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Lung Adenofibroma

MedGen UID:
1611615
•Concept ID:
C4524375
•
Neoplastic Process
Synonym: Pulmonary Adenofibroma

Definition

A very rare benign neoplasm that arises from the lung. It is characterized by the presence of a stromal and an epithelial component. It resembles the adenofibromas that arise from the organs of the female reproductive system. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLung Adenofibroma

Recent clinical studies

Etiology

Pulmonary Adenofibromas: A Clinicopathologic Correlation of 13 Cases.
Lindholm KE, Sansano-Valero I, Rodriguez JL, Ramon Y Cajal S, Moran CA
Am J Surg Pathol 2020 Jul;44(7):917-921. doi: 10.1097/PAS.0000000000001456. PMID: 32091433
Recurrent NAB2-STAT6 gene fusions and oestrogen receptor-α expression in pulmonary adenofibromas.
Fusco N, Guerini-Rocco E, Augello C, Terrasi A, Ercoli G, Fumagalli C, Vacirca D, Braidotti P, Parafioriti A, Jaconi M, Runza L, Ananthanarayanan V, Pagni F, Bosari S, Barberis M, Ferrero S
Histopathology 2017 May;70(6):906-917. Epub 2017 Feb 24 doi: 10.1111/his.13165. PMID: 28072477
Pulmonary adenofibroma: cytologic and clinicopathologic features of a rare benign primary lung lesion.
Vitkovski T, Zeltsman D, Esposito M, Morgenstern N
Diagn Cytopathol 2013 Nov;41(11):991-6. Epub 2012 May 30 doi: 10.1002/dc.22874. PMID: 22645035
Benign and borderline clear cell adenofibromas of the ovary.
Bell DA, Scully RE
Cancer 1985 Dec 15;56(12):2922-31. doi: 10.1002/1097-0142(19851215)56:12<2922::aid-cncr2820561233>3.0.co;2-l. PMID: 4052962
Radiation carcinogenesis in experimental animals and its implications for radiation protection.
Broerse JJ, Hennen LA, van Zwieten MJ
Int J Radiat Biol Relat Stud Phys Chem Med 1985 Aug;48(2):167-87. doi: 10.1080/09553008514551171. PMID: 3894267

Diagnosis

A Case of Pulmonary Adenofibroma Treated by Thoracoscopic Resection.
Sonokawa T, Enomoto Y, Kunugi S, Terasaki Y, Usuda J
J Nippon Med Sch 2021;88(6):564-568. doi: 10.1272/jnms.JNMS.2021_88-516. PMID: 34980742
Prominent entrapment of respiratory epithelium in primary and metastatic intrapulmonary non-epithelial neoplasms: a frequent morphological pattern closely mimicking adenofibroma and other biphasic pulmonary lesions.
Erber R, Haller F, Hartmann A, Agaimy A
Virchows Arch 2020 Aug;477(2):195-205. Epub 2020 Mar 19 doi: 10.1007/s00428-020-02796-7. PMID: 32193604Free PMC Article
Napsin A is a specific marker for ovarian clear cell adenocarcinoma.
Yamashita Y, Nagasaka T, Naiki-Ito A, Sato S, Suzuki S, Toyokuni S, Ito M, Takahashi S
Mod Pathol 2015 Jan;28(1):111-7. Epub 2014 Apr 11 doi: 10.1038/modpathol.2014.61. PMID: 24721826
Pulmonary adenofibroma: clinicopathological study of 3 cases of a rare benign lung lesion and review of the literature.
Kumar R, Desai S, Pai T, Pramesh CS, Jambhekar NA
Ann Diagn Pathol 2014 Aug;18(4):238-43. Epub 2014 May 2 doi: 10.1016/j.anndiagpath.2014.04.002. PMID: 24908371
Fine needle aspiration cytology.
Lever JV, Trott PA, Webb AJ
J Clin Pathol 1985 Jan;38(1):1-11. doi: 10.1136/jcp.38.1.1. PMID: 2578481Free PMC Article

Therapy

Free radicals and neoplasia--some experimental findings and some possible implications.
Wallace JD
CRC Crit Rev Radiol Sci 1972 Jan;3(1):89-100. PMID: 4354613
More about isonicotinic acid hydrazide toxicity.
Food Cosmet Toxicol 1970 Oct;8(5):578-9. PMID: 4923938

Prognosis

A Case of Pulmonary Adenofibroma Treated by Thoracoscopic Resection.
Sonokawa T, Enomoto Y, Kunugi S, Terasaki Y, Usuda J
J Nippon Med Sch 2021;88(6):564-568. doi: 10.1272/jnms.JNMS.2021_88-516. PMID: 34980742
Pulmonary Adenofibromas: A Clinicopathologic Correlation of 13 Cases.
Lindholm KE, Sansano-Valero I, Rodriguez JL, Ramon Y Cajal S, Moran CA
Am J Surg Pathol 2020 Jul;44(7):917-921. doi: 10.1097/PAS.0000000000001456. PMID: 32091433
Synchronous Pulmonary Adenofibroma and Solitary Fibrous Tumor: Case Report and Review of the Literature.
Olson NJ, Czum JM, de Abreu FB, Linos K, Black CC
Int J Surg Pathol 2019 May;27(3):322-327. Epub 2018 Oct 26 doi: 10.1177/1066896918807302. PMID: 30360665
Napsin A is a specific marker for ovarian clear cell adenocarcinoma.
Yamashita Y, Nagasaka T, Naiki-Ito A, Sato S, Suzuki S, Toyokuni S, Ito M, Takahashi S
Mod Pathol 2015 Jan;28(1):111-7. Epub 2014 Apr 11 doi: 10.1038/modpathol.2014.61. PMID: 24721826
Comparative analysis of the expression patterns of metalloproteinases and their inhibitors in breast neoplasia, sporadic colorectal neoplasia, pulmonary carcinomas and malignant non-Hodgkin's lymphomas in humans.
Kossakowska AE, Huchcroft SA, Urbanski SJ, Edwards DR
Br J Cancer 1996 Jun;73(11):1401-8. doi: 10.1038/bjc.1996.266. PMID: 8645587Free PMC Article

Clinical prediction guides

Napsin A is a specific marker for ovarian clear cell adenocarcinoma.
Yamashita Y, Nagasaka T, Naiki-Ito A, Sato S, Suzuki S, Toyokuni S, Ito M, Takahashi S
Mod Pathol 2015 Jan;28(1):111-7. Epub 2014 Apr 11 doi: 10.1038/modpathol.2014.61. PMID: 24721826
Expression of the extracellular matrix metalloproteinase inducer (EMMPRIN) and the matrix metalloproteinase-2 in bronchopulmonary and breast lesions.
Caudroy S, Polette M, Tournier JM, Burlet H, Toole B, Zucker S, Birembaut P
J Histochem Cytochem 1999 Dec;47(12):1575-80. doi: 10.1177/002215549904701209. PMID: 10567441
Comparative analysis of the expression patterns of metalloproteinases and their inhibitors in breast neoplasia, sporadic colorectal neoplasia, pulmonary carcinomas and malignant non-Hodgkin's lymphomas in humans.
Kossakowska AE, Huchcroft SA, Urbanski SJ, Edwards DR
Br J Cancer 1996 Jun;73(11):1401-8. doi: 10.1038/bjc.1996.266. PMID: 8645587Free PMC Article
Radiation carcinogenesis in experimental animals and its implications for radiation protection.
Broerse JJ, Hennen LA, van Zwieten MJ
Int J Radiat Biol Relat Stud Phys Chem Med 1985 Aug;48(2):167-87. doi: 10.1080/09553008514551171. PMID: 3894267
Immunohistochemical identification of actomyosin-containing (myoepithelial) cells in non-neoplastic and neoplastic tissues.
Sasadaira H, Kameya T, Shimosato Y, Baba K, Amemiya R
Acta Pathol Jpn 1978 May;28(3):345-55. doi: 10.1111/j.1440-1827.1978.tb01260.x. PMID: 210618

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