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Ileal neuroendocrine tumor G1

MedGen UID:
155426
Concept ID:
C0745216
Neoplastic Process
Synonyms: Carcinoid tumor of ileum; Carcinoid Tumor of Ileum; carcinoid tumor of ileum; Carcinoid Tumor of the Ileum; carcinoid tumor of the ileum; carcinoid tumour of ileum; carcinoid tumour of the ileum; grade 1 neuroendocrine neoplasm of ileum; Ileal Carcinoid Tumor; ileal carcinoid tumor; ileal carcinoid tumour; Ileal NET G1; ileal NET G1; Ileal Neuroendocrine Tumor G1; ileal neuroendocrine tumor G1; ileum carcinoid tumor; ileum carcinoid tumor (disease); ileum carcinoid tumour; ileum carcinoid tumour (disease); ileum NET G1; ileum neuroendocrine neoplasm G1; ileum neuroendocrine tumor, well differentiated, low grade
SNOMED CT: Carcinoid tumor of ileum (425318003)
 
Monarch Initiative: MONDO:0006250

Definition

A well differentiated, low grade neuroendocrine neoplasm (carcinoid tumor) that arises from the ileum. The mitotic count is less than 2 per 10 HPF and/or the Ki67 index is equal to or less than 2 percent. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIleal neuroendocrine tumor G1

Professional guidelines

PubMed

Frilling A, Clift AK, Frampton AE, Bomanji J, Kaemmerer D, Al-Nahhas A, Alsafi A, Kidd M, Modlin IM, Hoersch D, Baum RP
Int J Med Sci 2021;18(10):2166-2175. Epub 2021 Mar 19 doi: 10.7150/ijms.51740. PMID: 33859524Free PMC Article
Koch W, Auernhammer CJ, Geisler J, Spitzweg C, Cyran CC, Ilhan H, Bartenstein P, Haug AR
Mol Imaging 2014;13:1-10. PMID: 24824963

Recent clinical studies

Etiology

Masui T, Ito T, Komoto I, Kojima S, Kasai Y, Tanabe M, Hara K, Hirano S, Okusaka T, Ichikawa Y, Kinugasa Y, Kokudo N, Kudo A, Sakurai A, Sugihara K, Date H, Haruma K, Hijioka S, Hirata K, Yamano H, Sakamine M, Kikuchi T, Fukushima M, Imamura M, Uemoto S
Int J Clin Oncol 2022 May;27(5):840-849. Epub 2022 Feb 18 doi: 10.1007/s10147-022-02130-y. PMID: 35178624Free PMC Article
Feola T, Puliani G, Sesti F, Modica R, Centello R, Minotta R, Cannavale G, Di Meglio S, Di Vito V, Lauretta R, Appetecchia M, Colao A, Lenzi A, Isidori AM, Faggiano A, Giannetta E
J Endocrinol Invest 2022 Apr;45(4):849-857. Epub 2022 Jan 18 doi: 10.1007/s40618-021-01715-0. PMID: 35040099
Altieri B, Barrea L, Modica R, Bottiglieri F, de Cicco F, Muscogiuri G, Circelli L, Savarese G, Di Somma C, Savastano S, Colao A, Faggiano A
Endocrine 2022 Feb;75(2):623-634. Epub 2021 Sep 17 doi: 10.1007/s12020-021-02869-w. PMID: 34533768
Frilling A, Clift AK, Frampton AE, Bomanji J, Kaemmerer D, Al-Nahhas A, Alsafi A, Kidd M, Modlin IM, Hoersch D, Baum RP
Int J Med Sci 2021;18(10):2166-2175. Epub 2021 Mar 19 doi: 10.7150/ijms.51740. PMID: 33859524Free PMC Article
Del Prete M, Di Sarno A, Modica R, Lassandro F, Giorgio A, Bianco A, Muto M, Gasperi M, Del Prete F, Colao A, Montesarchio V, Faggiano A; ENETS Centre of Excellence Multidisciplinary Group for Neuroendocrine Tumors in Naples (Italy)
J Endocrinol Invest 2017 Dec;40(12):1373-1380. Epub 2017 Jun 30 doi: 10.1007/s40618-017-0723-x. PMID: 28667452

Diagnosis

Feola T, Puliani G, Sesti F, Modica R, Centello R, Minotta R, Cannavale G, Di Meglio S, Di Vito V, Lauretta R, Appetecchia M, Colao A, Lenzi A, Isidori AM, Faggiano A, Giannetta E
J Endocrinol Invest 2022 Apr;45(4):849-857. Epub 2022 Jan 18 doi: 10.1007/s40618-021-01715-0. PMID: 35040099
Kasajima A, Konukiewitz B, Schlitter AM, Weichert W, Klöppel G
Virchows Arch 2022 Feb;480(2):359-368. Epub 2021 Sep 9 doi: 10.1007/s00428-021-03202-6. PMID: 34499237Free PMC Article
Frilling A, Clift AK, Frampton AE, Bomanji J, Kaemmerer D, Al-Nahhas A, Alsafi A, Kidd M, Modlin IM, Hoersch D, Baum RP
Int J Med Sci 2021;18(10):2166-2175. Epub 2021 Mar 19 doi: 10.7150/ijms.51740. PMID: 33859524Free PMC Article
Del Prete M, Di Sarno A, Modica R, Lassandro F, Giorgio A, Bianco A, Muto M, Gasperi M, Del Prete F, Colao A, Montesarchio V, Faggiano A; ENETS Centre of Excellence Multidisciplinary Group for Neuroendocrine Tumors in Naples (Italy)
J Endocrinol Invest 2017 Dec;40(12):1373-1380. Epub 2017 Jun 30 doi: 10.1007/s40618-017-0723-x. PMID: 28667452
Deroose CM, Hindié E, Kebebew E, Goichot B, Pacak K, Taïeb D, Imperiale A
J Nucl Med 2016 Dec;57(12):1949-1956. Epub 2016 Nov 3 doi: 10.2967/jnumed.116.179234. PMID: 27811124Free PMC Article

Therapy

Frilling A, Clift AK, Frampton AE, Bomanji J, Kaemmerer D, Al-Nahhas A, Alsafi A, Kidd M, Modlin IM, Hoersch D, Baum RP
Int J Med Sci 2021;18(10):2166-2175. Epub 2021 Mar 19 doi: 10.7150/ijms.51740. PMID: 33859524Free PMC Article
Del Prete M, Di Sarno A, Modica R, Lassandro F, Giorgio A, Bianco A, Muto M, Gasperi M, Del Prete F, Colao A, Montesarchio V, Faggiano A; ENETS Centre of Excellence Multidisciplinary Group for Neuroendocrine Tumors in Naples (Italy)
J Endocrinol Invest 2017 Dec;40(12):1373-1380. Epub 2017 Jun 30 doi: 10.1007/s40618-017-0723-x. PMID: 28667452
Koch W, Auernhammer CJ, Geisler J, Spitzweg C, Cyran CC, Ilhan H, Bartenstein P, Haug AR
Mol Imaging 2014;13:1-10. PMID: 24824963
Fiori S, Del Gobbo A, Gaudioso G, Caccamo L, Massironi S, Cavalcoli F, Bosari S, Ferrero S
Diagn Pathol 2013 Sep 13;8:148. doi: 10.1186/1746-1596-8-148. PMID: 24034980Free PMC Article
Panzuto F, Campana D, Fazio N, Brizzi MP, Boninsegna L, Nori F, Di Meglio G, Capurso G, Scarpa A, Dogliotti L, De Braud F, Tomassetti P, Delle Fave G, Falconi M
Neuroendocrinology 2012;96(1):32-40. Epub 2011 Dec 28 doi: 10.1159/000334038. PMID: 22205326

Prognosis

Masui T, Ito T, Komoto I, Kojima S, Kasai Y, Tanabe M, Hara K, Hirano S, Okusaka T, Ichikawa Y, Kinugasa Y, Kokudo N, Kudo A, Sakurai A, Sugihara K, Date H, Haruma K, Hijioka S, Hirata K, Yamano H, Sakamine M, Kikuchi T, Fukushima M, Imamura M, Uemoto S
Int J Clin Oncol 2022 May;27(5):840-849. Epub 2022 Feb 18 doi: 10.1007/s10147-022-02130-y. PMID: 35178624Free PMC Article
Feola T, Puliani G, Sesti F, Modica R, Centello R, Minotta R, Cannavale G, Di Meglio S, Di Vito V, Lauretta R, Appetecchia M, Colao A, Lenzi A, Isidori AM, Faggiano A, Giannetta E
J Endocrinol Invest 2022 Apr;45(4):849-857. Epub 2022 Jan 18 doi: 10.1007/s40618-021-01715-0. PMID: 35040099
Altieri B, Barrea L, Modica R, Bottiglieri F, de Cicco F, Muscogiuri G, Circelli L, Savarese G, Di Somma C, Savastano S, Colao A, Faggiano A
Endocrine 2022 Feb;75(2):623-634. Epub 2021 Sep 17 doi: 10.1007/s12020-021-02869-w. PMID: 34533768
Borga C, Dal Pozzo CA, Trevellin E, Bergamo F, Murgioni S, Milanetto AC, Pasquali C, Cillo U, Munari G, Martini C, De Carlo E, Zagonel V, Guzzardo V, Pennelli G, Dei Tos AP, Vettor R, Fassan M
Endocr Relat Cancer 2021 Jun 10;28(7):449-456. doi: 10.1530/ERC-21-0052. PMID: 33974555
Del Prete M, Di Sarno A, Modica R, Lassandro F, Giorgio A, Bianco A, Muto M, Gasperi M, Del Prete F, Colao A, Montesarchio V, Faggiano A; ENETS Centre of Excellence Multidisciplinary Group for Neuroendocrine Tumors in Naples (Italy)
J Endocrinol Invest 2017 Dec;40(12):1373-1380. Epub 2017 Jun 30 doi: 10.1007/s40618-017-0723-x. PMID: 28667452

Clinical prediction guides

Frilling A, Clift AK, Frampton AE, Bomanji J, Kaemmerer D, Al-Nahhas A, Alsafi A, Kidd M, Modlin IM, Hoersch D, Baum RP
Int J Med Sci 2021;18(10):2166-2175. Epub 2021 Mar 19 doi: 10.7150/ijms.51740. PMID: 33859524Free PMC Article
Rossi RE, Elli L, Branchi F, Conte D, Massironi S
Digestion 2021;102(5):722-730. Epub 2020 Dec 23 doi: 10.1159/000511850. PMID: 33361694
Del Prete M, Di Sarno A, Modica R, Lassandro F, Giorgio A, Bianco A, Muto M, Gasperi M, Del Prete F, Colao A, Montesarchio V, Faggiano A; ENETS Centre of Excellence Multidisciplinary Group for Neuroendocrine Tumors in Naples (Italy)
J Endocrinol Invest 2017 Dec;40(12):1373-1380. Epub 2017 Jun 30 doi: 10.1007/s40618-017-0723-x. PMID: 28667452
Panzuto F, Campana D, Fazio N, Brizzi MP, Boninsegna L, Nori F, Di Meglio G, Capurso G, Scarpa A, Dogliotti L, De Braud F, Tomassetti P, Delle Fave G, Falconi M
Neuroendocrinology 2012;96(1):32-40. Epub 2011 Dec 28 doi: 10.1159/000334038. PMID: 22205326
Deschamps L, Bacha D, Rebours V, Mebarki M, Bretagnol F, Panis Y, Bedossa P, Ruszniewski P, Couvelard A
Neuroendocrinology 2012;95(3):214-22. Epub 2011 Nov 29 doi: 10.1159/000329873. PMID: 22133596

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