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Ischemic disorder of spinal cord

MedGen UID:
155706
•Concept ID:
C0752130
•
Disease or Syndrome
Synonyms: Cord Ischemia, Spinal; Cord Ischemias, Spinal; Ischemia, Spinal Cord; Ischemias, Spinal Cord; Ischemic Myelopathies; Ischemic Myelopathy; Myelopathies, Ischemic; Myelopathy, Ischemic; Spinal Cord Ischemia; Spinal Cord Ischemias
SNOMED CT: Ischemic disorder of spinal cord (371029002); Ischemia of spinal cord (371029002); Spinal cord ischemia (371029002)

Definition

Reduced blood flow to the spinal cord which is supplied by the anterior spinal artery and the paired posterior spinal arteries. This condition may be associated with ARTERIOSCLEROSIS, trauma, emboli, diseases of the aorta, and other disorders. Prolonged ischemia may lead to INFARCTION of spinal cord tissue. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIschemic disorder of spinal cord

Professional guidelines

PubMed

CX3CL1/CX3CR1 signaling targets for the treatment of neurodegenerative diseases.
Subbarayan MS, Joly-Amado A, Bickford PC, Nash KR
Pharmacol Ther 2022 Mar;231:107989. Epub 2021 Sep 4 doi: 10.1016/j.pharmthera.2021.107989. PMID: 34492237
Primary central nervous system vasculitis - An update on diagnosis, differential diagnosis and treatment.
Kraemer M, Berlit P
J Neurol Sci 2021 May 15;424:117422. Epub 2021 Mar 27 doi: 10.1016/j.jns.2021.117422. PMID: 33832773
Traumatic spinal cord injury: current concepts and treatment update.
Rouanet C, Reges D, Rocha E, Gagliardi V, Silva GS
Arq Neuropsiquiatr 2017 Jun;75(6):387-393. doi: 10.1590/0004-282X20170048. PMID: 28658409

Recent clinical studies

Etiology

Strategies for prevention and treatment of spinal cord ischemia during F/BEVAR.
Motyl CM, Beck AW
Semin Vasc Surg 2022 Sep;35(3):297-305. Epub 2022 Jul 3 doi: 10.1053/j.semvascsurg.2022.06.005. PMID: 36153070
Neuromonitoring during descending aorta procedures.
Simon MV, Dong CC, Jacobs MJ, Mess WH
Handb Clin Neurol 2022;186:407-431. doi: 10.1016/B978-0-12-819826-1.00010-7. PMID: 35772899
Spinal Cord Protection for Thoracoabdominal Aortic Surgery.
Miller LK, Patel VI, Wagener G
J Cardiothorac Vasc Anesth 2022 Feb;36(2):577-586. Epub 2021 Jun 26 doi: 10.1053/j.jvca.2021.06.024. PMID: 34366215
Spinal Cord Infarction: Clinical and Radiological Features.
Yadav N, Pendharkar H, Kulkarni GB
J Stroke Cerebrovasc Dis 2018 Oct;27(10):2810-2821. Epub 2018 Aug 6 doi: 10.1016/j.jstrokecerebrovasdis.2018.06.008. PMID: 30093205
Current and emerging treatment options for spinal cord ischemia.
Nardone R, Pikija S, Mutzenbach JS, Seidl M, Leis S, Trinka E, Sellner J
Drug Discov Today 2016 Oct;21(10):1632-1641. Epub 2016 Jun 17 doi: 10.1016/j.drudis.2016.06.015. PMID: 27326910

Diagnosis

Neuromonitoring during descending aorta procedures.
Simon MV, Dong CC, Jacobs MJ, Mess WH
Handb Clin Neurol 2022;186:407-431. doi: 10.1016/B978-0-12-819826-1.00010-7. PMID: 35772899
Approach to Myelopathy and Myelitis.
Douglas AG, Xu DJ, Shah MP
Neurol Clin 2022 Feb;40(1):133-156. doi: 10.1016/j.ncl.2021.08.009. PMID: 34798966
Ischemic Spinal Cord Injury-Experimental Evidence and Evolution of Protective Measures.
Khachatryan Z, Haunschild J, von Aspern K, Borger MA, Etz CD
Ann Thorac Surg 2022 May;113(5):1692-1702. Epub 2021 Jan 9 doi: 10.1016/j.athoracsur.2020.12.028. PMID: 33434541
Spinal Cord Infarction: Clinical and Radiological Features.
Yadav N, Pendharkar H, Kulkarni GB
J Stroke Cerebrovasc Dis 2018 Oct;27(10):2810-2821. Epub 2018 Aug 6 doi: 10.1016/j.jstrokecerebrovasdis.2018.06.008. PMID: 30093205
Arteriovenous fistulae of the filum terminale.
Giordan E, Brinjikji W, Ciceri E, Lanzino G
J Neurointerv Surg 2018 Feb;10(2):191-197. Epub 2017 Sep 26 doi: 10.1136/neurintsurg-2017-013309. PMID: 28951393

Therapy

Strategies for prevention and treatment of spinal cord ischemia during F/BEVAR.
Motyl CM, Beck AW
Semin Vasc Surg 2022 Sep;35(3):297-305. Epub 2022 Jul 3 doi: 10.1053/j.semvascsurg.2022.06.005. PMID: 36153070
Spinal Cord Protection for Thoracoabdominal Aortic Surgery.
Miller LK, Patel VI, Wagener G
J Cardiothorac Vasc Anesth 2022 Feb;36(2):577-586. Epub 2021 Jun 26 doi: 10.1053/j.jvca.2021.06.024. PMID: 34366215
Interventions to improve perioperative neurologic outcomes.
Vandiver MS, Vacas S
Curr Opin Anaesthesiol 2020 Oct;33(5):661-667. doi: 10.1097/ACO.0000000000000905. PMID: 32769748Free PMC Article
Current and emerging treatment options for spinal cord ischemia.
Nardone R, Pikija S, Mutzenbach JS, Seidl M, Leis S, Trinka E, Sellner J
Drug Discov Today 2016 Oct;21(10):1632-1641. Epub 2016 Jun 17 doi: 10.1016/j.drudis.2016.06.015. PMID: 27326910
Spinal cord ischemia is multifactorial: what is the best protocol?
Melissano G, Bertoglio L, Mascia D, Rinaldi E, Del Carro U, Nardelli P, Chiesa R
J Cardiovasc Surg (Torino) 2016 Apr;57(2):191-201. Epub 2016 Jan 15 PMID: 26731537

Prognosis

Spinal Cord Infarction: Clinical and Radiological Features.
Yadav N, Pendharkar H, Kulkarni GB
J Stroke Cerebrovasc Dis 2018 Oct;27(10):2810-2821. Epub 2018 Aug 6 doi: 10.1016/j.jstrokecerebrovasdis.2018.06.008. PMID: 30093205
Ischemic Tolerance of the Brain and Spinal Cord: A Review.
Yunoki M, Kanda T, Suzuki K, Uneda A, Hirashita K, Yoshino K
Neurol Med Chir (Tokyo) 2017 Nov 15;57(11):590-600. Epub 2017 Sep 27 doi: 10.2176/nmc.ra.2017-0062. PMID: 28954945Free PMC Article
Postoperative management.
Schraag S
Best Pract Res Clin Anaesthesiol 2016 Sep;30(3):381-93. Epub 2016 Jun 9 doi: 10.1016/j.bpa.2016.06.001. PMID: 27650347
Acute Spinal Cord Injury.
Witiw CD, Fehlings MG
J Spinal Disord Tech 2015 Jul;28(6):202-10. doi: 10.1097/BSD.0000000000000287. PMID: 26098670
Thoracoabdominal aneurysm repair.
Webb TH, Williams GM
Cardiovasc Surg 1999 Oct;7(6):573-85. doi: 10.1016/s0967-2109(99)00048-4. PMID: 10519663

Clinical prediction guides

Spinal Cord Infarction: Clinical and Radiological Features.
Yadav N, Pendharkar H, Kulkarni GB
J Stroke Cerebrovasc Dis 2018 Oct;27(10):2810-2821. Epub 2018 Aug 6 doi: 10.1016/j.jstrokecerebrovasdis.2018.06.008. PMID: 30093205
Ischemic Tolerance of the Brain and Spinal Cord: A Review.
Yunoki M, Kanda T, Suzuki K, Uneda A, Hirashita K, Yoshino K
Neurol Med Chir (Tokyo) 2017 Nov 15;57(11):590-600. Epub 2017 Sep 27 doi: 10.2176/nmc.ra.2017-0062. PMID: 28954945Free PMC Article
Spinal cord injury following thoracic and thoracoabdominal aortic repairs.
Panthee N, Ono M
Asian Cardiovasc Thorac Ann 2015 Feb;23(2):235-46. Epub 2014 Sep 1 doi: 10.1177/0218492314548901. PMID: 25178467
Present and potential use of spinal cord stimulation to control chronic pain.
Song JJ, Popescu A, Bell RL
Pain Physician 2014 May-Jun;17(3):235-46. PMID: 24850105
Neuromonitoring.
Hacke W
J Neurol 1985;232(3):125-33. doi: 10.1007/BF00313886. PMID: 2993533

Recent systematic reviews

Therapeutic implications of cyclooxygenase (COX) inhibitors in ischemic injury.
Khan H, Sharma K, Kumar A, Kaur A, Singh TG
Inflamm Res 2022 Mar;71(3):277-292. Epub 2022 Feb 17 doi: 10.1007/s00011-022-01546-6. PMID: 35175358
A systematic review and meta-analysis of the occurrence of spinal cord ischemia after endovascular repair of thoracoabdominal aortic aneurysms.
Pini R, Faggioli G, Paraskevas KI, Alaidroos M, Palermo S, Gallitto E, Gargiulo M
J Vasc Surg 2022 Apr;75(4):1466-1477.e8. Epub 2021 Nov 1 doi: 10.1016/j.jvs.2021.10.015. PMID: 34736999
The Role of Therapeutic Hypothermia After Traumatic Spinal Cord Injury--A Systematic Review.
Alkabie S, Boileau AJ
World Neurosurg 2016 Feb;86:432-49. Epub 2015 Dec 22 doi: 10.1016/j.wneu.2015.09.079. PMID: 26433095
A systematic review of spinal cord injury and cerebrospinal fluid drainage after thoracic aortic endografting.
Wong CS, Healy D, Canning C, Coffey JC, Boyle JR, Walsh SR
J Vasc Surg 2012 Nov;56(5):1438-47. Epub 2012 Aug 9 doi: 10.1016/j.jvs.2012.05.075. PMID: 22884456
Spinal cord stimulation for chronic pain of neuropathic or ischaemic origin: systematic review and economic evaluation.
Simpson EL, Duenas A, Holmes MW, Papaioannou D, Chilcott J
Health Technol Assess 2009 Mar;13(17):iii, ix-x, 1-154. doi: 10.3310/hta13170. PMID: 19331797

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