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Tenosynovial giant cell tumor, localized type

MedGen UID:
Concept ID:
Neoplastic Process
Synonyms: Localized Giant Cell Tumor of the Tendon Sheath; Localized Nodular Tenosynovitides; Localized Nodular Tenosynovitis; Localized Pigmented Villonodular Synovitis; Nodular Tenosynovitides; Nodular Tenosynovitides, Localized; Nodular Tenosynovitis; Nodular Tenosynovitis, Localized; Tenosynovitides, Localized Nodular; Tenosynovitides, Nodular; Tenosynovitis, Localized Nodular; Tenosynovitis, Nodular
SNOMED CT: Nodular tenosynovitis (95413004); Tenosynovial giant cell tumor, localized (703702007)
Monarch Initiative: MONDO:0002399


A well-circumscribed, lobulated tumor, completely or partially covered by a fibrous capsule. It usually arises in the fingers. It is characterized by the presence of mononuclear cells, multinucleated osteoclast-like giant cells, hemosiderin-laden macrophages, foam cells, and an inflammatory infiltrate. The tumor is slow-growing, usually developing over several years. Clinical presentation includes painless edema of the affected site. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTenosynovial giant cell tumor, localized type

Professional guidelines


Mastboom MJL, Staals EL, Verspoor FGM, Rueten-Budde AJ, Stacchiotti S, Palmerini E, Schaap GR, Jutte PC, Aston W, Leithner A, Dammerer D, Takeuchi A, Thio Q, Niu X, Wunder JS, van de Sande MAJ; Tenosynovial Giant Cell Tumors (TGCT) Study Group
J Bone Joint Surg Am 2019 Jul 17;101(14):1309-1318. doi: 10.2106/JBJS.18.01147. PMID: 31318811

Recent clinical studies


Hamza A, Gidley PW, Learned KO, Hanna EY, Bell D
Head Neck 2020 Aug;42(8):1859-1873. Epub 2020 Feb 10 doi: 10.1002/hed.26106. PMID: 32040228
Nagase M, Araki A, Ishikawa N, Nagano N, Fujimoto M, Biyajima K, Yamagami N, Yamamoto S, Maruyama R
Int J Surg Pathol 2020 Jun;28(4):447-453. Epub 2019 Nov 26 doi: 10.1177/1066896919889672. PMID: 31771368

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