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Follicular thyroid adenoma

MedGen UID:
1550508
•Concept ID:
CN911516
•
Disease or Syndrome
Synonyms: adenoma of the thyroid; adenoma of the thyroid gland; adenoma of thyroid; adenoma of thyroid gland; adenoma, follicular cell, benign; follicular adenoma; follicular adenoma (morphologic abnormality); follicular adenoma of the thyroid; follicular adenoma of the thyroid gland; follicular adenoma of thyroid; follicular adenoma of thyroid gland; follicular thyroid adenoma; thyroid adenoma; thyroid adenoma (disease); thyroid follicle adenoma; Thyroid follicular adenoma; thyroid follicular adenoma; thyroid gland adenoma; thyroid gland follicular adenoma
 
HPO: HP:0011774
Monarch Initiative: MONDO:0005032

Definition

A benign, encapsulated tumor, arising from the follicular cells of the thyroid gland. It may be associated with thyroid hormone secretion but it does not have malignant characteristics. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  

Professional guidelines

PubMed

Search for New Target Genes of MicroRNA for Differential Diagnosis of Benign and Malignant Neoplasms of the Thyroid Gland by In Silico Methods.
Kononchuk VV, Kopeikina EV, Kalinina TS, Saik OV, Alekseenok EY, Kolyagina MK, Matashova VA, Shevchenko SP, Gulyaeva LF, Kushlinskii NE
Bull Exp Biol Med 2022 Jun;173(2):246-251. Epub 2022 Jun 23 doi: 10.1007/s10517-022-05527-x. PMID: 35737153
The utility of serum anti-thyroglobulin antibody and thyroglobulin in the preoperative differential diagnosis of thyroid follicular neoplasms.
Chen Z, Lin Y, Lai S, Wang P, Li J, Wang L, Guan H, Kuang J
Endocrine 2022 May;76(2):369-376. Epub 2022 Feb 2 doi: 10.1007/s12020-022-02993-1. PMID: 35112214
Molecular differential diagnosis of follicular thyroid carcinoma and adenoma based on gene expression profiling by using formalin-fixed paraffin-embedded tissues.
Pfeifer A, Wojtas B, Oczko-Wojciechowska M, Kukulska A, Czarniecka A, Eszlinger M, Musholt T, Stokowy T, Swierniak M, Stobiecka E, Rusinek D, Tyszkiewicz T, Kowal M, Jarzab M, Hauptmann S, Lange D, Paschke R, Jarzab B
BMC Med Genomics 2013 Oct 7;6:38. doi: 10.1186/1755-8794-6-38. PMID: 24099521Free PMC Article

Recent clinical studies

Etiology

Can TP53-mutant follicular adenoma be a precursor of anaplastic thyroid carcinoma?
Nikitski AV, Nikiforova MN, Yip L, Karslioglu-French E, Carty SE, Nikiforov YE
Endocr Relat Cancer 2021 Aug 6;28(9):621-630. doi: 10.1530/ERC-21-0095. PMID: 34264855
Ultrasonic identification and regression analysis of 294 thyroid follicular tumors.
Ou D, Yao J, Jin J, Yan M, Shi K, Zheng Q, Yang C, Xu D
J Cancer Res Ther 2020 Sep;16(5):1056-1062. doi: 10.4103/jcrt.JCRT_913_19. PMID: 33004747
The surgical dilemma of primary surgery for follicular thyroid neoplasms.
Staubitz JI, Musholt PB, Musholt TJ
Best Pract Res Clin Endocrinol Metab 2019 Aug;33(4):101292. Epub 2019 Jul 9 doi: 10.1016/j.beem.2019.101292. PMID: 31434622
Thyroid nodules: pathophysiological insight on oncogenesis and novel diagnostic techniques.
Krátký J, Vítková H, Bartáková J, Telička Z, Antošová M, Límanová Z, Jiskra J
Physiol Res 2014;63 Suppl 2(Suppl 2):S263-75. doi: 10.33549/physiolres.932818. PMID: 24908232
Follicular thyroid adenoma dominated by spindle cells: report of two unusual cases and literature review.
Agaimy A, Hahn T, Schroeder J, Elhag A
Int J Clin Exp Pathol 2012;5(2):143-51. Epub 2012 Feb 12 PMID: 22400075Free PMC Article

Diagnosis

Proteotypic Differences of Follicular-Patterned Thyroid Neoplasms.
Huang D, Zhang H, Li L, Ge W, Liu W, Dong Z, Gao J, Yao N, Fu W, Huang L, Guo T, Sun Y, Teng X
Front Endocrinol (Lausanne) 2022;13:854611. Epub 2022 Jul 6 doi: 10.3389/fendo.2022.854611. PMID: 35923625Free PMC Article
FAM172A promotes follicular thyroid carcinogenesis and may be a marker of FTC.
Xu PP, Zeng S, Xia XT, Ye ZH, Li MF, Chen MY, Xia T, Xu JJ, Jiao Q, Liu L, Li LX, Guo MG
Endocr Relat Cancer 2020 Nov;27(11):657-669. doi: 10.1530/ERC-20-0181. PMID: 33095186Free PMC Article
Ultrasonic identification and regression analysis of 294 thyroid follicular tumors.
Ou D, Yao J, Jin J, Yan M, Shi K, Zheng Q, Yang C, Xu D
J Cancer Res Ther 2020 Sep;16(5):1056-1062. doi: 10.4103/jcrt.JCRT_913_19. PMID: 33004747
The surgical dilemma of primary surgery for follicular thyroid neoplasms.
Staubitz JI, Musholt PB, Musholt TJ
Best Pract Res Clin Endocrinol Metab 2019 Aug;33(4):101292. Epub 2019 Jul 9 doi: 10.1016/j.beem.2019.101292. PMID: 31434622
Expression and clinicopathological role of miR146a in thyroid follicular carcinoma.
Pignatti E, Vighi E, Magnani E, Kara E, Roncati L, Maiorana A, Santi D, Madeo B, Cioni K, Carani C, Rochira V, Simoni M, Brigante G
Endocrine 2019 Jun;64(3):575-583. Epub 2019 Jan 30 doi: 10.1007/s12020-019-01845-9. PMID: 30701447

Therapy

Development and Validation of a Diagnostic Nomogram for the Preoperative Differentiation Between Follicular Thyroid Carcinoma and Follicular Thyroid Adenomas.
Tang P, Ren C, Shen L, Zhou Z
J Comput Assist Tomogr 2021 Jan-Feb 01;45(1):128-134. doi: 10.1097/RCT.0000000000001078. PMID: 33475318
A two miRNA classifier differentiates follicular thyroid carcinomas from follicular thyroid adenomas.
Stokowy T, Wojtaś B, Krajewska J, Stobiecka E, Dralle H, Musholt T, Hauptmann S, Lange D, Hegedüs L, Jarząb B, Krohn K, Paschke R, Eszlinger M
Mol Cell Endocrinol 2015 Jan 5;399:43-9. Epub 2014 Sep 26 doi: 10.1016/j.mce.2014.09.017. PMID: 25258301
Down-regulation of NR4A1 in follicular thyroid carcinomas is restored following lithium treatment.
Camacho CP, Latini FR, Oler G, Hojaij FC, Maciel RM, Riggins GJ, Cerutti JM
Clin Endocrinol (Oxf) 2009 Mar;70(3):475-83. Epub 2008 Aug 22 doi: 10.1111/j.1365-2265.2008.03349.x. PMID: 18727708Free PMC Article
Construction of cDNA libraries from microdissected benign and malignant thyroid tissue.
Kaserer K, Knezevic V, Pichlhöfer B, Scheuba C, Passler C, Worth J, Niederle B, Krizman D
Lab Invest 2002 Dec;82(12):1707-14. doi: 10.1097/01.lab.0000043121.48152.79. PMID: 12480920
Clonal origin of non-medullary thyroid tumours assessed by non-random X-chromosome inactivation.
Moniz S, Catarino AL, Marques AR, Cavaco B, Sobrinho L, Leite V
Eur J Endocrinol 2002 Jan;146(1):27-33. doi: 10.1530/eje.0.1460027. PMID: 11751063

Prognosis

Susceptibility Genes and Chromosomal Regions Associated With Non-Syndromic Familial Non-Medullary Thyroid Carcinoma: Some Pathogenetic and Diagnostic Keys.
Sánchez-Ares M, Cameselle-García S, Abdulkader-Nallib I, Rodríguez-Carnero G, Beiras-Sarasquete C, Puñal-Rodríguez JA, Cameselle-Teijeiro JM
Front Endocrinol (Lausanne) 2022;13:829103. Epub 2022 Feb 28 doi: 10.3389/fendo.2022.829103. PMID: 35295987Free PMC Article
Overexpression of mir-129-1, miR-146b, mir-183, and mir-197 in follicular thyroid carcinoma and adenoma tissues.
Sheikholeslami S, Shabani N, Shivaee S, Tavangar SM, Yeganeh M, Hedayati M, Lotfi J, Gholami H
Mol Cell Probes 2020 Jun;51:101536. Epub 2020 Feb 18 doi: 10.1016/j.mcp.2020.101536. PMID: 32081771
The surgical dilemma of primary surgery for follicular thyroid neoplasms.
Staubitz JI, Musholt PB, Musholt TJ
Best Pract Res Clin Endocrinol Metab 2019 Aug;33(4):101292. Epub 2019 Jul 9 doi: 10.1016/j.beem.2019.101292. PMID: 31434622
Thyroid nodules: pathophysiological insight on oncogenesis and novel diagnostic techniques.
Krátký J, Vítková H, Bartáková J, Telička Z, Antošová M, Límanová Z, Jiskra J
Physiol Res 2014;63 Suppl 2(Suppl 2):S263-75. doi: 10.33549/physiolres.932818. PMID: 24908232
Follicular thyroid adenoma dominated by spindle cells: report of two unusual cases and literature review.
Agaimy A, Hahn T, Schroeder J, Elhag A
Int J Clin Exp Pathol 2012;5(2):143-51. Epub 2012 Feb 12 PMID: 22400075Free PMC Article

Clinical prediction guides

Diagnostic significance of CyclinD1 and D2-40 expression for follicular neoplasm of the thyroid.
Liu J, Tao LL, Yu GY, Chen G, Wang Z, Mei KY, Xu XL, Shi XX, Li TL, Yin WH
Pathol Res Pract 2022 Jan;229:153739. Epub 2021 Dec 11 doi: 10.1016/j.prp.2021.153739. PMID: 34920294
Can TP53-mutant follicular adenoma be a precursor of anaplastic thyroid carcinoma?
Nikitski AV, Nikiforova MN, Yip L, Karslioglu-French E, Carty SE, Nikiforov YE
Endocr Relat Cancer 2021 Aug 6;28(9):621-630. doi: 10.1530/ERC-21-0095. PMID: 34264855
FAM172A promotes follicular thyroid carcinogenesis and may be a marker of FTC.
Xu PP, Zeng S, Xia XT, Ye ZH, Li MF, Chen MY, Xia T, Xu JJ, Jiao Q, Liu L, Li LX, Guo MG
Endocr Relat Cancer 2020 Nov;27(11):657-669. doi: 10.1530/ERC-20-0181. PMID: 33095186Free PMC Article
Expression and clinicopathological role of miR146a in thyroid follicular carcinoma.
Pignatti E, Vighi E, Magnani E, Kara E, Roncati L, Maiorana A, Santi D, Madeo B, Cioni K, Carani C, Rochira V, Simoni M, Brigante G
Endocrine 2019 Jun;64(3):575-583. Epub 2019 Jan 30 doi: 10.1007/s12020-019-01845-9. PMID: 30701447
Thyroid nodules: pathophysiological insight on oncogenesis and novel diagnostic techniques.
Krátký J, Vítková H, Bartáková J, Telička Z, Antošová M, Límanová Z, Jiskra J
Physiol Res 2014;63 Suppl 2(Suppl 2):S263-75. doi: 10.33549/physiolres.932818. PMID: 24908232

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