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Abnormal circulating osteocalcin level

MedGen UID:
1611785
•Concept ID:
C4531127
•
Finding
HPO: HP:0031427

Definition

A deviation from the normal concentration of osteocalcin in the blood circulation. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal circulating osteocalcin level

Recent clinical studies

Etiology

The role of osteocalcin in regulation of glycolipid metabolism and muscle function in children with osteogenesis imperfecta.
Zheng WB, Hu J, Zhao DC, Zhou BN, Wang O, Jiang Y, Xia WB, Xing XP, Li M
Front Endocrinol (Lausanne) 2022;13:898645. Epub 2022 Aug 2 doi: 10.3389/fendo.2022.898645. PMID: 35983511Free PMC Article
Role of Wnt-signaling inhibitors DKK-1 and sclerostin in bone fragility associated with Turner syndrome.
Chiarito M, Piacente L, Chaoul N, Pontrelli P, D'Amato G, Grandone A, Russo G, Street ME, Wasniewska MG, Brunetti G, Faienza MF
J Endocrinol Invest 2022 Jun;45(6):1255-1263. Epub 2022 Mar 2 doi: 10.1007/s40618-022-01760-3. PMID: 35237949Free PMC Article
The association between bone mineral density gene variants and osteocalcin at baseline, and in response to exercise: The Gene SMART study.
Hiam D, Voisin S, Yan X, Landen S, Jacques M, Papadimitriou ID, Munson F, Byrnes E, Brennan-Speranza TC, Levinger I, Eynon N
Bone 2019 Jun;123:23-27. Epub 2019 Mar 14 doi: 10.1016/j.bone.2019.03.015. PMID: 30878522
Complex regional pain syndrome: a vitamin K dependent entity?
Ediz L, Hiz O, Meral I, Alpayci M
Med Hypotheses 2010 Sep;75(3):319-23. Epub 2010 Apr 7 doi: 10.1016/j.mehy.2010.03.012. PMID: 20378261
Serum osteocalcin in rheumatoid arthritis and other inflammatory arthritides: relation between inflammatory activity and the effect of glucocorticoids and remission inducing drugs.
Ekenstam EA, Ljunghall S, Hällgren R
Ann Rheum Dis 1986 Jun;45(6):484-90. doi: 10.1136/ard.45.6.484. PMID: 3015056Free PMC Article

Diagnosis

Clinical significance of osteoblast precursors and osteoclast precursors in earlier diagnosis and monitoring of myeloma bone disease.
Fu R, Peng F, Liu H, Wang Y, Li L, Wang G, Song J, Shao Z
Ann Hematol 2016 Jun;95(7):1099-106. Epub 2016 Apr 27 doi: 10.1007/s00277-016-2657-3. PMID: 27118542
Bone histomorphometry and indicators of bone and mineral metabolism in wait-listed dialysis patients.
Keronen S, Martola L, Finne P, Burton IS, Kauppila L, Kröger H, Larsson TE, Honkanen E
Clin Nephrol 2016 Mar;85(3):127-34. doi: 10.5414/CN108709. PMID: 26833298
Novel effects of diets enriched with corn oil or with an olive oil/sunflower oil mixture on vitamin K metabolism and vitamin K-dependent proteins in young men.
Schurgers LJ, Shearer MJ, Soute BA, Elmadfa I, Harvey J, Wagner KH, Tomasch R, Vermeer C
J Lipid Res 2002 Jun;43(6):878-84. PMID: 12032162
Lumbar spine bone mineral density in diabetic children with recent onset.
De Schepper J, Smitz J, Rosseneu S, Bollen P, Louis O
Horm Res 1998;50(4):193-6. doi: 10.1159/000023273. PMID: 9838239
Blood levels of cytokines in brain-dead patients: relationship with circulating hormones and acute-phase reactants.
Amado JA, López-Espadas F, Vázquez-Barquero A, Salas E, Riancho JA, López-Cordovilla JJ, García-Unzueta MT
Metabolism 1995 Jun;44(6):812-6. doi: 10.1016/0026-0495(95)90198-1. PMID: 7540249

Therapy

Indirect evidence of hormone abuse. Proof of doping?
Minuto F, Barreca A, Melioli G
J Endocrinol Invest 2003 Sep;26(9):919-23. doi: 10.1007/BF03345244. PMID: 14964446
Bone disease in long-term adult kidney transplant patients with normal renal function.
Montalban C, de Francisco AL, Mariñoso ML, Zubimendi JA, García Unzueta M, Amado JA, Arias M
Kidney Int Suppl 2003 Jun;(85):S129-32. doi: 10.1046/j.1523-1755.63.s85.31.x. PMID: 12753284
Effects of a growth hormone receptor antagonist on bone markers in acromegaly.
Fairfield WP, Sesmilo G, Katznelson L, Pulaski K, Freda PU, Stavrou S, Kleinberg D, Klibanski A
Clin Endocrinol (Oxf) 2002 Sep;57(3):385-90. doi: 10.1046/j.1365-2265.2002.01624.x. PMID: 12201832
Novel effects of diets enriched with corn oil or with an olive oil/sunflower oil mixture on vitamin K metabolism and vitamin K-dependent proteins in young men.
Schurgers LJ, Shearer MJ, Soute BA, Elmadfa I, Harvey J, Wagner KH, Tomasch R, Vermeer C
J Lipid Res 2002 Jun;43(6):878-84. PMID: 12032162
Serum osteocalcin in rheumatoid arthritis and other inflammatory arthritides: relation between inflammatory activity and the effect of glucocorticoids and remission inducing drugs.
Ekenstam EA, Ljunghall S, Hällgren R
Ann Rheum Dis 1986 Jun;45(6):484-90. doi: 10.1136/ard.45.6.484. PMID: 3015056Free PMC Article

Prognosis

The association between bone mineral density gene variants and osteocalcin at baseline, and in response to exercise: The Gene SMART study.
Hiam D, Voisin S, Yan X, Landen S, Jacques M, Papadimitriou ID, Munson F, Byrnes E, Brennan-Speranza TC, Levinger I, Eynon N
Bone 2019 Jun;123:23-27. Epub 2019 Mar 14 doi: 10.1016/j.bone.2019.03.015. PMID: 30878522
Analysis of Circulating Mediators of Bone Remodeling in Prader-Willi Syndrome.
Brunetti G, Grugni G, Piacente L, Delvecchio M, Ventura A, Giordano P, Grano M, D'Amato G, Laforgia D, Crinò A, Faienza MF
Calcif Tissue Int 2018 Jun;102(6):635-643. Epub 2018 Jan 20 doi: 10.1007/s00223-017-0376-y. PMID: 29353451
Clinical significance of osteoblast precursors and osteoclast precursors in earlier diagnosis and monitoring of myeloma bone disease.
Fu R, Peng F, Liu H, Wang Y, Li L, Wang G, Song J, Shao Z
Ann Hematol 2016 Jun;95(7):1099-106. Epub 2016 Apr 27 doi: 10.1007/s00277-016-2657-3. PMID: 27118542
Bone histomorphometry and indicators of bone and mineral metabolism in wait-listed dialysis patients.
Keronen S, Martola L, Finne P, Burton IS, Kauppila L, Kröger H, Larsson TE, Honkanen E
Clin Nephrol 2016 Mar;85(3):127-34. doi: 10.5414/CN108709. PMID: 26833298
Bone loss is correlated to the severity of growth hormone deficiency in adult patients with hypopituitarism.
Colao A, Di Somma C, Pivonello R, Loche S, Aimaretti G, Cerbone G, Faggiano A, Corneli G, Ghigo E, Lombardi G
J Clin Endocrinol Metab 1999 Jun;84(6):1919-24. doi: 10.1210/jcem.84.6.5742. PMID: 10372687

Clinical prediction guides

Osteogenic Circulating Endothelial Progenitor Cells are Associated with Vascular Aging of the Large Arteries in Rheumatoid Arthritis.
Chan YH, Ngai MC, Chen Y, Wu MZ, Yu YJ, Zhen Z, Lai K, Chung HY, Lau CS, Tse HF, Yiu KH
Clin Interv Aging 2022;17:287-294. Epub 2022 Mar 17 doi: 10.2147/CIA.S337118. PMID: 35321150Free PMC Article
The association between bone mineral density gene variants and osteocalcin at baseline, and in response to exercise: The Gene SMART study.
Hiam D, Voisin S, Yan X, Landen S, Jacques M, Papadimitriou ID, Munson F, Byrnes E, Brennan-Speranza TC, Levinger I, Eynon N
Bone 2019 Jun;123:23-27. Epub 2019 Mar 14 doi: 10.1016/j.bone.2019.03.015. PMID: 30878522
Analysis of Circulating Mediators of Bone Remodeling in Prader-Willi Syndrome.
Brunetti G, Grugni G, Piacente L, Delvecchio M, Ventura A, Giordano P, Grano M, D'Amato G, Laforgia D, Crinò A, Faienza MF
Calcif Tissue Int 2018 Jun;102(6):635-643. Epub 2018 Jan 20 doi: 10.1007/s00223-017-0376-y. PMID: 29353451
Clinical significance of osteoblast precursors and osteoclast precursors in earlier diagnosis and monitoring of myeloma bone disease.
Fu R, Peng F, Liu H, Wang Y, Li L, Wang G, Song J, Shao Z
Ann Hematol 2016 Jun;95(7):1099-106. Epub 2016 Apr 27 doi: 10.1007/s00277-016-2657-3. PMID: 27118542
Indirect evidence of hormone abuse. Proof of doping?
Minuto F, Barreca A, Melioli G
J Endocrinol Invest 2003 Sep;26(9):919-23. doi: 10.1007/BF03345244. PMID: 14964446

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