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Peripheral nervous system cancer

MedGen UID:: 155556
•Concept ID:: C0751428
•: Neoplastic Process

Synonyms:	Peripheral Nerve Neoplasms, Malignant; Peripheral Nervous System Malignant Neoplasms
SNOMED CT:	Peripheral nerve cancer (254986007); Cancer of peripheral nerve (254986007); Malignant tumor of peripheral nerve (254986007)

Monarch Initiative:	MONDO:0021089

Definition

Malignant growth of cells in the peripheral nervous system (PNS)or Autonomic Nervous System (ANS), without specification as to location [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVPeripheral nervous system cancer

Pathological Conditions, Signs and Symptoms
- Pathological process
  - Disease
    - Neoplasm
      - Malignant neoplastic disease
        Malignant neoplasm of nervous system
        Peripheral nervous system cancer
        Granular cell cancer
        Malignant cutaneous granular cell skin tumor
        Malignant gastric granular cell tumor
        Malignant peripheral nerve sheath tumor
        Adult malignant schwannoma
        Cervical Malignant Peripheral Nerve Sheath Tumor
        Childhood malignant schwannoma
        Epithelioid malignant peripheral nerve sheath tumor
        Epithelioid Malignant Peripheral Nerve Sheath Tumor of the Skin
        Recurrent Epithelioid Malignant Peripheral Nerve Sheath Tumor
        Refractory Epithelioid Malignant Peripheral Nerve Sheath Tumor
        Esophageal Malignant Peripheral Nerve Sheath Tumor
        High Grade Malignant Peripheral Nerve Sheath Tumor
        Intraocular Malignant Peripheral Nerve Sheath Tumor
        Low Grade Malignant Peripheral Nerve Sheath Tumor
        Malignant cardiac peripheral nerve sheath neoplasm
        Malignant glandular tumor of peripheral nerve sheath
        Malignant melanocytic neoplasm of the peripheral nerve sheath
        Malignant melanocytic peripheral nerve sheath tumor of mediastinum
        Melanotic psammomatous malignant peripheral nerve sheath tumor
        Malignant perineurioma
        Malignant Peripheral Nerve Sheath Tumor of the Skin
        Malignant Peripheral Nerve Sheath Tumor with Mesenchymal Differentiation
        Malignant triton tumor
        Mediastinal Malignant Peripheral Nerve Sheath Tumor
        Metastatic Malignant Peripheral Nerve Sheath Tumor
        Advanced Malignant Peripheral Nerve Sheath Tumor
        Locally Advanced Malignant Peripheral Nerve Sheath Tumor
        NF1-Associated Malignant Peripheral Nerve Sheath Tumor
        Penile Malignant Peripheral Nerve Sheath Tumor
        Radiation-Induced Malignant Peripheral Nerve Sheath Tumor
        Recurrent Malignant Peripheral Nerve Sheath Tumor
        Refractory Malignant Peripheral Nerve Sheath Tumor
        Sinonasal Malignant Peripheral Nerve Sheath Tumor
        Sporadic Malignant Peripheral Nerve Sheath Tumor
        Thyroid Gland Malignant Peripheral Nerve Sheath Tumor
        Unresectable Malignant Peripheral Nerve Sheath Tumor
        Metastatic Paraganglioma
        Malignant adrenal gland pheochromocytoma
        Metastatic Adrenal Gland Composite Pheochromocytoma
        Metastatic Extra-Adrenal Paraganglioma
        Malignant carotid body paraganglioma
        Malignant jugulotympanic paraganglioma
        Metastatic Bladder Paraganglioma
        Metastatic Cardiac Paraganglioma
        Metastatic Intrathoracic Paravertebral Paraganglioma
        Peripheral ganglioneuroblastoma
        Adrenal gland ganglioneuroblastoma
        Adrenal Gland Ganglioneuroblastoma, Intermixed
        Adrenal Gland Ganglioneuroblastoma, Nodular
        Mediastinum ganglioneuroblastoma
        Peripheral Neuroblastoma
        Mediastinum neuroblastoma
        Neuroblastoma of the Adrenal Gland and Sympathetic Nervous System
        Adrenal gland neuroblastoma
        Peripheral primitive neuroectodermal tumor
        Askin tumor
        Localized Askin Tumor
        Recurrent Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor
        Localized Peripheral Primitive Neuroectodermal Tumor
        Localized Peripheral Primitive Neuroectodermal Tumor of Bone
        Neuroblastoma
        Cerebral neuroblastoma
        Childhood Neuroblastoma
        Congenital neuroblastoma
        Differentiating neuroblastoma
        Esthesioneuroblastoma
        Extracranial neuroblastoma
        Ganglioneuroblastoma
        Hereditary Neuroblastoma
        High Risk Neuroblastoma
        Localized neuroblastoma
        Metastatic Neuroblastoma
        Neuroblastoma, susceptibility to, 1
        Neuroblastoma, susceptibility to, 2
        Neuroblastoma, susceptibility to, 3
        Poorly Differentiated Neuroblastoma
        Recurrent Neuroblastoma
        Refractory Neuroblastoma
        Regional Neuroblastoma
        Resectable Neuroblastoma
        Retinoblastoma
        Sellar Neuroblastoma
        Stage 1 Neuroblastoma
        Stage 2 Neuroblastoma
        Stage 3 Neuroblastoma
        Stage 4 Neuroblastoma
        Undifferentiated Neuroblastoma
        Unresectable Neuroblastoma
        Peripheral primitive neuroectodermal tumor of bone
        Metastatic Peripheral Primitive Neuroectodermal Tumor of Bone
        Recurrent Peripheral Primitive Neuroectodermal Tumor of Bone
        Peripheral primitive neuroectodermal tumor of soft tissues
        Peripheral Primitive Neuroectodermal Tumor of the Kidney
        Recurrent Peripheral Primitive Neuroectodermal Tumor
        Refractory Peripheral Primitive Neuroectodermal Tumor

Professional guidelines

PubMed

Pancreas Cancer-Associated Pain Management.

Coveler AL, Mizrahi J, Eastman B, Apisarnthanarax SJ, Dalal S, McNearney T, Pant S; Precision Promise Consortium
Oncologist 2021 Jun;26(6):e971-e982. Epub 2021 May 12 doi: 10.1002/onco.13796. PMID: 33885205 Free PMC Article

The Diagnosis and Management of Neurofibromatosis Type 1.

Ly KI, Blakeley JO
Med Clin North Am 2019 Nov;103(6):1035-1054. doi: 10.1016/j.mcna.2019.07.004. PMID: 31582003

Health Supervision for Children With Neurofibromatosis Type 1.

Miller DT, Freedenberg D, Schorry E, Ullrich NJ, Viskochil D, Korf BR; COUNCIL ON GENETICS; AMERICAN COLLEGE OF MEDICAL GENETICS AND GENOMICS
Pediatrics 2019 May;143(5) doi: 10.1542/peds.2019-0660. PMID: 31010905

See all (1081)

Recent clinical studies

Etiology

Peripheral nervous system adverse events associated with immune checkpoint inhibitors.

Rossi S, Gelsomino F, Rinaldi R, Muccioli L, Comito F, Di Federico A, De Giglio A, Lamberti G, Andrini E, Mollica V, D'Angelo R, Baccari F, Zenesini C, Madia P, Raschi E, Cortelli P, Ardizzoni A, Guarino M
J Neurol 2023 Jun;270(6):2975-2986. Epub 2023 Feb 17 doi: 10.1007/s00415-023-11625-1. PMID: 36800019 Free PMC Article

Microtubule and tubulin binding and regulation of microtubule dynamics by the antibody drug conjugate (ADC) payload, monomethyl auristatin E (MMAE): Mechanistic insights into MMAE ADC peripheral neuropathy.

Best RL, LaPointe NE, Azarenko O, Miller H, Genualdi C, Chih S, Shen BQ, Jordan MA, Wilson L, Feinstein SC, Stagg NJ
Toxicol Appl Pharmacol 2021 Jun 15;421:115534. Epub 2021 Apr 20 doi: 10.1016/j.taap.2021.115534. PMID: 33852878

Diagnostic Pathology of Tumors of Peripheral Nerve.

Belakhoua SM, Rodriguez FJ
Neurosurgery 2021 Feb 16;88(3):443-456. doi: 10.1093/neuros/nyab021. PMID: 33588442 Free PMC Article

Perineural Invasion and Perineural Tumor Spread in Head and Neck Cancer.

Bakst RL, Glastonbury CM, Parvathaneni U, Katabi N, Hu KS, Yom SS
Int J Radiat Oncol Biol Phys 2019 Apr 1;103(5):1109-1124. Epub 2018 Dec 15 doi: 10.1016/j.ijrobp.2018.12.009. PMID: 30562546

A contouring guide for head and neck cancers with perineural invasion.

Ko HC, Gupta V, Mourad WF, Hu KS, Harrison LB, Som PM, Bakst RL
Pract Radiat Oncol 2014 Nov-Dec;4(6):e247-58. Epub 2014 Mar 26 doi: 10.1016/j.prro.2014.02.001. PMID: 25407876

See all (8253)

Diagnosis

The Role of Extracellular Vesicles in Cancer-Nerve Crosstalk of the Peripheral Nervous System.

Guo Y, Gil Z
Cells 2022 Apr 11;11(8) doi: 10.3390/cells11081294. PMID: 35455973 Free PMC Article

Neoplastic nerve lesions.

Patel DK, Gwathmey KG
Neurol Sci 2022 May;43(5):3019-3038. Epub 2022 Feb 23 doi: 10.1007/s10072-022-05951-x. PMID: 35195810

Peripheral Nervous System Involvement.

Thaisetthawatkul P, Dyck PJB
Hematol Oncol Clin North Am 2020 Dec;34(6):1091-1098. Epub 2020 Sep 10 doi: 10.1016/j.hoc.2020.07.004. PMID: 33099426

Plexus and peripheral nerve metastasis.

Gwathmey KG
Handb Clin Neurol 2018;149:257-279. doi: 10.1016/B978-0-12-811161-1.00017-7. PMID: 29307357

Morton's neuroma.

Adams WR 2nd
Clin Podiatr Med Surg 2010 Oct;27(4):535-45. doi: 10.1016/j.cpm.2010.06.004. PMID: 20934103

See all (11291)

Therapy

Peripheral nervous system adverse events associated with immune checkpoint inhibitors.

Prevention and Management of Chemotherapy-Induced Peripheral Neuropathy in Survivors of Adult Cancers: ASCO Guideline Update.

Loprinzi CL, Lacchetti C, Bleeker J, Cavaletti G, Chauhan C, Hertz DL, Kelley MR, Lavino A, Lustberg MB, Paice JA, Schneider BP, Lavoie Smith EM, Smith ML, Smith TJ, Wagner-Johnston N, Hershman DL
J Clin Oncol 2020 Oct 1;38(28):3325-3348. Epub 2020 Jul 14 doi: 10.1200/JCO.20.01399. PMID: 32663120

Effects of exercise during chemotherapy on chemotherapy-induced peripheral neuropathy: a multicenter, randomized controlled trial.

Kleckner IR, Kamen C, Gewandter JS, Mohile NA, Heckler CE, Culakova E, Fung C, Janelsins MC, Asare M, Lin PJ, Reddy PS, Giguere J, Berenberg J, Kesler SR, Mustian KM
Support Care Cancer 2018 Apr;26(4):1019-1028. Epub 2017 Dec 14 doi: 10.1007/s00520-017-4013-0. PMID: 29243164 Free PMC Article

Cancer of the Peripheral Nerve in Neurofibromatosis Type 1.

Staedtke V, Bai RY, Blakeley JO
Neurotherapeutics 2017 Apr;14(2):298-306. doi: 10.1007/s13311-017-0518-y. PMID: 28349408 Free PMC Article

Prevention and management of chemotherapy-induced peripheral neuropathy in survivors of adult cancers: American Society of Clinical Oncology clinical practice guideline.

Hershman DL, Lacchetti C, Dworkin RH, Lavoie Smith EM, Bleeker J, Cavaletti G, Chauhan C, Gavin P, Lavino A, Lustberg MB, Paice J, Schneider B, Smith ML, Smith T, Terstriep S, Wagner-Johnston N, Bak K, Loprinzi CL; American Society of Clinical Oncology
J Clin Oncol 2014 Jun 20;32(18):1941-67. Epub 2014 Apr 14 doi: 10.1200/JCO.2013.54.0914. PMID: 24733808

See all (6920)

Prognosis

Crosstalk between the peripheral nervous system and breast cancer influences tumor progression.

Hu J, Chen W, Shen L, Chen Z, Huang J
Biochim Biophys Acta Rev Cancer 2022 Nov;1877(6):188828. Epub 2022 Oct 22 doi: 10.1016/j.bbcan.2022.188828. PMID: 36283598

Neoplastic nerve lesions.

Patel DK, Gwathmey KG
Neurol Sci 2022 May;43(5):3019-3038. Epub 2022 Feb 23 doi: 10.1007/s10072-022-05951-x. PMID: 35195810

Immune Checkpoint Inhibitors and Neurotoxicity.

Zhao Z, Zhang C, Zhou L, Dong P, Shi L
Curr Neuropharmacol 2021;19(8):1246-1263. doi: 10.2174/1570159X19666201230151224. PMID: 33380303 Free PMC Article

Peripheral Nervous System Involvement.

Thaisetthawatkul P, Dyck PJB
Hematol Oncol Clin North Am 2020 Dec;34(6):1091-1098. Epub 2020 Sep 10 doi: 10.1016/j.hoc.2020.07.004. PMID: 33099426

Perineural Invasion and Perineural Tumor Spread in Head and Neck Cancer.

Bakst RL, Glastonbury CM, Parvathaneni U, Katabi N, Hu KS, Yom SS
Int J Radiat Oncol Biol Phys 2019 Apr 1;103(5):1109-1124. Epub 2018 Dec 15 doi: 10.1016/j.ijrobp.2018.12.009. PMID: 30562546

See all (6139)

Clinical prediction guides

Efficacy and safety of mirogabalin for chemotherapy-induced peripheral neuropathy: a prospective single-arm trial (MiroCIP study).

Misawa S, Denda T, Kodama S, Suzuki T, Naito Y, Kogawa T, Takada M, Suichi T, Shiosakai K, Kuwabara S; MiroCIP study group
BMC Cancer 2023 Nov 11;23(1):1098. doi: 10.1186/s12885-023-11560-4. PMID: 37951905 Free PMC Article

Impact of acupuncture and integrative therapies on chemotherapy-induced peripheral neuropathy: A multicentered, randomized controlled trial.

Ben-Arye E, Hausner D, Samuels N, Gamus D, Lavie O, Tadmor T, Gressel O, Agbarya A, Attias S, David A, Schiff E
Cancer 2022 Oct;128(20):3641-3652. Epub 2022 Aug 12 doi: 10.1002/cncr.34422. PMID: 35960141

Role of the Autonomic Nervous System in the Tumor Micro-Environment and its Therapeutic Potential.

Xu Z, Shioda S, Masahisa J, Kawakami Y, Ohtaki H, Lim HC, Wang S, Zhao X, Liu Y, Zhou D, Guo Y
Curr Pharm Des 2017;23(11):1687-1692. doi: 10.2174/1381612822666161025152942. PMID: 27784236

Incidence, prevalence, and predictors of chemotherapy-induced peripheral neuropathy: A systematic review and meta-analysis.

Seretny M, Currie GL, Sena ES, Ramnarine S, Grant R, MacLeod MR, Colvin LA, Fallon M
Pain 2014 Dec;155(12):2461-2470. Epub 2014 Sep 23 doi: 10.1016/j.pain.2014.09.020. PMID: 25261162

Perineural invasion in cancer: a review of the literature.

Liebig C, Ayala G, Wilks JA, Berger DH, Albo D
Cancer 2009 Aug 1;115(15):3379-91. doi: 10.1002/cncr.24396. PMID: 19484787

See all (5500)

Recent systematic reviews

Can Physical Exercise Prevent Chemotherapy-Induced Peripheral Neuropathy in Patients With Cancer? A Systematic Review and Meta-analysis.

Lopez-Garzon M, Cantarero-Villanueva I, Postigo-Martin P, González-Santos Á, Lozano-Lozano M, Galiano-Castillo N
Arch Phys Med Rehabil 2022 Nov;103(11):2197-2208. Epub 2022 Mar 7 doi: 10.1016/j.apmr.2022.02.008. PMID: 35271844

Yoga, mindfulness-based stress reduction and stress-related physiological measures: A meta-analysis.

Pascoe MC, Thompson DR, Ski CF
Psychoneuroendocrinology 2017 Dec;86:152-168. Epub 2017 Aug 30 doi: 10.1016/j.psyneuen.2017.08.008. PMID: 28963884

Clinical practice guidelines on the evidence-based use of integrative therapies during and after breast cancer treatment.

Greenlee H, DuPont-Reyes MJ, Balneaves LG, Carlson LE, Cohen MR, Deng G, Johnson JA, Mumber M, Seely D, Zick SM, Boyce LM, Tripathy D
CA Cancer J Clin 2017 May 6;67(3):194-232. Epub 2017 Apr 24 doi: 10.3322/caac.21397. PMID: 28436999 Free PMC Article

American Cancer Society Head and Neck Cancer Survivorship Care Guideline.

Cohen EE, LaMonte SJ, Erb NL, Beckman KL, Sadeghi N, Hutcheson KA, Stubblefield MD, Abbott DM, Fisher PS, Stein KD, Lyman GH, Pratt-Chapman ML
CA Cancer J Clin 2016 May;66(3):203-39. Epub 2016 Mar 22 doi: 10.3322/caac.21343. PMID: 27002678

Incidence, prevalence, and predictors of chemotherapy-induced peripheral neuropathy: A systematic review and meta-analysis.

Seretny M, Currie GL, Sena ES, Ramnarine S, Grant R, MacLeod MR, Colvin LA, Fallon M
Pain 2014 Dec;155(12):2461-2470. Epub 2014 Sep 23 doi: 10.1016/j.pain.2014.09.020. PMID: 25261162

See all (290)

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Peripheral nervous system cancer

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Clinical resources

Practice guidelines

Consumer resources

Reviews

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