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Neurogenic thoracic outlet syndrome

MedGen UID:
155880
•Concept ID:
C0751549
•
Disease or Syndrome
Synonyms: Neurogenic Thoracic Outlet Syndrome; Thoracic Outlet Syndrome, Neurogenic
SNOMED CT: Neurogenic thoracic outlet syndrome (2040007)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0015061
Orphanet: ORPHA100073

Definition

Neurogenic thoracic outlet syndrome (NTOS) is a form of thoracic outlet syndrome (TOS; see this term) that presents with pain, paresthesias and weakness in an upper extremity and is divided into true NTOS and disputed NTOS. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNeurogenic thoracic outlet syndrome

Professional guidelines

PubMed

Neurogenic Thoracic Outlet Syndrome in Athletes - Nonsurgical Treatment Options.
Warrick A, Davis B
Curr Sports Med Rep 2021 Jun 1;20(6):319-326. doi: 10.1249/JSR.0000000000000854. PMID: 34099610
Physical Therapy Management of Neurogenic Thoracic Outlet Syndrome.
Collins E, Orpin M
Thorac Surg Clin 2021 Feb;31(1):61-69. doi: 10.1016/j.thorsurg.2020.09.003. PMID: 33220772
Work-Related Neurogenic Thoracic Outlet Syndrome: Diagnosis and Treatment.
Franklin GM
Phys Med Rehabil Clin N Am 2015 Aug;26(3):551-61. Epub 2015 Jun 19 doi: 10.1016/j.pmr.2015.04.004. PMID: 26231965

Recent clinical studies

Etiology

Neurogenic thoracic outlet syndrome: When to consider the diagnosis and current management options.
Kam Fai Ho K, Guazzo L, Muller J
Aust J Gen Pract 2023 Sep;52(9):627-632. doi: 10.31128/AJGP-09-22-6571. PMID: 37666785
Neurogenic Thoracic Outlet Syndrome.
Dengler NF, Pedro MT, Kretschmer T, Heinen C, Rosahl SK, Antoniadis G
Dtsch Arztebl Int 2022 Oct 28;119(43):735-742. doi: 10.3238/arztebl.m2022.0296. PMID: 35978467Free PMC Article
Surgery Versus Continued Conservative Treatment for Neurogenic Thoracic Outlet Syndrome: the First Randomised Clinical Trial (STOPNTOS Trial).
Goeteyn J, Pesser N, Houterman S, van Sambeek MRHM, van Nuenen BFL, Teijink JAW
Eur J Vasc Endovasc Surg 2022 Jul;64(1):119-127. Epub 2022 May 7 doi: 10.1016/j.ejvs.2022.05.003. PMID: 35537641
Neurogenic Thoracic Outlet Syndrome in Athletes - Nonsurgical Treatment Options.
Warrick A, Davis B
Curr Sports Med Rep 2021 Jun 1;20(6):319-326. doi: 10.1249/JSR.0000000000000854. PMID: 34099610
Physical therapy management, surgical treatment, and patient-reported outcomes measures in a prospective observational cohort of patients with neurogenic thoracic outlet syndrome.
Balderman J, Abuirqeba AA, Eichaker L, Pate C, Earley JA, Bottros MM, Jayarajan SN, Thompson RW
J Vasc Surg 2019 Sep;70(3):832-841. Epub 2019 Mar 7 doi: 10.1016/j.jvs.2018.12.027. PMID: 30852035

Diagnosis

Neurogenic Thoracic Outlet Syndrome.
Dengler NF, Pedro MT, Kretschmer T, Heinen C, Rosahl SK, Antoniadis G
Dtsch Arztebl Int 2022 Oct 28;119(43):735-742. doi: 10.3238/arztebl.m2022.0296. PMID: 35978467Free PMC Article
Neurogenic Thoracic Outlet Syndrome in Athletes - Nonsurgical Treatment Options.
Warrick A, Davis B
Curr Sports Med Rep 2021 Jun 1;20(6):319-326. doi: 10.1249/JSR.0000000000000854. PMID: 34099610
Physical Therapy Management of Neurogenic Thoracic Outlet Syndrome.
Collins E, Orpin M
Thorac Surg Clin 2021 Feb;31(1):61-69. doi: 10.1016/j.thorsurg.2020.09.003. PMID: 33220772
Physical therapy management, surgical treatment, and patient-reported outcomes measures in a prospective observational cohort of patients with neurogenic thoracic outlet syndrome.
Balderman J, Abuirqeba AA, Eichaker L, Pate C, Earley JA, Bottros MM, Jayarajan SN, Thompson RW
J Vasc Surg 2019 Sep;70(3):832-841. Epub 2019 Mar 7 doi: 10.1016/j.jvs.2018.12.027. PMID: 30852035
Thoracic outlet syndrome.
Kuhn JE, Lebus V GF, Bible JE
J Am Acad Orthop Surg 2015 Apr;23(4):222-32. doi: 10.5435/JAAOS-D-13-00215. PMID: 25808686

Therapy

Neurogenic Thoracic Outlet Syndrome.
Dengler NF, Pedro MT, Kretschmer T, Heinen C, Rosahl SK, Antoniadis G
Dtsch Arztebl Int 2022 Oct 28;119(43):735-742. doi: 10.3238/arztebl.m2022.0296. PMID: 35978467Free PMC Article
Surgery Versus Continued Conservative Treatment for Neurogenic Thoracic Outlet Syndrome: the First Randomised Clinical Trial (STOPNTOS Trial).
Goeteyn J, Pesser N, Houterman S, van Sambeek MRHM, van Nuenen BFL, Teijink JAW
Eur J Vasc Endovasc Surg 2022 Jul;64(1):119-127. Epub 2022 May 7 doi: 10.1016/j.ejvs.2022.05.003. PMID: 35537641
Redo surgery for neurogenic thoracic outlet syndrome is useful.
Goeteyn J, Van Der Sanden L, Pesser N, Houterman S, van Sambeek MRHM, van Nuenen BFL, Teijink JAW
J Vasc Surg 2022 Aug;76(2):531-537.e1. Epub 2022 Mar 31 doi: 10.1016/j.jvs.2022.03.863. PMID: 35367561
Neurogenic Thoracic Outlet Syndrome in Athletes - Nonsurgical Treatment Options.
Warrick A, Davis B
Curr Sports Med Rep 2021 Jun 1;20(6):319-326. doi: 10.1249/JSR.0000000000000854. PMID: 34099610
Physical therapy management, surgical treatment, and patient-reported outcomes measures in a prospective observational cohort of patients with neurogenic thoracic outlet syndrome.
Balderman J, Abuirqeba AA, Eichaker L, Pate C, Earley JA, Bottros MM, Jayarajan SN, Thompson RW
J Vasc Surg 2019 Sep;70(3):832-841. Epub 2019 Mar 7 doi: 10.1016/j.jvs.2018.12.027. PMID: 30852035

Prognosis

Novel Diagnostic and Treatment Techniques for Neurogenic Thoracic Outlet Syndrome.
Wagner ER, Gottschalk MB, Ahmed AS, Graf AR, Karzon AL
Tech Hand Up Extrem Surg 2023 Jun 1;27(2):100-114. doi: 10.1097/BTH.0000000000000419. PMID: 36515356
Diagnosis of Neurogenic Thoracic Outlet Syndrome Based on the Clinical Status.
Hwang JS, Kim J, Kim S, Bae KJ, Lee Y, Baek GH
Ann Vasc Surg 2021 Oct;76:454-462. Epub 2021 Apr 24 doi: 10.1016/j.avsg.2021.03.051. PMID: 33905846
How Common Is Thoracic Outlet Syndrome?
Illig KA, Rodriguez-Zoppi E
Thorac Surg Clin 2021 Feb;31(1):11-17. doi: 10.1016/j.thorsurg.2020.09.001. PMID: 33220767
Physical therapy management, surgical treatment, and patient-reported outcomes measures in a prospective observational cohort of patients with neurogenic thoracic outlet syndrome.
Balderman J, Abuirqeba AA, Eichaker L, Pate C, Earley JA, Bottros MM, Jayarajan SN, Thompson RW
J Vasc Surg 2019 Sep;70(3):832-841. Epub 2019 Mar 7 doi: 10.1016/j.jvs.2018.12.027. PMID: 30852035
Thoracic outlet syndrome.
Kuhn JE, Lebus V GF, Bible JE
J Am Acad Orthop Surg 2015 Apr;23(4):222-32. doi: 10.5435/JAAOS-D-13-00215. PMID: 25808686

Clinical prediction guides

Neurogenic Thoracic Outlet Syndrome.
Dengler NF, Pedro MT, Kretschmer T, Heinen C, Rosahl SK, Antoniadis G
Dtsch Arztebl Int 2022 Oct 28;119(43):735-742. doi: 10.3238/arztebl.m2022.0296. PMID: 35978467Free PMC Article
Surgery Versus Continued Conservative Treatment for Neurogenic Thoracic Outlet Syndrome: the First Randomised Clinical Trial (STOPNTOS Trial).
Goeteyn J, Pesser N, Houterman S, van Sambeek MRHM, van Nuenen BFL, Teijink JAW
Eur J Vasc Endovasc Surg 2022 Jul;64(1):119-127. Epub 2022 May 7 doi: 10.1016/j.ejvs.2022.05.003. PMID: 35537641
Physical therapy management, surgical treatment, and patient-reported outcomes measures in a prospective observational cohort of patients with neurogenic thoracic outlet syndrome.
Balderman J, Abuirqeba AA, Eichaker L, Pate C, Earley JA, Bottros MM, Jayarajan SN, Thompson RW
J Vasc Surg 2019 Sep;70(3):832-841. Epub 2019 Mar 7 doi: 10.1016/j.jvs.2018.12.027. PMID: 30852035
Thoracic outlet syndrome.
Kuhn JE, Lebus V GF, Bible JE
J Am Acad Orthop Surg 2015 Apr;23(4):222-32. doi: 10.5435/JAAOS-D-13-00215. PMID: 25808686
Entrapment neuropathies.
England JD
Curr Opin Neurol 1999 Oct;12(5):597-602. doi: 10.1097/00019052-199910000-00014. PMID: 10590897

Recent systematic reviews

Considerations for Surgical Treatment of Neurogenic Thoracic Outlet Syndrome: A Meta-Analysis of Patient-Reported Outcomes.
Blondin M, Garner GL, Hones KM, Nichols DS, Cox EA, Chim H
J Hand Surg Am 2023 Jun;48(6):585-594. Epub 2023 Apr 11 doi: 10.1016/j.jhsa.2023.03.005. PMID: 37055338
Thoracic Outlet Syndrome Part II: Consensus on the Management of Neurogenic Thoracic Outlet Syndrome by the European Association of Neurosurgical Societies' Section of Peripheral Nerve Surgery.
Rochkind S, Ferraresi S, Denisova N, Garozzo D, Heinen C, Alimehmeti R, Capone C, Barone DG, Zdunczyk A, Pedro MT, Antoniadis G, Kaiser R, Dubuisson A, Pondaag W, Kretschmer T, Rasulic L, Dengler NF
Neurosurgery 2023 Feb 1;92(2):251-257. Epub 2022 Dec 6 doi: 10.1227/neu.0000000000002232. PMID: 36542350
Outcomes of Surgical Management of Neurogenic Thoracic Outlet Syndrome: A Systematic Review and Bayesian Perspective.
Yin ZG, Gong KT, Zhang JB
J Hand Surg Am 2019 May;44(5):416.e1-416.e17. Epub 2018 Aug 16 doi: 10.1016/j.jhsa.2018.06.120. PMID: 30122304

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