopic thyroid tissue
        Thyrotoxicosis with diffuse goiter
        Thyrotoxicosis with toxic multinodular goiter
        Thyrotoxicosis with toxic single thyroid nodule
        Hyperthyroxinemia
        Thyroid hormone resistance syndrome
        Hypothyroidism
        Acquired hypothyroidism
        Central hypothyroidism
        Compensated hypothyroidism
        Congenital hypothyroidism
        Iodine Deficiency Hypothyroidism
        Myxedema
        Primary hypothyroidism
        Transient hypothyroxinemia
        Wolff-Chaikoff Phenomenon
        Non-Neoplastic Thyroid Gland Disorder
        Abscess of thyroid
        Atrophy of thyroid
        Congenital Thyroid Gland Disorder
        Diffuse C-Cell Hyperplasia
        Reactive C-Cell Hyperplasia
        Thyroid dysgenesis
        Thyroid Gland Rosai-Dorfman Disease
        Thyroiditis
        Transient congenital hypothyroidism
        Thyroid C cell hyperplasia
        Neoplastic C-Cell Hyperplasia
        Thyroid nodule
        Thyroid adenoma
        Thyroid tumor
        Benign thyroid gland neoplasm
        Intrathyroidal Thymoma
        Malignant tumor of thyroid gland
        Papillary thyroid carcinoma
        Thyroid gland atypical follicular adenoma
        Thyroid gland carcinoma
        Thyroid Gland Follicular Tumor of Uncertain Malignant Potential
        Thyroid Gland Histiocytic and Dendritic Cell Neoplasm
        Thyroid Gland Noninvasive Follicular Neoplasm with Papillary-Like Nuclear Features
        Thyroid Gland Oncocytic Neoplasm
        Thyroid Gland Paraganglioma
        Thyroid Gland Solitary Fibrous Tumor
        Thyroid Gland Teratoma
        Thyroid hyalinizing trabecular adenoma
        Thyroid lymphoma
        Laryngeal disorder
        Congenital laryngomalacia
        Disorder of voice
        Dysphonia
        Hoarse voice
        Loss of voice
        Laryngeal edema
        Laryngeal granuloma
        Laryngeal Precancerous Condition
        Leukoplakia of larynx
        Laryngeal stenosis
        Laryngeal tuberculosis
        Laryngitis
        Acute laryngitis
        Chronic laryngitis
        Croup
        Viral laryngitis
        Laryngocele
        Laryngopharyngeal reflux
        Neoplasm of the larynx
        Benign laryngeal neoplasm
        Glottis neoplasm
        Laryngeal carcinoma
        Laryngeal neuroendocrine neoplasm
        Laryngeal papillomatosis
        Laryngeal Soft Tissue Neoplasm
        Larynx cancer
        Subglottis neoplasm
        Supraglottis neoplasm
        Non-Neoplastic Laryngeal Disorder
        Agenesis of larynx
        Disorder of vocal cord
        Laryngeal atresia
        Laryngeal cleft
        Laryngeal Mucositis
        Laryngeal web
        Supraglottitis
        Vocal cord dysfunction
        Imperfect vocal cord adduction
        Laryngospasm
        Vocal cord paralysis
        Neoplasm of neck
        Benign neoplasm of neck
        Benign Parapharyngeal Neoplasm
        Benign Retropharyngeal Neoplasm
        Schwannoma of jugular foramen
        Ectopic Cervical Thymoma
        Jugular Foramen Neoplasm
        Jugular foramen meningioma
        Malignant tumor of neck
        Malignant Parapharyngeal Neoplasm
        Malignant Retropharyngeal Neoplasm
        Metastatic Malignant Neoplasm in the Neck
        Neck Carcinoma
        Parapharyngeal Neoplasm
        Primary Parapharyngeal Meningioma
        Retropharyngeal Neoplasm
        Non-Neoplastic Neck Disorder

Professional guidelines

PubMed

Manipulation and mobilisation for neck pain contrasted against an inactive control or another active treatment.

Gross A, Langevin P, Burnie SJ, Bédard-Brochu MS, Empey B, Dugas E, Faber-Dobrescu M, Andres C, Graham N, Goldsmith CH, Brønfort G, Hoving JL, LeBlanc F
Cochrane Database Syst Rev 2015 Sep 23;(9):CD004249. doi: 10.1002/14651858.CD004249.pub4. PMID: 26397370

See all (1)

Recent clinical studies

Etiology

The effects of active break and postural shift interventions on recovery from and recurrence of neck and low back pain in office workers: A 3-arm cluster-randomized controlled trial.

Akkarakittichoke N, Waongenngarm P, Janwantanakul P
Musculoskelet Sci Pract 2021 Dec;56:102451. Epub 2021 Aug 20 doi: 10.1016/j.msksp.2021.102451. PMID: 34450361

Contemporary Management of Vascular Anomalies of the Head and Neck-Part 1: Vascular Malformations: A Review.

Gallant SC, Chewning RH, Orbach DB, Trenor CC 3rd, Cunningham MJ
JAMA Otolaryngol Head Neck Surg 2021 Feb 1;147(2):197-206. doi: 10.1001/jamaoto.2020.4353. PMID: 33237296

Cervical musculoskeletal disorders in patients with temporomandibular dysfunction: A systematic review and meta-analysis.

de Oliveira-Souza AIS, de O Ferro JK, Barros MMMB, Oliveira DA
J Bodyw Mov Ther 2020 Oct;24(4):84-101. Epub 2020 May 11 doi: 10.1016/j.jbmt.2020.05.001. PMID: 33218570

Role and Management of a Head and Neck Department during the COVID-19 Outbreak in Lombardy.

Saibene AM, Allevi F, Biglioli F, Felisati G
Otolaryngol Head Neck Surg 2020 Jun;162(6):795-796. Epub 2020 Apr 7 doi: 10.1177/0194599820917914. PMID: 32255735

Head-and-neck dermatitis: Diagnostic difficulties and management pearls.

Maarouf M, Saberian C, Lio PA, Shi VY
Pediatr Dermatol 2018 Nov;35(6):748-753. Epub 2018 Aug 28 doi: 10.1111/pde.13642. PMID: 30152560

See all (48396)

Diagnosis

Multimodality treatment of vascular anomalies of the head and neck.

Dorrity J, Mack J, Wong K, Richter GT
J Oral Pathol Med 2022 Nov;51(10):860-871. Epub 2022 Jul 25 doi: 10.1111/jop.13322. PMID: 35674677

New Practical Aspects of Sweet Syndrome.

Joshi TP, Friske SK, Hsiou DA, Duvic M
Am J Clin Dermatol 2022 May;23(3):301-318. Epub 2022 Feb 14 doi: 10.1007/s40257-022-00673-4. PMID: 35157247 Free PMC Article

Advances in the diagnosis and management of IgG4 related disease.

Lanzillotta M, Mancuso G, Della-Torre E
BMJ 2020 Jun 16;369:m1067. doi: 10.1136/bmj.m1067. PMID: 32546500

Neck-Tongue Syndrome.

Hu N, Dougherty C
Curr Pain Headache Rep 2016 Apr;20(4):27. doi: 10.1007/s11916-016-0555-y. PMID: 26984539

Torticollis.

Tomczak KK, Rosman NP
J Child Neurol 2013 Mar;28(3):365-78. Epub 2012 Dec 26 doi: 10.1177/0883073812469294. PMID: 23271760

See all (39144)

Therapy

New Practical Aspects of Sweet Syndrome.

Joshi TP, Friske SK, Hsiou DA, Duvic M
Am J Clin Dermatol 2022 May;23(3):301-318. Epub 2022 Feb 14 doi: 10.1007/s40257-022-00673-4. PMID: 35157247 Free PMC Article

Advances in the diagnosis and management of IgG4 related disease.

Lanzillotta M, Mancuso G, Della-Torre E
BMJ 2020 Jun 16;369:m1067. doi: 10.1136/bmj.m1067. PMID: 32546500

Ergonomic interventions for preventing work-related musculoskeletal disorders of the upper limb and neck among office workers.

Hoe VC, Urquhart DM, Kelsall HL, Zamri EN, Sim MR
Cochrane Database Syst Rev 2018 Oct 23;10(10):CD008570. doi: 10.1002/14651858.CD008570.pub3. PMID: 30350850 Free PMC Article

Upper thoracic spine mobilization and mobility exercise versus upper cervical spine mobilization and stabilization exercise in individuals with forward head posture: a randomized clinical trial.

Cho J, Lee E, Lee S
BMC Musculoskelet Disord 2017 Dec 12;18(1):525. doi: 10.1186/s12891-017-1889-2. PMID: 29233164 Free PMC Article

Exercises for mechanical neck disorders.

Gross A, Kay TM, Paquin JP, Blanchette S, Lalonde P, Christie T, Dupont G, Graham N, Burnie SJ, Gelley G, Goldsmith CH, Forget M, Hoving JL, Brønfort G, Santaguida PL; Cervical Overview Group
Cochrane Database Syst Rev 2015 Jan 28;1(1):CD004250. doi: 10.1002/14651858.CD004250.pub5. PMID: 25629215 Free PMC Article

See all (25655)

Prognosis

Advances in the diagnosis and management of IgG4 related disease.

Lanzillotta M, Mancuso G, Della-Torre E
BMJ 2020 Jun 16;369:m1067. doi: 10.1136/bmj.m1067. PMID: 32546500

Very late xerostomia, dysphagia, and neck fibrosis after head and neck radiotherapy.

Baudelet M, Van den Steen L, Tomassen P, Bonte K, Deron P, Huvenne W, Rottey S, De Neve W, Sundahl N, Van Nuffelen G, Duprez F
Head Neck 2019 Oct;41(10):3594-3603. Epub 2019 Jul 22 doi: 10.1002/hed.25880. PMID: 31329343

Survival outcomes after treatment of cancer of the oral cavity (1985-2015).

Zanoni DK, Montero PH, Migliacci JC, Shah JP, Wong RJ, Ganly I, Patel SG
Oral Oncol 2019 Mar;90:115-121. Epub 2019 Feb 15 doi: 10.1016/j.oraloncology.2019.02.001. PMID: 30846169 Free PMC Article

Head and neck inflammatory pseudotumor: Case series and review of the literature.

Kansara S, Bell D, Johnson J, Zafereo M
Neuroradiol J 2016 Dec;29(6):440-446. Epub 2016 Sep 20 doi: 10.1177/1971400916665377. PMID: 27650653 Free PMC Article

Torticollis.

Tomczak KK, Rosman NP
J Child Neurol 2013 Mar;28(3):365-78. Epub 2012 Dec 26 doi: 10.1177/0883073812469294. PMID: 23271760

See all (31083)

Clinical prediction guides

New Practical Aspects of Sweet Syndrome.

Joshi TP, Friske SK, Hsiou DA, Duvic M
Am J Clin Dermatol 2022 May;23(3):301-318. Epub 2022 Feb 14 doi: 10.1007/s40257-022-00673-4. PMID: 35157247 Free PMC Article

Associations between abdominal obesity indices and diabetic complications: Chinese visceral adiposity index and neck circumference.

Wan H, Wang Y, Xiang Q, Fang S, Chen Y, Chen C, Zhang W, Zhang H, Xia F, Wang N, Lu Y
Cardiovasc Diabetol 2020 Jul 31;19(1):118. doi: 10.1186/s12933-020-01095-4. PMID: 32736628 Free PMC Article

Advances in the diagnosis and management of IgG4 related disease.

Lanzillotta M, Mancuso G, Della-Torre E
BMJ 2020 Jun 16;369:m1067. doi: 10.1136/bmj.m1067. PMID: 32546500

Upper thoracic spine mobilization and mobility exercise versus upper cervical spine mobilization and stabilization exercise in individuals with forward head posture: a randomized clinical trial.

Cho J, Lee E, Lee S
BMC Musculoskelet Disord 2017 Dec 12;18(1):525. doi: 10.1186/s12891-017-1889-2. PMID: 29233164 Free PMC Article

Somatosensory tinnitus: Current evidence and future perspectives.

Ralli M, Greco A, Turchetta R, Altissimi G, de Vincentiis M, Cianfrone G
J Int Med Res 2017 Jun;45(3):933-947. Epub 2017 May 28 doi: 10.1177/0300060517707673. PMID: 28553764 Free PMC Article

See all (28408)

Recent systematic reviews

Ergonomic interventions for preventing work-related musculoskeletal disorders of the upper limb and neck among office workers.

Hoe VC, Urquhart DM, Kelsall HL, Zamri EN, Sim MR
Cochrane Database Syst Rev 2018 Oct 23;10(10):CD008570. doi: 10.1002/14651858.CD008570.pub3. PMID: 30350850 Free PMC Article

Headache and pregnancy: a systematic review.

Negro A, Delaruelle Z, Ivanova TA, Khan S, Ornello R, Raffaelli B, Terrin A, Reuter U, Mitsikostas DD; European Headache Federation School of Advanced Studies (EHF-SAS)
J Headache Pain 2017 Oct 19;18(1):106. doi: 10.1186/s10194-017-0816-0. PMID: 29052046 Free PMC Article

Effectiveness of Occupational Therapy Interventions for Musculoskeletal Shoulder Conditions: A Systematic Review.

Marik TL, Roll SC
Am J Occup Ther 2017 Jan/Feb;71(1):7101180020p1-7101180020p11. doi: 10.5014/ajot.2017.023127. PMID: 28027039 Free PMC Article

Exercises for mechanical neck disorders.

Temporomandibular joint disorders.

Buescher JJ
Am Fam Physician 2007 Nov 15;76(10):1477-82. PMID: 18052012

See all (2169)