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Predominantly dermal neutrophilic infiltrate

MedGen UID:
1613083
•Concept ID:
C4531256
•
Disease or Syndrome
HPO: HP:0031236

Definition

Collection of neutrophils in the dermis. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPredominantly dermal neutrophilic infiltrate

Recent clinical studies

Etiology

Heparin-Induced Bullous Hemorrhagic Dermatosis: A Report of an Exceptionally Exuberant Case and Literature Review.
Cortez de Almeida RF, Vita Campos C, Daxbacher EL, Jeunon T
Am J Dermatopathol 2021 Jul 1;43(7):497-505. doi: 10.1097/DAD.0000000000001787. PMID: 33795557
Clinical, histological, immunological presentations and outcomes of bullous systemic lupus erythematosus: 10 New cases and a literature review of 118 cases.
de Risi-Pugliese T, Cohen Aubart F, Haroche J, Moguelet P, Grootenboer-Mignot S, Mathian A, Ingen-Housz-Oro S, Hie M, Wendremaire N, Aucouturier F, Lepelletier F, Miyara M, Bader-Meunier B, Rémy P, Fabien N, Francès C, Barete S, Amoura Z
Semin Arthritis Rheum 2018 Aug;48(1):83-89. Epub 2017 Nov 4 doi: 10.1016/j.semarthrit.2017.11.003. PMID: 29191376
Prolonged urticaria with purpura: the spectrum of clinical and histopathologic features in a prospective series of 22 patients exhibiting the clinical features of urticarial vasculitis.
Lee JS, Loh TH, Seow SC, Tan SH
J Am Acad Dermatol 2007 Jun;56(6):994-1005. doi: 10.1016/j.jaad.2006.10.962. PMID: 17504716
Tumour necrosis factor alpha is pro-inflammatory in normal human skin and modulates cutaneous adhesion molecule expression.
Groves RW, Allen MH, Ross EL, Barker JN, MacDonald DM
Br J Dermatol 1995 Mar;132(3):345-52. doi: 10.1111/j.1365-2133.1995.tb08666.x. PMID: 7536438
Linear IgA bullous dermatosis. Characterization of a subset of patients with concurrent IgA and IgG anti-basement membrane autoantibodies.
Chan LS, Traczyk T, Taylor TB, Eramo LR, Woodley DT, Zone JJ
Arch Dermatol 1995 Dec;131(12):1432-7. doi: 10.1001/archderm.131.12.1432. PMID: 7492134

Diagnosis

Acute generalized exanthematous pustulosis associated with clindamycin in a patient with Hailey-Hailey disease.
Casillas AC, Barragan VA, Alhalaseh Y, Modi MB, Lake E, Speiser JJ
J Cutan Pathol 2023 Oct;50(10):864-868. Epub 2023 Jul 10 doi: 10.1111/cup.14488. PMID: 37430411
Heparin-Induced Bullous Hemorrhagic Dermatosis: A Report of an Exceptionally Exuberant Case and Literature Review.
Cortez de Almeida RF, Vita Campos C, Daxbacher EL, Jeunon T
Am J Dermatopathol 2021 Jul 1;43(7):497-505. doi: 10.1097/DAD.0000000000001787. PMID: 33795557
Postoperative Pyoderma Gangrenosum Following Video-Assisted Thoracic Surgery.
Tolkachjov SN, Sun PY, Bridges AG
J Drugs Dermatol 2017 Jul 1;16(7):711-713. PMID: 28697227
The spectrum of histopathologic findings in cutaneous lesions in patients with Still disease.
Larson AR, Laga AC, Granter SR
Am J Clin Pathol 2015 Dec;144(6):945-51. doi: 10.1309/AJCPZE77UAPSMDCD. PMID: 26573002
Idiopathic lymphoplasmacellular mucositis-dermatitis.
Brix WK, Nassau SR, Patterson JW, Cousar JB, Wick MR
J Cutan Pathol 2010 Apr;37(4):426-31. Epub 2009 Jul 15 doi: 10.1111/j.1600-0560.2009.01371.x. PMID: 19614724

Therapy

Acute generalized exanthematous pustulosis associated with clindamycin in a patient with Hailey-Hailey disease.
Casillas AC, Barragan VA, Alhalaseh Y, Modi MB, Lake E, Speiser JJ
J Cutan Pathol 2023 Oct;50(10):864-868. Epub 2023 Jul 10 doi: 10.1111/cup.14488. PMID: 37430411
Impact of topical emollient, steroids alone or combined with calcipotriol, on the immune infiltrate and clinical outcome in psoriasis.
Heim M, Irondelle M, Duteil L, Cardot-Leccia N, Rocchi S, Passeron T, Tulic MK
Exp Dermatol 2022 Nov;31(11):1764-1778. Epub 2022 Aug 19 doi: 10.1111/exd.14657. PMID: 36054319Free PMC Article
Role of distinct fibroblast lineages and immune cells in dermal repair following UV radiation-induced tissue damage.
Rognoni E, Goss G, Hiratsuka T, Sipilä KH, Kirk T, Kober KI, Lui PP, Tsang VS, Hawkshaw NJ, Pilkington SM, Cho I, Ali N, Rhodes LE, Watt FM
Elife 2021 Dec 23;10 doi: 10.7554/eLife.71052. PMID: 34939928Free PMC Article
Heparin-Induced Bullous Hemorrhagic Dermatosis: A Report of an Exceptionally Exuberant Case and Literature Review.
Cortez de Almeida RF, Vita Campos C, Daxbacher EL, Jeunon T
Am J Dermatopathol 2021 Jul 1;43(7):497-505. doi: 10.1097/DAD.0000000000001787. PMID: 33795557
Postoperative Pyoderma Gangrenosum Following Video-Assisted Thoracic Surgery.
Tolkachjov SN, Sun PY, Bridges AG
J Drugs Dermatol 2017 Jul 1;16(7):711-713. PMID: 28697227

Prognosis

In situ characterization of the human host response to Leishmania panamensis.
Palma GI, Saravia NG
Am J Dermatopathol 1997 Dec;19(6):585-90. doi: 10.1097/00000372-199712000-00006. PMID: 9415615
Sweet's syndrome in a skin clinic in Singapore: an epidemiology study.
Goh CL, Alora M, Kohar Y
Ann Acad Med Singap 1996 Mar;25(2):222-7. PMID: 8799010

Clinical prediction guides

Impact of topical emollient, steroids alone or combined with calcipotriol, on the immune infiltrate and clinical outcome in psoriasis.
Heim M, Irondelle M, Duteil L, Cardot-Leccia N, Rocchi S, Passeron T, Tulic MK
Exp Dermatol 2022 Nov;31(11):1764-1778. Epub 2022 Aug 19 doi: 10.1111/exd.14657. PMID: 36054319Free PMC Article
Sweet's Syndrome: An Evidence-Based Report.
Bhat YJ, Hassan I, Sajad P, Akhtar S, Sheikh S
J Coll Physicians Surg Pak 2015 Jul;25(7):525-7. PMID: 26208558
Amicrobial pustulosis-like rash in a patient with Crohn's disease under anti-TNF-alpha blocker.
Lee HY, Pelivani N, Beltraminelli H, Hegyi I, Yawalkar N, Borradori L
Dermatology 2011;222(4):304-10. Epub 2011 Jul 15 doi: 10.1159/000329428. PMID: 21757882
Histiocytoid neutrophilic dermatoses and panniculitides: variations on a theme.
Chow S, Pasternak S, Green P, Tremaine R, Reardon M, Murray S, Northgrave S, Walsh N
Am J Dermatopathol 2007 Aug;29(4):334-41. doi: 10.1097/DAD.0b013e31811ec968. PMID: 17667165
Light and electron microscopic analysis of tattoos treated by Q-switched ruby laser.
Taylor CR, Anderson RR, Gange RW, Michaud NA, Flotte TJ
J Invest Dermatol 1991 Jul;97(1):131-6. doi: 10.1111/1523-1747.ep12478570. PMID: 2056183

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