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Abnormal lymphocyte proliferation

MedGen UID:
Concept ID:
Cell or Molecular Dysfunction
HPO: HP:0031378


Any abnormality in the multiplication or reproduction of lymphocytes, which results in the expansion of a cell population. [from HPO]

Conditions with this feature

Immunodeficiency 87 and autoimmunity
MedGen UID:
Concept ID:
Disease or Syndrome
Immunodeficiency-87 and autoimmunity (IMD87) is an autosomal recessive immunologic disorder with wide phenotypic variation and severity. Affected individuals usually present in infancy or early childhood with increased susceptibility to infections, often Epstein-Barr virus (EBV), as well as with lymphadenopathy or autoimmune manifestations, predominantly hemolytic anemia. Laboratory studies may show low or normal lymphocyte numbers, often with skewed T-cell subset ratios. The disorder results primarily from defects in T-cell function, which causes both immunodeficiency and overall immune dysregulation (summary by Serwas et al., 2019 and Fournier et al., 2021).

Professional guidelines


Albinger N, Pfeifer R, Nitsche M, Mertlitz S, Campe J, Stein K, Kreyenberg H, Schubert R, Quadflieg M, Schneider D, Kühn MWM, Penack O, Zhang C, Möker N, Ullrich E
Blood Cancer J 2022 Apr 13;12(4):61. doi: 10.1038/s41408-022-00660-2. PMID: 35418180Free PMC Article
Thenappan T, Ormiston ML, Ryan JJ, Archer SL
BMJ 2018 Mar 14;360:j5492. doi: 10.1136/bmj.j5492. PMID: 29540357Free PMC Article
Davis AS, Viera AJ, Mead MD
Am Fam Physician 2014 May 1;89(9):731-8. PMID: 24784336

Recent clinical studies


Shilkofski JA, Khan OA, Salib NK
J Endod 2020 Sep;46(9):1330-1336. Epub 2020 Jun 18 doi: 10.1016/j.joen.2020.06.010. PMID: 32565334


Shilkofski JA, Khan OA, Salib NK
J Endod 2020 Sep;46(9):1330-1336. Epub 2020 Jun 18 doi: 10.1016/j.joen.2020.06.010. PMID: 32565334
Arcas-García A, Garcia-Prat M, Magallón-Lorenz M, Martín-Nalda A, Drechsel O, Ossowski S, Alonso L, Rivière JG, Soler-Palacín P, Colobran R, Sayós J, Martínez-Gallo M, Franco-Jarava C
Clin Exp Immunol 2020 Apr;200(1):61-72. Epub 2020 Jan 19 doi: 10.1111/cei.13405. PMID: 31799703Free PMC Article
Mirandola P, Gobbi G, Masselli E, Micheloni C, Di Marcantonio D, Queirolo V, Chiodera P, Meschi T, Vitale M
J Immunol 2011 Nov 1;187(9):4721-32. Epub 2011 Sep 30 doi: 10.4049/jimmunol.1003258. PMID: 21964026
Waldmann TA
Dermatol Clin 1990 Oct;8(4):593-607. PMID: 2249353

Clinical prediction guides

Marriott SJ, Trinh D, Brady JN
Oncogene 1992 Sep;7(9):1749-55. PMID: 1501887

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