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Malignant tumor of neck

MedGen UID:
155434
•Concept ID:
C0746787
•
Neoplastic Process
Synonyms: Cancer of Neck; Cancer of the Neck; Cancer, Neck; Cancers, Neck; Neck Cancer; Neck Cancers
SNOMED CT: Malignant tumor of neck (363489000)
 
Monarch Initiative: MONDO:0021310

Definition

A primary or metastatic malignant neoplasm that affects the anatomic structures of the neck region. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMalignant tumor of neck

Professional guidelines

PubMed

Oesophageal cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up.
Obermannová R, Alsina M, Cervantes A, Leong T, Lordick F, Nilsson M, van Grieken NCT, Vogel A, Smyth EC; ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org
Ann Oncol 2022 Oct;33(10):992-1004. Epub 2022 Jul 29 doi: 10.1016/j.annonc.2022.07.003. PMID: 35914638
Updated diagnostic criteria and nomenclature for neurofibromatosis type 2 and schwannomatosis: An international consensus recommendation.
Plotkin SR, Messiaen L, Legius E, Pancza P, Avery RA, Blakeley JO, Babovic-Vuksanovic D, Ferner R, Fisher MJ, Friedman JM, Giovannini M, Gutmann DH, Hanemann CO, Kalamarides M, Kehrer-Sawatzki H, Korf BR, Mautner VF, MacCollin M, Papi L, Rauen KA, Riccardi V, Schorry E, Smith MJ, Stemmer-Rachamimov A, Stevenson DA, Ullrich NJ, Viskochil D, Wimmer K, Yohay K; International Consensus Group on Neurofibromatosis Diagnostic Criteria (I-NF-DC), Huson SM, Wolkenstein P, Evans DG
Genet Med 2022 Sep;24(9):1967-1977. Epub 2022 Jun 9 doi: 10.1016/j.gim.2022.05.007. PMID: 35674741
Thyroid cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up†.
Filetti S, Durante C, Hartl D, Leboulleux S, Locati LD, Newbold K, Papotti MG, Berruti A; ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org
Ann Oncol 2019 Dec 1;30(12):1856-1883. doi: 10.1093/annonc/mdz400. PMID: 31549998

Recent clinical studies

Etiology

A transcriptomic map of EGFR-induced epithelial-to-mesenchymal transition identifies prognostic and therapeutic targets for head and neck cancer.
Schinke H, Shi E, Lin Z, Quadt T, Kranz G, Zhou J, Wang H, Hess J, Heuer S, Belka C, Zitzelsberger H, Schumacher U, Genduso S, Riecken K, Gao Y, Wu Z, Reichel CA, Walz C, Canis M, Unger K, Baumeister P, Pan M, Gires O
Mol Cancer 2022 Sep 8;21(1):178. doi: 10.1186/s12943-022-01646-1. PMID: 36076232Free PMC Article
Paragangliomas of the head and neck.
Valero C, Ganly I
J Oral Pathol Med 2022 Nov;51(10):897-903. Epub 2022 Feb 23 doi: 10.1111/jop.13286. PMID: 35178777
HNSCC: Tumour Antigens and Their Targeting by Immunotherapy.
von Witzleben A, Wang C, Laban S, Savelyeva N, Ottensmeier CH
Cells 2020 Sep 15;9(9) doi: 10.3390/cells9092103. PMID: 32942747Free PMC Article
Soft Tissue Special Issue: Fibroblastic and Myofibroblastic Neoplasms of the Head and Neck.
Baranov E, Hornick JL
Head Neck Pathol 2020 Mar;14(1):43-58. Epub 2020 Jan 16 doi: 10.1007/s12105-019-01104-3. PMID: 31950474Free PMC Article
Essentials of oral cancer.
Rivera C
Int J Clin Exp Pathol 2015;8(9):11884-94. Epub 2015 Sep 1 PMID: 26617944Free PMC Article

Diagnosis

Models of head and neck squamous cell carcinoma using bioengineering approaches.
Bonartsev AP, Lei B, Kholina MS, Menshikh KA, Svyatoslavov DS, Samoylova SI, Sinelnikov MY, Voinova VV, Shaitan KV, Kirpichnikov MP, Reshetov IV
Crit Rev Oncol Hematol 2022 Jul;175:103724. Epub 2022 May 21 doi: 10.1016/j.critrevonc.2022.103724. PMID: 35609774
Paragangliomas of the head and neck.
Valero C, Ganly I
J Oral Pathol Med 2022 Nov;51(10):897-903. Epub 2022 Feb 23 doi: 10.1111/jop.13286. PMID: 35178777
Chordoma of the Head and Neck: A Review.
Wasserman JK, Gravel D, Purgina B
Head Neck Pathol 2018 Jun;12(2):261-268. Epub 2017 Oct 4 doi: 10.1007/s12105-017-0860-8. PMID: 28980142Free PMC Article
Clinical Practice Guideline: Evaluation of the Neck Mass in Adults.
Pynnonen MA, Gillespie MB, Roman B, Rosenfeld RM, Tunkel DE, Bontempo L, Brook I, Chick DA, Colandrea M, Finestone SA, Fowler JC, Griffith CC, Henson Z, Levine C, Mehta V, Salama A, Scharpf J, Shatzkes DR, Stern WB, Youngerman JS, Corrigan MD
Otolaryngol Head Neck Surg 2017 Sep;157(2_suppl):S1-S30. doi: 10.1177/0194599817722550. PMID: 28891406
Kaposiform haemangioendothelioma of the head and neck.
Wong BL, Lee VN, Tikka T, Kim D, Dwivedi RC
Crit Rev Oncol Hematol 2016 Aug;104:156-68. Epub 2016 Jun 16 doi: 10.1016/j.critrevonc.2016.06.005. PMID: 27365122

Therapy

Inhibiting the inhibitors: Development of the IAP inhibitor xevinapant for the treatment of locally advanced squamous cell carcinoma of the head and neck.
Ferris RL, Harrington K, Schoenfeld JD, Tahara M, Esdar C, Salmio S, Schroeder A, Bourhis J
Cancer Treat Rev 2023 Feb;113:102492. Epub 2022 Nov 30 doi: 10.1016/j.ctrv.2022.102492. PMID: 36640618
Xevinapant or placebo plus chemoradiotherapy in locally advanced squamous cell carcinoma of the head and neck: TrilynX phase III study design.
Bourhis J, Burtness B, Licitra LF, Nutting C, Schoenfeld JD, Omar M, Bouisset F, Nauwelaerts H, Urfer Y, Zanna C, Cohen EE
Future Oncol 2022 May;18(14):1669-1678. Epub 2022 Feb 17 doi: 10.2217/fon-2021-1634. PMID: 35172587
Photobiomodulation or low-level laser therapy in the management of cancer therapy-induced mucositis, dermatitis and lymphedema.
Bensadoun RJ
Curr Opin Oncol 2018 Jul;30(4):226-232. doi: 10.1097/CCO.0000000000000452. PMID: 29794809
Nutritional interventions in head and neck cancer patients undergoing chemoradiotherapy: a narrative review.
Bossola M
Nutrients 2015 Jan 5;7(1):265-76. doi: 10.3390/nu7010265. PMID: 25569622Free PMC Article
Defining risk levels in locally advanced head and neck cancers: a comparative analysis of concurrent postoperative radiation plus chemotherapy trials of the EORTC (#22931) and RTOG (# 9501).
Bernier J, Cooper JS, Pajak TF, van Glabbeke M, Bourhis J, Forastiere A, Ozsahin EM, Jacobs JR, Jassem J, Ang KK, Lefèbvre JL
Head Neck 2005 Oct;27(10):843-50. doi: 10.1002/hed.20279. PMID: 16161069

Prognosis

Epidemiological Trends of Head and Neck Cancer: A Population-Based Study.
Guo K, Xiao W, Chen X, Zhao Z, Lin Y, Chen G
Biomed Res Int 2021;2021:1738932. Epub 2021 Jul 14 doi: 10.1155/2021/1738932. PMID: 34337000Free PMC Article
The Management of Head and Neck Sarcoma.
Han S, Yin X, Xu W, Wang Y, Han W
J Craniofac Surg 2020 Mar/Apr;31(2):e189-e192. doi: 10.1097/SCS.0000000000006162. PMID: 31934973
Prognosis of subglottic carcinoma: Is it really worse?
Coskun H, Mendenhall WM, Rinaldo A, Rodrigo JP, Suárez C, Strojan P, López F, Mondin V, Saba NF, Shaha AR, Smee R, Takes RP, Ferlito A
Head Neck 2019 Feb;41(2):511-521. Epub 2018 Jun 26 doi: 10.1002/hed.25172. PMID: 29947111
The value of quality-of-life questionnaires in head and neck cancer.
Verdonck-de Leeuw IM, van Nieuwenhuizen A, Leemans CR
Curr Opin Otolaryngol Head Neck Surg 2012 Apr;20(2):142-7. doi: 10.1097/MOO.0b013e32834f5fd7. PMID: 22249168
Ewing tumors of the head and neck.
Whaley JT, Indelicato DJ, Morris CG, Hinerman RW, Amdur RJ, Mendenhall WM, Keole SR, Marcus RB Jr
Am J Clin Oncol 2010 Aug;33(4):321-6. doi: 10.1097/COC.0b013e3181aaca71. PMID: 19841575

Clinical prediction guides

A novel neutrophil extracellular trap signature to predict prognosis and immunotherapy response in head and neck squamous cell carcinoma.
Li Q, Chen W, Li Q, Mao J, Chen X
Front Immunol 2022;13:1019967. Epub 2022 Sep 23 doi: 10.3389/fimmu.2022.1019967. PMID: 36225931Free PMC Article
FOXD1 expression in head and neck squamous carcinoma: a study based on TCGA, GEO and meta-analysis.
Huang J, Liang B, Wang T
Biosci Rep 2021 Jul 30;41(7) doi: 10.1042/BSR20210158. PMID: 34269372Free PMC Article
Peripheral neck nerve tumor: A 73-case study and literature review.
Boumaza K, Michel G, Salaud C, Bossard C, Espitalier F, Malard O
Eur Ann Otorhinolaryngol Head Neck Dis 2019 Nov;136(6):455-460. Epub 2019 Sep 16 doi: 10.1016/j.anorl.2019.09.005. PMID: 31537489
CT-based delineation of organs at risk in the head and neck region: DAHANCA, EORTC, GORTEC, HKNPCSG, NCIC CTG, NCRI, NRG Oncology and TROG consensus guidelines.
Brouwer CL, Steenbakkers RJ, Bourhis J, Budach W, Grau C, Grégoire V, van Herk M, Lee A, Maingon P, Nutting C, O'Sullivan B, Porceddu SV, Rosenthal DI, Sijtsema NM, Langendijk JA
Radiother Oncol 2015 Oct;117(1):83-90. Epub 2015 Aug 13 doi: 10.1016/j.radonc.2015.07.041. PMID: 26277855
Introduction.
Wakely PE Jr
Semin Diagn Pathol 2015 Jul;32(4):249. Epub 2015 Feb 4 doi: 10.1053/j.semdp.2014.12.005. PMID: 25744436

Recent systematic reviews

Managing Cachexia in Head and Neck Cancer: a Systematic Scoping Review.
Mäkitie AA, Alabi RO, Orell H, Youssef O, Almangush A, Homma A, Takes RP, López F, de Bree R, Rodrigo JP, Ferlito A
Adv Ther 2022 Apr;39(4):1502-1523. Epub 2022 Feb 27 doi: 10.1007/s12325-022-02074-9. PMID: 35224702Free PMC Article
Radiotherapy and the survival of dental implants: a systematic review.
Shokouhi B, Cerajewska T
Br J Oral Maxillofac Surg 2022 May;60(4):422-429. Epub 2021 Sep 16 doi: 10.1016/j.bjoms.2021.09.006. PMID: 34903387
Exercise and Nutrition Interventions in Patients with Head and Neck Cancer during Curative Treatment: A Systematic Review and Meta-Analysis.
Bye A, Sandmael JA, Stene GB, Thorsen L, Balstad TR, Solheim TS, Pripp AH, Oldervoll LM
Nutrients 2020 Oct 22;12(11) doi: 10.3390/nu12113233. PMID: 33105699Free PMC Article
Prevention and Treatment of Chemotherapy and Radiotherapy Induced Oral Mucositis.
Daugėlaitė G, Užkuraitytė K, Jagelavičienė E, Filipauskas A
Medicina (Kaunas) 2019 Jan 22;55(2) doi: 10.3390/medicina55020025. PMID: 30678228Free PMC Article
Low level laser therapy/photobiomodulation in the management of side effects of chemoradiation therapy in head and neck cancer: part 1: mechanisms of action, dosimetric, and safety considerations.
Zecha JA, Raber-Durlacher JE, Nair RG, Epstein JB, Sonis ST, Elad S, Hamblin MR, Barasch A, Migliorati CA, Milstein DM, Genot MT, Lansaat L, van der Brink R, Arnabat-Dominguez J, van der Molen L, Jacobi I, van Diessen J, de Lange J, Smeele LE, Schubert MM, Bensadoun RJ
Support Care Cancer 2016 Jun;24(6):2781-92. Epub 2016 Mar 16 doi: 10.1007/s00520-016-3152-z. PMID: 26984240Free PMC Article

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